Christopher J Earley

Professor

1977 …2018
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Research Output 1977 2018

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2018

A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1

Catoire, H., Sarayloo, F., Mourabit Amari, K., Apuzzo, S., Grant, A., Rochefort, D., Xiong, L., Montplaisir, J., Earley, C. J., Turecki, G., Dion, P. A. & Rouleau, G. A., Dec 1 2018, In : Scientific Reports. 8, 1, 12173

Research output: Contribution to journalArticle

Restless Legs Syndrome
Genome-Wide Association Study
Genes
Genetic Promoter Regions
Co-Repressor Proteins

Connecting clinical aspects to corticomotor excitability in restless legs syndrome: a TMS study

Salas, R. M. E., Kalloo, A., Earley, C. J., Celnik, P., Cruz, T. E., Foster, K., Cantarero, G. & Allen, R. P., Sep 1 2018, In : Sleep Medicine. 49, p. 105-112 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Transcranial Magnetic Stimulation
Polysomnography
Neurobiology
Dopamine Agonists

Diurnal variation of default mode network in patients with restless legs syndrome

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W., Jan 1 2018, In : Sleep Medicine. 41, p. 1-8 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parietal Lobe
Circadian Rhythm
Arousal
Thalamus

Efficacy of ferric carboxymaltose (FCM) 500 mg dose for the treatment of Restless Legs Syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J., Feb 1 2018, In : Sleep Medicine. 42, p. 7-12 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Iron
Visual Analog Scale
Therapeutics

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

on behalf of the & International Restless Legs Syndrome Study Group (IRLSSG), Jan 1 2018, In : Sleep Medicine. 41, p. 27-44 18 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Advisory Committees
Practice Guidelines
Consensus
Iron

New Insights into the Neurobiology of Restless Legs Syndrome

Ferré, S., García-Borreguero, D., Allen, R. P. & Earley, C. J., Jan 1 2018, (Accepted/In press) In : Neuroscientist.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Neurobiology
Arousal
Iron
Corpus Striatum

Pivotal role of adenosine neurotransmission in Restless Legs Syndrome

Ferré, S., Quiroz, C., Guitart, X., Rea, W., Seyedian, A., Moreno, E., Casadó-Anguera, V., Díaz-Ríos, M., Casadó, V., Clemens, S., Allen, R. P., Earley, C. J. & García-Borreguero, D., Jan 8 2018, In : Frontiers in Neuroscience. 11, JAN, 722

Research output: Contribution to journalArticle

Restless Legs Syndrome
Synaptic Transmission
Adenosine
Sleep
Leg

The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome

for the, Jan 1 2018, In : Mayo Clinic Proceedings. 93, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Opioid Analgesics
Oxycodone
Methadone
Chronic Pain

TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson’s Disease with Opposite Effects

Mohtashami, S., He, Q., Ruskey, J. A., Zhou, S., Dion, P. A., Allen, R. P., Earley, C. J., Fon, E. A., Xiong, L., Dupre, N., Dauvilliers, Y., Rouleau, G. A. & Gan-Or, Z., Mar 1 2018, In : Journal of Molecular Neuroscience. 64, 3, p. 341-345 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parkinson Disease
Single Nucleotide Polymorphism
Genome-Wide Association Study
Gene Frequency
2017

Allocating provider resources to diagnose and treat restless legs syndrome: a cost-utility analysis

Padula, W. V., Phelps, C. E., Moran, D. & Earley, C., Oct 1 2017, In : Sleep Medicine. 38, p. 44-49 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Cost-Benefit Analysis
Quality-Adjusted Life Years
Costs and Cost Analysis
Nervous System Diseases

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

23andMe Research Team, Nov 1 2017, In : The Lancet Neurology. 16, 11, p. 898-907 10 p.

Research output: Contribution to journalArticle

Intervening leg movements disrupt PLMS sequences

Hiranniramol, K., Fulda, S., Skeba, P., Earley, C. J. & Allen, R. P., Jan 1 2017, In : Sleep. 40, 1

Research output: Contribution to journalArticle

Leg
Sleep
Periodicity
Polysomnography

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

Yepes, G., Guitart, X., Rea, W., Newman, A. H., Allen, R. P., Earley, C. J., Quiroz, C. & Ferré, S., Dec 1 2017, In : Annals of Neurology. 82, 6, p. 951-960 10 p.

Research output: Contribution to journalArticle

Cyclohexanecarboxylic Acids
Optogenetics
Corpus Striatum
Restless Legs Syndrome
Dopamine Agonists
2016

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

Quiroz, C., Gulyani, S., Ruiqian, W., Bonaventura, J., Cutler, R., Pearson, V., Allen, R. P., Earley, C. J., Mattson, M. P. & Ferré, S., Dec 1 2016, In : Neuropharmacology. 111, p. 160-168 9 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Purinergic P1 Receptors
Iron
Brain
Sleep
Restless Legs Syndrome
Iron
Brain
Substantia Nigra
Sleep

Case–Control and Family-Based Association Study of Specific PTPRD Variants in Restless Legs Syndrome

Gan-Or, Z., Zhou, S., Johnson, A., Montplaisir, J. Y., Allen, R. P., Earley, C. J., Desautels, A., Dion, P. A., Xiong, L. & Rouleau, G. A., Sep 1 2016, In : Movement Disorders Clinical Practice. 3, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Single Nucleotide Polymorphism
Haplotypes
Class 2 Receptor-Like Protein Tyrosine Phosphatases
Population

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J., Sep 1 2016, In : Sleep Medicine. 25, p. 16-23 8 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Placebos
Therapeutics
Visual Analog Scale
Iron
Connectome
Restless Legs Syndrome
Pharmacology
Dopamine Receptors
Cell Adhesion Molecules

Default mode network disturbances in restless legs syndrome/Willis–Ekbom disease

Ku, J., Lee, Y. S., Chang, H. W., Earley, C. J., Allen, R. P. & Cho, Y. W., Jul 1 2016, In : Sleep Medicine. 23, p. 6-11 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parietal Lobe
Thalamus
Asymptomatic Diseases
Gyrus Cinguli

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity

Skeba, P., Fulda, S., Hiranniramol, K., Earley, C. J. & Allen, R. P., Sep 21 2016, (Accepted/In press) In : Sleep and Breathing. p. 1-7 7 p.

Research output: Contribution to journalArticle

Leg
Sleep
Guidelines
Muscles

In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: Iron, glutamate, and adenosine

Ferré, S., Earley, C., Gulyani, S. & Garcia-Borreguero, D., Mar 8 2016, (Accepted/In press) In : Sleep Medicine.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Dopamine Agents
Adenosine
Glutamic Acid
Iron

Inter-movement interval as a primary stable measure of periodic limb movements of sleep

Skeba, P., Hiranniramol, K., Earley, C. J. & Allen, R. P., 2016, In : Sleep Medicine. 17, p. 138-143 6 p.

Research output: Contribution to journalArticle

Sleep
Extremities
Leg
Restless Legs Syndrome
Biological Phenomena
2015

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

Moon, H. J., Chang, Y., Lee, Y. S., Song, H., Chang, H. W., Ku, J., Allen, R. P., Earley, C. J. & Cho, Y. W., Jan 1 2015, In : Medical Devices: Evidence and Research. 8, p. 341-350 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Magnetic resonance imaging
Brain
Iron
Tissue

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome

Gan-Or, Z., Zhou, S., Ambalavanan, A., Leblond, C. S., Xie, P., Johnson, A., Spiegelman, D., Allen, R. P., Earley, C. J., Desautels, A., Montplaisir, J. Y., Dion, P. A., Xiong, L. & Rouleau, G. A., Sep 1 2015, In : Sleep Medicine. 16, 9, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Exome
Genetic Loci
Nucleic Acid Regulatory Sequences
Genome-Wide Association Study

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation

Hone-Blanchet, A., Salas, R. E., Celnik, P., Kalloo, A., Schar, M., Puts, N. A. J., Harris, A. D., Barker, P. B., Fecteau, S., Earley, C. J., Allen, R. P. & Edden, R. A., Mar 5 2015, In : Journal of Neuroscience Methods. 242, p. 52-57 6 p.

Research output: Contribution to journalArticle

Transcranial Magnetic Stimulation
Magnetic Resonance Spectroscopy
Neurotransmitter Agents
Motor Cortex
Hand

Gray matter alteration in patients with restless legs syndrome: A voxel-based morphometry study

Chang, Y., Chang, H. W., Song, H., Ku, J., Earley, C. J., Allen, R. P. & Cho, Y. W., Jan 1 2015, In : Clinical Imaging. 39, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Parahippocampal Gyrus
Parietal Lobe
Cerebellum
Gray Matter

MATPLM1, A MATLAB script for scoring of periodic limb movements: Preliminary validation with visual scoring

Huang, A. S., Skeba, P., Yang, M. S., Sgambati, F. P., Earley, C. J. & Allen, R. P., Dec 1 2015, In : Sleep Medicine. 16, 12, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

Sleep
Extremities
Restless Legs Syndrome
Sleep Apnea Syndromes
Leg

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P., Jun 1 2015, In : Sleep Medicine. 16, 6, p. 775-778 4 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Sleep
Pain
Polysomnography
Ferritins

Response to "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P., Jul 1 2015, In : Sleep Medicine. 16, 7, p. 898 1 p.

Research output: Contribution to journalArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain

Response to the letter "Characterization of the painful restless legs syndrome"

Cho, Y. W., Song, M. L., Earley, C. J. & Allen, R. P., Nov 1 2015, In : Sleep Medicine. 16, 11, p. 1448 1 p., 2862

Research output: Contribution to journalArticle

Nocturnal Myoclonus Syndrome
Restless Legs Syndrome
Pain
2014

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Earley, C. J., Connor, J., Garcia-Borreguero, D., Jenner, P., Winkelman, J., Zee, P. C. & Allen, R., Nov 1 2014, In : Sleep Medicine. 15, 11, p. 1288-1301 14 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Homeostasis
Iron
Brain
Animal Models

Altered white matter integrity in primary restless legs syndrome patients: Diffusion tensor imaging study

Chang, Y., Paik, J. S., Lee, H. J., Chang, H. W., Moon, H. J., Allen, R. P., Earley, C. J. & Cho, Y. W., 2014, In : Neurological Research. 36, 8, p. 769-774 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Diffusion Tensor Imaging
Anisotropy
Corpus Callosum
Brain

Diurnal variations in brain iron concentrations in BXD RI mice

Unger, E. L., Jones, B. C., Bianco, L. E., Allen, R. P. & Earley, C. J., Mar 28 2014, In : Neuroscience. 263, p. 54-59 6 p.

Research output: Contribution to journalArticle

Iron
Mesencephalon
Brain
Inbred Strains Mice
Spleen
Restless Legs Syndrome
Thalamus
Magnetic Resonance Imaging
Parahippocampal Gyrus
Temporal Lobe
Restless Legs Syndrome
Guidelines
Dopamine Agonists
Therapeutics
Opioid Analgesics

Low brain iron effects and reversibility on striatal dopamine dynamics

Unger, E. L., Bianco, L. E., Jones, B. C., Allen, R. P. & Earley, C. J., 2014, In : Experimental Neurology. 261, p. 462-468 7 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine
Iron
Brain
Mesencephalon

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease)

Mehmood, T., Auerbach, M., Earley, C. J. & Allen, R. P., Dec 1 2014, In : Sleep Medicine. 15, 12, p. 1473-1476 4 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Iron-Deficiency Anemias
Iron
Hemoglobins
Dextrans

Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording

Yang, M. S., Montplaisir, J., Desautels, A., Winkelman, J. W., Cramer Bornemann, M. A., Earley, C. J. & Allen, R. P., Jan 2014, In : Sleep Medicine. 15, 1, p. 132-137 6 p.

Research output: Contribution to journalArticle

Wakefulness
Electromyography
Immobilization
Noise
Leg
2013

Association of restless legs syndrome variants in Korean patients with restless legs syndrome

Kim, M. K., Cho, Y. W., Shin, W. C., Cho, J. W., Shon, Y. M., Kim, J. H., Yang, K. I., Earley, C. J. & Allen, R. P., Dec 1 2013, In : Sleep. 36, 12, p. 1787-1791 5 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Genome-Wide Association Study
Odds Ratio
Genetic Epistasis
Population

Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal

Unger, E. L., Earley, C. J., Thomsen, L. L., Jones, B. C. & Allen, R. P., Aug 29 2013, In : Neuroscience. 246, p. 179-185 7 p.

Research output: Contribution to journalArticle

Iron
Brain
Therapeutics
iron isomaltoside 1000
Mesencephalon

Increased synaptic dopamine in the putamen in restless legs syndrome

Earley, C. J., Kuwabara, H., Wong, D. F., Gamaldo, C., Salas, R. E., Brašíc, J. R., Ravert, H. T., Dannals, R. F. & Allen, R. P., Jan 1 2013, In : Sleep. 36, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Putamen
Dopamine Receptors
Dopamine
Positron-Emission Tomography

Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice

Jellen, L. C., Lu, L., Wang, X., Unger, E. L., Earley, C. J., Allen, R. P., Williams, R. W. & Jones, B. C., Nov 2 2013, In : Neuroscience. 252, p. 13-23 11 p.

Research output: Contribution to journalArticle

Mesencephalon
Dopamine
Iron
Genes
Restless Legs Syndrome

Lower molecular weight intravenous iron dextran for restless legs syndrome

Cho, Y. W., Allen, R. P. & Earley, C. J., Mar 2013, In : Sleep Medicine. 14, 3, p. 274-277 4 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Dextrans
Iron
Molecular Weight
Therapeutics

Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: Comparison with chronic osteoarthritis

Cho, Y. W., Na, G. Y., Lim, J. G., Kim, S. H., Kim, H. S., Earley, C. J. & Allen, R. P., Dec 2013, In : Sleep Medicine. 14, 12, p. 1387-1392 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Diabetic Neuropathies
Peripheral Nervous System Diseases
Osteoarthritis
Chronic Pain

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease

Patton, S. M., Cho, Y. W., Clardy, T. W., Allen, R. P., Earley, C. J. & Connor, J. R., Jun 7 2013, In : Fluids and Barriers of the CNS. 10, 1, 20

Research output: Contribution to journalArticle

Restless Legs Syndrome
Proteomics
Cerebrospinal Fluid
Proteins
prostaglandin R2 D-isomerase

Thalamic glutamate/glutamine in restless legs syndrome increased and related to disturbed sleep

Allen, R. P., Barker, P. B., Horska, A. & Earley, C. J., May 28 2013, In : Neurology. 80, 22, p. 2028-2034 7 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Glutamine
Glutamic Acid
Sleep
Creatine

The long-term treatment of restless legs syndrome/Willis-Ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: A report from the International Restless Legs Syndrome Study Group

Garcia-Borreguero, D., Kohnen, R., Silber, M. H., Winkelman, J. W., Earley, C. J., Högl, B., Manconi, M., Montplaisir, J., Inoue, Y. & Allen, R. P., Jul 2013, In : Sleep Medicine. 14, 7, p. 675-684 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Practice Guidelines
Consensus
Guidelines
Therapeutics

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

Allen, R. P., Auerbach, S., Bahrain, H., Auerbach, M. & Earley, C. J., Apr 2013, In : American Journal of Hematology. 88, 4, p. 261-264 4 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Iron-Deficiency Anemias
Iron
Sleep
Hematologic Tests

Willis-ekbom disease foundation revised consensus statement on the management of restless legs syndrome

Silber, M. H., Becker, P. M., Earley, C., Garcia-Borreguero, D. & Ondo, W. G., 2013, In : Mayo Clinic Proceedings. 88, 9, p. 977-986 10 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Consensus
Dopamine Agonists
2012

Assessing health-related quality of life in patients with restless legs syndrome in Korea: Comparison with other chronic medical diseases

Cho, Y. W., Kim, D. H., Allen, R. P. & Earley, C. J., Oct 2012, In : Sleep Medicine. 13, 9, p. 1158-1163 6 p.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Korea
Chronic Disease
Quality of Life
Depression