Constance Leonie Smith-Hicks

Director.Asst Professor

20002018
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Research Output 2000 2018

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Article
2018

A PIGH mutation leading to GPI deficiency is associated with developmental delay and autism

Nguyen, T. T. M., Mahida, S., Smith-Hicks, C. & Campeau, P. M. Jan 1 2018 (Accepted/In press) In : Human mutation.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Autistic Disorder
Mutation
Febrile Seizures
Muscle Hypotonia
Developmental Disabilities
Intellectual Disability
Epilepsy
Mutation

Monogenic disorders that mimic the phenotype of Rett syndrome

Srivastava, S., Desai, S., Cohen, J., Smith-Hicks, C., Barañano, K., Fatemi, A. & Naidu, S. B. Jan 10 2018 (Accepted/In press) In : Neurogenetics. p. 1-7 7 p.

Research output: Contribution to journalArticle

Rett Syndrome
Methyl-CpG-Binding Protein 2
Phenotype
Exome
Hand
2017

Evaluation of QTc in Rett syndrome: Correlation with age, severity, and genotype

Crosson, J., Srivastava, S., Bibat, G. M., Gupta, S., Kantipuly, A., Smith-Hicks, C., Myers, S. M., Sanyal, A., Yenokyan, G., Brenner, J. & Naidu, S. R. 2017 (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

Rett Syndrome
Genotype
Mutation
Electrocardiography
Sudden Death
Down Syndrome
Pyramidal Cells
Messenger RNA
Learning
Neurons
Vigabatrin
Infantile Spasms
Neuroimaging

Randomized open-label trial of dextromethorphan in Rett syndrome

Smith-Hicks, C. L., Gupta, S., Ewen, J. B., Hong, M., Kratz, L., Kelley, R., Tierney, E., Vaurio, R., Bibat, G., Sanyal, A., Yenokyan, G., Brereton, N., Johnston, M. V. & Naidu, S. Oct 17 2017 In : Neurology. 89, 16, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Dextromethorphan
Rett Syndrome
Seizures
Checklist
Electroencephalography
2013

GABAergic dysfunction in pediatric neuro-developmental disorders

Smith-Hicks, C. L. Dec 19 2013 In : Frontiers in Cellular Neuroscience. 7, DEC, 269

Research output: Contribution to journalArticle

Neuronal Plasticity
gamma-Aminobutyric Acid
Nervous System
Pediatrics
2011

Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

Alberi, L., Liu, S., Wang, Y., Badie, R., Smith-Hicks, C., Wu, J., Pierfelice, T. J., Abazyan, B., Mattson, M. P., Kuhl, D., Pletnikov, M., Worley, P. F. & Gaiano, N. Feb 10 2011 In : Neuron. 69, 3, p. 437-444 8 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Neurons
Learning
Long-Term Potentiation
Short-Term Memory
2010
Comorbidity
Stroke
Neurons
Epilepsy
Hippocampus

SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells

Smith-Hicks, C., Xiao, B., Deng, R., Ji, Y., Zhao, X., Shepherd, J. D., Posern, G., Kuhl, D., Huganir, R. L., Ginty, D. D., Worley, P. F. & Linden, D. J. Sep 2010 In : Nature Neuroscience. 13, 9, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cultured Cells
Bacterial Artificial Chromosomes
Depression
Transfection
2008

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

Park, S., Park, J. M., Kim, S., Kim, J. A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., Huganir, R. L., Linden, D. J. & Worley, P. F. Jul 10 2008 In : Neuron. 59, 1, p. 70-83 14 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Peptide Elongation Factor 2
Metabotropic Glutamate Receptors
Metabotropic Glutamate 5 Receptor
Calcium-Calmodulin-Dependent Protein Kinases
2007

A double blind randomized placebo control trial of levetiracetam in Tourette syndrome

Smith-Hicks, C. L., Bridges, D. D., Paynter, N. P. & Singer, H. S. Sep 15 2007 In : Movement disorders : official journal of the Movement Disorder Society. 22, 12, p. 1764-1770 7 p.

Research output: Contribution to journalArticle

etiracetam
Tics
Tourette Syndrome
Placebos
Random Allocation
2005

Case 9: pregnant? Who's pregnant? Memory loss in a young woman.

Smith-Hicks, C. 2005 In : MedGenMed Medscape General Medicine. 7, 2, p. 59 1 p.

Research output: Contribution to journalArticle

Memory Disorders
Demyelinating Diseases
Hypoglycemia
Pregnancy
2000

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

Smith-Hicks, C. L., Sizer, K. C., Powers, J. F., Tischler, A. S. & Costantini, F. Feb 15 2000 In : The EMBO journal. 19, 4, p. 612-622 11 p.

Research output: Contribution to journalArticle

Multiple Endocrine Neoplasia Type 2b
Ganglioneuroma
Pheochromocytoma
Hyperplasia
Proto-Oncogene Proteins c-ret