Christopher Gocke

Associate Professor

1992 …2019
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Research Output 1992 2019

Article

34-Year-old woman with hypotension, respiratory failure, fever, and an abdominal mass

Lee, P. C., Gocke, C., Harris, E. D., Pillsbury, H. E., Bergin, C. J., Vosti, K. L., Melmon, K. L. & Clinkingbeard, C., 1993, In : Western Journal of Medicine. 158, 5, p. 499-505 7 p.

Research output: Contribution to journalArticle

Adrenal Gland Neoplasms
Pheochromocytoma
Respiratory Insufficiency
Hypotension
Differential Diagnosis

47-Year-old woman with six-week history of lower extremity weakness and eosinophilia

Lee, P. C., Gocke, C., Harris, E. D., Anderson, M. E., Bergin, C. J., Price, J. M. & Lindsey, J. W., 1992, In : Western Journal of Medicine. 156, 5, p. 517-522 6 p.

Research output: Contribution to journalArticle

Eosinophilia
Lower Extremity
Hand
Hypesthesia
Paresthesia

A fatal clostridium infection in an allogeneic stem cell transplant recipient [3]

Jain, M., Titanji, R., Rapoport, A. P., Wang, W., Gocke, C., Cross, A. & Akpek, G., Sep 2005, In : Bone Marrow Transplantation. 36, 5, p. 455-457 3 p.

Research output: Contribution to journalArticle

Transplantation Conditioning
Clostridium Infections
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Homologous Transplantation

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis

Miller, B. A., Zhang, M. Y., Gocke, C., De Souza, C., Osmani, A. H., Lynch, C., Davies, J., Bell, L. & Osmani, S. A., Apr 1999, In : Experimental Hematology. 27, 4, p. 742-750 9 p.

Research output: Contribution to journalArticle

Hematopoiesis
Aspergillus nidulans
Genes
Intercellular Signaling Peptides and Proteins
Fungi

Alterations in the RB, p16, and cyclin D1 cell cycle control pathway in osteosarcomas

Belchis, D. A., Gocke, C. & Geradts, J., 2000, In : Pediatric Pathology and Molecular Medicine. 19, 5, p. 377-389 13 p.

Research output: Contribution to journalArticle

Retinoblastoma
Cyclin D1
Osteosarcoma
Cell Cycle Checkpoints
Loss of Heterozygosity

A molecular fraction collecting tool for the ABI 310 automated sequencer

Lin, M-T., Rich, R. G., Shipley, R. F., Hafez, M. J., Tseng, L. H., Murphy, K. M., Gocke, C. & Eshleman, J., Nov 2007, In : Journal of Molecular Diagnostics. 9, 5, p. 598-603 6 p.

Research output: Contribution to journalArticle

Polyacrylamide Gel Electrophoresis
Gels
DNA
Capillary Electrophoresis
Mutation

Analysis of hematopoietic stem cell transplant engraftment: Use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy

Lin, M-T., Tseng, L. H., Beierl, K., Harada, S., Hafez, M. J., Eshleman, J. & Gocke, C., Dec 2011, In : Diagnostic Molecular Pathology. 20, 4, p. 194-202 9 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Hematopoietic Stem Cells
Microsatellite Repeats
Alleles
Transplants

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting

Lokhandwala, P., Riel, S. L., Haley, L., Lu, C., Chen, Y., Silberstein, J., Zhu, Y., Zheng, G., Lin, M-T., Gocke, C., Partin, A. W., Antonarakis, E., Luo, J. & Eshleman, J., Jan 1 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Circulating Neoplastic Cells
Prostatic Neoplasms
Castration
Ligands

A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations

Levis, M. J., Perl, A. E., Altman, J. K., Gocke, C., Bahceci, E., Hill, J., Liu, C., Xie, Z., Carson, A. R., McClain, V., Stenzel, T. T. & Miller, J. E., Apr 24 2018, In : Blood advances. 2, 8, p. 825-831 7 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Acute Myeloid Leukemia
Mutation
DNA
fms-Like Tyrosine Kinase 3

A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML

Lin, M-T., Tseng, L. H., Dudley, J. C., Riel, S., Tsai, H., Zheng, G., Pratz, K., Levis, M. J. & Gocke, C., Dec 1 2015, In : Molecular Diagnosis and Therapy. 19, 6, p. 409-417 9 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Acute Myeloid Leukemia
Polymerase Chain Reaction
Clone Cells
Molecular Pathology

A phase i trial of the VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced solid tumors and differentiated thyroid cancers

Kurzrock, R., Ball, D. W., Zahurak, M. L., Nelkin, B. D., Subbiah, V., Ahmed, S., O'Connor, A., Karunsena, E., Parkinson, R., Bishop, J. A., Ha, Y., Sharma, R., Gocke, C., Zinner, R., Rudek-Renaut, M., Sherman, S. I. & Azad, N., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5475-5484 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Mitogen-Activated Protein Kinase Kinases
Thyroid Neoplasms
Protein-Tyrosine Kinases
Neoplasms

A polycythemia vera JAK2 mutation masquerading as a duodenal cancer mutation

Lee, J., Axilbund, J., Dalton, W., Laheru, D., Watkins, S., Chu, D., Cravero, K., Button, B., Kyker-Snowman, K., Waters, I., Gocke, C., Lauring, J. & Park, B. H., Dec 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 12, p. 1495-1498 4 p.

Research output: Contribution to journalArticle

Duodenal Neoplasms
Polycythemia Vera
Mutation
Cheek
Neoplasms

Application of traditional clinical pathology quality control techniques to molecular pathology

Liang, S. L., Lin, M-T., Hafez, M. J., Gocke, C., Murphy, K. M., Sokoll, L. J. & Eshleman, J., Mar 2008, In : Journal of Molecular Diagnostics. 10, 2, p. 142-146 5 p.

Research output: Contribution to journalArticle

Clinical Pathology
Molecular Pathology
Quality Control
Microsatellite Repeats
Minisatellite Repeats
Homologous Transplantation
Acute Myeloid Leukemia
Prospective Studies
Transplants
Survival

A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia: Diagnostic challenges in clinical laboratory practice

Jinawath, N., Norris-Kirby, A., Smith, B. D., Gocke, C., Batista, D., Griffin, C. A. & Murphy, K. M., Jul 2009, In : Journal of Molecular Diagnostics. 11, 4, p. 359-363 5 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Fluorescence In Situ Hybridization
Polymerase Chain Reaction
Cytogenetic Analysis
Gene Fusion

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Gerber, J. M., Zeidner, J. F., Morse, S., Blackford, A. L., Perkins, B., Yanagisawa, B., Zhang, H., Morsberger, L., Karp, J., Ning, Y., Gocke, C., Rosner, G., Smith, B. D. & Jones, R. J., Apr 30 2016, In : Haematologica. 101, 5, p. 607-616 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Leukemia
Phenotype
Aldehyde Dehydrogenase
Stem Cells

Auer rod-like inclusions in a low-grade B-cell leukemia

Hristov, A. C., Saladino, A., Nava, V. E. & Gocke, C., Aug 2010, In : Annals of Diagnostic Pathology. 14, 4, p. 292-295 4 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
B-Cell Chronic Lymphocytic Leukemia
Needles
B-Lymphocytes
Neoplasms

A unique, histopathologic lesion in a subset of patients with spontaneous pneumothorax

Belchis, D. A., Shekitka, K. & Gocke, C., Dec 2012, In : Archives of Pathology and Laboratory Medicine. 136, 12, p. 1522-1527 6 p.

Research output: Contribution to journalArticle

Pneumothorax
Hope
Fibrosis
Pathology
Pleurisy

A virtual pyrogram generator to resolve complex pyrosequencing results

Chen, G., Olson, M. T., O'Neill, A., Norris, A., Beierl, K., Harada, S., Debeljak, M., Rivera-Roman, K., Finley, S., Stafford, A., Gocke, C., Lin, M-T. & Eshleman, J., Mar 2012, In : Journal of Molecular Diagnostics. 14, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

Mutation
Codon
Software
p53 Genes
Organism Cloning

Bone Marrow Findings in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide

Miller, K. P., Venkataraman, G., Gocke, C., Batista, D., Borowitz, M. J., Burns, K., Pratz, K. & Duffield, A. S., Oct 7 2019, In : American journal of clinical pathology. 152, 5, p. 675-685 11 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Tretinoin
Bone Marrow
Megakaryocytes
Biopsy

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers

Dudley, J., Tseng, L. H., Rooper, L., Harris, M., Haley, L., Chen, G., Gocke, C., Eshleman, J. & Lin, M-T., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Neoplasms
Neoadjuvant Therapy
Codon

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Osman, A., Gocke, C. & Gladstone, D., Feb 1 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Clone Cells
Immunoglobulin Heavy Chains
Immunoglobulin Genes
Cohort Studies

Characterization of chronic myeloid leukemia stem cells.

Gerber, J. M., Qin, L., Kowalski, J., Smith, B. D., Griffin, C. A., Vala, M. S., Collector, M. I., Perkins, B., Zahurak, M., Matsui, W., Gocke, C., Sharkis, S. J., Levitsky, H. I. & Jones, R. J., Jan 2011, In : American Journal of Hematology. 86, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stem Cells
Aldehyde Dehydrogenase
Leukemia

Circulating clonotypic B cells in classic Hodgkin lymphoma

Jones, R. J., Gocke, C., Kasamon, Y. L., Miller, C. B., Perkins, B., Barber, J. P., Vala, M. S., Gerber, J. M., Gellert, L. L., Siedner, M., Lemas, M. V., Brennan, S., Ambinder, R. F. & Matsui, W., 2009, In : Blood. 113, 23, p. 5920-5926 7 p.

Research output: Contribution to journalArticle

Hodgkin Disease
B-Lymphocytes
Cells
Reed-Sternberg Cells
Cell Line

Circulating RNA as a tumor marker: Detection of 5T4 mRNA in breast and lung cancer patient serum

Kopreski, M. S., Benko, F. A. & Gocke, C., 2001, In : Annals of the New York Academy of Sciences. 945, p. 172-178 7 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Lung Neoplasms
RNA
Breast Neoplasms
Messenger RNA

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA
Neoplasms
Adenocarcinoma
Recurrence

Clinical and pathologic features of secondary acute promyelocytic leukemia

Duffield, A. S., Aoki, J., Levis, M. J., Cowan, K., Gocke, C., Burns, K., Borowitz, M. J. & Vuica-Ross, M., Mar 2012, In : American Journal of Clinical Pathology. 137, 3, p. 395-402 8 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Acute Myeloid Leukemia
Granulocyte Precursor Cells
Myelodysplastic Syndromes
Mutation Rate

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

Zheng, G., Tseng, L. H., Chen, G., Haley, L., Illei, P. B., Gocke, C., Eshleman, J. & Lin, M-T., Oct 24 2015, In : BMC Cancer. 15, 1, 779.

Research output: Contribution to journalArticle

Phosphotransferases
Mutation
Proto-Oncogene Proteins B-raf
Melanoma
Lung Neoplasms
Open Access
Melanoma
Mutation
Phosphotransferases
Codon
Incidence

Clinical mutational profiling of 1006 lung cancers by next generation sequencing

Illei, P. B., Belchis, D. A., Tseng, L. H., Nguyen, D., De Marchi, F., Haley, L., Riel, S., Beierl, K., Zheng, G., Brahmer, J., Askin, F. B., Gocke, C., Eshleman, J., Forde, P. & Lin, M-T., Jan 1 2017, In : Oncotarget. 8, 57, p. 96684-96696 13 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Sequence Deletion
Missense Mutation
Gene Frequency
Melanoma
Colon
Neoplasm Metastasis
Carcinoma
Bone and Bones

Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways in lung cancers

De Marchi, F., Haley, L., Fryer, H., Ibrahim, J., Beierl, K., Zheng, G., Gocke, C., Eshleman, J., Belchis, D. A., Illei, P. B. & Lin, M-T., Feb 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinases
Epidermal Growth Factor Receptor
Lung Neoplasms
Mutation

Clinical validation of coexisting driver mutations in colorectal cancers

Zheng, G., Tseng, L. H., Haley, L., Ibrahim, J., Bynum, J., Xian, R., Gocke, C., Eshleman, J. & Lin, M-T., Apr 1 2019, In : Human pathology. 86, p. 12-20 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Mitogen-Activated Protein Kinases
Proto-Oncogene Proteins B-raf
Phosphatidylinositol 3-Kinase
Lung Neoplasms
Mutation
Second Primary Neoplasms
Single Nucleotide Polymorphism
Neoplasms

Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing

Lin, M-T., Mosier, S. L., Thiess, M., Beierl, K. F., Debeljak, M., Tseng, L. H., Chen, G., Yegnasubramanian, S., Ho, H., Cope, L., Wheelan, S., Gocke, C. & Eshleman, J., 2014, In : American Journal of Clinical Pathology. 141, 6, p. 856-866 11 p.

Research output: Contribution to journalArticle

Mutation
Genome
Paraffin
Formaldehyde
Neoplasms

Clonal immunoglobulin DNA in the plasma of patients with AIDS lymphoma

Wagner-Johnston, N., Gellert, L., Gocke, C., Lemas, M. V., Lee, J., Martínez-Maza, O. & Ambinder, R. F., May 5 2011, In : Blood. 117, 18, p. 4860-4862 3 p.

Research output: Contribution to journalArticle

Immunoglobulins
Lymphoma
Acquired Immunodeficiency Syndrome
Plasmas
DNA

C-Myc immunohistochemistry in diffuse large B cell lymphoma

Gocke, C., Dec 10 2014, In : Pathology Case Reviews. 19, 5, p. 234-238 5 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Immunohistochemistry
Burkitt Lymphoma
Oncogene Proteins
Oncogenes

Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: Diagnostic and clinical implications

Tsiatis, A. C., Norris-Kirby, A., Rich, R. G., Hafez, M. J., Gocke, C., Eshleman, J. & Murphy, K. M., Jul 1 2010, In : Journal of Molecular Diagnostics. 12, 4, p. 425-432 8 p.

Research output: Contribution to journalArticle

Freezing
Codon
Mutation
Oncogenes
Epidermal Growth Factor Receptor

Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma

Bendandi, M., Gocke, C., Kobrin, C., Benko, F. A., Sternas, L. A., Pennington, R., Watson, T. M., Reynolds, C. W., Gause, B. L., Duffey, P. L., Jaffe, E. S., Creekmore, S. P., Longo, D. L. & Kwak, L. W., Oct 1999, In : Nature Medicine. 5, 10, p. 1171-1177 7 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
Granulocyte Colony-Stimulating Factor
Tumors
Monocytes
Lymphoma

Cytosine Deamination Is a Major Cause of Baseline Noise in Next-Generation Sequencing

Chen, G., Mosier, S., Gocke, C., Lin, M-T. & Eshleman, J., Oct 1 2014, In : Molecular Diagnosis and Therapy. 18, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Deamination
Cytosine
Noise
Artifacts

Detection of chromosomal translocation in hematologic malignancies by a novel DNA-based Looped Ligation Assay (LOLA)

Harada, S., Sizzle, E., Lin, M-T. & Gocke, C., Jul 1 2017, In : Clinical Chemistry. 63, 7, p. 1278-1287 10 p.

Research output: Contribution to journalArticle

Genetic Translocation
Hematologic Neoplasms
Ligation
Follicular Lymphoma
Assays

Detection of minor clones with internal tandem duplication mutations of FLT3 gene in acute myeloid leukemia using delta-PCR

Beierl, K., Tseng, L. H., Beierl, R., Haley, L., Gocke, C., Eshleman, J. & Lin, M-T., Mar 2013, In : Diagnostic Molecular Pathology. 22, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Clone Cells
Polymerase Chain Reaction
Mutation
Genes

Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer

Kopreski, M. S., Benko, F. A., Kwee, C., Leitzel, K. E., Eskander, E., Lipton, A. & Gocke, C., 1997, In : British Journal of Cancer. 76, 10, p. 1293-1299 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
Serum
Polymerase Chain Reaction
Healthy Volunteers

Detection of tumor messenger RNA in the serum of patients with malignant melanoma

Kopreski, M. S., Benko, F. A., Kwak, L. W. & Gocke, C., Aug 1999, In : Clinical Cancer Research. 5, 8, p. 1961-1965 5 p.

Research output: Contribution to journalArticle

Melanoma
Messenger RNA
Monophenol Monooxygenase
Serum
Neoplasms

Development of an integrated assay for detection of BCR-ABL RNA

Winn-Deen, E. S., Helton, B., Van Atta, R., Wong, W., Peralta, J., Wang, J., Tsongalis, G. J., Belloni, D., Chan, D., Eshleman, J., Gocke, C., Jobbagy, Z., Beppu, L. & Radich, J. P., Sep 2007, In : Clinical Chemistry. 53, 9, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

Assays
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
RNA
Reverse Transcription
Polymerase Chain Reaction

Do circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility? A report of the association for molecular pathology

Gold, B., Cankovic, M., Furtado, L. V., Meier, F. & Gocke, C., May 1 2015, In : Journal of Molecular Diagnostics. 17, 3, p. 209-224 16 p.

Research output: Contribution to journalArticle

Exosomes
Circulating Neoplastic Cells
Molecular Pathology
Nucleic Acids
Neoplasms

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Hematopoiesis
Bone Marrow Transplantation
Leukemia