Christine Hann

Associate Professor

19982020
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Research Output 1998 2020

2020

Expression of Programmed Cell Death Ligand 1 and Associated Lymphocyte Infiltration in Olfactory Neuroblastoma

London, N. R., Rooper, L. M., Bishop, J. A., Xu, H., Bernhardt, L. J., Ishii, M., Hann, C. L., Taube, J. M., Izumchenko, E., Gaykalova, D. A. & Gallia, G. L., Jan 1 2020, (Accepted/In press) In : World neurosurgery.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
Cell Death
Lymphocytes
Ligands
CD274 Antigen
2019

Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

Anagnostou, V., Forde, P. M., White, J. R., Niknafs, N., Hruban, C., Naidoo, J., Marrone, K., Ashok Sivakumar, I. K., Bruhm, D. C., Rosner, S., Phallen, J., Leal, A., Adleff, V., Smith, K. N., Cottrell, T. R., Rhymee, L., Palsgrove, D. N., Hann, C. L., Levy, B., Feliciano, J. & 16 others, Georgiades, C., Verde, F., Illei, P., Li, Q. K., Gabrielson, E., Brock, M. V., Isbell, J. M., Sauter, J. L., Taube, J., Scharpf, R. B., Karchin, R., Pardoll, D. M., Chaft, J. E., Hellmann, M. D., Brahmer, J. R. & Velculescu, V. E., Jan 1 2019, In : Cancer Research. 79, 6, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
DNA
Neoplasms
Therapeutics
Confidence Intervals

Efficacy and safety of rovalpituzumab tesirine in third-line and beyond patients with DLL3-expressing, relapsed/refractory small-cell lung cancer: Results from the phase II TrINITY study

Morgensztern, D., Besse, B., Greillier, L., Santana-Davila, R., Ready, N., Hann, C. L., Glisson, B. S., Farago, A. F., Dowlati, A., Rudin, C. M., Le Moulec, S., Lally, S., Yalamanchili, S., Wolf, J., Govindan, R. & Carbone, D. P., Dec 1 2019, In : Clinical Cancer Research. 25, 23, p. 6958-6966 9 p.

Research output: Contribution to journalArticle

Open Access
Small Cell Lung Carcinoma
Safety
Immunohistochemistry
Rabbits
delta protein

Lung cancer and family-centered concerns

Feliciano, J., Chang, A., Venkatraman, D., Brooks, S., Zagaja, C., Ettinger, D. S., Hann, C., Naidoo, J., Voong, K., Hales, R., Turner, M., Peterson, V. & Bodurtha, J. N., Jan 1 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Lung Neoplasms
Focus Groups
Caregivers
Neoplasms
Family Health

Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort

Ready, N. E., Ott, P. A., Hellmann, M. D., Zugazagoitia, J., Hann, C. L., de Braud, F., Antonia, S. J., Ascierto, P. A., Moreno, V., Atmaca, A., Salvagni, S., Taylor, M., Amin, A., Camidge, D. R., Horn, L., Calvo, E., Li, A., Lin, W. H., Callahan, M. K. & Spigel, D. R., Jan 1 2019, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Open Access
Small Cell Lung Carcinoma
Survival
ipilimumab
nivolumab
Disease Progression
Non-Small Cell Lung Carcinoma
Pneumonia
Radiotherapy
Thorax
Ligands

The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis

Suresh, K., Naidoo, J., Zhong, Q., Xiong, Y., Mammen, J., De Flores, M. V., Cappelli, L., Balaji, A., Palmer, T., Forde, P. M., Anagnostou, V., Ettinger, D. S., Marrone, K. A., Kelly, R. J., Hann, C. L., Levy, B., Feliciano, J. L., Lin, C. T., Feller-Kopman, D., Lerner, A. D. & 8 others, Lee, H., Shafiq, M., Yarmus, L., Lipson, E. J., Soloski, M., Brahmer, J. R., Danoff, S. K. & D'Alessio, F., Oct 1 2019, In : Journal of Clinical Investigation. 129, 10, p. 4305-4315 11 p.

Research output: Contribution to journalArticle

Open Access
Alveolar Epithelial Cells
Bronchoalveolar Lavage
Pneumonia
Immunotherapy
T-Lymphocytes
2018
Metformin
Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Drug Therapy

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes

Lung and Thymic Carcinoids

Hann, C. & Forde, P., Sep 1 2018, In : Endocrinology and Metabolism Clinics of North America. 47, 3, p. 699-709 11 p.

Research output: Contribution to journalReview article

Carcinoid Tumor
Ectopic Hormones
Multiple Endocrine Neoplasia
Thymus Neoplasms
Lung

NCCN guidelines® insights: Small cell lung cancer, version 2.2018 featured updates to the NCCN guidelines

Kalemkerian, G. P., Loo, B. W., Akerley, W., Attia, A., Bassetti, M., Boumber, Y., Decker, R., Dobelbower, M. C., Dowlati, A., Downey, R. J., Florsheim, C., Ganti, A. K. P., Grecula, J. C., Gubens, M. A., Hann, C., Hayman, J. A., Heist, R. S., Koczywas, M., Merritt, R. E., Mohindra, N. & 11 others, Molina, J., Moran, C. A., Morgensztern, D., Pokharel, S., Portnoy, D. C., Rhodes, D., Rusthoven, C., Santana-Davila, R., Williams, C. C., Hoffmann, K. G. & Hughes, M., Oct 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 10, p. 1171-1182 12 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Guidelines
Disease Management
Immunotherapy
Signs and Symptoms

Randomized, double-blind, phase II study of temozolomide in combination with either veliparib or placebo in patients with relapsed-sensitive or refractory small-cell lung cancer

Pietanza, M. C., Waqar, S. N., Krug, L. M., Dowlati, A., Hann, C., Chiappori, A., Owonikoko, T. K., Woo, K. M., Cardnell, R. J., Fujimoto, J., Long, L., Diao, L., Wang, J., Bensman, Y., Hurtado, B., de Groot, P., Sulman, E. P., Wistuba, I. I., Chen, A., Fleisher, M. & 4 others, Heymach, J. V., Kris, M. G., Rudin, C. M. & Byers, L. A., Aug 10 2018, In : Journal of Clinical Oncology. 36, 23, p. 2386-2394 9 p.

Research output: Contribution to journalArticle

temozolomide
Small Cell Lung Carcinoma
Placebos
Disease-Free Survival
Survival

Rediagnosis of lung cancer as NUT midline carcinoma based on clues from tumor genomic profiling

Baras, A., Naidoo, J., Hann, C., Illei, P. B., Reninger, C. W. & Lauring, J., May 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 5, p. 467-472 6 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Carcinoma
Neoplasms
Investigational Therapies
DNA Sequence Analysis

Small cell and neuroendocrine tumors of the lung

Hann, C., Wu, M. A., Rekhtman, N. & Rudin, C. M., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 671-700 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuroendocrine Tumors
Lung

Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032

Ready, N., Farago, A. F., de Braud, F., Atmaca, A., Hellmann, M. D., Schneider, J. G., Spigel, D. R., Moreno, V., Chau, I., Hann, C., Eder, J. P., Steele, N. L., Pieters, A., Fairchild, J. & Antonia, S. J., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Disease Progression
Topotecan
Therapeutics
Drug Therapy
nivolumab
2016

A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

Sun, H., Luo, L., Lal, B., Ma, X., Chen, L., Hann, C., Fulton, A. M., Leahy, D. J., Laterra, J. J. & Li, M., Feb 4 2016, In : Nature Communications. 7, 10339.

Research output: Contribution to journalArticle

metastasis
antibodies
Tumors
tumors
cancer

A randomized phase II study of linsitinib (OSI-906) versus Topotecan in patients with relapsed small-cell lung cancer

Chiappori, A. A., Otterson, G. A., Dowlati, A., Traynor, A. M., Horn, L., Owonikoko, T. K., Ross, H. J., Hann, C., Hejleh, T. A., Nieva, J., Zhao, X., Schell, M. & Sullivan, D. M., Oct 1 2016, In : Oncologist. 21, 10, p. 1163-1164 2 p.

Research output: Contribution to journalArticle

Topotecan
Small Cell Lung Carcinoma
Confidence Intervals
Growth Factor Receptors
Thrombocytopenia

Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?

Bunn, P. A., Minna, J. D., Augustyn, A., Gazdar, A. F., Ouadah, Y., Krasnow, M. A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P. P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J. T., Byers, L. A., Wynes, M. W., McFadden, D. G., MacPherson, D., Hann, C. & 34 others, Farago, A. F., Dive, C., Teicher, B. A., Peacock, C. D., Johnson, J. E., Cobb, M. H., Wendel, H. G., Spigel, D., Sage, J., Yang, P., Pietanza, M. C., Krug, L. M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C. L., Park, K., Einhorn, L. H., Edelman, M. J., Giaccone, G., Gerber, D. E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D. R., Slotman, B. J., Blackhall, F., Goss, G., Thomas, R., Rudin, C. M. & Hirsch, F. R., 2016, In : Journal of Thoracic Oncology. 11, 4, p. 453-474 22 p.

Research output: Contribution to journalArticle

Targeted doxorubicin delivery to brain tumors via minicells: Proof of principle using dogs with spontaneously occurring tumors as a model

MacDiarmid, J. A., Langova, V., Bailey, D., Pattison, S. T., Pattison, S. L., Christensen, N., Armstrong, L. R., Brahmbhatt, V. N., Smolarczyk, K., Harrison, M. T., Costa, M., Mugridge, N. B., Sedliarou, I., Grimes, N. A., Kiss, D. L., Stillman, B., Hann, C., Gallia, G. L., Graham, R. M. & Brahmbhatt, H., Apr 1 2016, In : PLoS One. 11, 4, e0151832.

Research output: Contribution to journalArticle

doxorubicin
Brain Neoplasms
Doxorubicin
Tumors
Brain

Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508)

Belani, C. P., Dahlberg, S. E., Rudin, C. M., Fleisher, M., Chen, H. X., Takebe, N., Velasco, M. R., Tester, W. J., Sturtz, K., Hann, C., Shanks, J. C., Monga, M., Ramalingam, S. S. & Schiller, J. H., 2016, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

HhAntag691
Small Cell Lung Carcinoma
Circulating Neoplastic Cells
Arm
Drug Therapy
2015

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

Mohammad, H., Smitheman, K., Kamat, C., Soong, D., Federowicz, K., VanAller, G., Schneck, J., Carson, J., Liu, Y., Butticello, M., Bonnette, W., Gorman, S., Degenhardt, Y., Bai, Y., McCabe, M., Pappalardi, M., Kasparec, J., Tian, X., McNulty, K., Rouse, M. & 13 others, McDevitt, P., Ho, T., Crouthamel, M., Hart, T., Concha, N., McHugh, C., Miller, W., Dhanak, D., Tummino, P., Carpenter, C., Johnson, N., Hann, C. & Kruger, R., Jul 13 2015, In : Cancer Cell. 28, 1, p. 57-69 13 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Lysine
Epigenomics
DNA
Neoplasms

A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E2511)

Owonikoko, T. K., Dahlberg, S. E., Khan, S. A., Gerber, D. E., Dowell, J., Moss, R. A., Belani, C. P., Hann, C., Aggarwal, C. & Ramalingam, S. S., Jul 1 2015, In : Lung Cancer. 89, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Etoposide
Cisplatin
Safety
Research

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

Poirier, J. T., Gardner, E. E., Connis, N., Moreira, A. L., De Stanchina, E., Hann, C. & Rudin, C. M., Nov 26 2015, In : Oncogene. 34, 48, p. 5869-5878 10 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
DNA Methylation
Heterografts
Cluster Analysis
Cell Line

Treatment of small-cell lung cancer: American society of clinical oncology endorsement of the American college of chest physicians guideline

Rudin, C. M., Ismaila, N., Hann, C., Malhotra, N., Movsas, B., Norris, K., Pietanza, M. C., Ramalingam, S. S., Turrisi, A. T. & Giaccone, G., Dec 1 2015, In : Journal of Clinical Oncology. 33, 34, p. 4106-4111 6 p.

Research output: Contribution to journalArticle

Medical Oncology
Small Cell Lung Carcinoma
Thorax
Guidelines
Physicians
2014

Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines

Webster, M. R., Kamat, C., Connis, N., Zhao, M., Weeraratna, A. T., Rudek, M. A., Hann, C. L. & Meyers, C. L. F., Feb 2014, In : Molecular Cancer Therapeutics. 13, 2, p. 297-306 10 p.

Research output: Contribution to journalArticle

Clodronic Acid
Prodrugs
Melanoma
Cell Line
Diphosphonates

Rapamycin rescues ABT-737 efficacy in small cell lung cancer

Gardner, E. E., Connis, N., Poirier, J. T., Cope, L., Dobromilskaya, I., Gallia, G. L., Rudin, C. M. & Hann, C., May 15 2014, In : Cancer Research. 74, 10, p. 2846-2856 11 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Sirolimus
Clinical Trials
ABT-737
Neoplasms

Systemic therapy, clinical outcomes, and overall survival in locally advanced or metastatic pulmonary carcinoid: A brief report

Forde, P., Hooker, C. M., Boikos, S. A., Petrini, I., Giaccone, G., Rudin, C. M., Yang, S. C., Illei, P. B., Hann, C., Ettinger, D. S., Brahmer, J. & Kelly, R. J., Mar 2014, In : Journal of Thoracic Oncology. 9, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Carcinoid Tumor
Lung
Survival
Therapeutics
Disease-Free Survival
2013

Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer

Zinn, R. L., Gardner, E. E., Dobromilskaya, I., Murphy, S., Marchionni, L., Hann, C. & Rudin, C. M., Mar 2 2013, In : Molecular Cancer. 12, 1, 16.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Chloroquine
Autophagy
Heterografts
Therapeutics

ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer

Zinn, R. L., Gardner, E. E., Marchionni, L., Murphy, S. C., Dobromilskaya, I., Hann, C. & Rudin, C. M., Jun 2013, In : Molecular Cancer Therapeutics. 12, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Small Cell Lung Carcinoma
Phosphorylation
Heterografts
Cell Line

Erlotinib inhibits growth of a patient-derived chordoma xenograft

Siu, I. M., Ruzevick, J., Zhao, Q., Connis, N., Jiao, Y., Bettegowda, C., Xia, X., Burger, P. C., Hann, C. & Gallia, G. L., Nov 15 2013, In : PLoS One. 8, 11, e78895.

Research output: Contribution to journalArticle

Chordoma
Epidermal Growth Factor Receptor
Heterografts
Tumors
Growth

Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer

Rudin, C. M., Brahmer, J., Juergens, R. A., Hann, C., Ettinger, D. S., Sebree, R., Smith, R., Aftab, B. T., Huang, P. & Liu, J., May 2013, In : Journal of Thoracic Oncology. 8, 5, p. 619-623 5 p.

Research output: Contribution to journalArticle

Pemetrexed
Itraconazole
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Therapeutics

Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo

Kamat, C. D., Shmueli, R. B., Connis, N., Rudin, C. M., Green, J. & Hann, C., Apr 2013, In : Molecular Cancer Therapeutics. 12, 4, p. 405-415 11 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Nanoparticles
Esters
Polymers
p53 Genes

Selective tropism of seneca valley virus for variant subtype small cell lung cancer

Poirier, J. T., Dobromilskaya, I., Moriarty, W. F., Peacock, C. D., Hann, C. & Rudin, C. M., Jul 17 2013, In : Journal of the National Cancer Institute. 105, 14, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

Tropism
Small Cell Lung Carcinoma
Heterografts
Viruses
Transcription Factors

Tumor lysis syndrome in limited-stage small-cell lung cancer

Boikos, S. A., Forde, P. M., Chatterjee, S. & Hann, C. L., Jul 2013, In : Journal of Thoracic Oncology. 8, 7

Research output: Contribution to journalArticle

Tumor Lysis Syndrome
Small Cell Lung Carcinoma
2012

Establishment and characterization of a primary human chordoma xenograft model. Laboratory investigation

Siu, I. M., Salmasi, V., Orr, B. A., Zhao, Q., Binder, Z. A., Tran, C., Ishii, M., Riggins, G. J., Hann, C. & Gallia, G. L., Apr 2012, In : Journal of Neurosurgery. 116, 4, p. 801-809 9 p.

Research output: Contribution to journalArticle

Chordoma
Heterografts
Neoplasms
Staining and Labeling
Nude Mice

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

Rudin, C. M., Hann, C., Garon, E. B., Ribeiro De Oliveira, M., Bonomi, P. D., Camidge, D. R., Chu, Q., Giaccone, G., Khaira, D., Ramalingam, S. S., Ranson, M. R., Dive, C., McKeegan, E. M., Chyla, B. J., Dowell, B. L., Chakravartty, A., Nolan, C. E., Rudersdorf, N., Busman, T. A., Mabry, M. H. & 4 others, Krivoshik, A. P., Humerickhouse, R. A., Shapiro, G. I. & Gandhi, L., Jun 1 2012, In : Clinical Cancer Research. 18, 11, p. 3163-3169 7 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Biomarkers
Gastrin-Releasing Peptide
Keratin-19
Circulating Neoplastic Cells

Response

Gallia, G. L., Siu, I. M., Zhao, Q., Orr, B. A. & Hann, C., Apr 2012, In : Journal of Neurosurgery. 116, 4, p. 800 1 p.

Research output: Contribution to journalArticle

2011

Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells

Webster, M. R., Zhao, M., Rudek-Renaut, M., Hann, C. & Meyers, C. L., Oct 13 2011, In : Journal of Medicinal Chemistry. 54, 19, p. 6647-6656 10 p.

Research output: Contribution to journalArticle

Clodronic Acid
Prodrugs
Diphosphonates
Non-Small Cell Lung Carcinoma
Calcium Metabolism Disorders

Glioblastoma multiforme in the Muir-Torre syndrome

Binder, Z. A., Johnson, M. W., Joshi, A., Hann, C., Griffin, C. A., Olivi, A., Riggins, G. J. & Gallia, G. L., Jun 2011, In : Clinical Neurology and Neurosurgery. 113, 5, p. 411-415 5 p.

Research output: Contribution to journalArticle

Muir-Torre Syndrome
Glioblastoma
DNA Mismatch Repair
MutS Homolog 2 Protein
Sebaceous Glands

Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo

Osanyingbemi-Obidi, J., Dobromilskaya, I., Illei, P. B., Hann, C. & Rudin, C. M., Dec 2011, In : Molecular Cancer Research. 9, 12, p. 1746-1754 9 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Carcinogenesis
Amyloid Precursor Protein Secretases
Non-Small Cell Lung Carcinoma
Lung

Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features

Rudin, C. M., Poirier, J. T., Senzer, N. N., Stephenson, J., Loesch, D., Burroughs, K. D., Reddy, P. S., Hann, C. & Hallenbeck, P. L., Feb 15 2011, In : Clinical Cancer Research. 17, 4, p. 888-895 8 p.

Research output: Contribution to journalArticle

Picornaviridae
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Viruses
Small Cell Carcinoma

Phase I study of navitoclax (ABT-263), a novel bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

Gandhi, L., Camidge, D. R., De Oliveira, M. R., Bonomi, P., Gandara, D., Khaira, D., Hann, C., McKeegan, E. M., Litvinovich, E., Hemken, P. M., Dive, C., Enschede, S. H., Nolan, C., Chiu, Y. L., Busman, T., Xiong, H., Krivoshik, A. P., Humerickhouse, R., Shapiro, G. I. & Rudin, C. M., Mar 1 2011, In : Journal of Clinical Oncology. 29, 7, p. 909-916 8 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Neoplasms
Gastrin-Releasing Peptide
Carcinoid Tumor
Thrombocytopenia

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors

LoRusso, P. M., Rudin, C. M., Reddy, J. C., Tibes, R., Weiss, G. J., Borad, M. J., Hann, C., Brahmer, J., Chang, I., Darbonne, W. C., Graham, R. A., Zerivitz, K. L., Low, J. A. & Von Hoff, D. D., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2502-2511 10 p.

Research output: Contribution to journalArticle

HhAntag691
Medulloblastoma
Basal Cell Carcinoma
Neoplasms
Hyponatremia
2010

Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme

Holdhoff, M., Supko, J. G., Gallia, G. L., Hann, C., Bonekamp, D., Ye, X., Cao, B., Olivi, A. & Grossman, S. A., Apr 2010, In : Journal of Neuro-Oncology. 97, 2, p. 241-245 5 p.

Research output: Contribution to journalArticle

Glioblastoma
Oral Administration
Blood-Brain Barrier
Glioma
Neoplasms

Radiotherapy in small-cell lung cancer

Hatim, H., Hann, C. & Hales, R., Oct 2010, In : Oncology. 24, 11

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Radiotherapy
Oncolytic Viruses
Somatomedin Receptors
Neuroendocrine Cells

Radiotherapy in small-cell lung cancer.

Husain, H., Hann, C. & Hales, R., Oct 2010, In : Oncology. 24, 11

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Radiotherapy
Oncolytic Viruses
Somatomedin Receptors
Neuroendocrine Cells
2009

Inferior Vena Cava Interruption

Streiff, M. B., Hann, C. & Ginsberg, J., Feb 4 2009, Evidence-Based Hematology. John Wiley and Sons, p. 99-109 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inferior Vena Cava

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

Gallia, G. L., Tyler, B. M., Hann, C., Siu, I. M., Giranda, V. L., Vescovi, A. L., Brem, H. & Riggins, G. J., Feb 1 2009, In : Molecular Cancer Therapeutics. 8, 2, p. 386-393 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Growth
Cell Line
Polymers