Chunhong Liu

Research Associate

20102018
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Research Output 2010 2018

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Article
2018

Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors

Liu, C., Yu, T., Xing, Z., Jiang, X., Li, Y., Pao, A., Mu, J., Wallace, P. K., Stoica, G., Bakin, A. V. & Yu, Y. E., Jan 1 2018, In : Oncotarget. 9, 4, p. 4773-4786 14 p.

Research output: Contribution to journalArticle

Megakaryocyte-Erythroid Progenitor Cells
Chromosomes, Human, Pair 21
Granulocyte-Macrophage Progenitor Cells
Human Chromosomes
Down Syndrome
2017

Structural variants caused by Alu insertions are associated with risks for many human diseases

Payer, L. M., Steranka, J. P., Yang, W. R., Kryatova, M., Medabalimi, S., Ardeljan, D., Liu, C., Boeke, J. D., Avramopoulos, D. & Burns, K., May 16 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 20, p. E3984-E3992

Research output: Contribution to journalArticle

Alu Elements
Inborn Genetic Diseases
Genome-Wide Association Study
DNA
Single Nucleotide Polymorphism
2015

Genetic dissection of the Down syndrome critical region

Jiang, X., Liu, C., Yu, T., Zhang, L., Meng, K., Xing, Z., Belichenko, P. V., Kleschevnikov, A. M., Pao, A., Peresie, J., Wie, S., Mobley, W. C. & Yu, Y. E., 2015, In : Human Molecular Genetics. 24, 22, p. 6540-6551 12 p.

Research output: Contribution to journalArticle

Dissection
Down Syndrome
Chromosomes, Human, Pair 21
Human Chromosomes
Chromosome Disorders

Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models

Mendioroz, M., Do, C., Jiang, X., Liu, C., Darbary, H. K., Lang, C. F., Lin, J., Thomas, A., Abu-Amero, S., Stanier, P., Temkin, A., Yale, A., Liu, M. M., Li, Y., Salas, M., Kerkel, K., Capone, G. T., Silverman, W. P., Yu, Y. E., Moore, G. & 2 others, Wegiel, J. & Tycko, B., Nov 25 2015, In : Genome Biology. 16, 1, 263.

Research output: Contribution to journalArticle

Down syndrome
aneuploidy
methylation
Aneuploidy
DNA methylation
2014

Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice

Liu, C., Morishima, M., Jiang, X., Yu, T., Meng, K., Ray, D., Pao, A., Ye, P., Parmacek, M. S. & Yu, Y. E., 2014, In : Human Genetics. 133, 6, p. 743-753 11 p.

Research output: Contribution to journalArticle

Down Syndrome
Chromosomes
Cardiovascular Abnormalities
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 21

Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT

Koochekpour, S., Willard, S. S., Shourideh, M., Ali, S., Liu, C., Azabdaftari, G., Saleem, M. & Attwood, K., Jul 26 2014, In : International Journal of Biological Sciences. 10, 8, p. 834-845 12 p.

Research output: Contribution to journalArticle

African American
prostatic neoplasms
African Americans
cancer
Prostatic Neoplasms

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of down syndrome-related developmental cognitive deficits

Zhang, L., Meng, K., Jiang, X., Liu, C., Pao, A., Belichenko, P. V., Kleschevnikov, A. M., Josselyn, S., Liang, P., Ye, P., Mobley, W. C. & Yu, Y. E., Feb 2014, In : Human Molecular Genetics. 23, 3, p. 578-589 12 p., ddt446.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 17
Human Chromosomes
Down Syndrome
Long-Term Potentiation
2012

Genetic analysis of Down syndrome facilitated by mouse chromosome engineering

Zhang, L., Fu, D., Belichenko, P. V., Liu, C., Kleschevnikov, A. M., Pao, A., Liang, P., Clapcote, S. J., Mobley, W. C. & Yu, Y. E., Jan 2012, In : Bioengineered Bugs. 3, 1, p. 8-12 5 p.

Research output: Contribution to journalArticle

Chromosomes
Down Syndrome
Genes
Medical Genetics
Conservation
2011

Erratum: Genetic analysis of Down syndrome-associated heart defects in mice (Human Genetics DOI: 10.1007/s00439-011-0980-2)

Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In : Human Genetics. 130, 5, p. 633 1 p.

Research output: Contribution to journalArticle

Medical Genetics
Down Syndrome

Genetic analysis of Down syndrome-associated heart defects in mice

Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In : Human Genetics. 130, 5, p. 623-632 10 p.

Research output: Contribution to journalArticle

Down Syndrome
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 10
Human Chromosomes
Embryonic Structures

MICER targeting vectors for manipulating the mouse genome.

Liu, C., Szurek, P. F. & Yu, Y. E., 2011, In : Methods in molecular biology (Clifton, N.J.). 693, p. 245-256 12 p.

Research output: Contribution to journalArticle

Genome
Gene Targeting
Chromosomes
Insertional Mutagenesis
Human Development

Mouse models for down syndrome-associated developmental cognitive disabilities

Liu, C., Belichenko, P. V., Zhang, L., Fu, D., Kleschevnikov, A. M., Baldini, A., Antonarakis, S. E., Mobley, W. C. & Yu, Y. E., Nov 2011, In : Developmental Neuroscience. 33, 5, p. 404-413 10 p.

Research output: Contribution to journalArticle

Developmental Disabilities
Down Syndrome
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 10
Human Chromosomes
2010

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

Yu, T., Li, Z., Jia, Z., Clapcote, S. J., Liu, C., Li, S., Asrar, S., Pao, A., Chen, R., Fan, N., Carattini-Rivera, S., Bechard, A. R., Spring, S., Henkelman, R. M., Stoica, G., Matsui, S. I., Nowak, N. J., Roder, J. C., Chen, C., Bradley, A. & 1 others, Yu, Y. E., May 4 2010, In : Human Molecular Genetics. 19, 14, p. 2780-2791 12 p., ddq179.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Human Chromosomes
Down Syndrome
Developmental Disabilities
Phenotype

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice

Yu, T., Clapcote, S. J., Li, Z., Liu, C., Pao, A., Bechard, A. R., Carattini-Rivera, S., Matsui, S. I., Roder, J. C., Baldini, A., Mobley, W. C., Bradley, A. & Yu, Y. E., Jun 2010, In : Mammalian Genome. 21, 5-6, p. 258-267 10 p.

Research output: Contribution to journalArticle

Chromosome Deletion
Intellectual Disability
Chromosome Disorders
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 10

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

Yu, T., Liu, C., Belichenko, P., Clapcote, S. J., Li, S., Pao, A., Kleschevnikov, A., Bechard, A. R., Asrar, S., Chen, R., Fan, N., Zhou, Z., Jia, Z., Chen, C., Roder, J. C., Liu, B., Baldini, A., Mobley, W. C. & Yu, Y. E., 2010, In : Brain Research. 1366, p. 162-171 10 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Long-Term Potentiation
Trisomy
Human Chromosomes
Down Syndrome