Clint T Allen

Associate Professor

20072020

Research output per year

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Research Output

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Article
2020
Open Access

Inhibition of MDSC trafficking with SX-682, a CXCR1/2 inhibitor, enhances NK-cell immunotherapy in head and neck cancer models

Greene, S., Robbins, Y., Mydlarz, W. K., Huynh, A. P., Schmitt, N. C., Friedman, J., Horn, L. A., Palena, C., Schlom, J., Maeda, D. Y., Zebala, J. A., Clavijo, P. E. & Allen, C., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1420-1431 12 p.

Research output: Contribution to journalArticle

Neoadjuvant PD-1 immune checkpoint blockade reverses functional immunodominance among tumor antigen–specific T cells

Friedman, J., Moore, E. C., Zolkind, P., Robbins, Y., Clavijo, P. E., Sun, L., Greene, S., Morisada, M. V., Mydlarz, W. K., Schmitt, N., Hodge, J. W., Schreiber, H., van Waes, C., Uppaluri, R. & Allen, C., Feb 1 2020, In : Clinical Cancer Research. 26, 3, p. 679-689 11 p.

Research output: Contribution to journalArticle

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations

Fabian, K. P., Padget, M. R., Donahue, R. N., Solocinski, K., Robbins, Y., Allen, C. T., Lee, J. H., Rabizadeh, S., Soon-Shiong, P., Schlom, J. & Hodge, J. W., May 20 2020, In : Journal for immunotherapy of cancer. 8, 1, e000450.

Research output: Contribution to journalArticle

Open Access

Tumor control via targeting pd-l1 with chimeric antigen receptor modified nk cells

Robbins, Y., Greene, S., Friedman, J., Clavijo, P. E., Van Waes, C., Fabian, K. P., Padget, M. R., Sater, H. A., Lee, J. H., Soon-Shiong, P., Gulley, J., Schlom, J., Hodge, J. W. & Allen, C. T., Jul 2020, In : eLife. 9, p. 1-18 18 p., e54854.

Research output: Contribution to journalArticle

Open Access
2019

Direct and antibody-dependent cell-mediated cytotoxicity of head and neck squamous cell carcinoma cells by high-affinity natural killer cells

Friedman, J., Padget, M., Lee, J., Schlom, J., Hodge, J. & Allen, C., Mar 2019, In : Oral Oncology. 90, p. 38-44 7 p.

Research output: Contribution to journalArticle

Dual antagonist of cIAP/XIAP ASTX660 sensitizes HPV- and HPV+ head and neck cancers to TNFα, TRAIL, and radiation therapy

Xiao, R., An, Y., Ye, W., Derakhshan, A., Cheng, H., Yang, X., Allen, C., Chen, Z., Schmitt, N. C. & Van Waes, C., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6463-6474 12 p.

Research output: Contribution to journalArticle

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

Patel, P., Sun, L., Robbins, Y., Clavijo, P. E., Friedman, J., Silvin, C., Van Waes, C., Cook, J., Mitchell, J. & Allen, C., Nov 2 2019, In : OncoImmunology. 8, 11, e1638207.

Research output: Contribution to journalArticle

Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

Nambiar, D. K., Aguilera, T., Cao, H., Kwok, S., Kong, C., Bloomstein, J., Wang, Z., Rangan, V. S., Jiang, D., Von Eyben, R., Liang, R., Agarwal, S., Dimitrios Colevas, A., Korman, A., Allen, C. T., Uppaluri, R., Koong, A. C., Giaccia, A. & Le, Q. T., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5553-5567 15 p.

Research output: Contribution to journalArticle

Open Access

Host immunity following near-infrared photoimmunotherapy is enhanced with PD-1 checkpoint blockade to eradicate established antigenic tumors

Nagaya, T., Friedman, J., Maruoka, Y., Ogata, F., Okuyama, S., Clavijo, P. E., Choyke, P. L., Allen, C. & Kobayashi, H., Mar 2019, In : Cancer Immunology Research. 7, 3, p. 401-413 13 p.

Research output: Contribution to journalArticle

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy

Sun, L., Clavijo, P. E., Robbins, Y., Patel, P., Friedman, J., Greene, S., Das, R., Silvin, C., Van Waes, C., Horn, L. A., Schlom, J., Palena, C., Maeda, D., Zebala, J. & Allen, C. T., 2019, In : JCI Insight. 4, 7, e126853.

Research output: Contribution to journalArticle

Open Access

Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

Allen, C. T., Lee, S., Norberg, S. M., Kovalovsky, D., Ye, H., Clavijo, P. E., Hu-Lieskovan, S., Schlegel, R., Schlom, J., Strauss, J., Gulley, J. L., Trepel, J. & Hinrichs, C. S., May 3 2019, In : Journal for immunotherapy of cancer. 7, 1, 119.

Research output: Contribution to journalArticle

Open Access

Semaphorin4D inhibition improves response to immune-checkpoint blockade via attenuation of MDSC recruitment and function

Clavijo, P. E., Friedman, J., Robbins, Y., Moore, E. C., Smith, E., Zauderer, M., Evans, E. E. & Allen, C. T., Feb 2019, In : Cancer Immunology Research. 7, 2, p. 282-291 10 p.

Research output: Contribution to journalArticle

Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy

Warner, B. M., Baer, A. N., Lipson, E. J., Allen, C., Hinrichs, C., Rajan, A., Pelayo, E., Beach, M., Gulley, J. L., Madan, R. A., Feliciano, J., Grisius, M., Long, L., Powers, A., Kleiner, D. E., Cappelli, L. & Alevizos, I., Sep 1 2019, In : Oncologist. 24, 9, p. 1259-1269 11 p.

Research output: Contribution to journalArticle

2018

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

Xiao, R., Allen, C. T., Tran, L., Patel, P., Park, S. J., Chen, Z., Van Waes, C. & Schmitt, N., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Cancer immunogenomic approach to neoantigen discovery in a checkpoint blockade responsive murine model of oral cavity squamous cell carcinoma

Zolkind, P., Przybylski, D., Marjanovic, N., Nguyen, L., Lin, T., Johanns, T., Alexandrov, A., Zhou, L., Allen, C. T., Miceli, A. P., Schreiber, R. D., Artyomov, M., Dunn, G. P. & Uppaluri, R., 2018, In : Oncotarget. 9, 3, p. 4109-4119 11 p.

Research output: Contribution to journalArticle

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types

Hicks, K. C., Fantini, M., Donahue, R. N., Schwab, A., Knudson, K. M., Tritsch, S. R., Jochems, C., Clavijo, P. E., Allen, C. T., Hodge, J. W., Tsang, K. Y., Schlom, J. & Gameiro, S. R., Nov 2 2018, In : OncoImmunology. 7, 11, e1466018.

Research output: Contribution to journalArticle

Exploring the rationale for combining ionizing radiation and immune checkpoint blockade in head and neck cancer

Morisada, M., Chamberlin, M. & Allen, C. T., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Friedman, J., Morisada, M., Sun, L., Moore, E. C., Padget, M., Hodge, J. W., Schlom, J., Gameiro, S. R. & Allen, C. T., Jun 21 2018, In : Journal for immunotherapy of cancer. 6, 1, 59.

Research output: Contribution to journalArticle

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

Moore, E. C., Sun, L., Clavijo, P. E., Friedman, J., Harford, J. B., Saleh, A. D., Van Waes, C., Chang, E. H. & Allen, C. T., Apr 27 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis

Ahn, J., Bishop, J. A., Roden, R. B. S., Allen, C. T. & Best, S. R. A., Jan 2018, In : Laryngoscope. 128, 1, p. E27-E32

Research output: Contribution to journalArticle

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

Sun, L., Moore, E., Berman, R., Clavijo, P. E., Saleh, A., Chen, Z., Van Waes, C., Davies, J., Friedman, J. & Allen, C. T., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

2017

Anti-PD-L1 efficacy can be enhanced by inhibition of myeloid-derived suppressor cells with a selective inhibitor of PI3Kd/g

Davis, R. J., Moore, E. C., Clavijo, P. E., Friedman, J., Cash, H., Chen, Z., Silvin, C., Van Waes, C. & Allen, C. T., May 15 2017, In : Cancer Research. 77, 10, p. 2607-2619 13 p.

Research output: Contribution to journalArticle

Cisplatin alters antitumor immunity and synergizes with PD-1/PD-L1 inhibition in head and neck squamous cell carcinoma

Tran, L., Allen, C. T., Xiao, R., Moore, E., Davis, R., Park, S. J., Spielbauer, K., Van Waes, C. & Schmitt, N. C., Dec 2017, In : Cancer Immunology Research. 5, 12, p. 1141-1151 11 p.

Research output: Contribution to journalArticle

Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer

Morisada, M., Moore, E. C., Hodge, R., Friedman, J., Cash, H. A., Hodge, J. W., Mitchell, J. B. & Allen, C. T., Aug 1 2017, In : Oral Oncology. 71, p. 87-94 8 p.

Research output: Contribution to journalArticle

Induction of tumor regression by intratumoral STING agonists combined with anti–programmed death-L1 blocking antibody in a preclinical squamous cell carcinoma model

Gadkaree, S. K., Fu, J., Sen, R., Korrer, M. J., Allen, C. T. & Kim, Y. J., Jun 1 2017, In : Head and Neck. 39, 6, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

Laryngotracheal Stenosis: Risk Factors for Tracheostomy Dependence and Dilation Interval

Gadkaree, S. K., Pandian, V., Best, S., Motz, K. M., Allen, C., Kim, Y., Akst, L. & Hillel, A. T., Feb 1 2017, In : Otolaryngology - Head and Neck Surgery (United States). 156, 2, p. 321-328 8 p.

Research output: Contribution to journalArticle

Murray secretion scale and fiberoptic endoscopic evaluation of swallowing in predicting aspiration in dysphagic patients

Kuo, C. W., Allen, C. T., Huang, C. C. & Lee, C. J., Jun 1 2017, In : European Archives of Oto-Rhino-Laryngology. 274, 6, p. 2513-2519 7 p.

Research output: Contribution to journalArticle

Office-based vs traditional operating room management of recurrent respiratory papillomatosis impact of patient characteristics and disease severity

Tatar, E. Ç., Kupfer, R. A., Barry, J. Y., Allen, C. T. & Merati, A. L., Jan 1 2017, In : JAMA Otolaryngology - Head and Neck Surgery. 143, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

Morisada, M., Clavijo, P. E., Moore, E., Sun, L., Chamberlin, M., Van Waes, C., Hodge, J. W., Mitchell, J. B., Friedman, J. & Allen, C. T., Nov 21 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

Clavijo, P. E., Moore, E. C., Chen, J., Davis, R. J., Friedman, J., Kim, Y., Van Waes, C., Chen, Z. & Allen, C. T., Jan 1 2017, In : Oncotarget. 8, 34, p. 55804-55820 17 p.

Research output: Contribution to journalArticle

Syngeneic mouse models of oral cancer are effectively targetedbyanti-cd44-basedNIR-PIT

Nagaya, T., Nakamura, Y., Okuyama, S., Ogata, F., Maruoka, Y., Choyke, P. L., Allen, C. & Kobayashi, H., Dec 2017, In : Molecular Cancer Research. 15, 12, p. 1667-1677 11 p.

Research output: Contribution to journalArticle

2016

Anatomic Derkay Score Is Associated with Voice Handicap in Laryngeal Papillomatosis in Adults

Kupfer, R. A., Çadalli Tatar, E., Barry, J. O., Allen, C. T. & Merati, A. L., 2016, In : Otolaryngology - Head and Neck Surgery (United States). 154, 4, p. 689-692 4 p.

Research output: Contribution to journalArticle

Enhanced tumor control with combination mtor and pd-l1 inhibition in syngeneic oral cavity cancers

Moore, E. C., Cash, H. A., Caruso, A. M., Uppaluri, R., Hodge, J. W., Van Waes, C. & Allen, C. T., Jul 1 2016, In : Cancer immunology research. 4, 7, p. 611-620 10 p.

Research output: Contribution to journalArticle

Established T cell-inflamed tumors rejected after adaptive resistance was reversed by combination STING activation and PD-1 pathway blockade

Moore, E., Clavijo, P. E., Davis, R., Cash, H., Van Waes, C., Kim, Y. & Allen, C., Dec 2016, In : Cancer Immunology Research. 4, 12, p. 1061-1071 11 p.

Research output: Contribution to journalArticle

Evaluating the utility of serological testing in laryngotracheal stenosis

Hall, S. R., Allen, C. T., Merati, A. L. & Mayerhoff, R. M., 2016, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer

Davis, R. J., Van Waes, C. & Allen, C. T., Jan 15 2016, (Accepted/In press) In : Oral Oncology.

Research output: Contribution to journalArticle

Pools of programmed death-ligand within the oral cavity tumor microenvironment: Variable alteration by targeted therapies

Shah, S., Caruso, A., Cash, H., Waes, C. V. & Allen, C. T., Aug 1 2016, In : Head and Neck. 38, 8, p. 1176-1186 11 p.

Research output: Contribution to journalArticle

2015

Immunohistochemical analysis of NF-κB in human tumor tissue

Allen, C. T. & van Waes, C., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 459-468 10 p.

Research output: Contribution to journalArticle

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

Cash, H., Shah, S., Moore, E., Caruso, A., Uppaluri, R., Van Waes, C. & Allen, C., 2015, In : Oncotarget. 6, 34, p. 36400-36417 18 p.

Research output: Contribution to journalArticle

Tracheal mass

Purcell, P., Meyer, T. & Allen, C., Mar 1 2015, In : JAMA Otolaryngology - Head and Neck Surgery. 141, 3, p. 291-292 2 p.

Research output: Contribution to journalArticle

2014

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

Nottingham, L. K., Yan, C. H., Yang, X., Si, H., Coupar, J., Bian, Y., Cheng, T. F., Allen, C., Arun, P., Gius, D., Dang, L., Van Waes, C. & Chen, Z., Feb 27 2014, In : Oncogene. 33, 9, p. 1135-1147 13 p.

Research output: Contribution to journalArticle

Risk stratification in endoscopic airway surgery: Is inpatient observation necessary?

Allen, C. T., Lee, C. J., Meyer, T. K., Hillel, A. D. & Merati, A. L., Nov 1 2014, In : American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 35, 6, p. 747-752 6 p.

Research output: Contribution to journalArticle

2013

Endoscopic keel placement to treat and prevent anterior glottic webs

Paniello, R. C., Desai, S. C., Allen, C. T. & Khosla, S. M., Nov 2013, In : Annals of Otology, Rhinology and Laryngology. 122, 11, p. 672-678 7 p.

Research output: Contribution to journalArticle

Oral hairy leukoplakia in an HIV- negative patient

Graboyes, E. M., Allen, C. T., Chernock, R. D. & Diaz, J. A., Jun 2013, In : Ear, Nose and Throat Journal. 92, 6, E12.

Research output: Contribution to journalArticle

Prevalence of diabetes mellitus and its impact on disease severity in adult recurrent respiratory papillomatosis

Lee, C. J., Allen, C. T. & Merati, A. L., Oct 1 2013, In : Otolaryngology - Head and Neck Surgery (United States). 149, 4, p. 603-607 5 p.

Research output: Contribution to journalArticle

2012

Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer

Judd, N. P., Allen, C. T., Winkler, A. E. & Uppaluri, R., Sep 2012, In : Otolaryngology - Head and Neck Surgery (United States). 147, 3, p. 493-500 8 p.

Research output: Contribution to journalArticle

2011

Pathology quiz case 1: Diagnosis

Desai, S. C., Allen, C., Chernock, R. & Haughey, B., May 1 2011, In : Archives of Otolaryngology - Head and Neck Surgery. 137, 5, p. 526+528

Research output: Contribution to journalArticle

TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer

Lu, H., Yang, X., Duggal, P., Allen, C. T., Yan, B., Cohen, J., Nottingham, L., Romano, R. A., Sinha, S., King, K. E., Weinberg, W. C., Chen, Z. & Van Waes, C., Nov 1 2011, In : Cancer Research. 71, 21, p. 6867-6877 11 p.

Research output: Contribution to journalArticle

ΔNp63 versatilely regulates a broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation

Yang, X., Lu, H., Yan, B., Romano, R. A., Bian, Y., Friedman, J., Duggal, P., Allen, C., Chuang, R., Ehsanian, R., Si, H., Sinha, S., Van Waes, C. & Chen, Z., May 15 2011, In : Cancer Research. 71, 10, p. 3688-3700 13 p.

Research output: Contribution to journalArticle