Chih-Yung Lee

Research Associate

20042019
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Research Output 2004 2019

2019

Dynamics of mRNA entry into stress granules

Lee, C-Y. & Seydoux, G., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 116-117 2 p.

Research output: Contribution to journalArticle

Messenger RNA
Eukaryotic Cells
Proteins

P Granules Protect RNA Interference Genes from Silencing by piRNAs

Ouyang, J. P. T., Folkmann, A., Bernard, L., Lee, C-Y., Seroussi, U., Charlesworth, A. G., Claycomb, J. M. & Seydoux, G., Sep 23 2019, In : Developmental Cell. 50, 6, p. 716-728.e6

Research output: Contribution to journalArticle

Gene Silencing
RNA Interference
Germ Cells
Genes
RNA
2017
Epigenomics
Germ Cells
Chromatin
Transcription Factors
Down-Regulation
2014

Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis

Brookheart, R. T., Lee, C-Y. & Espenshade, P., Jan 31 2014, In : Journal of Biological Chemistry. 289, 5, p. 2725-2735 11 p.

Research output: Contribution to journalArticle

Casein Kinase I
Sterol Regulatory Element Binding Proteins
Sterols
Homeostasis
Oxygen

Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 sites in Caenorhabditis elegans

Paix, A., Wang, Y., Smith, H. E., Lee, C-Y., Calidas, D., Lu, T., Smith, J., Schmidt, H., Krause, M. W. & Seydoux, G., Dec 1 2014, In : Genetics. 198, 4, p. 1347-1356 10 p.

Research output: Contribution to journalArticle

CRISPR-Associated Proteins
Caenorhabditis elegans
DNA
Genome
Genes
2012

Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation

Porter, J. R., Lee, C-Y., Espenshade, P. & Iglesias, P. A., Sep 15 2012, In : Molecular Biology of the Cell. 23, 18, p. 3764-3774 11 p.

Research output: Contribution to journalArticle

Oxygen
DNA
Sterol Regulatory Element Binding Proteins
Prolyl Hydroxylases
Hypoxia
2011

Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding

Lee, C-Y., Yeh, T. L., Hughes, B. T. & Espenshade, P., Oct 21 2011, In : Molecular Cell. 44, 2, p. 225-234 10 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Transcription Factors
Hydroxylation
Oxygen
DNA

The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor

Yeh, T. L., Lee, C-Y., Amzel, M. L., Espenshade, P. & Bianchet, M. A., Apr 13 2011, In : Structure. 19, 4, p. 503-514 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Sterols
Oxygen
Transcription Factors
Schizosaccharomyces pombe Proteins
2009

Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast

Lee, C-Y., Stewart, E. V., Hughes, B. T. & Espenshade, P., Jan 21 2009, In : The EMBO journal. 28, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Yeast
Yeasts
Oxygen
Degradation

Plug and play modular strategies for synthetic retrotransposons

An, W., Davis, E. S., Thompson, T. L., O'Donnell, K. A., Lee, C-Y. & Boeke, J. D., Nov 2009, In : Methods. 49, 3, p. 227-235 9 p.

Research output: Contribution to journalArticle

Retroelements
Synthetic Biology
Assays
Cell Culture Techniques
Genome
2007

4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress

Hughes, A. L., Lee, C-Y., Bien, C. M. & Espenshade, P., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 24388-24396 9 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Sterols
Yeast
Oxygen
Chemical activation

SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast.

Sehgal, A., Lee, C-Y. & Espenshade, P., Aug 10 2007, In : PLoS Genetics. 3, 8

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Retroelements
Schizosaccharomyces
Schizosaccharomyces pombe
sterol
2006

Physical and functional interactions between Escherichia coli MutY and endonuclease VIII

Lu, A. L., Lee, C-Y., Li, L. & Li, X., Jan 1 2006, In : Biochemical Journal. 393, 1, p. 381-387 7 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Escherichia coli
DNA Glycosylases
Adenine
DNA
2004

An Escherichia coli MutY mutant without the six-helix barrel domain is a dimer in solution and assembles cooperatively into multisubunit complexes with DNA

Lee, C-Y., Bai, H., Houle, R., Wilson, G. M. & Lu, A. L., Dec 10 2004, In : Journal of Biological Chemistry. 279, 50, p. 52653-52663 11 p.

Research output: Contribution to journalArticle

Dimers
Escherichia coli
DNA
DNA Glycosylases
Molecules