Christopher M Heaphy

Assistant Professor

20022020

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Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression

Garcia-Rizo, C., Fernandez-Egea, E., Miller, B. J., Oliveira, C., Justicia, A., Griffith, J. K., Heaphy, C. M., Bernardo, M. & Kirkpatrick, B., Feb 1 2013, In : Brain, Behavior, and Immunity. 28, p. 49-53 5 p.

Research output: Contribution to journalArticle

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia

Rodriguez, F. J., Brosnan-Cashman, J. A., Allen, S. J., Vizcaino, M. A., Giannini, C., Camelo-Piragua, S., Webb, M., Matsushita, M., Wadhwani, N., Tabbarah, A., Hamideh, D., Jiang, L., Chen, L., Arvanitis, L. D., Alnajar, H. H., Barber, J. R., Rodríguez-Velasco, A., Orr, B. & Heaphy, C. M., Jan 2019, In : Brain Pathology. 29, 1, p. 126-140 15 p.

Research output: Contribution to journalArticle

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas

Hackeng, W. M., Schelhaas, W., Morsink, F. H. M., Heidsma, C. M., van Eeden, S., Valk, G. D., Vriens, M. R., Heaphy, C. M., Nieveen van Dijkum, E. J. M., Offerhaus, G. J. A., Dreijerink, K. M. A. & Brosens, L. A. A., Jun 1 2020, In : Endocrine Pathology. 31, 2, p. 108-118 11 p.

Research output: Contribution to journalArticle

Open Access

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases

Dogeas, E., Karagkounis, G., Heaphy, C. M., Hirose, K., Pawlik, T. M., Wolfgang, C. L., Meeker, A., Hruban, R. H., Cameron, J. L. & Choti, M. A., Apr 2014, In : Journal of the American College of Surgeons. 218, 4, p. 628-635 8 p.

Research output: Contribution to journalArticle

A novel loss-of-function mutation in TP53 in an endometrial cancer cell line and uterine papillary serous carcinoma model

Liu, Z., Wan, G., Heaphy, C., Bisoffi, M., Griffith, J. K. & Hu, C. A. A., Mar 1 2007, In : Molecular and Cellular Biochemistry. 297, 1-2, p. 179-187 9 p.

Research output: Contribution to journalArticle

Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration

Hackeng, W. M., Morsink, F. H. M., Moons, L. M. G., Heaphy, C. M., Offerhaus, G. J. A., Dreijerink, K. M. A. & Brosens, L. A. A., Apr 1 2020, In : Diagnostic cytopathology. 48, 4, p. 308-315 8 p.

Research output: Contribution to journalArticle

Open Access

Assessment of the frequency of allelic imbalance in human tissue using a multiplex polymerase chain reaction system

Heaphy, C. M., Hines, W. C., Butler, K. S., Haaland, C. M., Heywood, G., Fischer, E. G., Bisoffi, M. & Griffith, J. K., Apr 2007, In : Journal of Molecular Diagnostics. 9, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Association between cancer-free survival and telomere DNA content in prostate tumors

Fordyce, C. A., Heaphy, C. M., Joste, N. E., Smith, A. Y., Hunt, W. C. & Griffith, J. K., Feb 2005, In : Journal of Urology. 173, 2, p. 610-614 5 p.

Research output: Contribution to journalArticle

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation

Martínez, H., Nagurney, M., Wang, Z. X., Eberhart, C. G., Heaphy, C. M., Curtis, M. T. & Rodriguez, F. J., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 8, p. 703-708 6 p.

Research output: Contribution to journalArticle

Open Access

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 2019, In : Brain Pathology. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access

Chemiluminescent measurement of telomere DNA content in biopsies

Fordyce, C. A., Heaphy, C. M. & Griffith, J. K., Jan 1 2002, In : BioTechniques. 33, 1, p. 144-148 5 p.

Research output: Contribution to journalArticle

Open Access

Chromophobe hepatocellular carcinoma with abrupt anaplasia: A proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features

Wood, L. D., Heaphy, C. M., Daniel, H. D. J., Naini, B. V., Lassman, C. R., Arroyo, M. R., Kamel, I. R., Cosgrove, D. P., Boitnott, J. K., Meeker, A. K. & Torbenson, M. S., Dec 1 2013, In : Modern Pathology. 26, 12, p. 1586-1593 8 p.

Research output: Contribution to journalArticle

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer

Julin, B., Shui, I., Heaphy, C. M., Joshu, C. E., Meeker, A. K., Giovannucci, E., De Vivo, I. & Platz, E. A., Feb 17 2015, In : British journal of cancer. 112, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle

Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas

Butler, K. S., Hines, W. C., Heaphy, C. M. & Griffith, J. K., Oct 2012, In : Cancer medicine. 1, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Open Access

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Feb 15 2018, In : Prostate. 78, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization

Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K. & Bisoffi, M., Sep 21 2009, In : International journal of oncology. 35, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

Cejas, P., Drier, Y., Dreijerink, K. M. A., Brosens, L. A. A., Deshpande, V., Epstein, C. B., Conemans, E. B., Morsink, F. H. M., Graham, M. K., Valk, G. D., Vriens, M. R., Castillo, C. F. D., Ferrone, C. R., Adar, T., Bowden, M., Whitton, H. J., Da Silva, A., Font-Tello, A., Long, H. W., Gaskell, E. & 7 others, Shoresh, N., Heaphy, C. M., Sicinska, E., Kulke, M. H., Chung, D. C., Bernstein, B. E. & Shivdasani, R. A., Aug 1 2019, In : Nature medicine. 25, 8, p. 1264-1269 6 p.

Research output: Contribution to journalArticle

Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas

Rodriguez, F. J., Vizcaino, M. A., Blakeley, J. & Heaphy, C. M., Sep 20 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-3 3 p.

Research output: Contribution to journalArticle

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

Jiao, Y., Killela, P. J., Reitman, Z. J., Rasheed, B. A., Heaphy, C. M., de Wilde, R. F., Rodriguez, F. J., Rosemberg, S., Oba-Shinjo, S. M., Marie, S. K. N., Bettegowda, C., Agrawal, N., Lipp, E., Pirozzi, C. J., Lopez, G. Y., He, Y., Friedman, H. S., Friedman, A. H., Riggins, G. J., Holdhoff, M. & 9 others, Burger, P., McLendon, R. E., Bigner, D. D., Vogelstein, B., Meeker, A. K., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Yan, H., Jul 2012, In : Oncotarget. 3, 7, p. 709-722 14 p.

Research output: Contribution to journalArticle

Open Access

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Cochran, R. L., Cidado, J., Kim, M., Zabransky, D. J., Croessmann, S., Chu, D., Wong, H. Y., Beaver, J. A., Cravero, K., Erlanger, B., Parsons, H., Heaphy, C. M., Meeker, A. K., Lauring, J. & Park, B. H., Jan 1 2015, In : Oncotarget. 6, 28, p. 25240-25251 12 p.

Research output: Contribution to journalArticle

Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

Graham, M. K., Kim, J., Da, J., Brosnan-Cashman, J. A., Rizzo, A., Del Valle, J. A. B., Chia, L., Rubenstein, M., Davis, C., Zheng, Q., Cope, L., Considine, M., Haffner, M., De Marzo, A. M., Meeker, A. K. & Heaphy, C. M., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2480-2491 12 p.

Research output: Contribution to journalArticle

Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas

Felsenstein, M., Trujillo, M. A., Huang, B., Nanda, N., Jiang, Z., Jeong, Y. J., Pflüger, M., Goggins, M. G., Hruban, R. H., Thompson, E. D., Heaphy, C. M., Roberts, N. J. & Wood, L. D., Jul 1 2020, In : Laboratory Investigation. 100, 7, p. 1003-1013 11 p.

Research output: Contribution to journalArticle

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups with Differing Risks of Liver Metastases

Pea, A., Yu, J., Marchionni, L., Noe, M., Luchini, C., Pulvirenti, A., De Wilde, R. F., Brosens, L. A., Rezaee, N., Javed, A., Chianchiano, P., Gobbo, S., Regi, P., Salvia, R., Bassi, C., He, J., Weiss, M. J., Cameron, J. L., Offerhaus, G. J. A., Hruban, R. H. & 5 others, Lawlor, R. T., Scarpa, A., Heaphy, C. M., Wood, L. D. & Wolfgang, C. L., Mar 1 2020, In : Annals of surgery. 271, 3, p. 566-573 8 p.

Research output: Contribution to journalArticle

Genomic instability demonstrates similarity between DCIS and invasive carcinomas

Heaphy, C. M., Bisoffi, M., Joste, N. E., Baumgartner, K. B., Baumgartner, R. N. & Griffith, J. K., Sep 1 2009, In : Breast Cancer Research and Treatment. 117, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

High extratumoral mast cell counts are associated with a higher risk of adverse prostate cancer outcomes

Sullivan, H. H., Heaphy, C. M., Kulac, I., Cuka, N., Lu, J., Barber, J. R., de Marzo, A. M., Lotan, T. L., Joshu, C. E. & Sfanos, K. S., Jan 1 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 3, p. 668-675 8 p.

Research output: Contribution to journalArticle

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors

Shekhani, M. T., Barber, J. R., Bezerra, S. M., Heaphy, C. M., Gonzalez Roibon, N. D., Taheri, D., Reis, L. O., Guner, G., Joshu, C. E., Netto, G. J. & Meeker, A. K., Aug 1 2016, In : Human Pathology. 54, p. 106-112 7 p.

Research output: Contribution to journalArticle

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Rahmanto, Y. S., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T. L. & Shih, I. M., Jan 1 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis

Kwon, J. H., Kim, H. J., Park, D. H., Lee, Y. J., Heaphy, C. M., Klöppel, G., Hruban, R. H. & Hong, S. M., Jul 12 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

Influence of in Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber, K. A., Heaphy, C. M., Rohrmann, S., Gonzalez, B., Bienstock, J. L., Agurs-Collins, T., Platz, E. A. & Meeker, A. K., 2016, In : Prostate Cancer. 2016, 3691650.

Research output: Contribution to journalArticle

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Bodelon, C., Heaphy, C. M., Meeker, A. K., Geller, B., Vacek, P. M., Weaver, D. L., Chicoine, R. E., Shepherd, J. A., Mahmoudzadeh, A. P., Patel, D. A., Brinton, L. A., Sherman, M. E. & Gierach, G. L., Oct 30 2015, In : BMC cancer. 15, 1, 823.

Research output: Contribution to journalArticle

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

De Wilde, R. F., Heaphy, C. M., Maitra, A., Meeker, A. K., Edil, B. H., Wolfgang, C. L., Ellison, T. A., Schulick, R. D., Molenaar, I. Q., Valk, G. D., Vriens, M. R., Rinkes, I. H. M. B., Offerhaus, G. J. A., Hruban, R. H. & Matsukuma, K. E., Jul 1 2012, In : Modern Pathology. 25, 7, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

Open Access

Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors

Trujillo, K. A., Heaphy, C. M., Mai, M., Vargas, K. M., Jones, A. C., Vo, P., Butler, K. S., Joste, N. E., Bisoffi, M. & Griffith, J. K., Sep 15 2011, In : International Journal of Cancer. 129, 6, p. 1310-1321 12 p.

Research output: Contribution to journalArticle

Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas

Nguyen, D. N., Heaphy, C. M., De Wilde, R. F., Orr, B. A., Odia, Y., Eberhart, C. G., Meeker, A. K. & Rodriguez, F. J., May 1 2013, In : Brain Pathology. 23, 3, p. 237-243 7 p.

Research output: Contribution to journalArticle

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

Konishi, H., Mohseni, M., Tamaki, A., Garay, J. P., Croessmann, S., Karnan, S., Ota, A., Wong, H. Y., Konishi, Y., Karakas, B., Tahir, K., Abukhdeir, A. M., Gustin, J. P., Cidado, J., Wang, G. M., Cosgrove, D., Cochran, R., Jelovac, D., Higgins, M. J., Arena, S. & 11 others, Hawkins, L., Lauring, J., Gross, A. L., Heaphy, C. M., Hosokawa, Y., Gabrielson, E., Meeker, A. K., Visvanathan, K., Argani, P., Bachman, K. E. & Park, B. H., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17773-17778 6 p.

Research output: Contribution to journalArticle

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S., Meeker, A. K., Heaphy, C. M., Graham, M. K. & Demarzo, A. M., Jan 1 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Organ-wide telomeric status in diseased and disease-free prostatic tissues

Heaphy, C. M., Fleet, T. M., Treat, E. G., Lee, S. J., Smith, A. Y., Davis, M. S., Griffith, J. K., Fischer, E. G. & Bisoffi, M., Sep 15 2010, In : Prostate. 70, 13, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumours

Kim, J. Y., Brosnan-Cashman, J. A., Kim, J., An, S., Lee, K. B., Kim, H., Park, D. Y., Jang, K. T., Oh, Y. H., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Apr 2020, In : Pathology. 52, 3, p. 336-347 12 p.

Research output: Contribution to journalArticle

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

Esopi, D., Graham, M. K., Brosnan-Cashman, J. A., Meyers, J., Vaghasia, A., Gupta, A., Kumar, B., Haffner, M., Heaphy, C. M., De Marzo, A. M., Meeker, A. K., Nelson, W. G., Wheelan, S. & Yegnasubramanian, S., Jan 1 2020, (Accepted/In press) In : Cellular Oncology.

Research output: Contribution to journalArticle

Open Access

Prediagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Van Blarigan, E. L., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Aug 1 2015, In : Cancer Prevention Research. 8, 8, p. 737-742 6 p.

Research output: Contribution to journalArticle

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Heaphy, C. M., Subhawong, A. P., Hong, S. M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., Shih, I. M., Iacobuzio-Donahue, C. A., Maitra, A., Li, Q. K., Eberhart, C. G., Taube, J. M., Rakheja, D., Kurman, R. J., Wu, T. C., Roden, R. B. & 5 others, Argani, P., De Marzo, A. M., Terracciano, L., Torbenson, M. & Meeker, A. K., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1608-1615 8 p.

Research output: Contribution to journalArticle