Christopher A Ross

Professor

1976 …2019

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2019

Cysteamine Protects Neurons from Mutant Huntingtin Toxicity

Arbez, N., Roby, E., Akimov, S., Eddings, C., Ren, M., Wang, X. & Ross, C. A., Jan 1 2019, In : Journal of Huntington's Disease. 8, 2, p. 129-143 15 p.

Research output: Contribution to journalArticle

Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease

Kronenbuerger, M., Hua, J., Bang, J. Y. A., Ultz, K. E., Miao, X., Zhang, X., Pekar, J. J., Van Zijl, P. C., Duan, W., Margolis, R. L. & Ross, C. A., Jan 1 2019, (Accepted/In press) In : Neurodegenerative Diseases.

Research output: Contribution to journalArticle

Increased protein insolubility in brains from a subset of patients with schizophrenia

Nucifora, L., MacDonald, M. L., Lee, B. J., Peters, M., Norris, A. L., Orsburn, B. C., Yang, K., Gleason, K., Margolis, R. L., Pevsner, J. A., Tamminga, C. A., Sweet, R. A., Ross, C. A., Sawa, A. & Nucifora, F., Jan 1 2019, In : American Journal of Psychiatry. 176, 9, p. 730-743 14 p.

Research output: Contribution to journalArticle

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories

Ross, C. A., Reilmann, R., Cardoso, F., McCusker, E. A., Testa, C. M., Stout, J. C., Leavitt, B. R., Pei, Z., Landwehrmeyer, B., Martinez, A., Levey, J., Srajer, T., Bang, J. & Tabrizi, S. J., Jan 1 2019, (Accepted/In press) In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

Open Access

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Shani, V., Safory, H., Szargel, R., Wang, N., Cohen, T., Elghani, F. A., Hamza, H., Savyon, M., Radzishevsky, I., Shaulov, L., Rott, R., Lim, K. L., Ross, C. A., Bandopadhyay, R., Zhang, H. & Engelender, S., Dec 1 2019, In : Human molecular genetics. 28, 23, p. 3982-3996 15 p.

Research output: Contribution to journalArticle

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Eddings, C. R., Arbez, N., Akimov, S., Geva, M., Hayden, M. R. & Ross, C. A., Sep 1 2019, In : Neurobiology of Disease. 129, p. 118-129 12 p.

Research output: Contribution to journalArticle

2018

Altered brain iron content and deposition rate in Huntington's disease as indicated by quantitative susceptibility MRI

Chen, L., Hua, J., Ross, C. A., Cai, S., Van Zijl, P. C. & Li, X., Jan 1 2018, (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Contribution to journalArticle

Altered functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T

Hua, J., Blair, N. I. S., Paez, A., Choe, A., Barber, A. D., Brandt, A., Lim, I. A. L., Xu, F., Kamath, V., Pekar, J. J., Van Zijl, P. C., Ross, C. A. & Margolis, R. L., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

A new measure for end of life planning, preparation, and preferences in Huntington disease: HDQLIFE end of life planning

HDQLIFE Site Investigators and Coordinators, Jan 1 2018, In : Journal of Neurology. 265, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

G2019S LRRK2 increases stress susceptibility through inhibition of DAF-16 nuclear translocation in a 14-3-3 associated-manner in caenorhabditis elegans

Long, S., Guo, W., Hu, S., Su, F., Zeng, Y., Zeng, J., Tan, E. K., Ross, C. A. & Pei, Z., Nov 7 2018, In : Frontiers in Neuroscience. 12, NOV, 782.

Research output: Contribution to journalArticle

High and low levels of an NTRK2-driven genetic profile affect motor- and cognition-associated frontal gray matter in prodromal Huntington’s disease

PREDICT-HD Investigators and Coordinators of the Huntington, Jul 1 2018, In : Brain Sciences. 8, 7, 116.

Research output: Contribution to journalArticle

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Bowie, L. E., Maiuri, T., Alpaugh, M., Gabriel, M., Arbez, N., Galleguillos, D., Hung, C. L. K., Patel, S., Xia, J., Hertz, N. T., Ross, C. A., Litchfield, D. W., Sipione, S. & Truant, R., Jul 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. E7081-E7090

Research output: Contribution to journalArticle

Regional subcortical shape analysis in premanifest Huntington's disease

Tang, X., Ross, C. A., Johnson, H., Paulsen, J. S., Younes, L., Albin, R. L., Ratnanather, J. T. & Miller, M. I., Jan 1 2018, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F

Ayhan, F., Perez, B. A., Shorrock, H. K., Zu, T., Banez-Coronel, M., Reid, T., Furuya, H., Clark, H. B., Troncoso, J. C., Ross, C. A., Subramony, S. H., Ashizawa, T., Wang, E. T., Yachnis, A. T. & Ranum, L. P. W., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Whole-brain segmentation and change-point analysis of anatomical brain mri—application in premanifest huntington's disease

Wu, D., Faria, A. V., Younes, L., Ross, C. A., Mori, S. & Miller, M. I., Jun 9 2018, In : Journal of Visualized Experiments. 2018, 136, e57256.

Research output: Contribution to journalArticle

2017

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In : Nature Communications. 8, 14405.

Research output: Contribution to journalArticle

Abnormal grey matter arteriolar cerebral blood volume in schizophrenia measured with 3D inflow-based vascular-space-occupancy MRI at 7T

Hua, J., Brandt, A. S., Lee, S. W., Blair, N. I. S., Wu, Y., Lui, S., Patel, J., Faria, A. V., Lim, I. A. L., Unschuld, P. G., Pekar, J. J., Van Zijl, P. C., Ross, C. A. & Margolis, R. L., 2017, In : Schizophrenia Bulletin. 43, 3, p. 620-632 13 p.

Research output: Contribution to journalArticle

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease

McGarry, A., McDermott, M., Kieburtz, K., DeBlieck, E. A., Beal, F., Marder, K., Ross, C. A., Shoulson, I., Gilbert, P., Mallonee, W. M., Guttman, M., Wojcieszek, J., Kumar, R., LeDoux, M. S., Jenkins, M., Rosas, H. D., Nance, M., Biglan, K., Como, P., Dubinsky, R. M. & 40 others, Shannon, K. M., O'Suilleabhain, P., Chou, K., Walker, F., Martin, W., Wheelock, V. L., McCusker, E., Jankovic, J., Singer, C., Sanchez-Ramos, J., Scott, B., Suchowersky, O., Factor, S. A., Higgins, D. S., Molho, E., Revilla, F., Caviness, J. N., Friedman, J. H., Perlmutter, J. S., Feigin, A., Anderson, K., Rodriguez, R., McFarland, N. R., Margolis, R. L., Farbman, E. S., Raymond, L. A., Suski, V., Kostyk, S., Colcher, A., Seeberger, L., Epping, E., Esmail, S., Diaz, N., Alan Fung, W. L., Diamond, A., Frank, S., Hanna, P., Hermanowicz, N., Dure, L. S. & Cudkowicz, M., Jan 10 2017, In : Neurology. 88, 2, p. 152-159 8 p.

Research output: Contribution to journalArticle

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, May 1 2017, In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Evaluating cognition in individuals with Huntington disease: Neuro-QoL cognitive functioning measures

Lai, J. S., Goodnight, S., Downing, N. R., Ready, R. E., Paulsen, J. S., Kratz, A. L., Stout, J. C., McCormack, M. K., Cella, D., Ross, C. A., Russell, J. & Carlozzi, N. E., Dec 8 2017, (Accepted/In press) In : Quality of Life Research. p. 1-12 12 p.

Research output: Contribution to journalArticle

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder

Zhu, S., Cordner, Z. A., Xiong, J., Chiu, C. T., Artola, A., Zuo, Y., Nelson, A. D., Kim, T. Y., Zaika, N., Woolums, B. M., Hess, E. J., Wang, X., Chuang, D. M., Pletnikov, M., Jenkins, P. M., Tamashiro, K. & Ross, C. A., Sep 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. 10479-10484 6 p.

Research output: Contribution to journalArticle

Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease

Wu, D., Faria, A. V., Younes, L., Mori, S., Brown, T., Johnson, H., Paulsen, J. S., Ross, C. A. & Miller, M. I., 2017, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. C., Zhang, K., Ochaba, J., Geater, C., Morozko, E., Stocksdale, J., Glatzer, J. C., Pham, J. T., Ahmed, I., Peng, Q., Wadhwa, H., Pletnikova, O., Troncoso, J. C., Duan, W., Snyder, S. H., Ranum, L. P. W., Thompson, L. M. & 3 others, Lloyd, T., Ross, C. A. & Rothstein, J. D., Apr 5 2017, In : Neuron. 94, 1, p. 93-107.e6

Research output: Contribution to journalArticle

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Ratovitski, T., O'Meally, R. N., Jiang, M., Chaerkady, R., Chighladze, E., Stewart, J. C., Wang, X., Arbez, N., Roby, E., Alexandris, A., Duan, W., Vijayvargia, R., Seong, I. S., Lavery, D. J., Cole, R. N. & Ross, C. A., Aug 4 2017, In : Journal of Proteome Research. 16, 8, p. 2692-2708 17 p.

Research output: Contribution to journalArticle

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Arbez, N., Ratovitski, T., Roby, E., Chighladze, E., Stewart, J. C., Ren, M., Wang, X., Lavery, D. J. & Ross, C. A., Jan 1 2017, In : Journal of Biological Chemistry. 292, 47, p. 19238-19254 17 p.

Research output: Contribution to journalArticle

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R., Dec 6 2017, In : Science Translational Medicine. 9, 419, eaal2332.

Research output: Contribution to journalArticle

Resting-state functional MRI reveals altered brain connectivity and its correlation with motor dysfunction in a mouse model of Huntington's disease

Li, Q., Li, G., Wu, D., Lu, H., Hou, Z., Ross, C. A., Yang, Y., Zhang, J. & Duan, W., Dec 1 2017, In : Scientific Reports. 7, 1, 16742.

Research output: Contribution to journalArticle

2016

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7 Tesla

Brandt, A. S., Unschuld, P. G., Pradhan, S., Lim, I. A. L., Churchill, G., Harris, A. D., Hua, J., Barker, P. B., Ross, C. A., van Zijl, P. C. M., Edden, R. A. E. & Margolis, R. L., Apr 1 2016, In : Schizophrenia Research. 172, 1-3, p. 101-105 5 p.

Research output: Contribution to journalArticle

Analysis of differential gene expression mediated by clozapine in human postmortem brains

Lee, B. J., Marchionni, L., Andrews, C. E., Norris, A. L., Nucifora, L., Wu, Y. C., Wright, R. A., Pevsner, J. A., Ross, C. A., Margolis, R. L., Sawa, A. & Nucifora, F., Oct 28 2016, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis

Li, P., Sun, X., Xia, G., Arbez, N., Paul, S., Zhu, S., Peng, H. B., Ross, C. A., Koeppen, A. H., Margolis, R. L., Pulst, S. M., Ashizawa, T. & Rudnicki, D. D., Oct 1 2016, In : Annals of Neurology. 80, 4, p. 600-615 16 p.

Research output: Contribution to journalArticle

Clinical-genetic associations in the Prospective Huntington at Risk Observational Study (PHAROS) implications for clinical trials

The Huntington Study Group PHAROS Investigators, Jan 2016, In : JAMA Neurology. 73, 1, p. 102-110 9 p.

Research output: Contribution to journalArticle

Open Access

HDQLIFE: development and assessment of health-related quality of life in Huntington disease (HD)

Carlozzi, N. E., Schilling, S. G., Lai, J. S., Paulsen, J. S., Hahn, E. A., Perlmutter, J. S., Ross, C. A., Downing, N. R., Kratz, A. L., McCormack, M. K., Nance, M. A., Quaid, K. A., Stout, J. C., Gershon, R. C., Ready, R. E., Miner, J. A., Barton, S. K., Perlman, S. L., Rao, S. M., Frank, S. & 6 others, Shoulson, I., Marin, H., Geschwind, M. D., Dayalu, P., Goodnight, S. M. & Cella, D., Oct 1 2016, In : Quality of Life Research. 25, 10, p. 2441-2455 15 p.

Research output: Contribution to journalArticle

Linking white matter and deep gray matter alterations in premanifest Huntington disease

The PREDICT-HD Investigators and Coordinators of the Huntington Study Group, 2016, In : NeuroImage: Clinical. 11, p. 450-460 11 p.

Research output: Contribution to journalArticle

Melatonin attenuates hLRRK2-induced Sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease

Sun, X., Ran, D., Zhao, X., Huang, Y., Long, S., Liang, F., Guo, W., Nucifora, F., Gu, H., Lu, X., Chen, L., Zeng, J., Ross, C. A. & Pei, Z., May 1 2016, In : Molecular Medicine Reports. 13, 5, p. 3936-3944 9 p.

Research output: Contribution to journalArticle

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Dickey, A. S., Pineda, V. V., Tsunemi, T., Liu, P. P., Miranda, H. C., Gilmore-Hall, S. K., Lomas, N., Sampat, K. R., Buttgereit, A., Torres, M. J. M., Flores, A. L., Arreola, M., Arbez, N., Akimov, S. S., Gaasterland, T., Lazarowski, E. R., Ross, C. A., Yeo, G. W., Sopher, B. L., Magnuson, G. K. & 3 others, Pinkerton, A. B., Masliah, E. & La Spada, A. R., Jan 1 2016, In : Nature medicine. 22, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Quantitative susceptibility mapping suggests altered brain iron in premanifest Huntington disease

Van Bergen, J. M. G., Hua, J., Unschuld, P. G., Lim, I. A. L., Jones, C., Margolis, R. L., Ross, C. A., Van Zijl, P. C. & Li, X., May 1 2016, In : American Journal of Neuroradiology. 37, 5, p. 789-796 8 p.

Research output: Contribution to journalArticle

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models

Liu, J., Li, T., Thomas, J. M., Pei, Z., Jiang, H., Engelender, S., Ross, C. A. & Smith, W., Feb 15 2016, In : Human Molecular Genetics. 25, 4, p. 672-680 9 p.

Research output: Contribution to journalArticle

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Carvalho, J. O., Long, J. D., Westervelt, H. J., Smith, M. M., Bruce, J. M., Kim, J. I., Mills, J. A., Paulsen, J. S., De Soriano, I., Shadrick, C., Miller, A., Chiu, E., Preston, J., Goh, A., Antonopoulos, S., Loi, S., Chua, P., Komiti, A., Raymond, L., Decolongon, J. & 107 others, Fan, M., Coleman, A., Ross, C. A., Varvaris, M., Ong, M., Yoritomo, N., Mallonee, W. M., Suter, G., Samii, A., Freney, E. P., Macaraeg, A., Jones, R., Wood-Siverio, C., Factor, S. A., Barker, R. A., Mason, S., Guzman, N. V., McCusker, E., Griffith, J., Loy, C., McMillan, J., Gunn, D., Orth, M., Süßmuth, S., Barth, K., Trautmann, S., Schwenk, D., Eschenbach, C., Quaid, K., Wesson, M., Wojcieszek, J., Guttman, M., Sheinberg, A., Law, A., Karmalkar, I., Perlman, S., Clemente, B., Geschwind, M. D., Sha, S., Winer, J., Satris, G., Warner, T., Burrows, M., Rosser, A., Price, K., Hunt, S., Marshall, F., Chesire, A., Wodarski, M., Hickey, C., Panegyres, P., Lee, J., Tedesco, M., Maxwell, B., Perlmutter, J., Barton, S., Smith, S., Miedzybrodzka, Z., Rae, D., Vaughan, V., D'Alessandro, M., Craufurd, D., Bek, J., Howard, E., Mazzoni, P., Marder, K., Wasserman, P., Kumar, R., Erickson, D., Reeves, C., Nickels, B., Wheelock, V., Kjer, L., Martin, A., Farias, S., Martin, W., Suchowersky, O., King, P., Wieler, M., Sran, S., Ahmed, A., Rao, S., Reece, C., Bura, A., Mourany, L., Danzer, P., Montross, K., Harrington, D., Westervalt, H., Aylward, E., Moser, D. J., Williams, J., Downing, N., Magnotta, V. A., Johnson, H. J., Brashers-Krug, T., Vaidya, J., O'Leary, D., Young Kim, E., Lourens, S., Zhang, Y., Lu, W., Erwin, C., Nance, M., Bockholt, H. J., Evans, J. & Zschiegner, R., Feb 7 2016, In : Journal of Clinical and Experimental Neuropsychology. 38, 2, p. 217-226 10 p.

Research output: Contribution to journalArticle

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Nucifora, F., Nucifora, L., Ng, C. H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X. F., Li, T., Moore, D. J., Pletnikova, O., Troncoso, J. C., Sawa, A., Dawson, T. M., Smith, W., Lim, K. L. & Ross, C. A., Jun 7 2016, In : Nature Communications. 7, 11792.

Research output: Contribution to journalArticle

2015

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

Jin, J., Peng, Q., Hou, Z., Jiang, M., Wang, X., Langseth, A. J., Tao, M., Barker, P. B., Mori, S., Bergles, D. E., Ross, C. A., Detloff, P. J., Zhang, J. & Duan, W., Jan 1 2015, In : Human molecular genetics. 24, 9, p. 2508-2527 20 p.

Research output: Contribution to journalArticle

Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden

PREDICT-HD Investigators of the Huntington Study Group, Nov 12 2015, In : Journal of the International Neuropsychological Society. 21, 1, p. 8-21 14 p.

Research output: Contribution to journalArticle

Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype

Krause, A., Mitchell, C., Essop, F., Tager, S., Temlett, J., Stevanin, G., Ross, C., Rudnicki, D. & Margolis, R., Oct 1 2015, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 168, 7, p. 573-585 13 p.

Research output: Contribution to journalArticle

Multivariate clustering of progression profiles reveals different depression patterns in prodromal huntington disease

The PREDICT-HD Investigators and Coordinators of the Huntington Study Group, Nov 2015, In : Neuropsychology. 29, 6, p. 949-960 12 p.

Research output: Contribution to journalArticle

Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD

PREDICT-HD Investigators and Coordinators of the Huntington Study Group, Oct 2015, In : Movement Disorders. 30, 12, p. 1664-1672 9 p.

Research output: Contribution to journalArticle

Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12

O'Hearn, E. E., Hwang, H. S., Holmes, S. E., Rudnicki, D. D., Chung, D. W., Seixas, A. I., Cohen, R. L., Ross, C. A., Trojanowski, J. Q., Pletnikova, O., Troncoso, J. C. & Margolis, R. L., Nov 1 2015, In : Movement Disorders. 30, 13, p. 1813-1824 12 p.

Research output: Contribution to journalArticle

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

Sun, X., Li, P. P., Zhu, S., Cohen, R., Marque, L. O., Ross, C. A., Pulst, S. M., Chan, H. Y. E., Margolis, R. L. & Rudnicki, D. D., Jul 28 2015, In : Scientific reports. 5, 12521.

Research output: Contribution to journalArticle

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington’s disease (HD)

Ratovitski, T., Arbez, N., Stewart, J. C., Chighladze, E. & Ross, C. A., Jan 1 2015, In : Cell Cycle. 14, 11, p. 1716-1729 14 p.

Research output: Contribution to journalArticle

RAN Translation in Huntington Disease

Bañez-Coronel, M., Ayhan, F., Tarabochia, A. D., Zu, T., Perez, B. A., Tusi, S. K., Pletnikova, O., Borchelt, D. R., Ross, C. A., Margolis, R. L., Yachnis, A. T., Troncoso, J. C. & Ranum, L. P. W., Nov 18 2015, In : Neuron. 88, 4, p. 667-677 11 p.

Research output: Contribution to journalArticle