Chulan Kwon

Associate Professor

20042019
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Research Output 2004 2019

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Article
2019

In vitro generation of heart field-specific cardiac progenitor cells

Tampakakis, E., Miyamoto, M. & Kwon, C., Jul 1 2019, In : Journal of Visualized Experiments. 2019, 149, e59826.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Stem Cells
Heart Diseases
Organoids
Open Access
Induced Pluripotent Stem Cells
Neurons
Brain
Prosencephalon
Organoids

Regulation of cardiomyocyte maturation during critical perinatal window

Kannan, S. & Kwon, C., Jan 1 2019, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Cardiac Myocytes
Pluripotent Stem Cells
Biological Phenomena
Transcription Factors
Technology
2018

Precardiac organoids form two heart fields via Bmp/Wnt signaling

Andersen, P., Tampakakis, E., Jimenez, D. V., Kannan, S., Miyamoto, M., Shin, H. K., Saberi, A., Murphy, S., Sulistio, E., Chelko, S. & Kwon, C., Dec 1 2018, In : Nature Communications. 9, 1, 3140.

Research output: Contribution to journalArticle

Organoids
cells
Pluripotent Stem Cells
stem cells
Stem cells

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y. W., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. & 3 others, Nishizono, H., Fukuda, K. & Ieda, M., Sep 6 2018, In : Cell Stem Cell. 23, 3, p. 382-395 14 p.

Research output: Contribution to journalArticle

Somites
Pluripotent Stem Cells
Mesoderm
Clustered Regularly Interspaced Short Palindromic Repeats
Germ Layers

β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance

Gibbs, B. C., Shenje, L., Andersen, P., Miyamoto, M. & Kwon, C., Jan 1 2018, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Integrins
Maintenance
Stem cells
Stem Cells
Multipotent Stem Cells
2017

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Cardiomyopathies
Cardiac Myocytes
Transplantation
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Rats
Stem Cells
2016

Sall1 transiently marks undifferentiated heart precursors and regulates their fate

Morita, Y., Andersen, P., Hotta, A., Tsukahara, Y., Sasagawa, N., Hayashida, N., Koga, C., Nishikawa, M., Saga, Y., Evans, S. M., Koshiba-Takeuchi, K., Nishinakamura, R., Yoshida, Y., Kwon, C. & Takeuchi, J. K., Mar 1 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 158-162 5 p.

Research output: Contribution to journalArticle

Stem Cells
Heart Ventricles
Genes
Regenerative Medicine
Mesoderm
2015

Coins of the realm in atrioventricular junction development

Kwon, C. & Tomaselli, G. F., 2015, In : Circulation Research. 116, 3, p. 386-388 3 p.

Research output: Contribution to journalArticle

Heart Conduction System
Tricuspid Atresia
Wolff-Parkinson-White Syndrome
Numismatics
Wnt Signaling Pathway

Ex vivo culture of pharyngeal arches to study heart and muscle progenitors and their niche

Andersen, P. & Kwon, C., Jul 20 2015, In : Journal of Visualized Experiments. 2015, 101, p. 1-4 4 p., e52876.

Research output: Contribution to journalArticle

Branchial Region
Arches
Muscle
Myocardium
Head

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

Oh, Y., Cho, G. S., Li, Z., Hong, I., Kwon, C., Lee, G., Kim, Y. J., Tampakakis, E., Tung, L., Huganir, R., Dong, X., Kwon, C. & Lee, G., Jul 31 2015, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Myocardium
Neurons
Cardiac Myocytes
Optogenetics

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In : Nature. 519, 7544, p. 472-476 5 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Type 5 Cyclic Nucleotide Phosphodiesterases
Heart Diseases
Nitric Oxide

Transcriptional Landscape of Cardiomyocyte Maturation

Uosaki, H., Cahan, P., Lee, D., Wang, S., Miyamoto, M., Fernandez, L., Kass, D. A. & Kwon, C., Nov 24 2015, In : Cell Reports. 13, 8, p. 1705-1716 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Genes
Gene expression
Gene Regulatory Networks
Cardiology
2014

Mutations in Alström protein impair terminal differentiation of cardiomyocytes

Shenje, L. T., Andersen, P., Halushka, M. K., Lui, C., Fernandez, L., Collin, G. B., Amat-Alarcon, N., Meschino, W., Cutz, E., Chang, K., Yonescu, R., Batista, D., Chen, Y., Chelko, S., Crosson, J., Scheel, J., Vricella, L., Craig, B. D., Marosy, B. A., Mohr, D. W. & 8 others, Hetrick, K. N., Romm, J. M., Scott, A. F., Valle, D., Naggert, J. K., Kwon, C., Doheny, K. & Judge, D. P., Mar 4 2014, In : Nature Communications. 5, 3416.

Research output: Contribution to journalArticle

mutations
Cardiac Myocytes
Cells
proteins
cell division

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

Shenje, L. T., Andersen, P., Uosaki, H., Fernandez, L., Rainer, P. P., Cho, G. S., Lee, D., Zhong, W., Harvey, R. P., Kass, D. A. & Kwon, C., 2014, In : eLife. 3, p. e02164

Research output: Contribution to journalArticle

Intrinsic Factor
Arches
Stem Cells
Branchial Region
Mosaicism

Regenerative medicine for the heart: Perspectives on stem-cell therapy

Cho, G. S., Fernandez, L. & Kwon, C., Nov 10 2014, In : Antioxidants and Redox Signaling. 21, 14, p. 2018-2031 14 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Cardiac Myocytes
2013

Fibronectin mediates mesendodermal cell fate decisions

Cheng, P., Andersen, P., Hassel, D., Kaynak, B. L., Limphong, P., Juergensen, L., Kwon, C. & Srivastava, D., Jun 2013, In : Journal of Cell Science. 126, 12, p. 2587-2596 10 p.

Research output: Contribution to journalArticle

Mesoderm
Fibronectins
Endoderm
Zebrafish
Integrins

Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells

Uosaki, H., Magadum, A., Seo, K., Fukushima, H., Takeuchi, A., Nakagawa, Y., Moyes, K. W., Narazaki, G., Kuwahara, K., Laflamme, M., Matsuoka, S., Nakatsuji, N., Nakao, K., Kwon, C., Kass, D. A., Engel, F. B. & Yamashita, J. K., Dec 2013, In : Circulation: Cardiovascular Genetics. 6, 6, p. 624-633 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Cardiac Myocytes
Glycogen Synthase Kinase 3
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Extracellular Signal-Regulated MAP Kinases
2012

Direct Contact with Endoderm-Like Cells Efficiently Induces Cardiac Progenitors from Mouse and Human Pluripotent Stem Cells

Uosaki, H., Andersen, P., Shenje, L. T., Fernandez, L., Christiansen, S. L. & Kwon, C., Oct 2 2012, In : PLoS One. 7, 10, e46413.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Endoderm
direct contact
Stem cells
stem cells

Non-canonical Notch signaling: Emerging role and mechanism

Andersen, P., Uosaki, H., Shenje, L. T. & Kwon, C., May 2012, In : Trends in Cell Biology. 22, 5, p. 257-265 9 p.

Research output: Contribution to journalArticle

Ligands
Catenins
Developmental Biology
Diptera
Cell Biology
2011

A Genome-Wide Screen Reveals a Role for microRNA-1 in Modulating Cardiac Cell Polarity

King, I. N., Qian, L., Liang, J., Huang, Y., Shieh, J. T. C., Kwon, C. & Srivastava, D., Apr 19 2011, In : Developmental Cell. 20, 4, p. 497-510 14 p.

Research output: Contribution to journalArticle

Cell Polarity
Gene Dosage
MicroRNAs
Drosophila
Genes

Epigenetic factors and cardiac development

Van Weerd, J. H., Koshiba-Takeuchi, K., Kwon, C. & Takeuchi, J. K., Jul 15 2011, In : Cardiovascular Research. 91, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

Epigenomics
Chromatin Assembly and Disassembly
Congenital Heart Defects
Gene Regulatory Networks
Cardiology

Notch post-translationally regulates β-catenin protein in stem and progenitor cells

Kwon, C., Cheng, P., King, I. N., Andersen, P., Shenje, L., Nigam, V. & Srivastava, D., Oct 2011, In : Nature Cell Biology. 13, 10, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

Catenins
Stem Cells
Glycogen Synthase Kinase 3
Membranes
Neoplastic Stem Cells
2009

A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate

Kwon, C., Qian, L., Cheng, P., Nigam, V., Arnold, J. & Srivastava, D., 2009, In : Nature Cell Biology. 11, 8, p. 951-957 7 p.

Research output: Contribution to journalArticle

Catenins
Stem Cells
Cardiac Myocytes
Smooth Muscle Myocytes
Endothelial Cells
2008

Wnt/β-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis

Kwon, C., Cordes, K. R. & Srivastava, D., Dec 15 2008, In : Cell cycle (Georgetown, Tex.). 7, 24, p. 3815-3818 4 p.

Research output: Contribution to journalArticle

Catenins
Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Cause of Death
Heart Diseases
2007

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors

Kwon, C., Arnold, J., Hsiao, E. C., Taketo, M. M., Conklin, B. R. & Srivastava, D., Jun 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 10894-10899 6 p.

Research output: Contribution to journalArticle

Catenins
Stem Cells
Wnt Signaling Pathway
Mesoderm
Embryonic Stem Cells
2005

MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling

Kwon, C., Han, Z., Olson, E. N. & Srivastava, D., Dec 27 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 52, p. 18986-18991 6 p.

Research output: Contribution to journalArticle

Drosophila
Stem Cells
MicroRNAs
Cell Differentiation
Asymmetric Cell Division
2004

Opposing inputs by Hedgehog and brinker define a stripe of hairy expression in the Drosophila leg imaginal disc

Kwon, C., Hays, R., Fetting, J. & Orenic, T. V., Jun 2004, In : Development. 131, 11, p. 2681-2692 12 p.

Research output: Contribution to journalArticle

Imaginal Discs
Hedgehogs
Drosophila
Leg
Genes