Christopher M Heaphy

Assistant Professor

20022020

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Research Output

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Article
2002

Chemiluminescent measurement of telomere DNA content in biopsies

Fordyce, C. A., Heaphy, C. M. & Griffith, J. K., Jan 1 2002, In : BioTechniques. 33, 1, p. 144-148 5 p.

Research output: Contribution to journalArticle

Open Access
2005

Association between cancer-free survival and telomere DNA content in prostate tumors

Fordyce, C. A., Heaphy, C. M., Joste, N. E., Smith, A. Y., Hunt, W. C. & Griffith, J. K., Feb 2005, In : Journal of Urology. 173, 2, p. 610-614 5 p.

Research output: Contribution to journalArticle

2006

Protease nexin-1 expression is altered in human breast cancer

Candia, B. J., Hines, W. C., Heaphy, C. M., Griffith, J. K. & Orlando, R. A., May 31 2006, In : Cancer Cell International. 6, 16.

Research output: Contribution to journalArticle

Telomere content correlates with stage and prognosis in breast cancer

Fordyce, C. A., Heaphy, C. M., Bisoffi, M., Wyaco, J. L., Joste, N. E., Mangalik, A., Baumgartner, K. B., Baumgartner, R. N., Hunt, W. C. & Griffith, J. K., Sep 1 2006, In : Breast Cancer Research and Treatment. 99, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumors

Heaphy, C. M., Bisoffi, M., Fordyce, C. A., Haaland, C. M., Hines, W. C., Joste, N. E. & Griffith, J. K., Jul 1 2006, In : International Journal of Cancer. 119, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

2007

A novel loss-of-function mutation in TP53 in an endometrial cancer cell line and uterine papillary serous carcinoma model

Liu, Z., Wan, G., Heaphy, C., Bisoffi, M., Griffith, J. K. & Hu, C. A. A., Mar 1 2007, In : Molecular and Cellular Biochemistry. 297, 1-2, p. 179-187 9 p.

Research output: Contribution to journalArticle

Assessment of the frequency of allelic imbalance in human tissue using a multiplex polymerase chain reaction system

Heaphy, C. M., Hines, W. C., Butler, K. S., Haaland, C. M., Heywood, G., Fischer, E. G., Bisoffi, M. & Griffith, J. K., Apr 2007, In : Journal of Molecular Diagnostics. 9, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Telomere DNA content predicts breast cancer - Free survival interval

Heaphy, C. M., Baumgartner, K. B., Bisoffi, M., Baumgartner, R. N. & Griffith, J. K., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7037-7043 7 p.

Research output: Contribution to journalArticle

2009

Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization

Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K. & Bisoffi, M., Sep 21 2009, In : International journal of oncology. 35, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

Genomic instability demonstrates similarity between DCIS and invasive carcinomas

Heaphy, C. M., Bisoffi, M., Joste, N. E., Baumgartner, K. B., Baumgartner, R. N. & Griffith, J. K., Sep 1 2009, In : Breast Cancer Research and Treatment. 117, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis

Fernandez-Egea, E., Bernardo, M., Heaphy, C. M., Griffith, J. K., Parellada, E., Esmatjes, E., Conget, I., Nguyen, L., George, V., Stöppler, H. & Kirkpatrick, B., May 1 2009, In : Schizophrenia bulletin. 35, 2, p. 437-442 6 p.

Research output: Contribution to journalArticle

The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression

Subhawong, A. P., Heaphy, C. M., Argani, P., Konishi, Y., Kouprina, N., Nassar, H., Vang, R. & Meeker, A. K., Nov 1 2009, In : Modern Pathology. 22, 11, p. 1423-1431 9 p.

Research output: Contribution to journalArticle

2010

Organ-wide telomeric status in diseased and disease-free prostatic tissues

Heaphy, C. M., Fleet, T. M., Treat, E. G., Lee, S. J., Smith, A. Y., Davis, M. S., Griffith, J. K., Fischer, E. G. & Bisoffi, M., Sep 15 2010, In : Prostate. 70, 13, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

Telomere DNA Content in Prostate Biopsies Predicts Early Rise in Prostate-specific Antigen After Radical Prostatectomy for Prostate Cancer

Treat, E. G., Heaphy, C. M., Massie, L. W., Bisoffi, M., Smith, A. Y., Davis, M. S. & Griffith, J. K., Mar 1 2010, In : Urology. 75, 3, p. 724-729 6 p.

Research output: Contribution to journalArticle

2011

Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors

Trujillo, K. A., Heaphy, C. M., Mai, M., Vargas, K. M., Jones, A. C., Vo, P., Butler, K. S., Joste, N. E., Bisoffi, M. & Griffith, J. K., Sep 15 2011, In : International Journal of Cancer. 129, 6, p. 1310-1321 12 p.

Research output: Contribution to journalArticle

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

Konishi, H., Mohseni, M., Tamaki, A., Garay, J. P., Croessmann, S., Karnan, S., Ota, A., Wong, H. Y., Konishi, Y., Karakas, B., Tahir, K., Abukhdeir, A. M., Gustin, J. P., Cidado, J., Wang, G. M., Cosgrove, D., Cochran, R., Jelovac, D., Higgins, M. J., Arena, S. & 11 others, Hawkins, L., Lauring, J., Gross, A. L., Heaphy, C. M., Hosokawa, Y., Gabrielson, E., Meeker, A. K., Visvanathan, K., Argani, P., Bachman, K. E. & Park, B. H., Oct 25 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 43, p. 17773-17778 6 p.

Research output: Contribution to journalArticle

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Heaphy, C. M., Subhawong, A. P., Hong, S. M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., Shih, I. M., Iacobuzio-Donahue, C. A., Maitra, A., Li, Q. K., Eberhart, C. G., Taube, J. M., Rakheja, D., Kurman, R. J., Wu, T. C., Roden, R. B. & 5 others, Argani, P., De Marzo, A. M., Terracciano, L., Torbenson, M. & Meeker, A. K., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1608-1615 8 p.

Research output: Contribution to journalArticle

Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes

Heaphy, C. M., Subhawong, A. P., Gross, A. L., Konishi, Y., Kouprina, N., Argani, P., Visvanathan, K. & Meeker, A. K., Feb 1 2011, In : Modern Pathology. 24, 2, p. 194-200 7 p.

Research output: Contribution to journalArticle

Telomere length is related to alternative splice patterns of telomerase in thyroid tumors

Wang, Y., Meeker, A. K., Kowalski, J., Tsai, H. L., Somervell, H., Heaphy, C., Sangenario, L. E., Prasad, N., Westra, W. H., Zeiger, M. A. & Umbricht, C. B., Sep 1 2011, In : American Journal of Pathology. 179, 3, p. 1415-1424 10 p.

Research output: Contribution to journalArticle

The potential utility of telomere-related markers for cancer diagnosis

Heaphy, C. M. & Meeker, A. K., Jun 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 6, p. 1227-1238 12 p.

Research output: Contribution to journalArticle

2012

Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas

Butler, K. S., Hines, W. C., Heaphy, C. M. & Griffith, J. K., Oct 2012, In : Cancer medicine. 1, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Open Access

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

Jiao, Y., Killela, P. J., Reitman, Z. J., Rasheed, B. A., Heaphy, C. M., de Wilde, R. F., Rodriguez, F. J., Rosemberg, S., Oba-Shinjo, S. M., Marie, S. K. N., Bettegowda, C., Agrawal, N., Lipp, E., Pirozzi, C. J., Lopez, G. Y., He, Y., Friedman, H. S., Friedman, A. H., Riggins, G. J., Holdhoff, M. & 9 others, Burger, P., McLendon, R. E., Bigner, D. D., Vogelstein, B., Meeker, A. K., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Yan, H., Jul 2012, In : Oncotarget. 3, 7, p. 709-722 14 p.

Research output: Contribution to journalArticle

Open Access

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

De Wilde, R. F., Heaphy, C. M., Maitra, A., Meeker, A. K., Edil, B. H., Wolfgang, C. L., Ellison, T. A., Schulick, R. D., Molenaar, I. Q., Valk, G. D., Vriens, M. R., Rinkes, I. H. M. B., Offerhaus, G. J. A., Hruban, R. H. & Matsukuma, K. E., Jul 1 2012, In : Modern Pathology. 25, 7, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

2013

Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression

Garcia-Rizo, C., Fernandez-Egea, E., Miller, B. J., Oliveira, C., Justicia, A., Griffith, J. K., Heaphy, C. M., Bernardo, M. & Kirkpatrick, B., Feb 1 2013, In : Brain, Behavior, and Immunity. 28, p. 49-53 5 p.

Research output: Contribution to journalArticle

Chromophobe hepatocellular carcinoma with abrupt anaplasia: A proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features

Wood, L. D., Heaphy, C. M., Daniel, H. D. J., Naini, B. V., Lassman, C. R., Arroyo, M. R., Kamel, I. R., Cosgrove, D. P., Boitnott, J. K., Meeker, A. K. & Torbenson, M. S., Dec 1 2013, In : Modern Pathology. 26, 12, p. 1586-1593 8 p.

Research output: Contribution to journalArticle

Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas

Nguyen, D. N., Heaphy, C. M., De Wilde, R. F., Orr, B. A., Odia, Y., Eberhart, C. G., Meeker, A. K. & Rodriguez, F. J., May 1 2013, In : Brain Pathology. 23, 3, p. 237-243 7 p.

Research output: Contribution to journalArticle

Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death

Heaphy, C. M., Yoon, G. S., Peskoe, S. B., Joshu, C. E., Lee, T. K., Giovannucci, E., Mucci, L. A., Kenfield, S. A., Stampfer, M. J., Hicks, J. L., De Marzo, A. M., Platz, E. A. & Meeker, A. K., Oct 1 2013, In : Cancer discovery. 3, 10, p. 1130-1141 12 p.

Research output: Contribution to journalArticle

Tracking the clonal origin of lethal prostate cancer

Haffner, M. C., Mosbruger, T., Esopi, D. M., Fedor, H., Heaphy, C. M., Walker, D. A., Adejola, N., Gürel, M., Hicks, J., Meeker, A. K., Halushka, M. K., Simons, J. W., Isaacs, W. B., De Marzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4918-4922 5 p.

Research output: Contribution to journalArticle

2014

Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases

Dogeas, E., Karagkounis, G., Heaphy, C. M., Hirose, K., Pawlik, T. M., Wolfgang, C. L., Meeker, A., Hruban, R. H., Cameron, J. L. & Choti, M. A., Apr 2014, In : Journal of the American College of Surgeons. 218, 4, p. 628-635 8 p.

Research output: Contribution to journalArticle

Telomere length as a risk factor for hereditary prostate cancer

Hurwitz, L. M., Heaphy, C. M., Joshu, C. E., Isaacs, W. B., Konishi, Y., De Marzo, A. M., Isaacs, S. D., Wiley, K. E., Platz, E. A. & Meeker, A. K., Jan 1 2014, In : Prostate. 74, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

2015

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer

Julin, B., Shui, I., Heaphy, C. M., Joshu, C. E., Meeker, A. K., Giovannucci, E., De Vivo, I. & Platz, E. A., Feb 17 2015, In : British journal of cancer. 112, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Cochran, R. L., Cidado, J., Kim, M., Zabransky, D. J., Croessmann, S., Chu, D., Wong, H. Y., Beaver, J. A., Cravero, K., Erlanger, B., Parsons, H., Heaphy, C. M., Meeker, A. K., Lauring, J. & Park, B. H., Jan 1 2015, In : Oncotarget. 6, 28, p. 25240-25251 12 p.

Research output: Contribution to journalArticle

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Bodelon, C., Heaphy, C. M., Meeker, A. K., Geller, B., Vacek, P. M., Weaver, D. L., Chicoine, R. E., Shepherd, J. A., Mahmoudzadeh, A. P., Patel, D. A., Brinton, L. A., Sherman, M. E. & Gierach, G. L., Oct 30 2015, In : BMC cancer. 15, 1, 823.

Research output: Contribution to journalArticle

Prediagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Van Blarigan, E. L., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Aug 1 2015, In : Cancer Prevention Research. 8, 8, p. 737-742 6 p.

Research output: Contribution to journalArticle

Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial

Heaphy, C. M., Gaonkar, G., Peskoe, S. B., Joshu, C. E., De Marzo, A. M., Lucia, M. S., Goodman, P. J., Lippman, S. M., Thompson, I. M., Platz, E. A. & Meeker, A. K., Aug 1 2015, In : Prostate. 75, 11, p. 1160-1166 7 p.

Research output: Contribution to journalArticle

Telomere length alterations unique to invasive lobular carcinoma

Heaphy, C. M., Asch-Kendrick, R., Argani, P., Meeker, A. K. & Cimino-Mathews, A., Aug 1 2015, In : Human pathology. 46, 8, p. 1197-1203 7 p.

Research output: Contribution to journalArticle

Visualization of telomere integrity and function in vitro and in vivo using immunofluorescence techniques

Cesare, A. J., Heaphy, C. M. & O'Sullivan, R. J., Jan 1 2015, In : Current Protocols in Cytometry. 2015, p. 12.40.1-12.40.31

Research output: Contribution to journalArticle

2016

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas

Rodriguez, F. J., Vizcaino, M. A., Blakeley, J. & Heaphy, C. M., Sep 20 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-3 3 p.

Research output: Contribution to journalArticle

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors

Shekhani, M. T., Barber, J. R., Bezerra, S. M., Heaphy, C. M., Gonzalez Roibon, N. D., Taheri, D., Reis, L. O., Guner, G., Joshu, C. E., Netto, G. J. & Meeker, A. K., Aug 1 2016, In : Human Pathology. 54, p. 106-112 7 p.

Research output: Contribution to journalArticle

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Rahmanto, Y. S., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T. L. & Shih, I. M., Jan 1 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Influence of in Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber, K. A., Heaphy, C. M., Rohrmann, S., Gonzalez, B., Bienstock, J. L., Agurs-Collins, T., Platz, E. A. & Meeker, A. K., 2016, In : Prostate Cancer. 2016, 3691650.

Research output: Contribution to journalArticle

2017

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

2018

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Feb 15 2018, In : Prostate. 78, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis

Kwon, J. H., Kim, H. J., Park, D. H., Lee, Y. J., Heaphy, C. M., Klöppel, G., Hruban, R. H. & Hong, S. M., Jul 12 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle