Christopher Gocke

Associate Professor

1992 …2020

Research output per year

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Research Output

2020

Flow cytometric analysis of fine needle aspirates is affected by tumor subtype, but not by anatomic location nor technique

Wake, L. M., VandenBussche, C. J., Ali, S. Z., Wagner-Johnston, N. D., Burns, K. H., Gocke, C. D., Vuica-Ross, M., Borowitz, M. J. & Duffield, A. S., Jun 1 2020, In : Diagnostic cytopathology. 48, 6, p. 538-546 9 p.

Research output: Contribution to journalArticle

FLT3 inhibitors added to induction therapy induce deeper remissions

Levis, M., Shi, W., Chang, K., Laing, C., Pollner, R., Gocke, C., Adams, E., Berisha, F., Lameh, J. & Lesegretain, A., Jan 1 2020, In : Blood. 135, 1, p. 75-78 4 p.

Research output: Contribution to journalLetter

IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution

Rodriguez, E. F., De Marchi, F., Lokhandwala, P. M., Belchis, D., Xian, R., Gocke, C. D., Eshleman, J. R., Illei, P. & Li, M. T., Jan 1 2020, (Accepted/In press) In : Cancer medicine.

Research output: Contribution to journalArticle

Open Access

Multiclonal colorectal cancers with divergent histomorphological features and RAS mutations: one cancer or separate cancers?

Lin, M. T., Zheng, G., Tseng, L. H., Zhang, P., Ling, H., Azad, N., Gocke, C. D., Montgomery, E. & Eshleman, J. R., Apr 2020, In : Human pathology. 98, p. 120-128 9 p.

Research output: Contribution to journalArticle

The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing

Brian Dalton, W., Helmenstine, E., Pieterse, L., Li, B., Gocke, C. D., Donaldson, J., Xiao, Z., Gondek, L. P., Ghiaur, G., Gojo, I., Douglas Smith, B., Levis, M. J. & DeZern, A. E., Apr 14 2020, In : Blood Advances. 4, 7, p. 1192-1196 5 p.

Research output: Contribution to journalReview article

Open Access
2019

A phase i trial of the VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced solid tumors and differentiated thyroid cancers

Kurzrock, R., Ball, D. W., Zahurak, M. L., Nelkin, B. D., Subbiah, V., Ahmed, S., O'Connor, A., Karunsena, E., Parkinson, R., Bishop, J. A., Ha, Y., Sharma, R., Gocke, C., Zinner, R., Rudek-Renaut, M., Sherman, S. I. & Azad, N., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5475-5484 10 p.

Research output: Contribution to journalArticle

Bone Marrow Findings in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide

Miller, K. P., Venkataraman, G., Gocke, C., Batista, D., Borowitz, M. J., Burns, K., Pratz, K. & Duffield, A. S., Oct 7 2019, In : American journal of clinical pathology. 152, 5, p. 675-685 11 p.

Research output: Contribution to journalArticle

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Open Access

Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways in lung cancers

De Marchi, F., Haley, L., Fryer, H., Ibrahim, J., Beierl, K., Zheng, G., Gocke, C., Eshleman, J., Belchis, D. A., Illei, P. B. & Lin, M-T., Feb 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Clinical validation of coexisting driver mutations in colorectal cancers

Zheng, G., Tseng, L. H., Haley, L., Ibrahim, J., Bynum, J., Xian, R., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Apr 2019, In : Human pathology. 86, p. 12-20 9 p.

Research output: Contribution to journalArticle

Early noninvasive detection of response to targeted therapy in non–small cell lung cancer

Phallen, J., Leal, A., Woodward, B. D., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Fiksel, J., Medina, J. E., Cristiano, S., Palsgrove, D. N., Gocke, C., Bruhm, D. C., Keshavarzian, P., Adleff, V., Weihe, E., Anagnostou, V., Scharpf, R. B., Velculescu, V. E. & Husain, H., Jan 1 2019, In : Cancer Research. 79, 6, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Open Access

The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Zheng, G., Chen, P., Pallavajjalla, A., Haley, L., Gondek, L., Dezern, A., Ling, H., De Marchi, F., Lin, M. T. & Gocke, C., Oct 1 2019, In : American journal of hematology. 94, 10, p. 1141-1148 8 p.

Research output: Contribution to journalArticle

The Utility of NKX2.2 and TLE1 Immunohistochemistry in the Differentiation of Ewing Sarcoma and Synovial Sarcoma

Rooper, L., Sharma, R., Gocke, C. & Belchis, D. A., Mar 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 3, p. 174-179 6 p.

Research output: Contribution to journalReview article

Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: A case report and review of current challenges in molecular diagnostics

Romo, C. G., Palsgrove, D. N., Sivakumar, A., Elledge, C. R., Kleinberg, L. R., Chaichana, K. L., Gocke, C., Rodriguez, F. J. & Holdhoff, M., Feb 9 2019, In : Diagnostic Pathology. 14, 1, 16.

Research output: Contribution to journalArticle

Open Access
2018

A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations

Levis, M. J., Perl, A. E., Altman, J. K., Gocke, C., Bahceci, E., Hill, J., Liu, C., Xie, Z., Carson, A. R., McClain, V., Stenzel, T. T. & Miller, J. E., Apr 24 2018, In : Blood advances. 2, 8, p. 825-831 7 p.

Research output: Contribution to journalArticle

Final results of a randomized multicenter phase II study of alvocidib, cytarabine, and mitoxantrone versus cytarabine and daunorubicin (7 + 3) in newly diagnosed high-risk acute myeloid leukemia (AML)

Zeidner, J. F., Foster, M. C., Blackford, A. L., Litzow, M. R., Morris, L. E., Strickland, S. A., Lancet, J. E., Bose, P., Levy, M. Y., Tibes, R., Gojo, I., Gocke, C. D., Rosner, G. L., Little, R. F., Wright, J. J., Doyle, L. A., Smith, B. D. & Karp, J. E., Sep 2018, In : Leukemia Research. 72, p. 92-95 4 p.

Research output: Contribution to journalLetter

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Ware, A. D., Birkness, J., Duffield, A. S. & Gocke, C., Apr 2 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

PD-L1 expression in inflammatory myofibroblastic tumors

Cottrell, T. R., Duong, A. T., Gocke, C., Xu, H., Ogurtsova, A., Taube, J. M. & Belchis, D. A., Feb 15 2018, (Accepted/In press) In : Modern Pathology. p. 1-9 9 p.

Research output: Contribution to journalArticle

The evolution of earned, transparent, and quantifiable faculty salary compensation: The Johns Hopkins pathology experience

Burns, K., Borowitz, M. J., Carroll, K. C., Gocke, C., Hooper, J., Amukele, T. K., Tobian, A. A., Valentine, A., Kahl, R., Rodas-Eral, V., Boitnott, J. K., Jackson, J. B., Sanfilippo, F. & Hruban, R. H., Jan 1 2018, In : Academic Pathology. 5

Research output: Contribution to journalArticle

Validation Strategy for Ultrasensitive Mutation Detection

Debeljak, M., Noë, M., Riel, S. L., Haley, L. M., Norris, A. L., Anderson, D. A., Adams, E. M., Suenaga, M., Beierl, K. F., Lin, M-T., Goggins, M. S., Gocke, C. & Eshleman, J., Jul 5 2018, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-9 9 p.

Research output: Contribution to journalArticle

2017

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Osman, A., Gocke, C. & Gladstone, D., Feb 1 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

Clinical mutational profiling of 1006 lung cancers by next generation sequencing

Illei, P. B., Belchis, D., Tseng, L. H., Nguyen, D., De Marchi, F., Haley, L., Riel, S., Beierl, K., Zheng, G., Brahmer, J. R., Askin, F. B., Gocke, C. D., Eshleman, J. R., Forde, P. M. & Lin, M. T., Jan 1 2017, In : Oncotarget. 8, 57, p. 96684-96696 13 p.

Research output: Contribution to journalArticle

Detection of chromosomal translocation in hematologic malignancies by a novel DNA-based Looped Ligation Assay (LOLA)

Harada, S., Sizzle, E., Lin, M-T. & Gocke, C., Jul 1 2017, In : Clinical Chemistry. 63, 7, p. 1278-1287 10 p.

Research output: Contribution to journalArticle

Erratum to: Managing the genomic revolution in cancer diagnostics (Virchows Archiv, (2017), 471, 2, (175-194), 10.1007/s00428-017-2175-2)

Nguyen, D. & Gocke, C., Aug 1 2017, In : Virchows Archiv. 471, 2, p. 195-197 3 p.

Research output: Contribution to journalComment/debate

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Individualized Molecular Analyses Guide Efforts (IMAGE): A prospective study of molecular profiling of tissue and blood in metastatic triple-negative breast cancer

Parsons, H. A., Beaver, J., Cimino-Mathews, A. M., Ali, S. M., Axilbund, J., Chu, D., Connolly, R., Cochran, R. L., Croessmann, S., Clark, T. A., Gocke, C., Jeter, S. C., Kennedy, M. R., Lauring, J., Lee, J., Lipson, D., Miller, V. A., Otto, G. A., Rosner, G., Ross, J. S. & 10 others, Slater, S., Stephens, P. J., Vandenberg, D. A., Wolff, A. C., Young, L. E., Zabransky, D. J., Zhang, Z., Zorzi, J., Stearns, V. & Park, B. H., Jan 15 2017, In : Clinical Cancer Research. 23, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

Managing the genomic revolution in cancer diagnostics

Nguyen, D. & Gocke, C., Jun 21 2017, (Accepted/In press) In : Virchows Archiv. p. 1-21 21 p.

Research output: Contribution to journalArticle

Personalized medicine in the oncology clinic: Implementation and outcomes of the Johns Hopkins molecular tumor board

Brian Dalton, W., Forde, P. M., Kang, H., Connolly, R. M., Stearns, V., Gocke, C. D., Eshleman, J. R., Axilbund, J., Petry, D., Geoghegan, C., Wolff, A. C., Loeb, D. M., Pratilas, C. A., Meyer, C. F., Christenson, E. S., Slater, S. A., Ensminger, J., Parsons, H. A., Park, B. H. & Lauring, J., Jan 1 2017, In : JCO Precision Oncology. 2017, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

Whole-exome sequencing of metaplastic breast carcinoma indicates monoclonality with associated ductal carcinoma component

Avigdor, B. E., Beierl, K., Gocke, C., Zabransky, D. J., Cravero, K., Kyker-Snowman, K., Button, B., Chu, D., Croessmann, S., Cochran, R. L., Connolly, R., Park, B. H., Wheelan, S. & Cimino-Mathews, A. M., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4875-4884 10 p.

Research output: Contribution to journalArticle

2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

A polycythemia vera JAK2 mutation masquerading as a duodenal cancer mutation

Lee, J., Axilbund, J., Dalton, W., Laheru, D., Watkins, S., Chu, D., Cravero, K., Button, B., Kyker-Snowman, K., Waters, I., Gocke, C., Lauring, J. & Park, B. H., Dec 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 12, p. 1495-1498 4 p.

Research output: Contribution to journalArticle

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Gerber, J. M., Zeidner, J. F., Morse, S., Blackford, A. L., Perkins, B., Yanagisawa, B., Zhang, H., Morsberger, L., Karp, J., Ning, Y., Gocke, C., Rosner, G., Smith, B. D. & Jones, R. J., Apr 30 2016, In : Haematologica. 101, 5, p. 607-616 10 p.

Research output: Contribution to journalArticle

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma

Belchis, D. A., Tseng, L. H., Gniadek, T., Haley, L., Lokhandwala, P., Illei, P., Gocke, C. D., Forde, P., Brahmer, J., Askin, F. B., Eshleman, J. R. & Lin, M. T., Jan 1 2016, In : Oncotarget. 7, 29, p. 45237-45248 12 p.

Research output: Contribution to journalArticle

Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide

McCurdy, S. R., Iglehart, B. S., Batista, D., Gocke, C., Ning, Y., Knaus, H. A., Jackson, A., Leffell, M. S., Luznik, L. & Gojo, I., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C. D., Hruban, R. H. & Belchis, D. A., Feb 1 2016, In : Human pathology. 48, p. 117-121 5 p.

Research output: Contribution to journalArticle

Test feasibility of next-generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens

Zheng, G., Tsai, H., Tseng, L. H., Illei, P. B., Gocke, C., Eshleman, J., Netto, G. & Lin, M-T., May 1 2016, In : American Journal of Clinical Pathology. 145, 5, p. 696-702 7 p.

Research output: Contribution to journalArticle

The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells

Chang, E., Ganguly, S., Rajkhowa, T., Gocke, C. D., Levis, M. & Konig, H., May 1 2016, In : Leukemia. 30, 5, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

Tumor-infiltrating macrophages in post-transplant, relapsed classical Hodgkin lymphoma are donor-derived

Crane, G. M., Samols, M. A., Morsberger, L. A., Yonescu, R., Thiess, M. L., Batista, D., Ning, Y., Burns, K., Vuica-Ross, M., Borowitz, M. J., Gocke, C., Ambinder, R. F. & Duffield, A. S., Sep 1 2016, In : PLoS One. 11, 9, e0163559.

Research output: Contribution to journalArticle

2015

A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML

Lin, M. T., Tseng, L. H., Dudley, J. C., Riel, S., Tsai, H., Zheng, G., Pratz, K. W., Levis, M. J. & Gocke, C. D., Dec 1 2015, In : Molecular Diagnosis and Therapy. 19, 6, p. 409-417 9 p.

Research output: Contribution to journalArticle

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers

Dudley, J., Tseng, L. H., Rooper, L., Harris, M., Haley, L., Chen, G., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

Zheng, G., Tseng, L. H., Chen, G., Haley, L., Illei, P., Gocke, C. D., Eshleman, J. R. & Lin, M. T., Oct 24 2015, In : BMC cancer. 15, 1, 779.

Research output: Contribution to journalArticle