Christopher Gamper

Assistant Professor

19992019
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Research Output 1999 2019

1999

TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-κB activation

Van Eyndhoven, W. G., Gamper, C., Cho, E., Mackus, W. J. M. & Lederman, S., Jul 1999, In : Molecular Immunology. 36, 10, p. 647-658 12 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 3
Protein Isoforms
Messenger RNA
Zinc Fingers
B-Lymphocytes
2000

TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes

Gamper, C., Van Eyndhoven, W. G., Schweiger, E., Mossbacher, M., Koo, B. & Lederman, S., Jan 1 2000, In : Molecular Immunology. 37, 1-2, p. 73-84 12 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 3
Nuclear Pore
Amino Acids
nuclear pore protein p62
Yeasts
2001

Expression and function of TRAF-3 splice-variant isoforms in human lymphoma cell lines

Gamper, C., Omene, C. O., Van Eyndhoven, W. G., Glassman, G. D. & Lederman, S., 2001, In : Human Immunology. 62, 10, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 3
Lymphoma
Protein Isoforms
Cell Line
Messenger RNA
2008

Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia

Gamper, C., Takemoto, C. M., Schowinsky, J., Borowitz, M. J., Horwitz, M. S. & Strouse, J., May 2008, In : Pediatric Blood and Cancer. 50, 5, p. 1072-1075 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Myelodysplastic Syndromes
Physicians
Biopsy
Infection
2009

Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation

Gamper, C., Agoston, A. T., Nelson, W. G. & Powell, J., Aug 15 2009, In : Journal of Immunology. 183, 4, p. 2267-2276 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Epigenomics
Null Lymphocytes
Th2 Cells
2010
Clonal Anergy
Molecular Biology
Cell Differentiation
T-Lymphocytes
CD27 Antigens
2012
Sirolimus
Phosphatidylinositol 3-Kinase
T-Lymphocytes
Cell Differentiation
Proto-Oncogene Proteins c-akt

De Novo DNA methylation is required to restrict T helper lineage plasticity

Thomas, R. M., Gamper, C., Ladle, B., Powell, J. & Wells, A. D., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22900-22909 10 p.

Research output: Contribution to journalArticle

T-cells
DNA Methylation
Plasticity
T-Lymphocytes
Methylation
Sickle Cell Anemia
Bone Marrow Transplantation
Cyclophosphamide
Bone
Tissue Donors
2014
Cell Transplantation
Residual Neoplasm
Leukemia
Recurrence
Transplantation
Residual Neoplasm
Leukemia
Transplantation
Recurrence
Hematopoietic Stem Cell Transplantation
2016
Hematopoietic Stem Cell Transplantation
Cyclophosphamide
Transplantation
Tissue Donors
Graft vs Host Disease

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J., Jaffee, E., Hildeman, D. A. & Gamper, C., Sep 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Contribution to journalArticle

DNA Methylation
T-Lymphocytes
Wild Animals
DNA methyltransferase 3A
Methyltransferases

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

Poitras, J. L., Heiser, D., Li, L., Nguyen, B., Nagai, K., Duffield, A. S., Gamper, C. & Small, D., 2016, In : Oncotarget. 7, 43, p. 69124-69135 12 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Mutation
Neoplasms
Hematologic Neoplasms

High-dose Cyclophosphamide is Effective Therapy for Pediatric Severe Aplastic Anemia

Gamper, C. J., Takemoto, C. M., Chen, A. R., Symons, H. J., Loeb, D. M., Casella, J. F., Dezern, A. E., King, K. E., McGonigle, A. M., Jones, R. J. & Brodsky, R. A., Jul 27 2016, (Accepted/In press) In : Journal of Pediatric Hematology/Oncology.

Research output: Contribution to journalArticle

Aplastic Anemia
Cyclophosphamide
Pediatrics
Antilymphocyte Serum
Cyclosporine

Hoyeraal-Hreidarsson Syndrome due to PARN Mutations: Fourteen Years of Follow-Up

Burris, A. M., Ballew, B. J., Kentosh, J. B., Turner, C. E., Norton, S. A., Giri, N., Alter, B. P., Nellan, A., Gamper, C., Hartman, K. R. & Savage, S. A., Mar 1 2016, In : Pediatric Neurology. 56, p. 62-68 7 p.

Research output: Contribution to journalArticle

Mutation
Fetal Growth Retardation
Oral Leukoplakia
Skin Pigmentation
Urethral Stricture

Successful Treatment of Recurrent Autoimmune Cytopenias in the Context of Sinus Histiocytosis With Massive Lymphadenopathy Using Sirolimus

Cooper, S., Arceci, R. J., Gamper, C., Teachey, D. T. & Schafer, E. S., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 358-360 3 p.

Research output: Contribution to journalArticle

Sinus Histiocytosis
Sirolimus
Lymphoproliferative Disorders
Therapeutics
Autoimmunity
2017

Cyclophosphamide improves engraftment in patients with SCD and severe organ damage who undergo haploidentical PBSCT

Fitzhugh, C. D., Hsieh, M. M., Taylor, T., Coles, W., Roskom, K., Wilson, D., Wright, E., Jeffries, N., Gamper, C., Powell, J., Luznik, L. & Tisdale, J. F., Apr 25 2017, In : Blood Advances. 1, 11, p. 652-661 10 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Sickle Cell Anemia
Cyclophosphamide
Graft vs Host Disease
Tissue Donors

MTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation

Chornoguz, O., Hagan, R. S., Haile, A., Arwood, M. L., Gamper, C., Banerjee, A. & Powell, J., May 15 2017, In : Journal of Immunology. 198, 10, p. 3939-3948 10 p.

Research output: Contribution to journalArticle

Phosphorylation
T-Lymphocytes
Sirolimus
Mass Spectrometry
Phosphopeptides
Hematologic Neoplasms
Bone Marrow Transplantation
Cyclophosphamide
Young Adult
Transplantation
Bone Marrow Transplantation
Cyclophosphamide
Young Adult
Pediatrics
Transplants

Immunosuppressive therapy for pediatric aplastic anemia: A North American Pediatric Aplastic Anemia Consortium study

Rogers, Z. R., Nakano, T. A., Olson, T. S., Bertuch, A. A., Wang, W., Gillio, A., Coates, T. D., Chawla, A., Castillo, P., Kurre, P., Gamper, C., Bennett, C. M., Joshi, S., Geddis, A. E., Boklan, J., Nalepa, G., Rothman, J. A., Huang, J. N., Kupfer, G. M., Cada, M. & 9 others, Glader, B., Walkovich, K. J., Thompson, A. A., Hanna, R., Vlachos, A., Malsch, M., Weller, E. A., Williams, D. A. & Shimamura, A., Jan 1 2019, In : Haematologica. 104, 10, p. 1974-1983 10 p.

Research output: Contribution to journalArticle

Open Access
Aplastic Anemia
Immunosuppressive Agents
Pediatrics
Antilymphocyte Serum
Horses