Christopher Gocke

Associate Professor

1992 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1992 2019

Article

Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: Peripheral oligoclonal expansion of regulatory T cells

Kanakry, C. G., Hess, A. D., Gocke, C., Thoburn, C., Kos, F., Meyer, C., Briel, J., Luznik, L., Smith, B. D., Levitsky, H. & Karp, J., Jan 13 2011, In : Blood. 117, 2, p. 608-617 10 p.

Research output: Contribution to journalArticle

Chemotherapy
T-cells
Lymphocytes
Regulatory T-Lymphocytes
Acute Myeloid Leukemia

Early noninvasive detection of response to targeted therapy in non–small cell lung cancer

Phallen, J., Leal, A., Woodward, B. D., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Fiksel, J., Medina, J. E., Cristiano, S., Palsgrove, D. N., Gocke, C., Bruhm, D. C., Keshavarzian, P., Adleff, V., Weihe, E., Anagnostou, V., Scharpf, R. B., Velculescu, V. E. & Husain, H., Jan 1 2019, In : Cancer Research. 79, 6, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Circulating Neoplastic Cells
Therapeutics

Enrichment methods for mutation detection

Gocke, C., Benko, F. A., Kopreski, M. S. & Evans, D. B., 2000, In : Annals of the New York Academy of Sciences. 906, p. 31-38 8 p.

Research output: Contribution to journalArticle

Mutation
Renal Cell Carcinoma
Mutation
Neoplasms
Pediatrics
Neuroblastoma

Evaluation of the Cepheid GeneXpert BCR-ABL assay

Jobbagy, Z., van Atta, R., Murphy, K. M., Eshleman, J. & Gocke, C., Apr 2007, In : Journal of Molecular Diagnostics. 9, 2, p. 220-227 8 p.

Research output: Contribution to journalArticle

Reverse Transcriptase Polymerase Chain Reaction
Gene Fusion
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic Translocation
Microfluidics

Evolution of a trophoblastic tumor from an endometrioid carcinoma-A morphological and molecular analysis

Olson, M. T., Gocke, C., Giuntoli, R. L. & Shih, I. M., Mar 2011, In : International Journal of Gynecological Pathology. 30, 2, p. 117-120 4 p.

Research output: Contribution to journalArticle

Trophoblastic Neoplasms
Endometrioid Carcinoma
Clonal Evolution
Choriocarcinoma
Neoplastic Stem Cells
perfosfamide
Autologous Transplantation
Bone Marrow Transplantation
Non-Hodgkin's Lymphoma
Transplantation

Ex vivo graft purging and expansion of autologous blood progenitor cell products from patients with multiple myeloma

Yang, H., Robinson, S. N., Nieto, Y., Jones, R. J., Gocke, C., Lu, J., Giralt, S. A., Jones, R. B., Decker, W. K., Xing, D., Steiner, D., Champlin, R. E., McMannis, J. D., Ng, J., Thomas, M. W., Shah, N., Andersson, B. S., Parmar, S. & Shpall, E. J., Jul 15 2011, In : Cancer Research. 71, 14, p. 5040-5049 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Blood Cells
Stem Cells
Transplants
Blood Component Removal

False positives in multiplex PCR-based next-generation sequencing have unique signatures

McCall, C. M., Mosier, S., Thiess, M., Debeljak, M., Pallavajjalla, A., Beierl, K., Deak, K. L., Datto, M. B., Gocke, C., Lin, M-T. & Eshleman, J., 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 541-549 9 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Mutation
Neoplasms
Artifacts
Genes

Fine-needle aspiration of metastatic papillary thyroid carcinoma found in the liver

VandenBussche, C., Gocke, C. & Li, Q. K., May 2013, In : Diagnostic Cytopathology. 41, 5, p. 418-424 7 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Neoplasm Metastasis
Liver
Thyroidectomy
Chromatin

Flow cytometric findings in hemophagocytic lymphohistiocytosis

McCall, C. M., Mudali, S., Arceci, R. J., Small, D., Fuller, S., Gocke, C., Vuica-Ross, M., Burns, K., Borowitz, M. J. & Duffield, A. S., May 2012, In : American Journal of Clinical Pathology. 137, 5, p. 786-794 9 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Bone Marrow
Hematologic Neoplasms
Human Herpesvirus 4
Myelopoiesis

Flow cytometry of lesional skin enhances the evaluation of cutaneous B-cell lymphomas

Wu, J. M., Vonderheid, E., Gocke, C., Moresi, J. M., Liegeois, N. & Borowitz, M. J., Oct 2012, In : Journal of Cutaneous Pathology. 39, 10, p. 918-928 11 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Flow Cytometry
Skin
Polymerase Chain Reaction
Immunohistochemistry
Hydatidiform Mole
Choriocarcinoma
Ectopic Pregnancy
Gestational Trophoblastic Disease
Chorionic Gonadotropin

Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma

Ho, C. Y., Mosier, S., Safneck, J., Salomao, D. R., Miller, N. R., Eberhart, C. G., Gocke, C., Batista, D. & Rodriguez, F. J., Mar 1 2015, In : Brain Pathology. 25, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Meningioma
Single Nucleotide Polymorphism
Optic Nerve
Chromosomes
Optic Nerve Neoplasms
Glioma
Loss of Heterozygosity
Paraffin
Microsatellite Repeats
Formaldehyde
Granulocyte-Macrophage Colony-Stimulating Factor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferons
Cytogenetics
Protein-Tyrosine Kinases

Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection

Debeljak, M., Freed, D. N., Welch, J. A., Haley, L., Beierl, K., Iglehart, B. S., Pallavajjalla, A., Gocke, C., Leffell, M. S., Lin, M-T., Pevsner, J. A., Wheelan, S. & Eshleman, J., 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 495-503 9 p.

Research output: Contribution to journalArticle

Haplotypes
Single Nucleotide Polymorphism
Hematopoietic Stem Cell Transplantation
Microsatellite Repeats
HLA-A Antigens

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Chimerism
Haplotypes
Leukemia
Recurrence
Bone Marrow Transplantation

Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma

Belchis, D. A., Tseng, L. H., Gniadek, T., Haley, L., Lokhandwala, P., Illei, P. B., Gocke, C., Forde, P., Brahmer, J., Askin, F. B., Eshleman, J. & Lin, M-T., 2016, In : Oncotarget. 7, 29, p. 45237-45248 12 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Mutation
Clone Cells
Gene Frequency
Small Cell Carcinoma

High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias

Morisot, S., Wayne, A. S., Bohana-Kashtan, O., Kaplan, I. M., Gocke, C., Hildreth, R., Stetler-Stevenson, M., Walker, R. L., Davis, S., Meltzer, P. S., Wheelan, S., Brown, P. A., Jones, R. J., Shultz, L. D. & Civin, C. I., Nov 23 2010, In : Leukemia. 24, 11, p. 1859-1866 8 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Stem Cells
Gene Rearrangement
Transcriptome

Hodgkin lymphoma stem cells

Jones, R. J., Gocke, C., Ambinder, R. F. & Matsui, W., Oct 29 2009, In : Blood. 114, 18, p. 3971-3972 2 p.

Research output: Contribution to journalArticle

Stem cells

Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma

Kasamon, Y. L., Jones, R. J., Brodsky, R. A., Fuchs, E. J., Matsui, W., Luznik, L., Powell, J., Blackford, A. L., Goodrich, A., Gocke, C., Abrams, R. A., Ambinder, R. F. & Flinn, I. W., Oct 30 2009, In : Annals of Oncology. 21, 6, p. 1203-1210 8 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Stem Cell Transplantation
Disease-Free Survival
Autologous Transplantation
Transplants

Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia

Gladstone, D., Swinnen, L., Kasamon, Y., Blackford, A., Gocke, C., Griffin, C. A., Bolanos Meade, F. J. & Jones, R. J., Oct 2011, In : Leukemia and Lymphoma. 52, 10, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
B-Cell Chronic Lymphocytic Leukemia
Chromosome Aberrations
Mutation
DNA
Acute Myeloid Leukemia
Residual Neoplasm
Transplants
Polymerase Chain Reaction
Mutation

Individualized Molecular Analyses Guide Efforts (IMAGE): A prospective study of molecular profiling of tissue and blood in metastatic triple-negative breast cancer

Parsons, H. A., Beaver, J., Cimino-Mathews, A. M., Ali, S. M., Axilbund, J., Chu, D., Connolly, R., Cochran, R. L., Croessmann, S., Clark, T. A., Gocke, C., Jeter, S. C., Kennedy, M. R., Lauring, J., Lee, J., Lipson, D., Miller, V. A., Otto, G. A., Rosner, G., Ross, J. S. & 10 others, Slater, S., Stephens, P. J., Vandenberg, D. A., Wolff, A. C., Young, L. E., Zabransky, D. J., Zhang, Z., Zorzi, J., Stearns, V. & Park, B. H., Jan 15 2017, In : Clinical Cancer Research. 23, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Prospective Studies
Biopsy
Neoplasms
Medical Futility

K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate

Smith, B. D., Kasamon, Y. L., Kowalski, J., Gocke, C., Murphy, K., Miller, C. B., Garrett-Mayer, E., Tsai, H. L., Qin, L., Chia, C., Biedrzycki, B., Harding, T. C., Tu, G. H., Jones, R. J., Hege, K. & Levitsky, H. I., Jan 1 2010, In : Clinical Cancer Research. 16, 1, p. 338-347 10 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumor Burden
Immunotherapy
Vaccines
Giant Cell Tumors
Pancreatic Ducts
Oncogenes
Pancreas
Adenocarcinoma

Large cell lymphoma presenting as a flare of colitis in a patient with common variable immune deficiency

Dunnigan, M., Yfantis, H., Rapoport, A. P., Hosseinzadeh, K., Gocke, C. & Cross, R. K., Mar 2007, In : Digestive Diseases and Sciences. 52, 3, p. 830-834 5 p.

Research output: Contribution to journalArticle

Common Variable Immunodeficiency
X Ray Computed Tomography
Colitis
Inflammatory Bowel Diseases
Colonic Neoplasms

Large-vessel vasculitis as an early manifestation of chronic myelomonocytic leukemia

Park, J. K., Gelber, A., Zheng, G., McDevitt, M. A., Gocke, C. & Baer, A., Jul 10 2011, In : Journal of Clinical Oncology. 29, 20

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Paraneoplastic Syndromes
Arteritis
Vasculitis
Carotid Arteries

Liquid bead array technology in the detection of common translocations in acute and chronic leukemias

Shackelford, R. E., Jackson, K. D., Hafez, M. J. & Gocke, C., 2013, In : Methods in molecular biology (Clifton, N.J.). 999, p. 93-103 11 p.

Research output: Contribution to journalArticle

Leukemia
Hematologic Neoplasms
Technology
Polymerase Chain Reaction
Costs and Cost Analysis

Livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity (4G/4G) treated successfully with tissue plasminogen activator

Deng, A., Gocke, C., Hess, J., Heyman, M., Paltiel, M. & Gaspari, A., 2006, In : Archives of Dermatology. 142, 11, p. 1466-1469 4 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Tissue Plasminogen Activator
Blood Vessels
Thrombosis
Replication Protein C

Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas

Belchis, D. A., Meece, C. A., Benko, F. A., Rogan, P. K., Williams, R. A. & Gocke, C., Sep 1996, In : Diagnostic Molecular Pathology. 5, 3, p. 214-219 6 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Retinoblastoma
Loss of Heterozygosity
Osteosarcoma
Microsatellite Repeats

Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide

McCurdy, S. R., Iglehart, B. S., Batista, D., Gocke, C., Ning, Y., Knaus, H. A., Jackson, A., Leffell, M. S., Luznik, L. & Gojo, I., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Lymph node metastases of melanoma: Challenges for BRAF mutation detection

Chen, G., Dudley, J., Tseng, L. H., Smith, K., Gurda, G. T., Gocke, C., Eshleman, J. & Lin, M-T., Jan 1 2015, In : Human Pathology. 46, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

Melanoma
Lymph Nodes
Neoplasm Metastasis
Mutation
MAP Kinase Kinase 2

Lymphocytic progenitor cell origin and clonal evolution of human B- lineage acute lymphoblastic leukemia

Davi, F., Gocke, C., Smith, S. & Sklar, J., Jul 15 1996, In : Blood. 88, 2, p. 609-621 13 p.

Research output: Contribution to journalArticle

Clonal Evolution
Immunoglobulin Heavy Chain Genes
Immunoglobulin Heavy Chains
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Stem Cells

Lymphomatoid papulosis followed by pityriasis lichenoides: A common pathogenesis?

Vonderheid, E. C., Kadin, M. E. & Gocke, C., Dec 2011, In : American Journal of Dermatopathology. 33, 8, p. 835-840 6 p.

Research output: Contribution to journalArticle

Pityriasis Lichenoides
Lymphomatoid Papulosis
Molecular Biology
T-Lymphocytes

Managing the genomic revolution in cancer diagnostics

Nguyen, D. & Gocke, C., Jun 21 2017, (Accepted/In press) In : Virchows Archiv. p. 1-21 21 p.

Research output: Contribution to journalArticle

Neoplasms
Patient Care
Technology
Population
Therapeutics

Microsatellite instability confounds engraftment analysis of hematopoietic stem-cell transplantation

Tseng, L. H., Tang, J. L., Haley, L., Beierl, K., Gocke, C., Eshleman, J. & Lin, M-T., 2014, In : Applied Immunohistochemistry and Molecular Morphology. 22, 6, p. 416-420 5 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Hematopoietic Stem Cell Transplantation
Chimerism
Microsatellite Repeats
Chromosomes

Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors

Gerhard, G. S., Benko, F. A., Allen, R. G., Tresini, M., Kalbach, A., Cristofalo, V. J. & Gocke, C., 2002, In : Mechanisms of Ageing and Development. 123, 2-3, p. 155-166 12 p.

Research output: Contribution to journalArticle

Fibroblasts
Mitochondrial DNA
Skin
Point Mutation
Tissue Donors
Molecular Diagnostic Techniques
Molecular Pathology
Hematologic Neoplasms
Genetic Predisposition to Disease
Lymphoma

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Ware, A. D., Birkness, J., Duffield, A. S. & Gocke, C., Apr 2 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Leukemia

Molecular pathology: On the "plateau of productivity"

Gocke, C., Jul 2010, In : Pathology Case Reviews. 15, 4, p. 101-102 2 p.

Research output: Contribution to journalArticle

Molecular Pathology

Monomorphic post-transplant lymphoproliferative disorder of the tongue: Case report and review of literature

Gonzalez-Cuyar, L. F., Tavora, F., Burke, A. P., Gocke, C., Zimrin, A., Sauk, J. J. & Zhao, X. F., 2007, In : Diagnostic Pathology. 2, 1, 49.

Research output: Contribution to journalArticle

Lymphoproliferative Disorders
Tongue
Transplants
Immunosuppressive Agents
Mouth

Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia

Karp, J., Vener, T. I., Raponi, M., Ritchie, E. K., Smith, B. D., Gore, S. D., Morris, L. E., Feldman, E. J., Greer, J. M., Malek, S., Carraway, H. E., Ironside, V., Galkin, S., Levis, M. J., McDevitt, M. A., Roboz, G. R., Gocke, C., Derecho, C., Palma, J., Wang, Y. & 3 others, Kaufmann, S. H., Wright, J. J. & Garret-Mayer, E., Jan 5 2012, In : Blood. 119, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

tipifarnib
Chemotherapy
Pharmacogenetics
Etoposide
Acute Myeloid Leukemia

Multi-institutional retrospective cohort study of spontaneous pneumothorax

Belchis, D. A., Shekitka, K. & Gocke, C., Aug 2013, In : Pathology Research and Practice. 209, 8, p. 486-489 4 p.

Research output: Contribution to journalArticle

Pneumothorax
Cohort Studies
Retrospective Studies
Lung Diseases
Macrophages

Multiple myeloma presenting initially as a solitary pleural effusion later complicated by malignant plasmacytic ascites

Inoue, Y., Chua, K., McClure, R. F., Jimenez, M. C., Gocke, C., Badros, A. Z. & Takebe, N., Jun 2005, In : Leukemia Research. 29, 6, p. 715-718 4 p.

Research output: Contribution to journalArticle

Pleural Effusion
Multiple Myeloma
Ascites
Bone Marrow

Mutational profiling of colorectal cancers with microsatellite instability

Lin, E. I., Tseng, L. H., Gocke, C., Reil, S., Le, D., Azad, N. & Eshleman, J., 2015, In : Oncotarget. 6, 39, p. 42334-42344 11 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Colorectal Neoplasms
Mutation
Receptor Protein-Tyrosine Kinases
INDEL Mutation

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C., Hruban, R. H. & Belchis, D. A., Feb 1 2016, In : Human Pathology. 48, p. 117-121 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Mutation
Pancreas
Neoplasms

NCCN Oncology Research Program's Investigator Steering Committee and NCCN Best Practices Committee molecular profiling surveys

Kurzrock, R., Colevas, A. D., Olszanski, A., Akerley, W., Arteaga, C. L., Carson, W. E., Clark, J. W., DiPersio, J. F., Ettinger, D. S., Morgan, R. J., Schwartzberg, L. S., Venook, A. P., Gocke, C., Tait, J. & Stewart, F. M., Nov 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 11, p. 1337-1346 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Molecular Pathology
Research Personnel
Patient Care
Research

Non-p.V600E BRAF mutations are common using a more sensitive and broad detection tool

Carter, J., Tseng, L. H., Zheng, G., Dudley, J., Illei, P. B., Gocke, C., Eshleman, J. & Lin, M-T., Oct 1 2015, In : American Journal of Clinical Pathology. 144, 4, p. 620-628 9 p.

Research output: Contribution to journalArticle

Mutation
Colorectal Neoplasms
Exons
Melanoma
Molecular Pathology