Christopher Gocke

Associate Professor

1992 …2019
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Research Output 1992 2019

2019

A phase i trial of the VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced solid tumors and differentiated thyroid cancers

Kurzrock, R., Ball, D. W., Zahurak, M. L., Nelkin, B. D., Subbiah, V., Ahmed, S., O'Connor, A., Karunsena, E., Parkinson, R., Bishop, J. A., Ha, Y., Sharma, R., Gocke, C., Zinner, R., Rudek-Renaut, M., Sherman, S. I. & Azad, N., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5475-5484 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Mitogen-Activated Protein Kinase Kinases
Thyroid Neoplasms
Protein-Tyrosine Kinases
Neoplasms
Homologous Transplantation
Acute Myeloid Leukemia
Prospective Studies
Transplants
Survival

Bone Marrow Findings in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide

Miller, K. P., Venkataraman, G., Gocke, C., Batista, D., Borowitz, M. J., Burns, K., Pratz, K. & Duffield, A. S., Oct 7 2019, In : American journal of clinical pathology. 152, 5, p. 675-685 11 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Tretinoin
Bone Marrow
Megakaryocytes
Biopsy

Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

Lokhandwala, P., Tseng, L. H., Rodriguez, E., Zheng, G., Pallavajjalla, A., Gocke, C., Eshleman, J. & Lin, M-T., Jul 5 2019, In : BMC cancer. 19, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Melanoma
Mutation
Phosphotransferases
Codon
Incidence

Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase pathways in lung cancers

De Marchi, F., Haley, L., Fryer, H., Ibrahim, J., Beierl, K., Zheng, G., Gocke, C., Eshleman, J., Belchis, D. A., Illei, P. B. & Lin, M-T., Feb 1 2019, In : Archives of Pathology and Laboratory Medicine. 143, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinases
Epidermal Growth Factor Receptor
Lung Neoplasms
Mutation

Clinical validation of coexisting driver mutations in colorectal cancers

Zheng, G., Tseng, L. H., Haley, L., Ibrahim, J., Bynum, J., Xian, R., Gocke, C., Eshleman, J. & Lin, M-T., Apr 1 2019, In : Human pathology. 86, p. 12-20 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Mitogen-Activated Protein Kinases
Proto-Oncogene Proteins B-raf
Phosphatidylinositol 3-Kinase

Clinical Validation of Discordant Trunk Driver Mutations in Paired Primary and Metastatic Lung Cancer Specimens

Tseng, L. H., De Marchi, F., Pallavajjalla, A., Rodriguez, E., Xian, R., Belchis, D., Gocke, C., Eshleman, J., Illei, P. B. & Lin, M-T., Oct 7 2019, In : American journal of clinical pathology. 152, 5, p. 570-581 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Second Primary Neoplasms
Single Nucleotide Polymorphism
Neoplasms

Early noninvasive detection of response to targeted therapy in non–small cell lung cancer

Phallen, J., Leal, A., Woodward, B. D., Forde, P., Naidoo, J., Marrone, K., Brahmer, J., Fiksel, J., Medina, J. E., Cristiano, S., Palsgrove, D. N., Gocke, C., Bruhm, D. C., Keshavarzian, P., Adleff, V., Weihe, E., Anagnostou, V., Scharpf, R. B., Velculescu, V. E. & Husain, H., Jan 1 2019, In : Cancer Research. 79, 6, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Circulating Neoplastic Cells
Therapeutics
Hydatidiform Mole
Choriocarcinoma
Ectopic Pregnancy
Gestational Trophoblastic Disease
Chorionic Gonadotropin

The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Zheng, G., Chen, P., Pallavajjalla, A., Haley, L., Gondek, L., Dezern, A., Ling, H., De Marchi, F., Lin, M-T. & Gocke, C., Jan 1 2019, (Accepted/In press) In : American journal of hematology.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Gene Frequency
Genes
Mutation
Aplastic Anemia

The Utility of NKX2.2 and TLE1 Immunohistochemistry in the Differentiation of Ewing Sarcoma and Synovial Sarcoma

Rooper, L., Sharma, R., Gocke, C. & Belchis, D. A., Mar 1 2019, In : Applied Immunohistochemistry and Molecular Morphology. 27, 3, p. 174-179 6 p.

Research output: Contribution to journalReview article

Synovial Sarcoma
Ewing's Sarcoma
Immunohistochemistry
Staining and Labeling
Reverse Transcription

Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: A case report and review of current challenges in molecular diagnostics

Romo, C. G., Palsgrove, D. N., Sivakumar, A., Elledge, C. R., Kleinberg, L. R., Chaichana, K. L., Gocke, C., Rodriguez, F. J. & Holdhoff, M., Feb 9 2019, In : Diagnostic Pathology. 14, 1, 16.

Research output: Contribution to journalArticle

Open Access
Molecular Pathology
Glioblastoma
Oligodendroglioma
Chromosomes, Human, Pair 1
temozolomide
2018

A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations

Levis, M. J., Perl, A. E., Altman, J. K., Gocke, C., Bahceci, E., Hill, J., Liu, C., Xie, Z., Carson, A. R., McClain, V., Stenzel, T. T. & Miller, J. E., Apr 24 2018, In : Blood advances. 2, 8, p. 825-831 7 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Acute Myeloid Leukemia
Mutation
DNA
fms-Like Tyrosine Kinase 3
Renal Cell Carcinoma
Mutation
Neoplasms
Pediatrics
Neuroblastoma

Final results of a randomized multicenter phase II study of alvocidib, cytarabine, and mitoxantrone versus cytarabine and daunorubicin (7 + 3) in newly diagnosed high-risk acute myeloid leukemia (AML)

Zeidner, J. F., Foster, M. C., Blackford, A. L., Litzow, M. R., Morris, L. E., Strickland, S. A., Lancet, J. E., Bose, P., Levy, M. Y., Tibes, R., Gojo, I., Gocke, C., Rosner, G., Little, R. F., Wright, J. J., Doyle, L. A., Smith, B. D. & Karp, J., Sep 1 2018, In : Leukemia Research. 72, p. 92-95 4 p.

Research output: Contribution to journalLetter

alvocidib
Mitoxantrone
Daunorubicin
Cytarabine
Acute Myeloid Leukemia

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Ware, A. D., Birkness, J., Duffield, A. S. & Gocke, C., Apr 2 2018, (Accepted/In press) In : Virchows Archiv. p. 1-5 5 p.

Research output: Contribution to journalArticle

Polycythemia Vera
Leukemia

PD-L1 expression in inflammatory myofibroblastic tumors

Cottrell, T. R., Duong, A. T., Gocke, C., Xu, H., Ogurtsova, A., Taube, J. M. & Belchis, D. A., Feb 15 2018, (Accepted/In press) In : Modern Pathology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Neoplasms
T-Lymphocytes
Therapeutics
Mutation
Protein-Tyrosine Kinases
Antineoplastic Combined Chemotherapy Protocols
Vidarabine
Hematologic Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Cyclophosphamide

The evolution of earned, transparent, and quantifiable faculty salary compensation: The Johns Hopkins pathology experience

Burns, K., Borowitz, M. J., Carroll, K. C., Gocke, C., Hooper, J., Amukele, T. K., Tobian, A. A., Valentine, A., Kahl, R., Rodas-Eral, V., Boitnott, J. K., Jackson, J. B., Sanfilippo, F. & Hruban, R. H., Jan 1 2018, In : Academic Pathology. 5

Research output: Contribution to journalArticle

Salaries and Fringe Benefits
Pathology
Reward
Remuneration
Quality Improvement

Validation Strategy for Ultrasensitive Mutation Detection

Debeljak, M., Noë, M., Riel, S. L., Haley, L. M., Norris, A. L., Anderson, D. A., Adams, E. M., Suenaga, M., Beierl, K. F., Lin, M-T., Goggins, M. S., Gocke, C. & Eshleman, J., Jul 5 2018, (Accepted/In press) In : Molecular Diagnosis and Therapy. p. 1-9 9 p.

Research output: Contribution to journalArticle

Point Mutation
Gene Frequency
Haplotypes
Cell Line
Polymerase Chain Reaction
2017

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting

Lokhandwala, P., Riel, S. L., Haley, L., Lu, C., Chen, Y., Silberstein, J., Zhu, Y., Zheng, G., Lin, M-T., Gocke, C., Partin, A. W., Antonarakis, E., Luo, J. & Eshleman, J., Jan 1 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Circulating Neoplastic Cells
Prostatic Neoplasms
Castration
Ligands

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Osman, A., Gocke, C. & Gladstone, D., Feb 1 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Clone Cells
Immunoglobulin Heavy Chains
Immunoglobulin Genes
Cohort Studies

Clinical mutational profiling of 1006 lung cancers by next generation sequencing

Illei, P. B., Belchis, D. A., Tseng, L. H., Nguyen, D., De Marchi, F., Haley, L., Riel, S., Beierl, K., Zheng, G., Brahmer, J., Askin, F. B., Gocke, C., Eshleman, J., Forde, P. & Lin, M-T., Jan 1 2017, In : Oncotarget. 8, 57, p. 96684-96696 13 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Sequence Deletion
Missense Mutation
Gene Frequency

Detection of chromosomal translocation in hematologic malignancies by a novel DNA-based Looped Ligation Assay (LOLA)

Harada, S., Sizzle, E., Lin, M-T. & Gocke, C., Jul 1 2017, In : Clinical Chemistry. 63, 7, p. 1278-1287 10 p.

Research output: Contribution to journalArticle

Genetic Translocation
Hematologic Neoplasms
Ligation
Follicular Lymphoma
Assays

Erratum to: Managing the genomic revolution in cancer diagnostics (Virchows Archiv, (2017), 471, 2, (175-194), 10.1007/s00428-017-2175-2)

Nguyen, D. & Gocke, C., Aug 1 2017, In : Virchows Archiv. 471, 2, p. 195-197 3 p.

Research output: Contribution to journalComment/debate

Neoplasms

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Chimerism
Haplotypes
Leukemia
Recurrence
Bone Marrow Transplantation

Individualized Molecular Analyses Guide Efforts (IMAGE): A prospective study of molecular profiling of tissue and blood in metastatic triple-negative breast cancer

Parsons, H. A., Beaver, J., Cimino-Mathews, A. M., Ali, S. M., Axilbund, J., Chu, D., Connolly, R., Cochran, R. L., Croessmann, S., Clark, T. A., Gocke, C., Jeter, S. C., Kennedy, M. R., Lauring, J., Lee, J., Lipson, D., Miller, V. A., Otto, G. A., Rosner, G., Ross, J. S. & 10 others, Slater, S., Stephens, P. J., Vandenberg, D. A., Wolff, A. C., Young, L. E., Zabransky, D. J., Zhang, Z., Zorzi, J., Stearns, V. & Park, B. H., Jan 15 2017, In : Clinical Cancer Research. 23, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Prospective Studies
Biopsy
Neoplasms
Medical Futility

Managing the genomic revolution in cancer diagnostics

Nguyen, D. & Gocke, C., Jun 21 2017, (Accepted/In press) In : Virchows Archiv. p. 1-21 21 p.

Research output: Contribution to journalArticle

Neoplasms
Patient Care
Technology
Population
Therapeutics

Whole-exome sequencing of metaplastic breast carcinoma indicates monoclonality with associated ductal carcinoma component

Avigdor, B. E., Beierl, K., Gocke, C., Zabransky, D. J., Cravero, K., Kyker-Snowman, K., Button, B., Chu, D., Croessmann, S., Cochran, R. L., Connolly, R., Park, B. H., Wheelan, S. & Cimino-Mathews, A. M., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4875-4884 10 p.

Research output: Contribution to journalArticle

Exome
Ductal Carcinoma
Breast Neoplasms
Histology
Neoplasms
2016

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia

Braunstein, E., Li, R., Sobreira, N., Marosy, B., Hetrick, K., Doheny, K., Gocke, C., Valle, D., Brodsky, R. A. & Cheng, L., Jul 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

A polycythemia vera JAK2 mutation masquerading as a duodenal cancer mutation

Lee, J., Axilbund, J., Dalton, W., Laheru, D., Watkins, S., Chu, D., Cravero, K., Button, B., Kyker-Snowman, K., Waters, I., Gocke, C., Lauring, J. & Park, B. H., Dec 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 12, p. 1495-1498 4 p.

Research output: Contribution to journalArticle

Duodenal Neoplasms
Polycythemia Vera
Mutation
Cheek
Neoplasms

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Gerber, J. M., Zeidner, J. F., Morse, S., Blackford, A. L., Perkins, B., Yanagisawa, B., Zhang, H., Morsberger, L., Karp, J., Ning, Y., Gocke, C., Rosner, G., Smith, B. D. & Jones, R. J., Apr 30 2016, In : Haematologica. 101, 5, p. 607-616 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Leukemia
Phenotype
Aldehyde Dehydrogenase
Stem Cells
Melanoma
Colon
Neoplasm Metastasis
Carcinoma
Bone and Bones

Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation

Gondek, L., Zheng, G., Ghiaur, G., Dezern, A., Matsui, W., Yegnasubramanian, S., Lin, M-T., Levis, M. J., Eshleman, J., Varadhan, R., Tucker, N., Jones, R. J. & Gocke, C., Mar 15 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Hematopoiesis
Bone Marrow Transplantation
Leukemia

Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma

Belchis, D. A., Tseng, L. H., Gniadek, T., Haley, L., Lokhandwala, P., Illei, P. B., Gocke, C., Forde, P., Brahmer, J., Askin, F. B., Eshleman, J. & Lin, M-T., 2016, In : Oncotarget. 7, 29, p. 45237-45248 12 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Mutation
Clone Cells
Gene Frequency
Small Cell Carcinoma

Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide

McCurdy, S. R., Iglehart, B. S., Batista, D., Gocke, C., Ning, Y., Knaus, H. A., Jackson, A., Leffell, M. S., Luznik, L. & Gojo, I., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C., Hruban, R. H. & Belchis, D. A., Feb 1 2016, In : Human Pathology. 48, p. 117-121 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Mutation
Pancreas
Neoplasms

Test feasibility of next-generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens

Zheng, G., Tsai, H., Tseng, L. H., Illei, P. B., Gocke, C., Eshleman, J., Netto, G. & Lin, M-T., May 1 2016, In : American Journal of Clinical Pathology. 145, 5, p. 696-702 7 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Mutation
INDEL Mutation
Bone and Bones
Neoplasms

Tumor-infiltrating macrophages in post-transplant, relapsed classical Hodgkin lymphoma are donor-derived

Crane, G. M., Samols, M. A., Morsberger, L. A., Yonescu, R., Thiess, M. L., Batista, D., Ning, Y., Burns, K., Vuica-Ross, M., Borowitz, M. J., Gocke, C., Ambinder, R. F. & Duffield, A. S., Sep 1 2016, In : PLoS One. 11, 9, e0163559.

Research output: Contribution to journalArticle

Hodgkin disease
Transplants
Macrophages
Hodgkin Disease
Tumors
2015

A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML

Lin, M-T., Tseng, L. H., Dudley, J. C., Riel, S., Tsai, H., Zheng, G., Pratz, K., Levis, M. J. & Gocke, C., Dec 1 2015, In : Molecular Diagnosis and Therapy. 19, 6, p. 409-417 9 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Acute Myeloid Leukemia
Polymerase Chain Reaction
Clone Cells
Molecular Pathology

Challenges posed to pathologists in the detection of KRAS mutations in colorectal cancers

Dudley, J., Tseng, L. H., Rooper, L., Harris, M., Haley, L., Chen, G., Gocke, C., Eshleman, J. & Lin, M-T., Feb 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Neoplasms
Neoadjuvant Therapy
Codon

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

Zheng, G., Tseng, L. H., Chen, G., Haley, L., Illei, P. B., Gocke, C., Eshleman, J. & Lin, M-T., Oct 24 2015, In : BMC Cancer. 15, 1, 779.

Research output: Contribution to journalArticle

Phosphotransferases
Mutation
Proto-Oncogene Proteins B-raf
Melanoma
Lung Neoplasms

Do circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility? A report of the association for molecular pathology

Gold, B., Cankovic, M., Furtado, L. V., Meier, F. & Gocke, C., May 1 2015, In : Journal of Molecular Diagnostics. 17, 3, p. 209-224 16 p.

Research output: Contribution to journalArticle

Exosomes
Circulating Neoplastic Cells
Molecular Pathology
Nucleic Acids
Neoplasms

Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma

Ho, C. Y., Mosier, S., Safneck, J., Salomao, D. R., Miller, N. R., Eberhart, C. G., Gocke, C., Batista, D. & Rodriguez, F. J., Mar 1 2015, In : Brain Pathology. 25, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Meningioma
Single Nucleotide Polymorphism
Optic Nerve
Chromosomes
Optic Nerve Neoplasms

Lymph node metastases of melanoma: Challenges for BRAF mutation detection

Chen, G., Dudley, J., Tseng, L. H., Smith, K., Gurda, G. T., Gocke, C., Eshleman, J. & Lin, M-T., Jan 1 2015, In : Human Pathology. 46, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

Melanoma
Lymph Nodes
Neoplasm Metastasis
Mutation
MAP Kinase Kinase 2

Mutational profiling of colorectal cancers with microsatellite instability

Lin, E. I., Tseng, L. H., Gocke, C., Reil, S., Le, D., Azad, N. & Eshleman, J., 2015, In : Oncotarget. 6, 39, p. 42334-42344 11 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Colorectal Neoplasms
Mutation
Receptor Protein-Tyrosine Kinases
INDEL Mutation

NCCN Oncology Research Program's Investigator Steering Committee and NCCN Best Practices Committee molecular profiling surveys

Kurzrock, R., Colevas, A. D., Olszanski, A., Akerley, W., Arteaga, C. L., Carson, W. E., Clark, J. W., DiPersio, J. F., Ettinger, D. S., Morgan, R. J., Schwartzberg, L. S., Venook, A. P., Gocke, C., Tait, J. & Stewart, F. M., Nov 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 11, p. 1337-1346 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Molecular Pathology
Research Personnel
Patient Care
Research

Non-p.V600E BRAF mutations are common using a more sensitive and broad detection tool

Carter, J., Tseng, L. H., Zheng, G., Dudley, J., Illei, P. B., Gocke, C., Eshleman, J. & Lin, M-T., Oct 1 2015, In : American Journal of Clinical Pathology. 144, 4, p. 620-628 9 p.

Research output: Contribution to journalArticle

Mutation
Colorectal Neoplasms
Exons
Melanoma
Molecular Pathology

Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers

Haley, L., Tseng, L. H., Zheng, G., Dudley, J., Anderson, D. A., Azad, N., Gocke, C., Eshleman, J. & Lin, M-T., Oct 3 2015, In : Modern Pathology. 28, 10, p. 1390-1399 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Gene Frequency
Exons
Epidermal Growth Factor Receptor