Research Output 1977 2018

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2018

Diurnal variation of default mode network in patients with restless legs syndrome

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2018 In : Sleep Medicine. 41, p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Parietal Lobe
Circadian Rhythm
Arousal
Thalamus

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Allen, R. P., Picchietti, D. L., Auerbach, M., Cho, Y. W., Connor, J. R., Earley, C. J., Garcia-Borreguero, D., Kotagal, S., Manconi, M., Ondo, W., Ulfberg, J., Winkelman, J. W., On behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) Jan 1 2018 In : Sleep Medicine. 41, p. 27-44 18 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Advisory Committees
Practice Guidelines
Consensus
Iron
2017

Allocating provider resources to diagnose and treat restless legs syndrome: a cost-utility analysis

Padula, W. V., Phelps, C. E., Moran, D. & Earley, C. Oct 1 2017 In : Sleep Medicine. 38, p. 44-49 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Cost-Benefit Analysis
Costs and Cost Analysis
Quality-Adjusted Life Years
Nervous System Diseases

Intervening leg movements disrupt PLMS sequences

Hiranniramol, K., Fulda, S., Skeba, P., Earley, C. J. & Allen, R. P. Jan 1 2017 In : Sleep. 40, 1

Research output: Research - peer-reviewArticle

Leg
Sleep
Periodicity

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., Quiroz, C. & Ferré, S. Dec 1 2017 In : Annals of Neurology. 82, 6, p. 951-960 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Glutamic Acid
pramipexole
Optogenetics
Hypersensitivity
2016

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

Quiroz, C., Gulyani, S., Ruiqian, W., Bonaventura, J., Cutler, R., Pearson, V., Allen, R. P., Earley, C. J., Mattson, M. P. & Ferré, S. Dec 1 2016 In : Neuropharmacology. 111, p. 160-168 9 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Purinergic P1 Receptors
Iron
Brain
Sleep
Restless Legs Syndrome
Iron
Brain
Substantia Nigra
Sleep

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J. Sep 1 2016 In : Sleep Medicine. 25, p. 16-23 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Therapeutics
ferric carboxymaltose
Placebos
Visual Analog Scale
Connectome
Restless Legs Syndrome
Pharmacology
Dopamine
Dopamine Receptors

Default mode network disturbances in restless legs syndrome/Willis–Ekbom disease

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W. Jul 1 2016 In : Sleep Medicine. 23, p. 6-11 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Parietal Lobe
Thalamus
Limbic Lobe
Asymptomatic Diseases

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity

Skeba, P., Fulda, S., Hiranniramol, K., Earley, C. J. & Allen, R. P. Sep 21 2016 (Accepted/In press) In : Sleep and Breathing. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Leg
Sleep
Guidelines
Muscles

In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: Iron, glutamate, and adenosine

Ferré, S., Earley, C., Gulyani, S. & Garcia-Borreguero, D. Mar 8 2016 (Accepted/In press) In : Sleep Medicine.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Dopamine Agents
Adenosine
Glutamic Acid
Iron

Inter-movement interval as a primary stable measure of periodic limb movements of sleep

Skeba, P., Hiranniramol, K., Earley, C. J. & Allen, R. P. 2016 In : Sleep Medicine. 17, p. 138-143 6 p.

Research output: Research - peer-reviewArticle

Sleep
Extremities
Leg
Restless Legs Syndrome
Biological Phenomena
2015

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

Moon, H. J., Chang, Y., Lee, Y. S., Song, H., Chang, H. W., Ku, J., Allen, R. P., Earley, C. J. & Cho, Y. W. Jan 1 2015 In : Medical Devices: Evidence and Research. 8, p. 341-350 10 p.

Research output: Research - peer-reviewArticle

Magnetic resonance imaging
Brain
Tissue
Iron
Restless Legs Syndrome

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome

Gan-Or, Z., Zhou, S., Ambalavanan, A., Leblond, C. S., Xie, P., Johnson, A., Spiegelman, D., Allen, R. P., Earley, C. J., Desautels, A., Montplaisir, J. Y., Dion, P. A., Xiong, L. & Rouleau, G. A. Sep 1 2015 In : Sleep Medicine. 16, 9, p. 1151-1155 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Exome
Genetic Loci
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation

Hone-Blanchet, A., Salas, R. E., Celnik, P., Kalloo, A., Schar, M., Puts, N. A. J., Harris, A. D., Barker, P. B., Fecteau, S., Earley, C. J., Allen, R. P. & Edden, R. A. Mar 5 2015 In : Journal of Neuroscience Methods. 242, p. 52-57 6 p.

Research output: Research - peer-reviewArticle

Transcranial Magnetic Stimulation
Magnetic Resonance Spectroscopy
Neurotransmitter Agents
Motor Cortex
Hand

Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Chang, Y., Chang, H. W., Song, H., Ku, J., Earley, C. J., Allen, R. P. & Cho, Y. W. Jan 1 2015 In : Clinical Imaging. 39, 1, p. 20-25 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Gray Matter
Parahippocampal Gyrus
Parietal Lobe
Cerebellum

MATPLM1, A MATLAB script for scoring of periodic limb movements: Preliminary validation with visual scoring

Huang, A. S., Skeba, P., Yang, M. S., Sgambati, F. P., Earley, C. J. & Allen, R. P. Dec 1 2015 In : Sleep Medicine. 16, 12, p. 1541-1549 9 p.

Research output: Research - peer-reviewArticle

Sleep
Extremities
Restless Legs Syndrome
Sleep Apnea Syndromes
Leg

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jun 1 2015 In : Sleep Medicine. 16, 6, p. 775-778 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Sleep
Pain
Polysomnography
Ferritins

Response to "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Jul 1 2015 In : Sleep Medicine. 16, 7, p. 898 1 p.

Research output: Research - peer-reviewArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Response to the letter "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P. Nov 1 2015 In : Sleep Medicine. 16, 11, p. 1448 1 p., 2862

Research output: Research - peer-reviewArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain
2014

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Earley, C. J., Connor, J., Garcia-Borreguero, D., Jenner, P., Winkelman, J., Zee, P. C. & Allen, R. Nov 1 2014 In : Sleep Medicine. 15, 11, p. 1288-1301 14 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Homeostasis
Iron
Brain
Animal Models

Altered white matter integrity in primary restless legs syndrome patients: Diffusion tensor imaging study

Chang, Y., Paik, J. S., Lee, H. J., Chang, H. W., Moon, H. J., Allen, R. P., Earley, C. J. & Cho, Y. W. 2014 In : Neurological Research. 36, 8, p. 769-774 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Diffusion Tensor Imaging
White Matter
Anisotropy
Brain

Diurnal variations in brain iron concentrations in BXD RI mice

Unger, E. L., Jones, B. C., Bianco, L. E., Allen, R. P. & Earley, C. J. Mar 28 2014 In : Neuroscience. 263, p. 54-59 6 p.

Research output: Research - peer-reviewArticle

Iron
Brain
Mesencephalon
Inbred Strains Mice
Spleen
Restless Legs Syndrome
Thalamus
Magnetic Resonance Imaging
Parahippocampal Gyrus
Temporal Lobe
Restless Legs Syndrome
Guidelines
Therapeutics
Dopamine Agonists
Opioid Analgesics

Low brain iron effects and reversibility on striatal dopamine dynamics

Unger, E. L., Bianco, L. E., Jones, B. C., Allen, R. P. & Earley, C. J. 2014 In : Experimental Neurology. 261, p. 462-468 7 p.

Research output: Research - peer-reviewArticle

Corpus Striatum
Dopamine
Iron
Brain
Mesencephalon

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease)

Mehmood, T., Auerbach, M., Earley, C. J. & Allen, R. P. Dec 1 2014 In : Sleep Medicine. 15, 12, p. 1473-1476 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Iron-Deficiency Anemias
Iron
Surveys and Questionnaires
Hemoglobins

Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording

Yang, M. S., Montplaisir, J., Desautels, A., Winkelman, J. W., Cramer Bornemann, M. A., Earley, C. J. & Allen, R. P. Jan 2014 In : Sleep Medicine. 15, 1, p. 132-137 6 p.

Research output: Research - peer-reviewArticle

Wakefulness
Immobilization
Noise
Leg
Electromyography
2013

Association of restless legs syndrome variants in Korean patients with restless legs syndrome

Kim, M. K., Cho, Y. W., Shin, W. C., Cho, J. W., Shon, Y. M., Kim, J. H., Yang, K. I., Earley, C. J. & Allen, R. P. Dec 1 2013 In : Sleep. 36, 12, p. 1787-1791 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Odds Ratio
Genome-Wide Association Study
Population
Genetic Epistasis

Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal

Unger, E. L., Earley, C. J., Thomsen, L. L., Jones, B. C. & Allen, R. P. Aug 29 2013 In : Neuroscience. 246, p. 179-185 7 p.

Research output: Research - peer-reviewArticle

Iron
Brain
Therapeutics
iron isomaltoside 1000
Injections
Restless Legs Syndrome
Putamen
Dopamine Receptors
Dopamine
Positron-Emission Tomography

Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice

Jellen, L. C., Lu, L., Wang, X., Unger, E. L., Earley, C. J., Allen, R. P., Williams, R. W. & Jones, B. C. Nov 2 2013 In : Neuroscience. 252, p. 13-23 11 p.

Research output: Research - peer-reviewArticle

Mesencephalon
Dopamine
Iron
Genes
Brain

Lower molecular weight intravenous iron dextran for restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J. Mar 2013 In : Sleep Medicine. 14, 3, p. 274-277 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Dextrans
Iron
Molecular Weight
Therapeutics

Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: Comparison with chronic osteoarthritis

Cho, Y. W., Na, G. Y., Lim, J. G., Kim, S. H., Kim, H. S., Earley, C. J. & Allen, R. P. Dec 2013 In : Sleep Medicine. 14, 12, p. 1387-1392 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Diabetic Neuropathies
Peripheral Nervous System Diseases
Osteoarthritis
Chronic Pain

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease

Patton, S. M., Cho, Y. W., Clardy, T. W., Allen, R. P., Earley, C. J. & Connor, J. R. Jun 7 2013 In : Fluids and Barriers of the CNS. 10, 1, 20

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Proteomics
Cerebrospinal Fluid
Proteins
Leg

Thalamic glutamate/glutamine in restless legs syndrome increased and related to disturbed sleep

Allen, R. P., Barker, P. B., Horska, A. & Earley, C. J. May 28 2013 In : Neurology. 80, 22, p. 2028-2034 7 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Glutamine
Glutamic Acid
Sleep
Syndrome

The long-term treatment of restless legs syndrome/Willis-Ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: A report from the International Restless Legs Syndrome Study Group

Garcia-Borreguero, D., Kohnen, R., Silber, M. H., Winkelman, J. W., Earley, C. J., Högl, B., Manconi, M., Montplaisir, J., Inoue, Y. & Allen, R. P. Jul 2013 In : Sleep Medicine. 14, 7, p. 675-684 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Practice Guidelines
Consensus
Guidelines
Therapeutics

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

Allen, R. P., Auerbach, S., Bahrain, H., Auerbach, M. & Earley, C. J. Apr 2013 In : American Journal of Hematology. 88, 4, p. 261-264 4 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Iron-Deficiency Anemias
Iron
Sleep
Hematologic Tests

Willis-ekbom disease foundation revised consensus statement on the management of restless legs syndrome

Silber, M. H., Becker, P. M., Earley, C., Garcia-Borreguero, D. & Ondo, W. G. 2013 In : Mayo Clinic Proceedings. 88, 9, p. 977-986 10 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Consensus
Pharmaceutical Preparations
Dopamine Agonists
Expert Testimony
2012

Assessing health-related quality of life in patients with restless legs syndrome in Korea: Comparison with other chronic medical diseases

Cho, Y. W., Kim, D. H., Allen, R. P. & Earley, C. J. Oct 2012 In : Sleep Medicine. 13, 9, p. 1158-1163 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Korea
Chronic Disease
Quality of Life
Depression

Restless legs syndrome symptomatology, attitudes and beliefs among treated and untreated individuals

Ramsey, C. M., Spira, A. P., Carlson, A., Earley, C., Allen, R. & Lee, H. B. Dec 2012 In : Sleep Medicine. 13, 10, p. 1226-1231 6 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Therapeutics
Insurance Coverage
Causality
African Americans

Systems genetic analysis of multivariate response to iron deficiency in mice

Yin, L., Unger, E. L., Jellen, L. C., Earley, C. J., Allen, R. P., Tomaszewicz, A., Fleet, J. C. & Jones, B. C. Jun 1 2012 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 302, 11

Research output: Research - peer-reviewArticle

Multivariate Analysis
Iron
Genes
Diet
Principal Component Analysis

Systems genetic analysis of the effects of iron deficiency in mouse brain

Jellen, L. C., Unger, E. L., Lu, L., Williams, R. W., Rousseau, S., Wang, X., Earley, C. J., Allen, R. P., Miles, M. F. & Jones, B. C. May 2012 In : Neurogenetics. 13, 2, p. 147-157 11 p.

Research output: Research - peer-reviewArticle

Iron
Brain
Mesencephalon
Amino Acid Transport System X-AG
Quantitative Trait Loci
2011

A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome

Silver, N., Allen, R. P., Senerth, J. & Earley, C. J. May 2011 In : Sleep Medicine. 12, 5, p. 440-444 5 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Methadone
Dopamine Agonists
Therapeutics
Pergolide

Alterations in pain responses in treated and untreated patients with restless legs syndrome: Associations with sleep disruption

Edwards, R. R., Quartana, P. J., Allen, R. P., Greenbaum, S., Earley, C. J. & Smith, M. T. Jun 2011 In : Sleep Medicine. 12, 6, p. 603-609 7 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Sleep
Pain
Hot Temperature
Pain Threshold

Another dopamine agonist for treatment of restless legs syndrome

Earley, C. J. Aug 2011 In : The Lancet Neurology. 10, 8, p. 675-677 3 p.

Research output: Research - peer-reviewArticle

Tetrahydronaphthalenes
Cutaneous Administration
Restless Legs Syndrome
Thiophenes
Dopamine Agonists

Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: A multi-centred, placebo-controlled preliminary clinical trial

Allen, R. P., Adler, C. H., Du, W., Butcher, A., Bregman, D. B. & Earley, C. J. Oct 2011 In : Sleep Medicine. 12, 9, p. 906-913 8 p.

Research output: Research - peer-reviewArticle

Restless Legs Syndrome
Controlled Clinical Trials
Placebos
Safety
Therapeutics

Genetic analysis of iron-deficiency effects on the mouse spleen

Gibson, J. N., Jellen, L. C., Unger, E. L., Morahan, G., Mehta, M., Earley, C. J., Allen, R. P., Lu, L. & Jones, B. C. Oct 2011 In : Mammalian Genome. 22, 9-10, p. 556-562 7 p.

Research output: Research - peer-reviewArticle

Spleen
Iron
Splenomegaly
Quantitative Trait Loci
Homeostasis