Charles Jr Steenbergen

Professor

1976 …2019

Research output per year

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Research Output

2019

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness

Tuday, E., Nomura, Y., Ruhela, D., Nakano, M., Fu, X., Shah, A., Roman, B., Yamaguchi, A., An, S. S., Steenbergen, C., Baraban, J. M., Berkowitz, D. E. & Das, S., Jan 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 5, p. H1116-H1124

Research output: Contribution to journalArticle

miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Banavath, H. N., Roman, B., Mackowski, N., Biswas, D., Afzal, J., Nomura, Y., Solhjoo, S., O'Rourke, B., Kohr, M., Murphy, E., Steenbergen, C. & Das, S., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e012919

Research output: Contribution to journalArticle

Open Access

The secret messages between mitochondria and nucleus in muscle cell biology

Soledad, R. B., Charles, S. & Samarjit, D., May 15 2019, In : Archives of Biochemistry and Biophysics. 666, p. 52-62 11 p.

Research output: Contribution to journalReview article

2018

Does p53 Inhibition Suppress Myocardial Ischemia–Reperfusion Injury?

Yano, T., Abe, K., Tanno, M., Miki, T., Kuno, A., Miura, T. & Steenbergen, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

In vivo nanovector delivery of a heart-specific microrna-sponge

Kent, O. A., Steenbergen, C. J. & Das, S., Jun 15 2018, In : Journal of Visualized Experiments. 2018, 136, e57845.

Research output: Contribution to journalArticle

What You Eat Affects Your Shape

Murphy, E., Glancy, B. & Steenbergen, C., Jan 5 2018, In : Circulation research. 122, 1, p. 8-10 3 p.

Research output: Contribution to journalEditorial

2017

Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts

Shao, Q., Casin, K. M., Mackowski, N., Murphy, E., Steenbergen, C. J. & Kohr, M., May 1 2017, In : PLoS One. 12, 5, e0177315.

Research output: Contribution to journalArticle

Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets

Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C., Jan 1 2017, In : Journal of the American Heart Association. 6, 3, e004694.

Research output: Contribution to journalArticle

Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress

Kamalden, T. A., Macgregor-Das, A. M., Kannan, S. M., Dunkerly-Eyring, B., Khaliddin, N., Xu, Z., Fusco, A. P., Yazib, S. A., Chow, R. C., Duh, E. J., Halushka, M. K., Steenbergen, C. J. & Das, S., Nov 1 2017, In : Antioxidants and Redox Signaling. 27, 13, p. 913-930 18 p.

Research output: Contribution to journalArticle

Genetic testing improves identification of transthyretin amyloid (ATTR) subtype in cardiac amyloidosis

Brown, E. E., Lee, Y. Z. J., Halushka, M. K., Steenbergen, C. J., Johnson, N. M., Almansa, J., Tedford, R. J., Cingolani, O., Russell, S. D., Sharma, K. & Judge, D. P., May 11 2017, (Accepted/In press) In : Amyloid. p. 1-4 4 p.

Research output: Contribution to journalArticle

MiR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling

Hori, D., Dunkerly-Eyring, B., Nomura, Y., Biswas, D., Steppan, J., Henao-Mejia, J., Adachi, H., Santhanam, L., Berkowitz, D. E., Steenbergen, C., Flavell, R. A. & Das, S., Mar 2017, In : PloS one. 12, 3, e0174108.

Research output: Contribution to journalArticle

2016

Additive cardioprotection by pharmacological postconditioning with Hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation

Sun, J., Aponte, A. M., Menazza, S., Gucek, M., Steenbergen, C. J. & Murphy, E., May 1 2016, In : Cardiovascular Research. 110, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

A non-invasive method to produce pressure ulcers of varying severity in a spinal cord-injured rat model

Ahmed, A. K., Goodwin, C. R., Sarabia-Estrada, R., Lay, F., Ansari, A. M., Steenbergen, C. J., Pang, C., Cohen, R., Born, L. J., Matsangos, A. E., Ng, C., Marti, G. P., Abu-Bonsrah, N., Phillips, N. A., Suk, I., Sciubba, D. & Harmon, J., Jun 21 2016, (Accepted/In press) In : Spinal Cord.

Research output: Contribution to journalArticle

Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy

Ton, V. K., Bhonsale, A., Gilotra, N., Halushka, M. K., Steenbergen, C. J., Almansa, J., Brown, E., Tedford, R. J., Wittstein, I. S., Sharma, K., Russell, S. D. & Judge, D. P., Mar 7 2016, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Characterization of the sex-dependent myocardial S-nitrosothiol proteome

Shao, Q., Fallica, J., Casin, K. M., Murphy, E., Steenbergen, C. & Kohr, M. J., Feb 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 4, p. H505-H515

Research output: Contribution to journalArticle

Hibernating squirrels: SIRTin clues for organ protection after ischemia-reperfusion

Berkowitz, D. E., Steenbergen, C. J. & O'Rourke, B., Jun 1 2016, In : Anesthesiology. 124, 6, p. 1215-1217 3 p.

Research output: Contribution to journalArticle

Lack of Relationship Between Serum Cardiac Troponin I Level and Giant Cell Myocarditis Diagnosis and Outcomes

Gilotra, N. A., Minkove, N., Bennett, M. K., Tedford, R. J., Steenbergen, C., Judge, D. P., Halushka, M. K. & Russell, S. D., Jul 1 2016, In : Journal of cardiac failure. 22, 7, p. 583-585 3 p.

Research output: Contribution to journalLetter

2015

ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity

Belmonte, F., Das, S., Sysa-Shah, P., Sivakumaran, V., Stanley, B., Guo, X., Paolocci, N., Aon, M. A., Nagane, M., Kuppusamy, P., Steenbergen, C. & Gabrielson, K., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 8, p. H1271-H1280

Research output: Contribution to journalArticle

Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

Chan, A. T., Karakas, M. F., Vakrou, S., Afzal, J., Rittenbach, A., Lin, X., Wahl, R. L., Pomper, M. G., Steenbergen, C. J., Tsui, B. M. W., Elisseeff, J. H. & Abraham, M. R., Dec 2015, In : Biomaterials. 73, p. 1-11 11 p.

Research output: Contribution to journalArticle

Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria

Sun, J., Nguyen, T., Aponte, A. M., Menazza, S., Kohr, M. J., Roth, D. M., Patel, H. H., Murphy, E. & Steenbergen, C., May 1 2015, In : Cardiovascular research. 106, 2, p. 227-236 10 p.

Research output: Contribution to journalArticle

Molecular signature of nitroso-redox balance in idiopathic dilated cardiomyopathies

Menazza, S., Aponte, A., Sun, J., Gucek, M., Steenbergen, C. J. & Murphy, E., Sep 1 2015, In : Journal of the American Heart Association. 4, 9, e002251.

Research output: Contribution to journalArticle

Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation

Eskesen, K., Olsen, N. T., Dimaano, V. L., Fritz-Hansen, T., Sogaard, P., Chakir, K., Steenbergen, C., Kass, D. & Abraham, T. P., Dec 1 2015, In : SpringerPlus. 4, 1, 592.

Research output: Contribution to journalArticle

The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): A new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs

Jones, S. P., Tang, X. L., Guo, Y., Steenbergen, C., Lefer, D. J., Kukreja, R. C., Kong, M., Li, Q., Bhushan, S., Zhu, X., Du, J., Nong, Y., Stowers, H. L., Kondo, K., Hunt, G. N., Goodchild, T. T., Orr, A., Chang, C. C., Ockaili, R., Salloum, F. N. & 1 others, Bolli, R., Feb 13 2015, In : Circulation research. 116, 4, p. 572-586 15 p.

Research output: Contribution to journalArticle

2014

Erratum: H2S increases survival during sepsis: Protective effect of CHOP inhibition (Journal of Immunology (2014) 192 (1806-1814))

Ferlito, M., Wang, Q., Fulton, W. B., Colombani, P. M., Marchionni, L., Fox-Talbot, K., Paolocci, N. & Steenbergen, C., Apr 15 2014, In : Journal of Immunology. 192, 8, 1 p.

Research output: Contribution to journalComment/debate

Estrogen regulation of protein expression and signaling pathways in the heart

Murphy, E. & Steenbergen, C., Mar 1 2014, In : Biology of Sex Differences. 5, 1, 6.

Research output: Contribution to journalReview article

Glyceraldehyde-3-phosphate dehydrogenase acts as a mitochondrial trans-S-nitrosylase in the heart

Kohr, M. J., Murphy, E. & Steenbergen, C., Oct 27 2014, In : PloS one. 9, 10, e111448.

Research output: Contribution to journalArticle

H2S increases survival during sepsis: Protective effect of CHOP inhibition

Ferlito, M., Wang, Q., Fulton, W. B., Colombani, P. M., Marchionni, L., Fox-Talbot, K., Paolocci, N. & Steenbergen, C., Feb 15 2014, In : Journal of Immunology. 192, 4, p. 1806-1814 9 p.

Research output: Contribution to journalArticle

miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo

Das, S., Bedja, D., Campbell, N., Dunkerly, B., Chenna, V., Maitra, A. & Steenbergen, C., May 8 2014, In : PloS one. 9, 5, e96820.

Research output: Contribution to journalArticle

Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling

Yano, T., Ferlito, M., Aponte, A., Kuno, A., Miura, T., Murphy, E. & Steenbergen, C., Jan 1 2014, In : Circulation research. 114, 8, p. 1268-1280 13 p.

Research output: Contribution to journalArticle

Postconditioning leads to an increase in protein S-nitrosylation

Tong, G., Aponte, A. M., Kohr, M., Steenbergen, C. J., Murphy, E. & Sun, J., Mar 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 6

Research output: Contribution to journalArticle

Sex, drugs, and trial design: Sex influences the heart and drug responses

Murphy, E. & Steenbergen, C., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2375-2377 3 p.

Research output: Contribution to journalReview article

Signaling by S-nitrosylation in the heart

Murphy, E., Kohr, M., Menazza, S., Nguyen, T., Evangelista, A., Sun, J. & Steenbergen, C., Aug 2014, In : Journal of Molecular and Cellular Cardiology. 73, p. 18-25 8 p.

Research output: Contribution to journalReview article

Skeletal muscle ATP kinetics are impaired in frail mice

Akki, A., Yang, H., Gupta, A., Chacko, V. P., Yano, T., Leppo, M. K., Steenbergen, C., Walston, J. & Weiss, R. G., Feb 2014, In : AGE. 36, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death

Kohr, M. J., Evangelista, A. M., Ferlito, M., Steenbergen, C. & Murphy, E., Apr 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 67-74 8 p.

Research output: Contribution to journalArticle

Strengthening the skin with topical delivery of keratinocyte growth factor-1 using a novel DNA plasmid

Dou, C., Lay, F., Ansari, A. M., Rees, D. J., Ahmed, A. K., Kovbasnjuk, O., Matsangos, A. E., Du, J., Hosseini, S. M., Steenbergen, C., Fox-Talbot, K., Tabor, A. T., Williams, J. A., Liu, L., Marti, G. P. & Harmon, J. W., Apr 2014, In : Molecular Therapy. 22, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

2013

Cardioprotection and myocardial reperfusion: Pitfalls to clinical application

Heide, R. S. V. & Steenbergen, C., Aug 2 2013, In : Circulation research. 113, 4, p. 464-477 14 p.

Research output: Contribution to journalReview article

Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Gupta, A., Rohlfsen, C., Leppo, M. K., Chacko, V. P., Wang, Y., Steenbergen, C. & Weiss, R. G., Oct 1 2013, In : PloS one. 8, 10, e74675.

Research output: Contribution to journalArticle

Cyclophilin D modulates mitochondrial acetylome

Nguyen, T. T. M., Wong, R., Menazza, S., Sun, J., Chen, Y., Wang, G., Gucek, M., Steenbergen, C., Sack, M. N. & Murphy, E., Dec 6 2013, In : Circulation research. 113, 12, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

Did a classic preconditioning study provide a clue to the identity of the mitochondrial permeability transition pore?

Murphy, E. & Steenbergen, C., Sep 13 2013, In : Circulation research. 113, 7, p. 852-855 4 p.

Research output: Contribution to journalComment/debate

Essential role of nitric oxide in acute ischemic preconditioning: S-Nitros(yl)ation versus sGC/cGMP/PKG signaling?

Sun, J., Aponte, A. M., Kohr, M. J., Tong, G., Steenbergen, C. & Murphy, E., Jan 1 2013, In : Free Radical Biology and Medicine. 54, p. 105-112 8 p.

Research output: Contribution to journalArticle

Hypertrophy signaling pathways in experimental chronic aortic regurgitation

Olsen, N. T., Dimaano, V. L., Fritz-Hansen, T., Sogaard, P., Chakir, K., Eskesen, K., Steenbergen, C., Kass, D. A. & Abraham, T. P., Oct 1 2013, In : Journal of Cardiovascular Translational Research. 6, 5, p. 852-860 9 p.

Research output: Contribution to journalArticle

Integration and regression of implanted engineered human vascular networks during deep wound healing

Hanjaya-Putra, D., Shen, YU. I., Wilson, A., Fox-Talbot, K., Khetan, S., Burdick, J. A., Steenbergen, C. & Gerecht, S., 2013, In : Stem Cells Translational Medicine. 2, 4, p. 297-306 10 p.

Research output: Contribution to journalArticle

Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy

Bravo, P. E., Zimmerman, S. L., Luo, H. C., Pozios, I., Rajaram, M., Pinheiro, A., Steenbergen, C., Kamel, I. R., Wahl, R. L., Bluemke, D. A., Bengel, F. M., Abraham, M. R. & Abraham, T. P., Mar 1 2013, In : Circulation: Cardiovascular Imaging. 6, 2, p. 210-217 8 p.

Research output: Contribution to journalArticle

2012

2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology

Leone, O., Veinot, J. P., Angelini, A., Baandrup, U. T., Basso, C., Berry, G., Bruneval, P., Burke, M., Butany, J., Calabrese, F., D'Amati, G., Edwards, W. D., Fallon, J. T., Fishbein, M. C., Gallagher, P. J., Halushka, M. K., McManus, B., Pucci, A., Rodriguez, E. R., Saffitz, J. E. & 7 others, Sheppard, M. N., Steenbergen, C., Stone, J. R., Tan, C., Thiene, G., Van Der Wal, A. C. & Winters, G. L., Jul 1 2012, In : Cardiovascular Pathology. 21, 4, p. 245-274 30 p.

Research output: Contribution to journalArticle

A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy

Pramanik, D., Campbell, N. R., Das, S., Gupta, S., Chenna, V., Bisht, S., Sysa-Shah, P., Bedja, D., Karikari, C., Steenbergen, C., Gabrielson, K. L., Maitra, A. & Maitra, A., Jun 2012, In : Oncotarget. 3, 6, p. 640-650 11 p.

Research output: Contribution to journalArticle

Acute inhibition of GSK causes mitochondrial remodeling

Nguyen, T., Wong, R., Wang, G., Gucek, M., Steenbergen, C. & Murphy, E., Jun 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 11, p. H2439-H2445

Research output: Contribution to journalArticle

Creatine kinase - Mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved

Gupta, A., Akki, A., Wang, Y., Leppo, M. K., Chacko, V. P., Foster, D. B., Caceres, V., Shi, S., Kirk, J. A., Su, J., Lai, S., Paolocci, N., Steenbergen, C., Gerstenblith, G. & Weiss, R. G., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 291-302 12 p.

Research output: Contribution to journalArticle

Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium

Akki, A., Su, J., Yano, T., Gupta, A., Wang, Y., Leppo, M. K., Chacko, V. P., Steenbergen, C. & Weiss, R. G., Oct 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 7, p. H844-H852

Research output: Contribution to journalArticle

Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore (Journal of Biological Chemistry (2011) 286 (40184-40192))

Nguyen, T. T., Stevens, M. V., Kohr, M., Steenbergen, C., Sack, M. N. & Murphy, E., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34496-34498 3 p.

Research output: Contribution to journalComment/debate

Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteins

Sun, J., Kohr, M. J., Nguyen, T., Aponte, A. M., Connelly, P. S., Esfahani, S. G., Gucek, M., Daniels, M. P., Steenbergen, C. & Murphy, E., Jan 1 2012, In : Antioxidants and Redox Signaling. 16, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle