Chenguang Wang

Associate Professor

20052019
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Research Output 2005 2019

2019
Nonparametric Inference
Causal Inference
Randomized Clinical Trial
Bayesian Nonparametrics
Propensity Score

Propensity score-integrated composite likelihood approach for incorporating real-world evidence in single-arm clinical studies

Wang, C., Lu, N., Chen, W. C., Li, H., Tiwari, R., Xu, Y. & Yue, L. Q., Jan 1 2019, (Accepted/In press) In : Journal of biopharmaceutical statistics.

Research output: Contribution to journalArticle

Integrated Likelihood
Composite Likelihood
Propensity Score
Information Storage and Retrieval
Likelihood Functions

Propensity score-integrated power prior approach for incorporating real-world evidence in single-arm clinical studies

Wang, C., Li, H., Chen, W. C., Lu, N., Tiwari, R., Xu, Y. & Yue, L. Q., Jan 1 2019, In : Journal of biopharmaceutical statistics. 29, 5, p. 731-748 18 p.

Research output: Contribution to journalArticle

Open Access
Propensity Score
Information Science
Delivery of Health Care
Bayesian inference
Healthcare
Open Access
Bayes Theorem
Contraceptive Agents
Health Services
Public Health
Health
2018

A Bayesian design for phase I cancer therapeutic vaccine trials

Wang, C., Rosner, G. & Roden, R. S., Jan 1 2018, (Accepted/In press) In : Statistics in Medicine.

Research output: Contribution to journalArticle

Bayesian Design
Cancer Vaccines
Vaccine
Phase I Trial
Cancer
Graphical User Interface
Treatment Effects
Bayesian Analysis
Graphical user interfaces
Health care

Statistical methods to compare functional outcomes in randomized controlled trials with high mortality

Colantuoni, E. A., Scharfstein, D. O., Wang, C., Hashem, M. D., Leroux, A., Needham, D. & Girard, T. D., Jan 3 2018, In : BMJ (Clinical research ed.). 360, p. j5748

Research output: Contribution to journalArticle

Statistical Data Interpretation
Recovery of Function
Survival Analysis
Critical Illness
Randomized Controlled Trials
2017

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R., Hung, C-F. & Roden, R. S., Aug 1 2017, In : Journal of Virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

Papillomavirus Infections
Papillomaviridae
Mus musculus
papilloma
Papilloma

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Begum, A., Ewachiw, T., Jung, C., Huang, A., Norberg, K. J., Marchionni, L., McMillan, R., Penchev, V., Rajeshkumar, N. V., Maitra, A., Wood, L. D., Wang, C., Wolfgang, C., De Jesus-Acosta, A., Laheru, D., Shapiro, I. M., Padval, M., Pachter, J. A., Weaver, D. T., Rasheed, Z. A. & 1 others, Matsui, W., Jul 1 2017, In : PLoS One. 12, 7, e0180181.

Research output: Contribution to journalArticle

non-specific protein-tyrosine kinase
Focal Adhesion Protein-Tyrosine Kinases
Neoplastic Stem Cells
adenocarcinoma
Stem cells
2016

A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16 + cervical intraepithelial neoplasia 2/3 (CIN2/3)

Alvarez, R. D., Huh, W. K., Bae, S., Lamb, L. S., Conner, M. G., Boyer, J., Wang, C., Hung, C-F., Sauter, E., Paradis, M., Adams, E. A., Hester, S., Jackson, B. E., Wu, T. C. & Trimble, C. L., 2016, In : Gynecologic Oncology. 140, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

Cervical Intraepithelial Neoplasia
Vaccines
Vaccination
Therapeutics
Intralesional Injections

Bayesian analysis of heterogeneous treatment effects for patient-centered outcomes research

Henderson, N. C., Louis, T., Wang, C. & Varadhan, R., Sep 20 2016, (Accepted/In press) In : Health Services and Outcomes Research Methodology. p. 1-21 21 p.

Research output: Contribution to journalArticle

Patient Outcome Assessment
Bayes Theorem
Precision Medicine
Therapeutics
Software

Inference in randomized trials with death and missingness

Wang, C., Scharfstein, D. O., Colantuoni, E. A., Girard, T. D. & Yan, Y., 2016, (Accepted/In press) In : Biometrics.

Research output: Contribution to journalArticle

Randomized Trial
Sensitivity analysis
Cells
death
Composite materials

Nonparametric analysis of bivariate gap time with competing risks

Huang, C. Y., Wang, C. & Wang, M. C., Sep 1 2016, In : Biometrics. 72, 3, p. 780-790 11 p.

Research output: Contribution to journalArticle

Competing Risks
Cumulative Incidence Function
Recurrence
incidence
Nonparametric Estimator
2015

Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials

Zhang, Z., Wang, C. & Troendle, J. F., Apr 30 2015, In : Statistics in Medicine. 34, 9, p. 1467-1482 16 p.

Research output: Contribution to journalArticle

Multiple Endpoints
Clinical Trials
Testing
Conditional Power
Asthma

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C-F., Wu, T. C. & Roden, R. S., Jan 5 2015, In : PLoS One. 10, 1, e116389.

Research output: Contribution to journalArticle

cisplatin
Saponins
saponins
Cisplatin
adjuvants
2014

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors

Wu, C. Y., Yang, L. H., Yang, H. Y., Knoff, J., Peng, S., Lin, Y. H., Wang, C., Alvarez, R. D., Pai, S. I., Roden, R. S., Hung, C-F. & Wu, T. C., 2014, In : Clinical Cancer Research. 20, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Stromal Cells
Radiotherapy
Myeloid Cells
Neoplasms

Fully Bayesian inference under ignorable missingness in the presence of auxiliary covariates

Daniels, M. J., Wang, C. & Marcus, B. H., 2014, In : Biometrics. 70, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

Bayes Theorem
Bayesian inference
Covariates
Clinical Trials
Imputation

Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV pseudovirions

Wang, J. W., Jagu, S., Wang, C., Kitchener, H. C., Daayana, S., Stern, P. L., Pang, S., Day, P. M., Huh, W. K. & Roden, R. S., Jul 7 2014, In : PLoS One. 9, 7, e101576.

Research output: Contribution to journalArticle

Furin
Papillomaviridae
Neutralizing Antibodies
neutralizing antibodies
neutralization

Novel methylated biomarkers and a robust assay to detect circulating tumor dna in metastatic breast cancer

Fackler, M. J., Bujanda, Z. L., Umbricht, C. B., Teo, W. W., Cho, S., Zhang, Z., Visvanathan, K., Jeter, S., Argani, P., Wang, C., Lyman, J. P., De Brot, M., Ingle, J. N., Boughey, J., McGuire, K., King, T. A., Carey, L. A., Cope, L., Wolff, A. C. & Sukumar, S., Apr 15 2014, In : Cancer Research. 74, 8, p. 2160-2170 11 p.

Research output: Contribution to journalArticle

Biomarkers
Breast Neoplasms
Neoplasms
DNA
Tumor Burden

Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies

Wang, J. W., Jagu, S., Kwak, K., Wang, C., Peng, S., Kirnbauer, R. & Roden, R. S., Jan 20 2014, In : Virology. 449, p. 304-316 13 p.

Research output: Contribution to journalArticle

Furin
Neutralizing Antibodies
Virion
Amyloid Precursor Protein Secretases
Antibodies
Health Literacy
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Blood Glucose
Clinical Trials

Treatment of tumors with vitamin e suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects

Kang, T. H., Knoff, J., Yeh, W. H., Yang, B., Wang, C., Kim, Y. S., Kim, T. W., Wu, T. C. & Hung, C-F., Jul 29 2014, In : PLoS One. 9, 7, e103562.

Research output: Contribution to journalArticle

suppressor cells
T-cells
Vitamin E
Vitamins
vitamin E

Vaccination: Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions

Maldonado, L., Teague, J. E., Morrow, M. P., Jotova, I., Wu, T. C., Wang, C., Desmarais, C., Boyer, J. D., Tycko, B., Robins, H. S., Clark, R. A. & Trimble, C. L., Jan 29 2014, In : Science Translational Medicine. 6, 221

Research output: Contribution to journalArticle

Human papillomavirus 16
Vaccination
T-Lymphocytes
Antigens
Tissue Expansion
2013

A causal model for joint evaluation of placebo and treatment-specific effects in clinical trials

Zhang, Z., Kotz, R. M., Wang, C., Ruan, S. & Ho, M., Jun 2013, In : Biometrics. 69, 2, p. 318-327 10 p.

Research output: Contribution to journalArticle

Causal Model
Clinical Trials
placebos
clinical trials
Placebos

Assessing the heterogeneity of treatment effects via potential outcomes of individual patients

Zhang, Z., Wang, C., Nie, L. & Soon, G., Nov 2013, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 62, 5, p. 687-704 18 p.

Research output: Contribution to journalArticle

Potential Outcomes
Treatment Effects
Identifiability
Covariates
Repeated Measurements

Histone deacetylase inhibitor AR-42 enhances E7-specific CD8+ T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination

Lee, S. Y., Huang, Z., Kang, T. H., Soong, R. S., Knoff, J., Axenfeld, E., Wang, C., Alvarez, R. D., Chen, C. S., Hung, C-F. & Wu, T. C., Oct 2013, In : Journal of Molecular Medicine. 91, 10, p. 1221-1231 11 p.

Research output: Contribution to journalArticle

DNA Vaccines
Histone Deacetylase Inhibitors
Cellular Immunity
Vaccination
T-Lymphocytes

Multivalent Human Papillomavirus L1 DNA Vaccination Utilizing Electroporation

Kwak, K., Jiang, R., Jagu, S., Wang, J. W., Wang, C., Christensen, N. D. & Roden, R. S., Mar 25 2013, In : PLoS One. 8, 3, e60507.

Research output: Contribution to journalArticle

Electroporation
electroporation
Papillomaviridae
Vaccination
vaccination

Phylogenetic considerations in designing a broadly protective multimeric L2 vaccine

Jagu, S., Kwak, K., Schiller, J. T., Lowy, D. R., Kleanthous, H., Kalnin, K., Wang, C., Wang, H. K., Chow, L. T., Huh, W. K., Jaganathan, K. S., Chivukula, S. V. & Roden, R. S., Jun 2013, In : Journal of Virology. 87, 11, p. 6127-6136 10 p.

Research output: Contribution to journalArticle

Papillomaviridae
Papillomavirus Vaccines
Condylomata Acuminata
Vaccines
vaccines

Systems mapping of metabolic genes through control theory

Liu, G., Kong, L., Wang, Z., Wang, C. & Wu, R., Jun 30 2013, In : Advanced Drug Delivery Reviews. 65, 7, p. 918-928 11 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Quantitative Trait Loci
Phenotype
Metabolic Networks and Pathways
Genotype
2012

A computational framework for the inheritance pattern of genomic imprinting for complex traits

Wang, C., Wang, Z., Prows, D. R. & Wu, R., Jan 2012, In : Briefings in Bioinformatics. 13, 1, p. 34-45 12 p., bbr023.

Research output: Contribution to journalArticle

Genomic Imprinting
Inheritance Patterns
Genes
Acute Lung Injury
Atlases

A maximum likelihood approach to functional mapping of longitudinal binary traits

Wang, C., Li, H., Wang, Z., Wang, Y., Wang, N., Wang, Z. & Wu, R., Nov 2012, In : Statistical Applications in Genetics and Molecular Biology. 11, 6, 2.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Maximum likelihood
Likelihood Functions
Maximum Likelihood
Statistical Models

Bayesian Model Selection for Incomplete Data Using the Posterior Predictive Distribution

Daniels, M. J., Chatterjee, A. S. & Wang, C., Dec 2012, In : Biometrics. 68, 4, p. 1055-1063 9 p.

Research output: Contribution to journalArticle

Bayesian Model Selection
Predictive Distribution
Incomplete Data
Posterior distribution
Patient Selection
2011
Pattern-mixture Model
Missing at Random
Model Comparison
Incomplete Data
Sensitivity analysis

Bayesian approaches in medical device clinical trials: A discussion with examples in the regulatory setting

Bonangelino, P., Irony, T., Liang, S., Li, X., Mukhi, V., Ruan, S., Xu, Y., Yang, X. & Wang, C., Sep 2011, In : Journal of Biopharmaceutical Statistics. 21, 5, p. 938-953 16 p.

Research output: Contribution to journalArticle

Bayes Theorem
Bayesian Approach
Clinical Trials
Bayesian Methods
Equipment and Supplies

Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: A randomized study by the Children's Oncology Group (POG 9404)

Asselin, B. L., Devidas, M., Wang, C., Pullen, J., Borowitz, M. J., Hutchison, R., Lipshultz, S. E. & Camitta, B. M., Jul 28 2011, In : Blood. 118, 4, p. 874-883 10 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Pediatrics
Oncology
T-cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Causal Effect
Ventilation
Lung
Acute
Survival Distribution
2010
Binary Data
Longitudinal Data
Shrinkage
Breast Cancer
Ignorability

A model for transgenerational imprinting variation in complex traits

Wang, C., Wang, Z., Luo, J., Li, Q., Li, Y., Ahn, K., Prows, D. R. & Wu, R., 2010, In : PLoS One. 5, 7, e11396.

Research output: Contribution to journalArticle

Genomic Imprinting
genomic imprinting
Alleles
Quantitative Trait Loci
Genes

Functional mapping of genotype-environment interactions for soybean growth by a semiparametric approach

Li, Q., Huang, Z., Xu, M., Wang, C., Gai, J., Huang, Y., Pang, X. & Wu, R., Jun 2 2010, In : Plant Methods. 6, 1, 13.

Research output: Contribution to journalArticle

genotype-environment interaction
Quantitative Trait Loci
Soybeans
quantitative trait loci
Genotype

Imaging spontaneous MMTVneu transgenic murine mammary tumors: Targeting metabolic activity versus genetic products

Thakur, M. L., Devadhas, D., Zhang, K., Pestell, R. G., Wang, C., McCue, P. & Wickstrom, E., Jan 1 2010, In : Journal of Nuclear Medicine. 51, 1, p. 106-111 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Fluorodeoxyglucose F18
Oncogene Proteins
Neoplasms
Receptors, Vasoactive Intestinal Polypeptide, Type I
2009

Comments on: Missing data methods in longitudinal studies: A review

Daniels, M. J. & Wang, C., May 2009, In : Test. 18, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

Longitudinal Study
Missing Data
Review
Missing data
Longitudinal study

Dose-intensified compared with standard chemotherapy for nonmetastatic ewing sarcoma family of tumors: A children's oncology group study

Granowetter, L., Womer, R., Devidas, M., Krailo, M., Wang, C., Bernstein, M., Marina, N., Leavey, P., Gebhardt, M., Healey, J., Shamberger, R. C., Goorin, A., Miser, J., Meyer, J., Arndt, C. A. S., Sailer, S., Marcus, K., Perlman, E., Dickman, P. & Grier, H. E., May 20 2009, In : Journal of Clinical Oncology. 27, 15, p. 2536-2541 6 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Drug Therapy
Vincristine
Ifosfamide
Doxorubicin

Improved early event-free survival with imatinib in Philadelphia chromosome - Positive acute lymphoblastic leukemia: A Children's Oncology Group Study

Schultz, K. R., Bowman, W. P., Aledo, A., Slayton, W. B., Sather, H., Devidas, M., Wang, C., Davies, S. M., Gaynon, P. S., Trigg, M., Rutledge, R., Burden, L., Jorstad, D., Carroll, A., Heerema, N. A., Winick, N., Borowitz, M. J., Hunger, S. P., Carroll, W. L. & Camitta, B., Nov 1 2009, In : Journal of Clinical Oncology. 27, 31, p. 5175-5181 7 p.

Research output: Contribution to journalArticle

Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disease-Free Survival
Transplantation
Bone Marrow

Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data

Wen, S., Wang, C., Berg, A., Li, Y., Chang, M. M., Fillingim, R. B., Wallace, M. R., Staud, R., Kaplan, L. & Wu, R., Aug 11 2009, In : Algorithms for Molecular Biology. 4, 1, p. 11 1 p., 1748.

Research output: Contribution to journalArticle

Genomic Imprinting
DNA sequences
Nucleotides
Polymorphism
DNA Sequence

Risk haplotype analysis for bovine paratuberculosis

Pinedo, P. J., Wang, C., Li, Y., Rae, D. O. & Wu, R., Feb 2009, In : Mammalian Genome. 20, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

Paratuberculosis
Haplotypes
Single Nucleotide Polymorphism
Alleles
Cattle Diseases
2008

A computational model for sex-specific genetic architecture of complex traits in humans: Implications for mapping pain sensitivity

Wang, C., Cheng, Y., Liu, T., Li, Q., Fillingim, R. B., Wallace, M. R., Staud, R., Kaplan, L. & Wu, R., Apr 16 2008, In : Molecular Pain. 4, 13.

Research output: Contribution to journalArticle

Pain
Haplotypes
Sex Characteristics
Linkage Disequilibrium
Statistical Models
2007

A computational approach for functional mapping of quantitative trait loci that regulate thermal performance curves

Yap, J. S., Wang, C. & Wu, R., Jun 20 2007, In : PLoS One. 2, 6, e554.

Research output: Contribution to journalArticle

Quantitative Trait Loci
quantitative trait loci
Hot Temperature
heat
chromosome mapping

A general quantitative genetic model for haplotyping a complex trait in humans

Wu, S., Yang, J., Wang, C. & Wu, R., Aug 2007, In : Current Genomics. 8, 5, p. 343-350 8 p.

Research output: Contribution to journalArticle

Genetic Models
Haplotypes
Single Nucleotide Polymorphism
Diploidy
Uncertainty

Intensified PEG-L-asparaginase and antimetabolite-based therapy for treatment of higher risk precursor-B acute lymphoblastic leukemia: A report from the children's oncology group

Salzer, W. L., Devidas, M., Shuster, J. J., Wang, C., Chauvenet, A., Asselin, B. L., Camitta, B. M. & Kurtzberg, J., Jun 2007, In : Journal of Pediatric Hematology/Oncology. 29, 6, p. 369-375 7 p.

Research output: Contribution to journalArticle

Asparaginase
Antimetabolites
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytarabine
Disease-Free Survival
2006

DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth

Wu, K., Li, A., Rao, M., Liu, M., Dailey, V., Yang, Y., Di Vizio, D., Wang, C., Lisanti, M. P., Sauter, G., Russell, R. G., Cvekl, A. & Pestell, R. G., Oct 2006, In : Molecular and Cellular Biology. 26, 19, p. 7116-7129 14 p.

Research output: Contribution to journalArticle

Cyclin D1
Breast Neoplasms
DNA
Growth
Carcinogenesis