Christopher Gocke

Associate Professor

1992 …2019
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Research Output 1992 2019

alvocidib
Mitoxantrone
Daunorubicin
Cytarabine
Acute Myeloid Leukemia

The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells

Chang, E., Ganguly, S., Rajkhowa, T., Gocke, C., Levis, M. J. & Konig, H., Dec 21 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Methyltransferases
Myeloid Cells
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
DNA
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Bone Marrow
Tissue Donors
Lymphocytes

Utility of BRAF mutation detection in fine-needle aspiration biopsy samples read as "suspicious for papillary thyroid carcinoma"

Jara, S. M., Bhatnagar, R., Guan, H., Gocke, C., Ali, S. Z. & Tufano, R. P., Dec 1 2015, In : Head and Neck. 37, 12, p. 1788-1793 6 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Thyroidectomy
Mutation
Cell Biology
Thyroid Nodule
2014

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M-T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S., Gocke, C. & Eshleman, J., 2014, In : American Journal of Clinical Pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle

Mutation
Genome
Paraffin
Formaldehyde
Neoplasms

C-Myc immunohistochemistry in diffuse large B cell lymphoma

Gocke, C., Dec 10 2014, In : Pathology Case Reviews. 19, 5, p. 234-238 5 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Immunohistochemistry
Burkitt Lymphoma
Oncogene Proteins
Oncogenes

Cytosine Deamination Is a Major Cause of Baseline Noise in Next-Generation Sequencing

Chen, G., Mosier, S., Gocke, C., Lin, M-T. & Eshleman, J., Oct 1 2014, In : Molecular Diagnosis and Therapy. 18, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Deamination
Cytosine
Noise
Artifacts

False positives in multiplex PCR-based next-generation sequencing have unique signatures

McCall, C. M., Mosier, S., Thiess, M., Debeljak, M., Pallavajjalla, A., Beierl, K., Deak, K. L., Datto, M. B., Gocke, C., Lin, M-T. & Eshleman, J., 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 541-549 9 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Mutation
Neoplasms
Artifacts
Genes
Granulocyte-Macrophage Colony-Stimulating Factor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferons
Cytogenetics
Protein-Tyrosine Kinases

Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection

Debeljak, M., Freed, D. N., Welch, J. A., Haley, L., Beierl, K., Iglehart, B. S., Pallavajjalla, A., Gocke, C., Leffell, M. S., Lin, M-T., Pevsner, J. A., Wheelan, S. & Eshleman, J., 2014, In : Journal of Molecular Diagnostics. 16, 5, p. 495-503 9 p.

Research output: Contribution to journalArticle

Haplotypes
Single Nucleotide Polymorphism
Hematopoietic Stem Cell Transplantation
Microsatellite Repeats
HLA-A Antigens
Acute Myeloid Leukemia
Residual Neoplasm
Transplants
Polymerase Chain Reaction
Mutation

Microsatellite instability confounds engraftment analysis of hematopoietic stem-cell transplantation

Tseng, L. H., Tang, J. L., Haley, L., Beierl, K., Gocke, C., Eshleman, J. & Lin, M-T., 2014, In : Applied Immunohistochemistry and Molecular Morphology. 22, 6, p. 416-420 5 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Hematopoietic Stem Cell Transplantation
Chimerism
Microsatellite Repeats
Chromosomes

Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma

Tan, H. L., Sood, A., Rahimi, H. A., Wang, W., Gupta, N., Hicks, J., Mosier, S., Gocke, C., Epstein, J. I., Netto, G. J., Liu, W., Isaacs, W. B., Demarzo, A. M. & Lotan, T., 2014, In : Clinical Cancer Research. 20, 4, p. 890-903 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Small Cell Carcinoma
Retinoblastoma
Retinoblastoma Protein
Acinar Cell Carcinoma

Solitary plasmacytoma of the penile urethra treated with primary radiotherapy

Alcorn, S., Gocke, C., Woodard, C. A. & Tran, P. T., Oct 1 2014, In : Journal of Clinical Oncology. 32, 28, p. e95-e97

Research output: Contribution to journalArticle

Urethral Neoplasms
Penile Neoplasms
Plasmacytoma
Dermatitis
Urethra

The drowning heart: An ambiguous lymphoma

Miller, P. E., Gocke, C., Gocke, C., Cho, S. Y. & Houston, B. A., Sep 1 2014, In : American Journal of Medicine. 127, 9, p. 817-819 3 p.

Research output: Contribution to journalArticle

Pericardial Effusion
B-Cell Lymphoma
Lymphoma

Tumor cellularity as a quality assurance measure for accurate clinical detection of braf mutations in melanoma

Dudley, J. C., Gurda, G. T., Tseng, L. H., Anderson, D. A., Chen, G., Taube, J. M., Gocke, C., Eshleman, J. & Lin, M-T., 2014, In : Molecular Diagnosis and Therapy. 18, 4, p. 409-418 10 p.

Research output: Contribution to journalArticle

Melanoma
Mutation
Neoplasms
Molecular Pathology
Alleles

Detection of minor clones with internal tandem duplication mutations of FLT3 gene in acute myeloid leukemia using delta-PCR

Beierl, K., Tseng, L. H., Beierl, R., Haley, L., Gocke, C., Eshleman, J. & Lin, M-T., Mar 2013, In : Diagnostic Molecular Pathology. 22, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Clone Cells
Polymerase Chain Reaction
Mutation
Genes

Fine-needle aspiration of metastatic papillary thyroid carcinoma found in the liver

VandenBussche, C., Gocke, C. & Li, Q. K., May 2013, In : Diagnostic Cytopathology. 41, 5, p. 418-424 7 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Neoplasm Metastasis
Liver
Thyroidectomy
Chromatin

Liquid bead array technology in the detection of common translocations in acute and chronic leukemias

Shackelford, R. E., Jackson, K. D., Hafez, M. J. & Gocke, C., 2013, In : Methods in molecular biology (Clifton, N.J.). 999, p. 93-103 11 p.

Research output: Contribution to journalArticle

Leukemia
Hematologic Neoplasms
Technology
Polymerase Chain Reaction
Costs and Cost Analysis

Multi-institutional retrospective cohort study of spontaneous pneumothorax

Belchis, D. A., Shekitka, K. & Gocke, C., Aug 2013, In : Pathology Research and Practice. 209, 8, p. 486-489 4 p.

Research output: Contribution to journalArticle

Pneumothorax
Cohort Studies
Retrospective Studies
Lung Diseases
Macrophages
Peripheral T-Cell Lymphoma
Transplantation
Bone Marrow
Tissue Donors
Confidence Intervals

Software-automated counting of Ki-67 proliferation index correlates with pathologic grade and disease progression of follicular lymphomas

Samols, M. A., Smith, N. E., Gerber, J. M., Vuica-Ross, M., Gocke, C., Burns, K., Borowitz, M. J., Cornish, T. C. & Duffield, A. S., Oct 2013, In : American Journal of Clinical Pathology. 140, 4, p. 579-587 9 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Disease Progression
Software
Radiation
Drug Therapy

Tandem duplication PCR: An ultrasensitive assay for the detection of internal tandem duplications of the FLT3 Gene

Lin, M-T., Tseng, L. H., Beierl, K., Hsieh, A., Thiess, M., Chase, N., Stafford, A., Levis, M. J., Eshleman, J. & Gocke, C., Sep 2013, In : Diagnostic Molecular Pathology. 22, 3, p. 149-155 7 p.

Research output: Contribution to journalArticle

Gene Duplication
Residual Neoplasm
Acute Myeloid Leukemia
Leukemia
Clone Cells
Bone Marrow
Tissue Donors
Anemia
Donor Selection
Lymphocytosis
2012

A unique, histopathologic lesion in a subset of patients with spontaneous pneumothorax

Belchis, D. A., Shekitka, K. & Gocke, C., Dec 2012, In : Archives of Pathology and Laboratory Medicine. 136, 12, p. 1522-1527 6 p.

Research output: Contribution to journalArticle

Pneumothorax
Hope
Fibrosis
Pathology
Pleurisy

A virtual pyrogram generator to resolve complex pyrosequencing results

Chen, G., Olson, M. T., O'Neill, A., Norris, A., Beierl, K., Harada, S., Debeljak, M., Rivera-Roman, K., Finley, S., Stafford, A., Gocke, C., Lin, M-T. & Eshleman, J., Mar 2012, In : Journal of Molecular Diagnostics. 14, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

Mutation
Codon
Software
p53 Genes
Organism Cloning

Clinical and pathologic features of secondary acute promyelocytic leukemia

Duffield, A. S., Aoki, J., Levis, M. J., Cowan, K., Gocke, C., Burns, K., Borowitz, M. J. & Vuica-Ross, M., Mar 2012, In : American Journal of Clinical Pathology. 137, 3, p. 395-402 8 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Acute Myeloid Leukemia
Granulocyte Precursor Cells
Myelodysplastic Syndromes
Mutation Rate

Flow cytometric findings in hemophagocytic lymphohistiocytosis

McCall, C. M., Mudali, S., Arceci, R. J., Small, D., Fuller, S., Gocke, C., Vuica-Ross, M., Burns, K., Borowitz, M. J. & Duffield, A. S., May 2012, In : American Journal of Clinical Pathology. 137, 5, p. 786-794 9 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Bone Marrow
Hematologic Neoplasms
Human Herpesvirus 4
Myelopoiesis

Flow cytometry of lesional skin enhances the evaluation of cutaneous B-cell lymphomas

Wu, J. M., Vonderheid, E., Gocke, C., Moresi, J. M., Liegeois, N. & Borowitz, M. J., Oct 2012, In : Journal of Cutaneous Pathology. 39, 10, p. 918-928 11 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Flow Cytometry
Skin
Polymerase Chain Reaction
Immunohistochemistry

Molecular diagnostics of lymphomas

Rivera-Roman, K. & Gocke, C., Dec 7 2012, Principles of Molecular Diagnostics and Personalized Cancer Medicine. Wolters Kluwer Health Adis (ESP), p. 465-476 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Pathology
Lymphoma

Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia

Karp, J., Vener, T. I., Raponi, M., Ritchie, E. K., Smith, B. D., Gore, S. D., Morris, L. E., Feldman, E. J., Greer, J. M., Malek, S., Carraway, H. E., Ironside, V., Galkin, S., Levis, M. J., McDevitt, M. A., Roboz, G. R., Gocke, C., Derecho, C., Palma, J., Wang, Y. & 3 others, Kaufmann, S. H., Wright, J. J. & Garret-Mayer, E., Jan 5 2012, In : Blood. 119, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

tipifarnib
Chemotherapy
Pharmacogenetics
Etoposide
Acute Myeloid Leukemia

Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma

Kasamon, Y. L., Jacene, H. A., Gocke, C., Swinnen, L., Gladstone, D., Perkins, B., Link, B. K., Popplewell, L. L., Habermann, T. M., Herman, J. M., Matsui, W. H., Jones, R. J. & Ambinder, R. F., May 3 2012, In : Blood. 119, 18, p. 4129-4132 4 p.

Research output: Contribution to journalArticle

Hodgkin Disease
B-Lymphocytes
Bleomycin
Cells
Human Herpesvirus 4

Risk-based classification of leukemia by cytogenetic and multiplex molecular methods: Results from a multicenter validation study

Gocke, C., Mason, J., Brusca, L., Laosinchai-Wolf, W., Higgs, C., Newell, H., Masters, A., Friar, L., Karp, J., Griffiths, M., Wei, Q. & Labourier, E., Jul 2012, In : Blood Cancer Journal. 2, 7, e78.

Research output: Contribution to journalArticle

Validation Studies
Cytogenetics
Multicenter Studies
Leukemia
Workflow

Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITDAML

Sexauer, A., Perl, A., Yang, X., Borowitz, M. J., Gocke, C., Rajkhowa, T., Thiede, C., Frattini, M., Nybakken, G. E., Pratz, K., Karp, J., Smith, B. D. & Levis, M. J., Nov 15 2012, In : Blood. 120, 20, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Cells
Mutation
Cell Differentiation
Phosphotransferases

The importance of IGHV mutational status in del(11q) and del(17p) chronic lymphocytic leukemia

Gladstone, D., Blackford, A., Cho, E., Swinnen, L., Kasamon, Y., Gocke, C., Griffin, C. A., Bolanos Meade, F. J. & Jones, R. J., Apr 2012, In : Clinical Lymphoma, Myeloma and Leukemia. 12, 2, p. 132-137 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Cytogenetics
Survival
2011

Analysis of hematopoietic stem cell transplant engraftment: Use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy

Lin, M-T., Tseng, L. H., Beierl, K., Harada, S., Hafez, M. J., Eshleman, J. & Gocke, C., Dec 2011, In : Diagnostic Molecular Pathology. 20, 4, p. 194-202 9 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Hematopoietic Stem Cells
Microsatellite Repeats
Alleles
Transplants

Characterization of chronic myeloid leukemia stem cells.

Gerber, J. M., Qin, L., Kowalski, J., Smith, B. D., Griffin, C. A., Vala, M. S., Collector, M. I., Perkins, B., Zahurak, M., Matsui, W., Gocke, C., Sharkis, S. J., Levitsky, H. I. & Jones, R. J., Jan 2011, In : American Journal of Hematology. 86, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stem Cells
Aldehyde Dehydrogenase
Leukemia

Clonal immunoglobulin DNA in the plasma of patients with AIDS lymphoma

Wagner-Johnston, N., Gellert, L., Gocke, C., Lemas, M. V., Lee, J., Martínez-Maza, O. & Ambinder, R. F., May 5 2011, In : Blood. 117, 18, p. 4860-4862 3 p.

Research output: Contribution to journalArticle

Immunoglobulins
Lymphoma
Acquired Immunodeficiency Syndrome
Plasmas
DNA

Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: Peripheral oligoclonal expansion of regulatory T cells

Kanakry, C. G., Hess, A. D., Gocke, C., Thoburn, C., Kos, F., Meyer, C., Briel, J., Luznik, L., Smith, B. D., Levitsky, H. & Karp, J., Jan 13 2011, In : Blood. 117, 2, p. 608-617 10 p.

Research output: Contribution to journalArticle

Chemotherapy
T-cells
Lymphocytes
Regulatory T-Lymphocytes
Acute Myeloid Leukemia

Evolution of a trophoblastic tumor from an endometrioid carcinoma-A morphological and molecular analysis

Olson, M. T., Gocke, C., Giuntoli, R. L. & Shih, I. M., Mar 2011, In : International Journal of Gynecological Pathology. 30, 2, p. 117-120 4 p.

Research output: Contribution to journalArticle

Trophoblastic Neoplasms
Endometrioid Carcinoma
Clonal Evolution
Choriocarcinoma
Neoplastic Stem Cells
perfosfamide
Autologous Transplantation
Bone Marrow Transplantation
Non-Hodgkin's Lymphoma
Transplantation

Ex vivo graft purging and expansion of autologous blood progenitor cell products from patients with multiple myeloma

Yang, H., Robinson, S. N., Nieto, Y., Jones, R. J., Gocke, C., Lu, J., Giralt, S. A., Jones, R. B., Decker, W. K., Xing, D., Steiner, D., Champlin, R. E., McMannis, J. D., Ng, J., Thomas, M. W., Shah, N., Andersson, B. S., Parmar, S. & Shpall, E. J., Jul 15 2011, In : Cancer Research. 71, 14, p. 5040-5049 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Blood Cells
Stem Cells
Transplants
Blood Component Removal
Glioma
Loss of Heterozygosity
Paraffin
Microsatellite Repeats
Formaldehyde

Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia

Gladstone, D., Swinnen, L., Kasamon, Y., Blackford, A., Gocke, C., Griffin, C. A., Bolanos Meade, F. J. & Jones, R. J., Oct 2011, In : Leukemia and Lymphoma. 52, 10, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
B-Cell Chronic Lymphocytic Leukemia
Chromosome Aberrations
Mutation
DNA

Large-vessel vasculitis as an early manifestation of chronic myelomonocytic leukemia

Park, J. K., Gelber, A., Zheng, G., McDevitt, M. A., Gocke, C. & Baer, A., Jul 10 2011, In : Journal of Clinical Oncology. 29, 20

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Paraneoplastic Syndromes
Arteritis
Vasculitis
Carotid Arteries

Lymphomatoid papulosis followed by pityriasis lichenoides: A common pathogenesis?

Vonderheid, E. C., Kadin, M. E. & Gocke, C., Dec 2011, In : American Journal of Dermatopathology. 33, 8, p. 835-840 6 p.

Research output: Contribution to journalArticle

Pityriasis Lichenoides
Lymphomatoid Papulosis
Molecular Biology
T-Lymphocytes

Δ-PCR, a simple method to detect translocations and insertion/deletion mutations

Lin, M-T., Tseng, L. H., Rich, R. G., Hafez, M. J., Harada, S., Murphy, K. M., Eshleman, J. & Gocke, C., Jan 2011, In : Journal of Molecular Diagnostics. 13, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

INDEL Mutation
Follicular Lymphoma
Polymerase Chain Reaction
Mutation
Genetic Translocation
2010

Auer rod-like inclusions in a low-grade B-cell leukemia

Hristov, A. C., Saladino, A., Nava, V. E. & Gocke, C., Aug 2010, In : Annals of Diagnostic Pathology. 14, 4, p. 292-295 4 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
B-Cell Chronic Lymphocytic Leukemia
Needles
B-Lymphocytes
Neoplasms