Christopher M Heaphy

Assistant Professor

20022020

Research output per year

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2020

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas

Hackeng, W. M., Schelhaas, W., Morsink, F. H. M., Heidsma, C. M., van Eeden, S., Valk, G. D., Vriens, M. R., Heaphy, C. M., Nieveen van Dijkum, E. J. M., Offerhaus, G. J. A., Dreijerink, K. M. A. & Brosens, L. A. A., Jan 1 2020, (Accepted/In press) In : Endocrine Pathology.

Research output: Contribution to journalArticle

Open Access

Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration

Hackeng, W. M., Morsink, F. H. M., Moons, L. M. G., Heaphy, C. M., Offerhaus, G. J. A., Dreijerink, K. M. A. & Brosens, L. A. A., Apr 1 2020, In : Diagnostic cytopathology. 48, 4, p. 308-315 8 p.

Research output: Contribution to journalArticle

Open Access

Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas

Felsenstein, M., Trujillo, M. A., Huang, B., Nanda, N., Jiang, Z., Jeong, Y. J., Pflüger, M., Goggins, M. G., Hruban, R. H., Thompson, E. D., Heaphy, C. M., Roberts, N. J. & Wood, L. D., Jan 1 2020, (Accepted/In press) In : Laboratory Investigation.

Research output: Contribution to journalArticle

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups with Differing Risks of Liver Metastases

Pea, A., Yu, J., Marchionni, L., Noe, M., Luchini, C., Pulvirenti, A., De Wilde, R. F., Brosens, L. A., Rezaee, N., Javed, A., Chianchiano, P., Gobbo, S., Regi, P., Salvia, R., Bassi, C., He, J., Weiss, M. J., Cameron, J. L., Offerhaus, G. J. A., Hruban, R. H. & 5 others, Lawlor, R. T., Scarpa, A., Heaphy, C. M., Wood, L. D. & Wolfgang, C. L., Mar 1 2020, In : Annals of surgery. 271, 3, p. 566-573 8 p.

Research output: Contribution to journalArticle

High extratumoral mast cell counts are associated with a higher risk of adverse prostate cancer outcomes

Sullivan, H. H., Heaphy, C. M., Kulac, I., Cuka, N., Lu, J., Barber, J. R., de Marzo, A. M., Lotan, T. L., Joshu, C. E. & Sfanos, K. S., Jan 1 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 3, p. 668-675 8 p.

Research output: Contribution to journalArticle

Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumours

Kim, J. Y., Brosnan-Cashman, J. A., Kim, J., An, S., Lee, K. B., Kim, H., Park, D. Y., Jang, K. T., Oh, Y. H., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Apr 2020, In : Pathology. 52, 3, p. 336-347 12 p.

Research output: Contribution to journalArticle

2019

ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation

Martínez, H., Nagurney, M., Wang, Z. X., Eberhart, C. G., Heaphy, C. M., Curtis, M. T. & Rodriguez, F. J., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 8, p. 703-708 6 p.

Research output: Contribution to journalArticle

Open Access

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 1 2019, In : Brain Pathology. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

Cejas, P., Drier, Y., Dreijerink, K. M. A., Brosens, L. A. A., Deshpande, V., Epstein, C. B., Conemans, E. B., Morsink, F. H. M., Graham, M. K., Valk, G. D., Vriens, M. R., Castillo, C. F. D., Ferrone, C. R., Adar, T., Bowden, M., Whitton, H. J., Da Silva, A., Font-Tello, A., Long, H. W., Gaskell, E. & 7 others, Shoresh, N., Heaphy, C. M., Sicinska, E., Kulke, M. H., Chung, D. C., Bernstein, B. E. & Shivdasani, R. A., Aug 1 2019, In : Nature medicine. 25, 8, p. 1264-1269 6 p.

Research output: Contribution to journalArticle

Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

Graham, M. K., Kim, J., Da, J., Brosnan-Cashman, J. A., Rizzo, A., Del Valle, J. A. B., Chia, L., Rubenstein, M., Davis, C., Zheng, Q., Cope, L., Considine, M., Haffner, M. C., De Marzo, A. M., Meeker, A. K. & Heaphy, C. M., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2480-2491 12 p.

Research output: Contribution to journalArticle

Mannose Receptor–positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease

Zarif, J., Baena-Del Valle, J. A., Hicks, J. L., Heaphy, C. M., Vidal, I., Luo, J., Lotan, T., Hooper, J., Isaacs, W. B., Pienta, K. & Demarzo, A. M., Jul 1 2019, In : European Urology Oncology. 2, 4, p. 429-436 8 p.

Research output: Contribution to journalArticle

Open Access

Telomere alterations in neurofibromatosis type 1-associated solid tumors

Rodriguez, F. J., Graham, M. K., Brosnan-Cashman, J. A., Barber, J. R., Davis, C., Vizcaino, M. A., Palsgrove, D. N., Giannini, C., Pekmezci, M., Dahiya, S., Gokden, M., Noë, M., Wood, L. D., Pratilas, C. A., Morris, C. D., Belzberg, A., Blakeley, J. & Heaphy, C. M., Aug 28 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2018

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia

Rodriguez, F. J., Brosnan-Cashman, J. A., Allen, S. J., Vizcaino, M. A., Giannini, C., Camelo-Piragua, S., Webb, M., Matsushita, M., Wadhwani, N., Tabbarah, A., Hamideh, D., Jiang, L., Chen, L. L., Arvanitis, L. D., Alnajar, H. H., Barber, J. R., Rodríguez-Velasco, A., Orr, B. & Heaphy, C. M., Jan 1 2018, (Accepted/In press) In : Brain Pathology.

Research output: Contribution to journalArticle

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Feb 15 2018, In : Prostate. 78, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis

Kwon, J. H., Kim, H. J., Park, D. H., Lee, Y. J., Heaphy, C. M., Klöppel, G., Hruban, R. H. & Hong, S. M., Jul 12 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S., Meeker, A. K., Heaphy, C. M., Graham, M. K. & Demarzo, A. M., Jan 1 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations

Weber, K. A., Heaphy, C. M., Joshu, C. E., Lu, J., Rohrmann, S., Bienstock, J. L., Agurs-Collins, T., Meeker, A. K. & Platz, E. A., Aug 1 2018, In : Cancer Causes and Control. 29, 8, p. 759-767 9 p.

Research output: Contribution to journalArticle

Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association

Palsgrove, D. N., Brosnan-Cashman, J. A., Giannini, C., Raghunathan, A., Jentoft, M., Bettegowda, C., Gokden, M., Lin, D., Yuan, M., Lin, M. T., Heaphy, C. M. & Rodriguez, F. J., Jul 4 2018, (Accepted/In press) In : Modern Pathology. p. 1-14 14 p.

Research output: Contribution to journalArticle

2017

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

2016

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas

Rodriguez, F. J., Vizcaino, M. A., Blakeley, J. & Heaphy, C. M., Sep 20 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-3 3 p.

Research output: Contribution to journalArticle

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors

Shekhani, M. T., Barber, J. R., Bezerra, S. M., Heaphy, C. M., Gonzalez Roibon, N. D., Taheri, D., Reis, L. O., Guner, G., Joshu, C. E., Netto, G. J. & Meeker, A. K., Aug 1 2016, In : Human Pathology. 54, p. 106-112 7 p.

Research output: Contribution to journalArticle

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Rahmanto, Y. S., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T. L. & Shih, I. M., Jan 1 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Influence of in Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber, K. A., Heaphy, C. M., Rohrmann, S., Gonzalez, B., Bienstock, J. L., Agurs-Collins, T., Platz, E. A. & Meeker, A. K., 2016, In : Prostate Cancer. 2016, 3691650.

Research output: Contribution to journalArticle

2015

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer

Julin, B., Shui, I., Heaphy, C. M., Joshu, C. E., Meeker, A. K., Giovannucci, E., De Vivo, I. & Platz, E. A., Feb 17 2015, In : British journal of cancer. 112, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Cochran, R. L., Cidado, J., Kim, M., Zabransky, D. J., Croessmann, S., Chu, D., Wong, H. Y., Beaver, J. A., Cravero, K., Erlanger, B., Parsons, H., Heaphy, C. M., Meeker, A. K., Lauring, J. & Park, B. H., Jan 1 2015, In : Oncotarget. 6, 28, p. 25240-25251 12 p.

Research output: Contribution to journalArticle

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Bodelon, C., Heaphy, C. M., Meeker, A. K., Geller, B., Vacek, P. M., Weaver, D. L., Chicoine, R. E., Shepherd, J. A., Mahmoudzadeh, A. P., Patel, D. A., Brinton, L. A., Sherman, M. E. & Gierach, G. L., Oct 30 2015, In : BMC cancer. 15, 1, 823.

Research output: Contribution to journalArticle

Prediagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Van Blarigan, E. L., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Aug 1 2015, In : Cancer Prevention Research. 8, 8, p. 737-742 6 p.

Research output: Contribution to journalArticle

Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial

Heaphy, C. M., Gaonkar, G., Peskoe, S. B., Joshu, C. E., De Marzo, A. M., Lucia, M. S., Goodman, P. J., Lippman, S. M., Thompson, I. M., Platz, E. A. & Meeker, A. K., Aug 1 2015, In : Prostate. 75, 11, p. 1160-1166 7 p.

Research output: Contribution to journalArticle

Telomere length alterations unique to invasive lobular carcinoma

Heaphy, C. M., Asch-Kendrick, R., Argani, P., Meeker, A. K. & Cimino-Mathews, A., Aug 1 2015, In : Human pathology. 46, 8, p. 1197-1203 7 p.

Research output: Contribution to journalArticle

Visualization of telomere integrity and function in vitro and in vivo using immunofluorescence techniques

Cesare, A. J., Heaphy, C. M. & O'Sullivan, R. J., Jan 1 2015, In : Current Protocols in Cytometry. 2015, p. 12.40.1-12.40.31

Research output: Contribution to journalArticle

2014

Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases

Dogeas, E., Karagkounis, G., Heaphy, C. M., Hirose, K., Pawlik, T. M., Wolfgang, C. L., Meeker, A., Hruban, R. H., Cameron, J. L. & Choti, M. A., Apr 2014, In : Journal of the American College of Surgeons. 218, 4, p. 628-635 8 p.

Research output: Contribution to journalArticle

Telomere length as a risk factor for hereditary prostate cancer

Hurwitz, L. M., Heaphy, C. M., Joshu, C. E., Isaacs, W. B., Konishi, Y., De Marzo, A. M., Isaacs, S. D., Wiley, K. E., Platz, E. A. & Meeker, A. K., Jan 1 2014, In : Prostate. 74, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

2013

Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression

Garcia-Rizo, C., Fernandez-Egea, E., Miller, B. J., Oliveira, C., Justicia, A., Griffith, J. K., Heaphy, C. M., Bernardo, M. & Kirkpatrick, B., Feb 1 2013, In : Brain, Behavior, and Immunity. 28, p. 49-53 5 p.

Research output: Contribution to journalArticle

Chromophobe hepatocellular carcinoma with abrupt anaplasia: A proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features

Wood, L. D., Heaphy, C. M., Daniel, H. D. J., Naini, B. V., Lassman, C. R., Arroyo, M. R., Kamel, I. R., Cosgrove, D. P., Boitnott, J. K., Meeker, A. K. & Torbenson, M. S., Dec 1 2013, In : Modern Pathology. 26, 12, p. 1586-1593 8 p.

Research output: Contribution to journalArticle

Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas

Nguyen, D. N., Heaphy, C. M., De Wilde, R. F., Orr, B. A., Odia, Y., Eberhart, C. G., Meeker, A. K. & Rodriguez, F. J., May 1 2013, In : Brain Pathology. 23, 3, p. 237-243 7 p.

Research output: Contribution to journalArticle

Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death

Heaphy, C. M., Yoon, G. S., Peskoe, S. B., Joshu, C. E., Lee, T. K., Giovannucci, E., Mucci, L. A., Kenfield, S. A., Stampfer, M. J., Hicks, J. L., De Marzo, A. M., Platz, E. A. & Meeker, A. K., Oct 1 2013, In : Cancer discovery. 3, 10, p. 1130-1141 12 p.

Research output: Contribution to journalArticle

Tracking the clonal origin of lethal prostate cancer

Haffner, M. C., Mosbruger, T., Esopi, D. M., Fedor, H., Heaphy, C. M., Walker, D. A., Adejola, N., Gürel, M., Hicks, J., Meeker, A. K., Halushka, M. K., Simons, J. W., Isaacs, W. B., De Marzo, A. M., Nelson, W. G. & Yegnasubramanian, S., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4918-4922 5 p.

Research output: Contribution to journalArticle

2012

Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas

Butler, K. S., Hines, W. C., Heaphy, C. M. & Griffith, J. K., Oct 2012, In : Cancer medicine. 1, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Open Access

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

Jiao, Y., Killela, P. J., Reitman, Z. J., Rasheed, B. A., Heaphy, C. M., de Wilde, R. F., Rodriguez, F. J., Rosemberg, S., Oba-Shinjo, S. M., Marie, S. K. N., Bettegowda, C., Agrawal, N., Lipp, E., Pirozzi, C. J., Lopez, G. Y., He, Y., Friedman, H. S., Friedman, A. H., Riggins, G. J., Holdhoff, M. & 9 others, Burger, P., McLendon, R. E., Bigner, D. D., Vogelstein, B., Meeker, A. K., Kinzler, K. W., Papadopoulos, N., Diaz, L. A. & Yan, H., Jul 2012, In : Oncotarget. 3, 7, p. 709-722 14 p.

Research output: Contribution to journalArticle

Open Access

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

De Wilde, R. F., Heaphy, C. M., Maitra, A., Meeker, A. K., Edil, B. H., Wolfgang, C. L., Ellison, T. A., Schulick, R. D., Molenaar, I. Q., Valk, G. D., Vriens, M. R., Rinkes, I. H. M. B., Offerhaus, G. J. A., Hruban, R. H. & Matsukuma, K. E., Jul 1 2012, In : Modern Pathology. 25, 7, p. 1033-1039 7 p.

Research output: Contribution to journalArticle

2011

Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors

Trujillo, K. A., Heaphy, C. M., Mai, M., Vargas, K. M., Jones, A. C., Vo, P., Butler, K. S., Joste, N. E., Bisoffi, M. & Griffith, J. K., Sep 15 2011, In : International Journal of Cancer. 129, 6, p. 1310-1321 12 p.

Research output: Contribution to journalArticle