Christopher Gocke

Associate Professor

1992 …2019
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Research Output 1992 2019

Mutational profiling of colorectal cancers with microsatellite instability

Lin, E. I., Tseng, L. H., Gocke, C., Reil, S., Le, D., Azad, N. & Eshleman, J., 2015, In : Oncotarget. 6, 39, p. 42334-42344 11 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Colorectal Neoplasms
Mutation
Receptor Protein-Tyrosine Kinases
INDEL Mutation

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C., Hruban, R. H. & Belchis, D. A., Feb 1 2016, In : Human Pathology. 48, p. 117-121 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Mutation
Pancreas
Neoplasms

NCCN Oncology Research Program's Investigator Steering Committee and NCCN Best Practices Committee molecular profiling surveys

Kurzrock, R., Colevas, A. D., Olszanski, A., Akerley, W., Arteaga, C. L., Carson, W. E., Clark, J. W., DiPersio, J. F., Ettinger, D. S., Morgan, R. J., Schwartzberg, L. S., Venook, A. P., Gocke, C., Tait, J. & Stewart, F. M., Nov 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 11, p. 1337-1346 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Molecular Pathology
Research Personnel
Patient Care
Research

Non-p.V600E BRAF mutations are common using a more sensitive and broad detection tool

Carter, J., Tseng, L. H., Zheng, G., Dudley, J., Illei, P. B., Gocke, C., Eshleman, J. & Lin, M-T., Oct 1 2015, In : American Journal of Clinical Pathology. 144, 4, p. 620-628 9 p.

Research output: Contribution to journalArticle

Mutation
Colorectal Neoplasms
Exons
Melanoma
Molecular Pathology

Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature

Scheper, M. A., Nikitakis, N. G., Fernandes, R., Gocke, C., Ord, R. A. & Sauk, J. J., Aug 2005, In : Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 100, 2, p. 198-206 9 p.

Research output: Contribution to journalArticle

HIV
CD45 Antigens
Desmin
Keratins
Rare Diseases
Peripheral T-Cell Lymphoma
Transplantation
Bone Marrow
Tissue Donors
Confidence Intervals

p53 and APC mutations are detectable in the plasma and serum of patients with colorectal cancer (CRC) or adenomas

Gocke, C., Benko, F. A., Kopreski, M. S. & McGarrity, T. J., 2000, In : Annals of the New York Academy of Sciences. 906, p. 44-50 7 p.

Research output: Contribution to journalArticle

Adenoma
Colorectal Neoplasms
Plasmas
Mutation
Serum

PD-L1 expression in inflammatory myofibroblastic tumors

Cottrell, T. R., Duong, A. T., Gocke, C., Xu, H., Ogurtsova, A., Taube, J. M. & Belchis, D. A., Feb 15 2018, (Accepted/In press) In : Modern Pathology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Neoplasms
T-Lymphocytes
Therapeutics
Mutation
Protein-Tyrosine Kinases

Pentostatin-induced hypereosinophilia with eosinophilic gastroenteritis

Shouval, R., Duffield, A. S., Gocke, C., Lee, L. A. & Brodsky, R. A., Aug 2010, In : Leukemia and Lymphoma. 51, 8, p. 1567-1569 3 p.

Research output: Contribution to journalArticle

Pentostatin
Hairy Cell Leukemia
Gastroenteritis
Eosinophilia
Antineoplastic Agents

Performance and clinical evaluation of a sensitive multiplex assay for the rapid detection of common NPM1 mutations

Hafez, M., Ye, F., Jackson, K., Yang, Z., Karp, J., Labourier, E. & Gocke, C., Sep 2010, In : Journal of Molecular Diagnostics. 12, 5, p. 629-635 7 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Karyotype
RNA
Workflow

Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers

Haley, L., Tseng, L. H., Zheng, G., Dudley, J., Anderson, D. A., Azad, N., Gocke, C., Eshleman, J. & Lin, M-T., Oct 3 2015, In : Modern Pathology. 28, 10, p. 1390-1399 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Gene Frequency
Exons
Epidermal Growth Factor Receptor

Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma

Kasamon, Y. L., Jacene, H. A., Gocke, C., Swinnen, L., Gladstone, D., Perkins, B., Link, B. K., Popplewell, L. L., Habermann, T. M., Herman, J. M., Matsui, W. H., Jones, R. J. & Ambinder, R. F., May 3 2012, In : Blood. 119, 18, p. 4129-4132 4 p.

Research output: Contribution to journalArticle

Hodgkin Disease
B-Lymphocytes
Bleomycin
Cells
Human Herpesvirus 4

Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients

Badros, A. Z., Goloubeva, O., Rapoport, A. P., Ratterree, B., Gahres, N., Meisenberg, B., Takebe, N., Heyman, M., Zwiebel, J., Streicher, H., Gocke, C., Tomic, D., Flaws, J. A., Zhang, B. & Fenton, R. G., 2005, In : Journal of Clinical Oncology. 23, 18, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

Thalidomide
Antisense Oligonucleotides
Multiple Myeloma
Dexamethasone
oblimersen

Placental pathology in maternal and neonatal myeloproliferative disorders

Lentz, S. E., Coulson, C. C., Gocke, C. & Fantaskey, A. P., May 1998, In : Obstetrics and Gynecology. 91, 5 II SUPPL., p. 863 1 p.

Research output: Contribution to journalArticle

Neoplastic Pregnancy Complications
Myeloproliferative Disorders
Myeloid Leukemia
Acute Disease
Placenta

Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation

Ahsan, N., Holman, M. J., Gocke, C., Groff, J. A. & Yang, H. C., Aug 1997, In : Clinical Transplantation. 11, 4, p. 265-270 6 p.

Research output: Contribution to journalArticle

Pure Red-Cell Aplasia
Parvoviridae Infections
Organ Transplantation
Intravenous Immunoglobulins
Tacrolimus
alvocidib
Mitoxantrone
Daunorubicin
Cytarabine
Acute Myeloid Leukemia

Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma

Tan, H. L., Sood, A., Rahimi, H. A., Wang, W., Gupta, N., Hicks, J., Mosier, S., Gocke, C., Epstein, J. I., Netto, G. J., Liu, W., Isaacs, W. B., Demarzo, A. M. & Lotan, T., 2014, In : Clinical Cancer Research. 20, 4, p. 890-903 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Small Cell Carcinoma
Retinoblastoma
Retinoblastoma Protein
Acinar Cell Carcinoma

Resolution of pansclerotic morphea after treatment with antithymocyte globulin.

Song, P., Gocke, C., Wigley, F. & Boin, F., Sep 2009, In : Nature Reviews Rheumatology. 5, 9, p. 513-516 4 p.

Research output: Contribution to journalArticle

Localized Scleroderma
Antilymphocyte Serum
Methylprednisolone
Methotrexate
Upper Extremity

Risk-based classification of leukemia by cytogenetic and multiplex molecular methods: Results from a multicenter validation study

Gocke, C., Mason, J., Brusca, L., Laosinchai-Wolf, W., Higgs, C., Newell, H., Masters, A., Friar, L., Karp, J., Griffiths, M., Wei, Q. & Labourier, E., Jul 2012, In : Blood Cancer Journal. 2, 7, e78.

Research output: Contribution to journalArticle

Validation Studies
Cytogenetics
Multicenter Studies
Leukemia
Workflow

Serum BCL2/IGH DNA in follicular lymphoma patients: A minimal residual disease marker

Gocke, C., Kopreski, M. S., Benko, F. A., Sternas, L. & Kwak, L. W., 2000, In : Leukemia and Lymphoma. 39, 1-2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Residual Neoplasm
DNA
Serum
Transgenes

Software-automated counting of Ki-67 proliferation index correlates with pathologic grade and disease progression of follicular lymphomas

Samols, M. A., Smith, N. E., Gerber, J. M., Vuica-Ross, M., Gocke, C., Burns, K., Borowitz, M. J., Cornish, T. C. & Duffield, A. S., Oct 2013, In : American Journal of Clinical Pathology. 140, 4, p. 579-587 9 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Disease Progression
Software
Radiation
Drug Therapy

Solitary plasmacytoma of the penile urethra treated with primary radiotherapy

Alcorn, S., Gocke, C., Woodard, C. A. & Tran, P. T., Oct 1 2014, In : Journal of Clinical Oncology. 32, 28, p. e95-e97

Research output: Contribution to journalArticle

Urethral Neoplasms
Penile Neoplasms
Plasmacytoma
Dermatitis
Urethra

Somatic mutation screening: Identification of individuals harboring K- ras mutations with the use of plasma DNA

Kopreski, M. S., Benko, F. A., Borys, D. J., Khan, A., McGarrity, T. J. & Gocke, C., Jun 7 2000, In : Journal of the National Cancer Institute. 92, 11, p. 918-923 6 p.

Research output: Contribution to journalArticle

Mutation
DNA
ras Genes
Colorectal Neoplasms
Colonoscopy

Specimen identity testing using deoxyribonucleic acid analysis in clinical and surgical pathology setting

Harada, S. & Gocke, C., Jul 2010, In : Pathology Case Reviews. 15, 4, p. 116-120 5 p.

Research output: Contribution to journalArticle

Surgical Pathology
Clinical Pathology
Squamous Cell Carcinoma
DNA
Paraffin

Takayasu aortitis with acute dissection and hemopericardium

Tavora, F., Jeudy, J., Gocke, C. & Burke, A., Nov 2005, In : Cardiovascular Pathology. 14, 6, p. 320-323 4 p.

Research output: Contribution to journalArticle

Aortitis
Pericardial Effusion
Dissection
Adventitia
Aortic Diseases

Tandem duplication PCR: An ultrasensitive assay for the detection of internal tandem duplications of the FLT3 Gene

Lin, M-T., Tseng, L. H., Beierl, K., Hsieh, A., Thiess, M., Chase, N., Stafford, A., Levis, M. J., Eshleman, J. & Gocke, C., Sep 2013, In : Diagnostic Molecular Pathology. 22, 3, p. 149-155 7 p.

Research output: Contribution to journalArticle

Gene Duplication
Residual Neoplasm
Acute Myeloid Leukemia
Leukemia
Clone Cells
Bone Marrow
Tissue Donors
Anemia
Donor Selection
Lymphocytosis

Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: Therapy with sequential 1-β -D-arabinofuranosylcytosine, mitoxantrone, and bevacizumab

Karp, J., Gojo, I., Pili, R., Gocke, C., Greer, J., Guo, C., Qian, D., Morris, L., Tidwell, M., Chen, H. & Zwiebel, J., Jun 1 2004, In : Clinical Cancer Research. 10, 11, p. 3577-3585 9 p.

Research output: Contribution to journalArticle

Mitoxantrone
Cytarabine
Acute Myeloid Leukemia
Vascular Endothelial Growth Factor A
Therapeutics

Temperature-controlled SSCP analysis using a vertical slab gel unit

Benko, F. A., Gocke, C. & Patel, A., Feb 1996, In : American Biotechnology Laboratory. 14, 3, p. 44-46 3 p.

Research output: Contribution to journalArticle

Single-Stranded Conformational Polymorphism
Gels
Temperature

Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITDAML

Sexauer, A., Perl, A., Yang, X., Borowitz, M. J., Gocke, C., Rajkhowa, T., Thiede, C., Frattini, M., Nybakken, G. E., Pratz, K., Karp, J., Smith, B. D. & Levis, M. J., Nov 15 2012, In : Blood. 120, 20, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Cells
Mutation
Cell Differentiation
Phosphotransferases

Test feasibility of next-generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens

Zheng, G., Tsai, H., Tseng, L. H., Illei, P. B., Gocke, C., Eshleman, J., Netto, G. & Lin, M-T., May 1 2016, In : American Journal of Clinical Pathology. 145, 5, p. 696-702 7 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Mutation
INDEL Mutation
Bone and Bones
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Vidarabine
Hematologic Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Cyclophosphamide

The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells

Chang, E., Ganguly, S., Rajkhowa, T., Gocke, C., Levis, M. J. & Konig, H., Dec 21 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Methyltransferases
Myeloid Cells
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
DNA

The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Zheng, G., Chen, P., Pallavajjalla, A., Haley, L., Gondek, L., Dezern, A., Ling, H., De Marchi, F., Lin, M-T. & Gocke, C., Jan 1 2019, (Accepted/In press) In : American journal of hematology.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Gene Frequency
Genes
Mutation
Aplastic Anemia

The drowning heart: An ambiguous lymphoma

Miller, P. E., Gocke, C., Gocke, C., Cho, S. Y. & Houston, B. A., Sep 1 2014, In : American Journal of Medicine. 127, 9, p. 817-819 3 p.

Research output: Contribution to journalArticle

Pericardial Effusion
B-Cell Lymphoma
Lymphoma

The evolution of earned, transparent, and quantifiable faculty salary compensation: The Johns Hopkins pathology experience

Burns, K., Borowitz, M. J., Carroll, K. C., Gocke, C., Hooper, J., Amukele, T. K., Tobian, A. A., Valentine, A., Kahl, R., Rodas-Eral, V., Boitnott, J. K., Jackson, J. B., Sanfilippo, F. & Hruban, R. H., Jan 1 2018, In : Academic Pathology. 5

Research output: Contribution to journalArticle

Salaries and Fringe Benefits
Pathology
Reward
Remuneration
Quality Improvement
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Bone Marrow
Tissue Donors
Lymphocytes

The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia

Gocke, C., Osmani, S. A. & Miller, B. A., 2000, In : Histochemistry and Cell Biology. 114, 4, p. 293-301 9 p.

Research output: Contribution to journalArticle

Aspergillus
epithelium
genes
Epithelium
Genes

The importance of IGHV mutational status in del(11q) and del(17p) chronic lymphocytic leukemia

Gladstone, D., Blackford, A., Cho, E., Swinnen, L., Kasamon, Y., Gocke, C., Griffin, C. A., Bolanos Meade, F. J. & Jones, R. J., Apr 2012, In : Clinical Lymphoma, Myeloma and Leukemia. 12, 2, p. 132-137 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Cytogenetics
Survival

The nuclear migration gene nudC and human hematopoiesis

Gocke, C., Reaman, G. H., Stine, C., Zhang, M. Y., Osmani, S. A. & Miller, B. A., 2000, In : Leukemia and Lymphoma. 39, 5-6, p. 447-454 8 p.

Research output: Contribution to journalArticle

Hematopoiesis
Aspergillus nidulans
Leukemia, Erythroblastic, Acute
Messenger RNA
Granulocyte-Macrophage Colony-Stimulating Factor

The Utility of NKX2.2 and TLE1 Immunohistochemistry in the Differentiation of Ewing Sarcoma and Synovial Sarcoma

Rooper, L., Sharma, R., Gocke, C. & Belchis, D. A., Mar 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 3, p. 174-179 6 p.

Research output: Contribution to journalReview article

Synovial Sarcoma
Ewing's Sarcoma
Immunohistochemistry
Staining and Labeling
Reverse Transcription

Transmission of mitochondrial DNA heteroplasmy in normal pedigrees

Gocke, C., Benko, F. A. & Rogan, P. K., 1998, In : Human Genetics. 102, 2, p. 182-186 5 p.

Research output: Contribution to journalArticle

Pedigree
Mitochondrial DNA
Intergenic DNA
Cytosine
Electron Transport Complex IV

Treatment and outcomes of post-transplant lymphoproliferative disease: A single institution study

Buadi, F. K., Heyman, M. R., Gocke, C., Rapoport, A. P., Hakimian, R., Bartlett, S. T. & Sarkodee-Adoo, C., Mar 2007, In : American Journal of Hematology. 82, 3, p. 208-214 7 p.

Research output: Contribution to journalArticle

Lymphoproliferative Disorders
Transplants
Drug Therapy
Survival
B-Cell Lymphoma

True histiocytic lymphoma: A study of 12 cases based on Current definition

Kamel, O. W., Gocke, C., Kell, D. L., Cleary, M. L. & Warnke, R. A., 1995, In : Leukemia and Lymphoma. 18, 1-2, p. 81-86 6 p.

Research output: Contribution to journalArticle

Histiocytic Sarcoma
Immunoglobulin Light Chain Genes
Lymph Nodes
Immunoglobulin Heavy Chain Genes
Immunophenotyping

Tumor cellularity as a quality assurance measure for accurate clinical detection of braf mutations in melanoma

Dudley, J. C., Gurda, G. T., Tseng, L. H., Anderson, D. A., Chen, G., Taube, J. M., Gocke, C., Eshleman, J. & Lin, M-T., 2014, In : Molecular Diagnosis and Therapy. 18, 4, p. 409-418 10 p.

Research output: Contribution to journalArticle

Melanoma
Mutation
Neoplasms
Molecular Pathology
Alleles

Tumor-infiltrating macrophages in post-transplant, relapsed classical Hodgkin lymphoma are donor-derived

Crane, G. M., Samols, M. A., Morsberger, L. A., Yonescu, R., Thiess, M. L., Batista, D., Ning, Y., Burns, K., Vuica-Ross, M., Borowitz, M. J., Gocke, C., Ambinder, R. F. & Duffield, A. S., Sep 1 2016, In : PLoS One. 11, 9, e0163559.

Research output: Contribution to journalArticle

Hodgkin disease
Transplants
Macrophages
Hodgkin Disease
Tumors

Unusual leukemia presentations: Case 2. Granulocytic sarcoma of the colon

Tummala, M., Thomas, L., Gocke, C., Heyman, M. R. & Gojo, I., 2005, In : Journal of Clinical Oncology. 23, 24, p. 5840-5841 2 p.

Research output: Contribution to journalArticle

Myeloid Sarcoma
Combined Modality Therapy
Colonic Neoplasms
Colon
Leukemia

Utility of BRAF mutation detection in fine-needle aspiration biopsy samples read as "suspicious for papillary thyroid carcinoma"

Jara, S. M., Bhatnagar, R., Guan, H., Gocke, C., Ali, S. Z. & Tufano, R. P., Dec 1 2015, In : Head and Neck. 37, 12, p. 1788-1793 6 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Thyroidectomy
Mutation
Cell Biology
Thyroid Nodule

Validation Strategy for Ultrasensitive Mutation Detection

Debeljak, M., Noë, M., Riel, S. L., Haley, L. M., Norris, A. L., Anderson, D. A., Adams, E. M., Suenaga, M., Beierl, K. F., Lin, M-T., Goggins, M. S., Gocke, C. & Eshleman, J., Jul 5 2018, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-9 9 p.

Research output: Contribution to journalArticle

Point Mutation
Gene Frequency
Haplotypes
Cell Line
Polymerase Chain Reaction