Christine Marie Ladd-Acosta

Assistant Professor

20012019
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Research Output 2001 2019

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Article
2019

Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health

Ladd-Acosta, C. M., Feinberg, J. I., Brown, S. C., Lurmann, F. W., Croen, L. A., Hertz-Picciotto, I., Newschaffer, C. J., Feinberg, A. P., Fallin, D. D. & Volk, H., May 1 2019, In : Environment International. 126, p. 363-376 14 p.

Research output: Contribution to journalArticle

Open Access
pollution exposure
child health
methylation
atmospheric pollution
DNA

Familial confounding of the association between maternal smoking in pregnancy and autism spectrum disorder in offspring

Kalkbrenner, A. E., Meier, S. M., Madley-Dowd, P., Ladd-Acosta, C. M., Fallin, D. D., Parner, E. & Schendel, D., Jan 1 2019, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

Autistic Disorder
Smoking
Mothers
Pregnancy
Attention Deficit Disorder with Hyperactivity

Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight

Hannon, E., Schendel, D., Ladd-Acosta, C. M., Grove, J., Hansen, C. S., Hougaard, D. M., Bresnahan, M., Mors, O., Hollegaard, M. V., Bækvad-Hansen, M., Hornig, M., Mortensen, P. B., Børglum, A. D., Werge, T., Pedersen, M. G., Nordentoft, M., Buxbaum, J. D., Fallin, D. D., Bybjerg-Grauholm, J., Reichenberg, A. & 1 others, Mill, J., Apr 15 2019, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1770, 20180120.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Birth Weight
birth weight
neonates
2018

Case-control meta-analysis of blood DNA methylation and autism spectrum disorder

Andrews, S. V., Sheppard, B., Windham, G. C., Schieve, L. A., Schendel, D. E., Croen, L. A., Chopra, P., Alisch, R. S., Newschaffer, C. J., Warren, S. T., Feinberg, A. P., Fallin, D. D. & Ladd-Acosta, C. M., Jun 28 2018, In : Molecular Autism. 9, 1, 40.

Research output: Contribution to journalArticle

DNA Methylation
Meta-Analysis
Sample Size
Single Nucleotide Polymorphism
Siblings

Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

Felix, J. F., Joubert, B. R., Baccarelli, A. A., Sharp, G. C., Almqvist, C., Annesi-Maesano, I., Arshad, H., Baiz, N., Bakermans-Kranenburg, M. J., Bakulski, K. M., Binder, E. B., Bouchard, L., Breton, C. V., Brunekreef, B., Brunst, K. J., Burchard, E. G., Bustamante, M., Chatzi, L., Munthe-Kaas, M. C., Corpeleijn, E. & 104 others, Czamara, D., Dabelea, D., Smith, G. D., De Boever, P., Duijts, L., Dwyer, T., Eng, C., Eskenazi, B., Everson, T. M., Falahi, F., Fallin, D. D., Farchi, S., Fernandez, M. F., Gao, L., Gaunt, T. R., Ghantous, A., Gillman, M. W., Gonseth, S., Grote, V., Gruzieva, O., Håberg, S. E., Herceg, Z., Hivert, M. F., Holland, N., Holloway, J. W., Hoyo, C., Hu, D., Huang, R. C., Huen, K., Järvelin, M. R., Jima, D. D., Just, A. C., Karagas, M. R., Karlsson, R., Karmaus, W., Kechris, K. J., Kere, J., Kogevinas, M., Koletzko, B., Koppelman, G. H., Kupers, L. K., Ladd-Acosta, C. M., Lahti, J., Lambrechts, N., Langie, S. A. S., Lie, R. T., Liu, A. H., Magnus, M. C., Magnus, P., Maguire, R. L., Marsit, C. J., McArdle, W., Melen, E., Melton, P., Murphy, S. K., Nawrot, T. S., Nisticò, L., Nohr, E. A., Nordlund, B., Nystad, W., Oh, S. S., Oken, E., Page, C. M., Perron, P., Pershagen, G., Pizzi, C., Plusquin, M., Raikkonen, K., Reese, S. E., Reischl, E., Richiardi, L., Ring, S., Roy, R. P., Rzehak, P., Schoeters, G., Schwartz, D. A., Sebert, S., Snieder, H., Sørensen, T. I. A., Starling, A. P., Sunyer, J., Taylor, J. A., Tiemeier, H., Ullemar, V., Vafeiadi, M., Van Ijzendoorn, M. H., Vonk, J. M., Vriens, A., Vrijheid, M., Wang, P., Wiemels, J. L., Wilcox, A. J., Wright, R. J., Xu, C. J., Xu, Z., Yang, I. V., Yousefi, P., Zhang, H., Zhang, W., Zhao, S., Agha, G., Relton, C. L., Jaddoe, V. W. V. & London, S. J., Feb 1 2018, In : International Journal of Epidemiology. 47, 1, p. 22-23u dyx218.

Research output: Contribution to journalArticle

cohort analysis
maternal health
child health
epidemiology
pregnancy

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

iPSYCH-Broad ASD Group, Mar 28 2018, In : Genome Medicine. 10, 1, 19.

Research output: Contribution to journalArticle

DNA Methylation
Autistic Disorder
Parturition
Quantitative Trait Loci
Genome-Wide Association Study

Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samples

Hong, X., Sherwood, B., Ladd-Acosta, C. M., Peng, S., Ji, H. K., Hao, K., Burd, I., Bartell, T. R., Wang, G., Tsai, H. J., Liu, X., Ji, Y., Wahl, A., Caruso, D., Lee-Parritz, A., Zuckerman, B. & Wang, X., Mar 1 2018, (Accepted/In press) In : Epigenetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

Premature Birth
DNA Methylation
Fetal Blood
Mothers
Genome

In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: Pilot results from the aragon workers health study

Riffo-Campos, A. L., Fuentes-Trillo, A., Tang, W-Y., Soriano, Z., De Marco, G., Rentero-Garrido, P., Adam-Felici, V., Lendinez-Tortajada, V., Francesconi, K., Goessler, W., Ladd-Acosta, C. M., Leon-Latre, M., Casasnovas, J. A., Chaves, F. J., Navas Acien, A., Guallar, E. & Tellez-Plaza, M., Jun 5 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1748, 20170084.

Research output: Contribution to journalArticle

middle-aged adults
health care workers
atherosclerosis
Epigenomics
epigenetics

Integrating RNA Expression Identifies Candidate Gene for Orofacial Clefts

Ladd-Acosta, C. M. & Beaty, T. L., Jan 1 2018, In : Journal of Dental Research. 97, 1, p. 31-32 2 p.

Research output: Contribution to journalArticle

Cleft Lip
Cleft Palate
Genomics
RNA
Gene Expression
2017

Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder

Andrews, S. V., Ellis, S. E., Bakulski, K. M., Sheppard, B., Croen, L. A., Hertz-Picciotto, I., Newschaffer, C. J., Feinberg, A. P., Arking, D., Ladd-Acosta, C. M. & Fallin, D. D., Dec 1 2017, In : Nature Communications. 8, 1, 1011.

Research output: Contribution to journalArticle

methylation
Epigenomics
DNA Methylation
Blood
blood

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

Anney, R. J. L., Ripke, S., Anttila, V., Grove, J., Holmans, P., Huang, H., Klei, L., Lee, P. H., Medland, S. E., Neale, B., Robinson, E., Weiss, L. A., Zwaigenbaum, L., Yu, T. W., Wittemeyer, K., Willsey, A. J., Wijsman, E. M., Werge, T., Wassink, T. H., Waltes, R. & 143 others, Walsh, C. A., Wallace, S., Vorstman, J. A. S., Vieland, V. J., Vicente, A. M., Vanengeland, H., Tsang, K., Thompson, A. P., Szatmari, P., Svantesson, O., Steinberg, S., Stefansson, K., Stefansson, H., State, M. W., Soorya, L., Silagadze, T., Scherer, S. W., Schellenberg, G. D., Sandin, S., Sanders, S. J., Saemundsen, E., Rouleau, G. A., Rogé, B., Roeder, K., Roberts, W., Reichert, J., Reichenberg, A., Rehnström, K., Regan, R., Poustka, F., Poultney, C. S., Piven, J., Pinto, D., Pericak-Vance, M. A., Pejovic-Milovancevic, M., Pedersen, M. G., Pedersen, C. B., Paterson, A. D., Parr, J. R., Pagnamenta, A. T., Oliveira, G., Nurnberger, J. I., Nordentoft, M., Murtha, M. T., Mouga, S., Mortensen, P. B., Mors, O., Morrow, E. M., Moreno-De-Luca, D., Monaco, A. P., Minshew, N., Merikangas, A., McMahon, W. M., McGrew, S. G., Mattheisen, M., Martsenkovsky, I., Martin, D. M., Mane, S. M., Magnusson, P., Magalhaes, T., Maestrini, E., Lowe, J. K., Lord, C., Levitt, P., Martin, C. L., Ledbetter, D. H., Leboyer, M., Lecouteur, A. S., Ladd-Acosta, C. M., Kolevzon, A., Klauck, S. M., Jacob, S., Iliadou, B., Hultman, C. M., Hougaard, D. M., Hertz-Picciotto, I., Hendren, R., Hansen, C. S., Haines, J. L., Guter, S. J., Grice, D. E., Green, J. M., Green, A., Goldberg, A. P., Gillberg, C., Gilbert, J., Gallagher, L., Freitag, C. M., Fombonne, E., Folstein, S. E., Fernandez, B., Fallin, D. D., Ercan-Sencicek, A. G., Ennis, S., Duque, F., Duketis, E., Delorme, R., Derubeis, S., Dejonge, M. V., Dawson, G., Cuccaro, M. L., Correia, C. T., Conroy, J., Conceição, I. C., Chiocchetti, A. G., Celestino-Soper, P. B. S., Casey, J., Cantor, R. M., Café, C., Bybjerg-Grauholm, J., Brennan, S., Bourgeron, T., Bolton, P. F., Bölte, S., Bolshakova, N., Betancur, C., Bernier, R., Beaudet, A. L., Battaglia, A., Bal, V. H., Baird, G., Bailey, A. J., Bækvad-Hansen, M., Bader, J. S., Bacchelli, E., Anagnostou, E., Amaral, D., Almeida, J., Børglum, A. D., Buxbaum, J. D., Chakravarti, A., Cook, E. H., Coon, H., Geschwind, D. H., Gill, M., Hallmayer, J., Palotie, A., Santangelo, S., Sutcliffe, J. S., Arking, D., Devlin, B., Daly, M. J. & Hakonarson, H., May 22 2017, In : Molecular Autism. 8, 1, 21.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Meta-Analysis
Schizophrenia
Genome
Genomics

Patients with a Kabuki syndrome phenotype demonstrate DNA methylation abnormalities

Sobreira, N., Brucato, M., Zhang, L., Ladd-Acosta, C. M., Ongaco, C., Romm, J., Doheny, K., Mingroni-Netto, R. C., Bertola, D., Kim, C. A., Perez, A. B., Melaragno, M. I., Valle, D., Meloni, V. A. & Bjornsson, H. T., Dec 1 2017, In : European Journal of Human Genetics. 25, 12, p. 1335-1344 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Phenotype
Histones
Histone Code
Genes

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Psychiatric Genomics Consortium Autism Group & iPSYCH-Broad Autism Group, Jul 1 2017, In : Nature Genetics. 49, 7, p. 978-985 8 p.

Research output: Contribution to journalArticle

Autism Spectrum Disorder
Schizophrenia
Phenotype

Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort

Brucato, M., Ladd-Acosta, C. M., Li, M., Caruso, D., Hong, X., Kaczaniuk, J., Stuart, E., Fallin, D. D. & Wang, X., Nov 1 2017, In : Autism Research. 10, 11, p. 1878-1890 13 p.

Research output: Contribution to journalArticle

Fever
Parturition
Mothers
Infection
Surrogate Mothers

The Changing Epidemiology of Autism Spectrum Disorders

Lyall, K., Croen, L., Daniels, J., Fallin, D. D., Ladd-Acosta, C. M., Lee, B. K., Park, B. Y., Snyder, N. W., Schendel, D., Volk, H., Windham, G. C. & Newschaffer, C., Mar 20 2017, In : Annual Review of Public Health. 38, p. 81-102 22 p.

Research output: Contribution to journalArticle

Epidemiology
Endocrine Disruptors
Gene-Environment Interaction
Premature Birth
Air Pollution
2016

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Joubert, B. R., Felix, J. F., Yousefi, P., Bakulski, K. M., Just, A. C., Breton, C., Reese, S. E., Markunas, C. A., Richmond, R. C., Xu, C. J., Küpers, L. K., Oh, S. S., Hoyo, C., Gruzieva, O., Söderhäll, C., Salas, L. A., Baïz, N., Zhang, H., Lepeule, J., Ruiz, C. & 86 others, Ligthart, S., Wang, T., Taylor, J. A., Duijts, L., Sharp, G. C., Jankipersadsing, S. A., Nilsen, R. M., Vaez, A., Fallin, D. D., Hu, D., Litonjua, A. A., Fuemmeler, B. F., Huen, K., Kere, J., Kull, I., Munthe-Kaas, M. C., Gehring, U., Bustamante, M., Saurel-Coubizolles, M. J., Quraishi, B. M., Ren, J., Tost, J., Gonzalez, J. R., Peters, M. J., Håberg, S. E., Xu, Z., Van Meurs, J. B., Gaunt, T. R., Kerkhof, M., Corpeleijn, E., Feinberg, A. P., Eng, C., Baccarelli, A. A., Neelon, S., Bradman, A., Merid, S. K., Bergström, A., Herceg, Z., Hernandez-Vargas, H., Brunekreef, B., Pinart, M., Heude, B., Ewart, S., Yao, J., Lemonnier, N., Franco, O. H., Wu, M. C., Hofman, A., McArdle, W., Van Der Vlies, P., Falahi, F., Gillman, M. W., Barcellos, L. F., Kumar, A., Wickman, M., Guerra, S., Charles, M. A., Holloway, J., Auffray, C., Tiemeier, H. W., Smith, G. D., Postma, D., Hivert, M. F., Eskenazi, B., Vrijheid, M., Arshad, H., Antó, J. M., Dehghan, A., Karmaus, W., Annesi-Maesano, I., Sunyer, J., Ghantous, A., Pershagen, G., Holland, N., Murphy, S. K., Demeo, D. L., Burchard, E. G., Ladd-Acosta, C. M., Snieder, H., Nystad, W., Koppelman, G. H., Relton, C. L., Jaddoe, V. W. V., Wilcox, A., Melén, E. & London, S. J., Apr 7 2016, In : American Journal of Human Genetics. 98, 4, p. 680-696 17 p.

Research output: Contribution to journalArticle

DNA Methylation
Meta-Analysis
Smoking
Mothers
Newborn Infant

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy

Hong, X., Ladd-Acosta, C. M., Hao, K., Sherwood, B., Ji, H. K., Keet, C., Kumar, R., Caruso, D., Liu, X., Wang, G., Chen, Z., Ji, Y., Mao, G., Walker, S. O., Bartell, T. R., Ji, Z., Sun, Y., Tsai, H. J., Pongracic, J. A., Weeks, D. E. & 1 others, Wang, X., 2016, (Accepted/In press) In : The Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Methylation
Single Nucleotide Polymorphism
Quality Control
DNA Probes
DNA Methylation

Pleiotropic Mechanisms Indicated for Sex Differences in Autism

Mitra, I., Tsang, K., Ladd-Acosta, C. M., Croen, L. A., Aldinger, K. A., Hendren, R. L., Traglia, M., Lavillaureix, A., Zaitlen, N., Oldham, M. C., Levitt, P., Nelson, S., Amaral, D. G., Herz-Picciotto, I., Fallin, D. D. & Weiss, L. A., Nov 1 2016, In : PLoS Genetics. 12, 11, e1006425.

Research output: Contribution to journalArticle

Autistic Disorder
gender differences
Sex Characteristics
gender
sexual dimorphism

Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood

Ladd-Acosta, C. M., Shu, C., Lee, B. K., Gidaya, N., Singer, A., Schieve, L. A., Schendel, D. E., Jones, N., Daniels, J. L., Windham, G. C., Newschaffer, C. J., Croen, L. A., Feinberg, A. P. & Fallin, D. D., Jan 1 2016, In : Environmental Research. 144, p. 139-148 10 p.

Research output: Contribution to journalArticle

methylation
DNA Methylation
Epigenomics
Smoke
Tobacco Products

The role of epigenetics in genetic and environmental epidemiology

Ladd-Acosta, C. M. & Fallin, D. D., Feb 1 2016, In : Epigenomics. 8, 2, p. 271-283 13 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Epigenomics
Gene-Environment Interaction
Population
Epidemiology
2015

Epigenetic Signatures as Biomarkers of Exposure

Ladd-Acosta, C. M., Jun 1 2015, In : Current environmental health reports. 2, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Epigenomics
Biomarkers
Environmental Exposure
Health

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Hong, X., Hao, K., Ladd-Acosta, C. M., Hansen, K. D., Tsai, H. J., Liu, X., Xu, X., Thornton, T. A., Caruso, D., Keet, C., Sun, Y., Wang, G., Luo, W., Kumar, R., Fuleihan, R., Singh, A. M., Kim, J. S., Story, R. E., Gupta, R. S., Gao, P. & 12 others, Chen, Z., Walker, S. O., Bartell, T. R., Beaty, T. L., Fallin, D. D., Schleimer, R., Holt, P. G., Nadeau, K. C., Wood, R. A., Pongracic, J. A., Weeks, D. E. & Wang, X., 2015, In : Nature Communications. 6, 6304.

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Allergies
mediation
Food Hypersensitivity
genome
2014

Common DNA methylation alterations in multiple brain regions in autism

Ladd-Acosta, C. M., Hansen, K. D., Briem, E., Fallin, D. D., Kaufmann, W. E. & Feinberg, A. P., 2014, In : Molecular Psychiatry. 19, 8, p. 862-871 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Autistic Disorder
Brain
Epigenomics
Genome

Minfi: A flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

Aryee, M. J., Jaffe, A., Corrada-Bravo, H., Ladd-Acosta, C. M., Feinberg, A. P., Hansen, K. D. & Irizarry, R. A., May 15 2014, In : Bioinformatics. 30, 10, p. 1363-1369 7 p.

Research output: Contribution to journalArticle

DNA Microarray
DNA Methylation
Microarrays
Oligonucleotide Array Sequence Analysis
Throughput
2011

Accurate genome-scale percentage DNA methylation estimates from microarray data

Aryee, M. J., Wu, Z., Ladd-Acosta, C. M., Herb, B., Feinberg, A. P., Yegnasubramanian, S. & Irizarry, R. A., Apr 2011, In : Biostatistics. 12, 2, p. 197-210 14 p.

Research output: Contribution to journalArticle

DNA Methylation
Microarray Data
Methylation
Percentage
Genome
2010
DNA Methylation
Methylation
Genome
Viverridae
CpG Islands

Parent-of-origin effects in autism identified through genome-wide linkage analysis of 16,000 SNPs

Fradin, D., Cheslack-Postava, K., Ladd-Acosta, C. M., Newschaffer, C., Chakravarti, A., Arking, D., Feinberg, A. P. & Fallin, D. D., 2010, In : PLoS One. 5, 9, p. 1-8 8 p., e12513.

Research output: Contribution to journalArticle

Autistic Disorder
Single Nucleotide Polymorphism
linkage (genetics)
Genes
Genome

Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer

Zhu, C. Q., Ding, K., Strumpf, D., Weir, B. A., Meyerson, M., Pennell, N., Thomas, R. K., Naoki, K., Ladd-Acosta, C. M., Liu, N., Pintilie, M., Der, S., Seymour, L., Jurisica, I., Shepherd, F. A. & Tsao, M. S., Oct 10 2010, In : Journal of Clinical Oncology. 28, 29, p. 4417-4424 8 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Non-Small Cell Lung Carcinoma
Cisplatin
Genes
Observation
2009

Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Doi, A., Park, I. H., Wen, B., Murakami, P., Aryee, M. J., Irizarry, R., Herb, B., Ladd-Acosta, C. M., Rho, J., Loewer, S., Miller, J., Schlaeger, T., Daley, G. Q. & Feinberg, A. P., Dec 2009, In : Nature Genetics. 41, 12, p. 1350-1353 4 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cytosine
Guanine
Embryonic Stem Cells
Islands

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Irizarry, R. A., Ladd-Acosta, C. M., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., Ji, H. K., Potash, J. B., Sabunciyan, S. & Feinberg, A. P., Feb 2009, In : Nature Genetics. 41, 2, p. 178-186 9 p.

Research output: Contribution to journalArticle

CpG Islands
Colonic Neoplasms
Methylation
DNA Methylation
Epigenomics
2008

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

Ebert, B. L., Galili, N., Tamayo, P., Bosco, J., Mak, R., Pretz, J., Tanguturi, S., Ladd-Acosta, C. M., Stone, R., Golub, T. R. & Raza, A., Feb 2008, In : PLoS Medicine. 5, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
lenalidomide
Chromosome Deletion
Gene Expression Profiling
Proxy

Comprehensive high-throughput arrays for relative methylation (CHARM)

Irizarry, R. A., Ladd-Acosta, C. M., Carvalho, B., Wu, H., Brandenburg, S. A., Jeddeloh, J. A., Wen, B. & Feinberg, A. P., May 2008, In : Genome Research. 18, 5, p. 780-790 11 p.

Research output: Contribution to journalArticle

Methylation
DNA
Genome
CpG Islands
DNA Methylation

Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study

Shedden, K., Taylor, J. M. G., Enkemann, S. A., Tsao, M. S., Yeatman, T. J., Gerald, W. L., Eschrich, S., Jurisica, I., Giordano, T. J., Misek, D. E., Chang, A. C., Zhu, C. Q., Strumpf, D., Hanash, S., Shepherd, F. A., Ding, K., Seymour, L., Naoki, K., Pennell, N., Weir, B. & 20 others, Verhaak, R., Ladd-Acosta, C. M., Golub, T., Gruidl, M., Sharma, A., Szoke, J., Zakowski, M., Rusch, V., Kris, M., Viale, A., Motoi, N., Travis, W., Conley, B., Seshan, V. E., Meyerson, M., Kuick, R., Dobbin, K. K., Lively, T., Jacobson, J. W. & Beer, D. G., Aug 2008, In : Nature Medicine. 14, 8, p. 822-827 6 p.

Research output: Contribution to journalArticle

Validation Studies
Gene expression
Lung Neoplasms
Microarrays
Gene Expression

SNP-specific array-based allele-specific expression analysis

Bjornsson, H. T., Albert, T. J., Ladd-Acosta, C. M., Green, R. D., Rongione, M. A., Middle, C. M., Irizarry, R. A., Broman, K. W. & Feinberg, A. P., May 2008, In : Genome Research. 18, 5, p. 771-779 9 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Alleles
Inflammasomes
Gene Expression
Aminopeptidases
2007

DNA methylation signatures within the human brain

Ladd-Acosta, C. M., Pevsner, J. A., Sabunciyan, S., Yolken, R. H., Webster, M. J., Dinkins, T., Callinan, P. A., Fan, J. B., Potash, J. B. & Feinberg, A. P., 2007, In : American Journal of Human Genetics. 81, 6, p. 1304-1315 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Brain
Pons
Cerebellum
Genes

TXNIP regulates peripheral glucose metabolism in humans

Parikh, H., Carlsson, E., Chutkow, W. A., Johansson, L. E., Storgaard, H., Poulsen, P., Saxena, R., Ladd-Acosta, C. M., Schulze, P. C., Mazzini, M. J., Jensen, C. B., Krook, A., Björnholm, M., Tornqvist, H., Zierath, J. R., Ridderstråle, M., Altshuler, D., Lee, R. T., Vaag, A., Groop, L. C. & 1 others, Mootha, V. K., May 2007, In : PLoS Medicine. 4, 5, p. 868-879 12 p.

Research output: Contribution to journalArticle

Thioredoxins
Glucose
Type 2 Diabetes Mellitus
Proteins
Insulin
2005

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

Sweet-Cordero, A., Mukherjee, S., Subramanian, A., You, H., Roix, J. J., Ladd-Acosta, C. M., Mesirov, J., Golub, T. R. & Jacks, T., Jan 2005, In : Nature Genetics. 37, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

Gene Expression
Transcriptome
Neoplasms
Mutation
Lung Neoplasms

Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays

Dobbin, K. K., Beer, D. G., Meyerson, M., Yeatman, T. J., Gerald, W. L., Jacobson, J. W., Conley, B., Buetow, K. H., Heiskanen, M., Simon, R. M., Minna, J. D., Girard, L., Misek, D. E., Taylor, J. M. G., Hanash, S., Naoki, K., Hayes, D. N., Ladd-Acosta, C. M., Enkemann, S. A., Viale, A. & 1 others, Giordano, T. J., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 565-572 8 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Oligonucleotide Array Sequence Analysis
Gene Expression
Tumor Cell Line
RNA

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

Monti, S., Savage, K. J., Kutok, J. L., Feuerhake, F., Kurtin, P., Mihm, M., Wu, B., Pasqualucci, L., Neuberg, D., Aguiar, R. C. T., Cin, P. D., Ladd-Acosta, C. M., Pinkus, G. S., Salles, G., Harris, N. L., Dalla-Favera, R., Habermann, T. M., Aster, J. C., Golub, T. R. & Shipp, M. A., Mar 1 2005, In : Blood. 105, 5, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Tumors
Cells
Genes
Dendritic Cells
2003

Erratum: Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-α (Diabetes (2002) 51 (3176-3188))

Ruan, H., Miles, P. D. G., Ladd-Acosta, C. M., Ross, K., Golub, T. R., Olefsky, J. M. & Lodish, H. F., Feb 1 2003, In : Diabetes. 52, 2, p. 578 1 p.

Research output: Contribution to journalArticle

Adipose Tissue
Tumor Necrosis Factor-alpha
Genes

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification

Nutt, C. L., Mani, D. R., Betensky, R. A., Tamayo, P., Cairncross, J. G., Ladd-Acosta, C. M., Pohl, U., Hartmann, C., McLaughlin, M. E., Batchelor, T. T., Black, P. M., Von Deimling, A., Pomeroy, S. L., Golub, T. R. & Louis, D. N., Apr 1 2003, In : Cancer Research. 63, 7, p. 1602-1607 6 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Glioma
Glioblastoma
Gene Expression
Survival

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma

Savage, K. J., Monti, S., Kutok, J. L., Cattoretti, G., Neuberg, D., De Leval, L., Kurtin, P., Dal Cin, P., Ladd-Acosta, C. M., Feuerhake, F., Aguiar, R. C. T., Li, S., Salles, G., Berger, F., Jing, W., Pinkus, G. S., Habermann, T., Dalla-Favera, R., Harris, N. L., Aster, J. C. & 2 others, Golub, T. R. & Shipp, M. A., Dec 1 2003, In : Blood. 102, 12, p. 3871-3879 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
TNF Receptor-Associated Factor 1
B-Cell Lymphoma
Hodgkin Disease
STAT1 Transcription Factor
2002

Gene expression correlates of clinical prostate cancer behavior

Singh, D., Febbo, P. G., Ross, K., Jackson, D. G., Manola, J., Ladd-Acosta, C. M., Tamayo, P., Renshaw, A. A., D'Amico, A. V., Richie, J. P., Lander, E. S., Loda, M., Kantoff, P. W., Golub, T. R. & Sellers, W. R., Mar 2002, In : Cancer Cell. 1, 2, p. 203-209 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Gene Expression
Neoplasms
Neoplasm Grading
Microarray Analysis

Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-α: Implications for insulin resistance

Ruan, H., Miles, P. D. G., Ladd-Acosta, C. M., Ross, K., Golub, T. R., Olefsky, J. M. & Lodish, H. F., Nov 1 2002, In : Diabetes. 51, 11, p. 3176-3188 13 p.

Research output: Contribution to journalArticle

Insulin Resistance
Adipose Tissue
Tumor Necrosis Factor-alpha
Genes
Nonesterified Fatty Acids
2001

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

Bhattacharjee, A., Richards, W. G., Staunton, J., Li, C., Monti, S., Vasa, P., Ladd-Acosta, C. M., Beheshti, J., Bueno, R., Gillette, M., Loda, M., Weber, G., Mark, E. J., Lander, E. S., Wong, W., Johnson, B. E., Golub, T. R., Sugarbaker, D. J. & Meyerson, M., Nov 20 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 24, p. 13790-13795 6 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Carcinoma
Lung
Messenger RNA
Alveolar Epithelial Cells

Multiclass cancer diagnosis using tumor gene expression signatures

Ramaswamy, S., Tamayo, P., Rifkin, R., Mukherjee, S., Yeang, C. H., Angelo, M., Ladd-Acosta, C. M., Reich, M., Latulippe, E., Mesirov, J. P., Poggio, T., Gerald, W., Loda, M., Lander, E. S. & Golub, T. R., Dec 18 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 26, p. 15149-15154 6 p.

Research output: Contribution to journalArticle

Transcriptome
Neoplasms
Gene Expression
Molecular Pathology
Expressed Sequence Tags