Charles Holmes

Associate Professor

19982020

Research output per year

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Research Output

2020

Access to lifesaving medical resources for African countries: COVID-19 testing and response, ethics, and politics

Kavanagh, M. M., Erondu, N. A., Tomori, O., Dzau, V. J., Okiro, E. A., Maleche, A., Aniebo, I. C., Rugege, U., Holmes, C. B. & Gostin, L. O., May 30 2020, In : The Lancet. 395, 10238, p. 1735-1738 4 p.

Research output: Contribution to journalReview article

Open Access

Emerging priorities for HIV service delivery

Ford, N., Geng, E., Ellman, T., Orrell, C., Ehrenkranz, P., Sikazwe, I., Jahn, A., Rabkin, M., Ayisi Addo, S., Grimsrud, A., Rosen, S., Zulu, I., Reidy, W., Lejone, T., Apollo, T., Holmes, C., Kolling, A. F., Phate Lesihla, R., Nguyen, H. H., Bakashaba, B. & 4 others, Chitembo, L., Tiriste, G., Doherty, M. & Bygrave, H., Feb 1 2020, In : PLoS medicine. 17, 2, p. e1003028

Research output: Contribution to journalArticle

Open Access

Mortality estimates by age and sex among persons living with HIV after ART initiation in Zambia using electronic medical records supplemented with tracing a sample of lost patients: A cohort study

Kerkhoff, A. D., Sikombe, K., Eshun-Wilson, I., Sikazwe, I., Glidden, D. V., Pry, J. M., Somwe, P., Beres, L. K., Simbeza, S., Mwamba, C., Bukankala, C., Hantuba, C., Moore, C. B., Holmes, C. B., Padian, N. & Geng, E. H., May 1 2020, In : PLoS medicine. 17, 5, p. e1003107

Research output: Contribution to journalArticle

Open Access

Participation in adherence clubs and on-time drug pickup among HIV-infected adults in Zambia: A matched-pair cluster randomized trial

Roy, M., Bolton-Moore, C., Sikazwe, I., Mukumbwa-Mwenechanya, M., Efronson, E., Mwamba, C., Somwe, P., Kalunkumya, E., Lumpa, M., Sharma, A., Pry, J., Mutale, W., Ehrenkranz, P., Glidden, D. V., Padian, N., Topp, S., Geng, E. & Holmes, C. B., Jul 1 2020, In : PLoS medicine. 17, 7, p. e1003116

Research output: Contribution to journalArticle

Open Access

Patients’ Satisfaction with HIV Care Providers in Public Health Facilities in Lusaka: A Study of Patients who were Lost-to-Follow-Up from HIV Care and Treatment

Mukamba, N., Chilyabanyama, O. N., Beres, L. K., Simbeza, S., Sikombe, K., Padian, N., Holmes, C., Sikazwe, I., Geng, E. & Schwartz, S. R., Apr 1 2020, In : AIDS and behavior. 24, 4, p. 1151-1160 10 p.

Research output: Contribution to journalArticle

Open Access

Programas adaptados sobre el vih y cobertura universal de salud

Translated title of the contribution: Tailored hiv programmes and universal health coverageHolmes, C. B., Rabkin, M., Ford, N., Preko, P., Rosen, S., Ellman, T. & Ehrenkranz, P., Jan 1 2020, In : Bulletin of the World Health Organization. 98, 2, p. 87-94 8 p.

Research output: Contribution to journalArticle

Open Access

Redefining and revisiting cost estimates of routine ART care in Zambia: an analysis of ten clinics

Tucker, A., Tembo, T., Tampi, R. P., Mutale, J., Mukumba-Mwenechanya, M., Sharma, A., Dowdy, D. W., Moore, C. B., Geng, E., Holmes, C. B., Sikazwe, I. & Sohn, H., Feb 1 2020, In : Journal of the International AIDS Society. 23, 2, e25431.

Research output: Contribution to journalArticle

Open Access
2019

Accurate dried blood spots collection in the community using non-medically trained personnel could support scaling up routine viral load testing in resource limited settings

Sikombe, K., Hantuba, C., Musukuma, K., Sharma, A., Padian, N., Holmes, C., Czaicki, N., Simbeza, S., Somwe, P., Bolton-Moore, C., Sikazwe, I. & Geng, E., 2019, In : PloS one. 14, 10, e0223573.

Research output: Contribution to journalArticle

Open Access

A Review of Differentiated Service Delivery for HIV Treatment: Effectiveness, Mechanisms, Targeting, and Scale

Roy, M., Bolton Moore, C., Sikazwe, I. & Holmes, C. B., Aug 15 2019, In : Current HIV/AIDS reports. 16, 4, p. 324-334 11 p.

Research output: Contribution to journalReview article

Care Continuum and Postdischarge Outcomes among HIV-Infected Adults Admitted to the Hospital in Zambia

Haachambwa, L., Kandiwo, N., Zulu, P. M., Rutagwera, D., Geng, E., Holmes, C. B., Sinkala, E., Claassen, C. W., Mugavero, M. J., Wa Mwanza, M., Turan, J. M. & Vinikoor, M. J., Sep 30 2019, In : Open Forum Infectious Diseases. 6, 10, ofz336.

Research output: Contribution to journalArticle

Open Access

Correction: Retention and viral suppression in a cohort of HIV patients on antiretroviral therapy in Zambia: Regionally representative estimates using a multistage-sampling-based approach (PLoS Medicine (2019) 16:5 (e1002811) DOI: 10.1371/journal.pmed.1002811)

Sikazwe, I., Eshun-Wilson, I., Sikombe, K., Czaicki, N., Somwe, P., Mody, A., Simbeza, S., Glidden, D. V., Chizema, E., Mulenga, L. B., Padian, N., Duncombe, C. J., Bolton-Moore, C., Beres, L. K., Holmes, C. B. & Geng, E., 2019, In : PLoS medicine. 16, 8, e1002918.

Research output: Contribution to journalComment/debate

Open Access

Differentiated Care Preferences of Stable Patients on Antiretroviral Therapy in Zambia: A Discrete Choice Experiment

Eshun-Wilson, I., Mukumbwa-Mwenechanya, M., Kim, H. Y., Zannolini, A., Mwamba, C. P., Dowdy, D., Kalunkumya, E., Lumpa, M., Beres, L. K., Roy, M., Sharma, A., Topp, S. M., Glidden, D. V., Padian, N., Ehrenkranz, P., Sikazwe, I., Holmes, C. B., Bolton-Moore, C. & Geng, E. H., Aug 15 2019, In : Journal of acquired immune deficiency syndromes. 81, 5, p. 540-546 7 p.

Research output: Contribution to journalArticle

Employing the Payback Framework to Assess Implementation Science Research Utilization: Lessons From the USAID's PEPFAR HIV/AIDS Implementation Science Awards

Castor, D., Kimmel, A. L., McFall, A., Padian, N., Yansaneh, A., Wiant, S., Sandison, S., Holmes, C., Lucas, R., Stanton, D., Goosby, E. & Kottiri, B., Dec 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 82, p. S348-S356

Research output: Contribution to journalArticle

Global variations in mortality in adults after initiating antiretroviral treatment: An updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration

Johnson, L. F., Anderegg, N., Zaniewski, E., Eaton, J. W., Rebeiro, P. F., Carriquiry, G., Nash, D., Yotebieng, M., Ekouevi, D. K., Holmes, C. B., Choi, J. Y., Jiamsakul, A., Bakoyannis, G., Althoff, K. N., Sohn, A. H., Yiannoutsos, C. & Egger, M., Dec 15 2019, In : AIDS. 33, p. S283-S294

Research output: Contribution to journalArticle

Human-Centered Design Lessons for Implementation Science: Improving the Implementation of a Patient-Centered Care Intervention

Beres, L. K., Simbeza, S., Holmes, C. B., Mwamba, C., Mukamba, N., Sharma, A., Munamunungu, V., Mwachande, M., Sikombe, K., Bolton Moore, C., Mody, A., Koyuncu, A., Christopoulous, K., Jere, L., Pry, J., Ehrenkranz, P. D., Budden, A., Geng, E. & Sikazwe, I., Dec 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 82, p. S230-S243

Research output: Contribution to journalReview article

Longitudinal engagement trajectories and risk of death among new ART starters in Zambia: A group-based multi-trajectory analysis

Mody, A., Eshun-Wilson, I., Sikombe, K., Schwartz, S. R., Beres, L. K., Simbeza, S., Mukamba, N., Somwe, P., Bolton-Moore, C., Padian, N., Holmes, C. B., Sikazwe, I. & Geng, E. H., 2019, In : PLoS medicine. 16, 10, e1002959.

Research output: Contribution to journalArticle

Open Access

Operational characteristics of antiretroviral therapy clinics in Zambia: a time and motion analysis

Tampi, R. P., Tembo, T., Mukumba-Mwenechanya, M., Sharma, A., Dowdy, D. W., Holmes, C. B., Bolton-Moore, C., Sikazwe, I., Tucker, A. & Sohn, H., Apr 24 2019, In : BMC health services research. 19, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Personalized public health: An implementation research agenda for the HIV response and beyond

Geng, E. H., Holmes, C. B., Moshabela, M., Sikazwe, I. & Petersen, M. L., 2019, In : PLoS medicine. 16, 12, e1003020.

Research output: Contribution to journalEditorial

Open Access

Research to improve differentiated HIV service delivery interventions: Learning to learn as we do

Geng, E. H. & Holmes, C., May 1 2019, In : PLoS medicine. 16, 5, p. e1002809

Research output: Contribution to journalArticle

Open Access

Retention and viral suppression in a cohort of HIV patients on antiretroviral therapy in Zambia: Regionally representative estimates using a multistage-sampling-based approach

Sikazwe, I., Eshun-Wilsonid, I., Sikombe, K., Czaicki, N., Somwe, P., Mody, A., Simbeza, S., Glidden, D. V., Chizema, E., Mulenga, L. B., Padian, N., Duncombe, C. J., Bolton-Moore, C., Beres, L. K., Holmes, C. B. & Geng, E., May 2019, In : PLoS medicine. 16, 5, e1002811.

Research output: Contribution to journalArticle

Open Access

The missed potential of CD4 and viral load testing to improve clinical outcomes for people living with HIV in lower-resource settings

Ehrenkranz, P. D., Baptiste, S. L., Bygrave, H., Ellman, T., Doi, N., Grimsrud, A., Jahn, A., Kalua, T., Nyirenda, R. K., Odo, M. O., Ondoa, P., Vojnov, L. & Holmes, C. B., May 2019, In : PLoS medicine. 16, 5, e1002820.

Research output: Contribution to journalArticle

Open Access

We need to monitor mortality to improve public health programs: here's why and how to do it

Holmes, C., Sikazwe, I. & Geng, E., May 1 2019, In : International health. 11, 3, p. 159-162 4 p.

Research output: Contribution to journalArticle

Open Access
2018

Application of a Multistate Model to Evaluate Visit Burden and Patient Stability to Improve Sustainability of Human Immunodeficiency Virus Treatment in Zambia

Roy, M., Holmes, C., Sikazwe, I., Savory, T., Mwanza, M. W., Bolton Moore, C., Mulenga, K., Czaicki, N., Glidden, D. V., Padian, N. & Geng, E., Sep 28 2018, In : Clinical Infectious Diseases. 67, 8, p. 1269-1277 9 p.

Research output: Contribution to journalArticle

Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: Findings from a multistage sampling-based survey

Holmes, C. B., Sikazwe, I., Sikombe, K., Eshun-Wilson, I., Czaicki, N., Beres, L. K., Mukamba, N., Simbeza, S., Bolton Moore, C., Hantuba, C., Mwaba, P., Phiri, C., Padian, N., Glidden, D. V. & Geng, E., Jan 2018, In : PLoS medicine. 15, 1, e1002489.

Research output: Contribution to journalArticle

Estimating the real-world effects of expanding antiretroviral treatment eligibility: Evidence from a regression discontinuity analysis in Zambia

Mody, A., Sikazwe, I., Czaicki, N. L., Wa Mwanza, M., Savory, T., Sikombe, K., Beres, L. K., Somwe, P., Roy, M., Pry, J. M., Padian, N., Bolton-Moore, C., Holmes, C. B. & Geng, E. H., Jun 2018, In : PLoS medicine. 15, 6, e1002574.

Research output: Contribution to journalArticle

HIV drug resistance in low-income and middle-income countries

Hamers, R. L., Rinke de Wit, T. F. & Holmes, C. B., Oct 2018, In : The Lancet HIV. 5, 10, p. e588-e596

Research output: Contribution to journalReview article

HIV Self-Testing in Lusaka Province, Zambia: Acceptability, Comprehension of Testing Instructions, and Individual Preferences for Self-Test Kit Distribution in a Population-Based Sample of Adolescents and Adults

Zanolini, A., Chipungu, J., Vinikoor, M. J., Bosomprah, S., Mafwenko, M., Holmes, C. & Thirumurthy, H., Mar 1 2018, In : AIDS Research and Human Retroviruses. 34, 3, p. 254-260 7 p.

Research output: Contribution to journalArticle

Improved Retention with 6-Month Clinic Return Intervals for Stable Human Immunodeficiency Virus-Infected Patients in Zambia

Mody, A., Roy, M., Sikombe, K., Savory, T., Holmes, C., Bolton-Moore, C., Padian, N., Sikazwe, I. & Geng, E., Jan 15 2018, In : Clinical Infectious Diseases. 66, 2, p. 237-243 7 p.

Research output: Contribution to journalArticle

Increased prevalence of pregnancy and comparative risk of program attrition among individuals starting HIV treatment in East Africa

Holmes, C. B., Yiannoutsos, C. T., Elul, B., Bukusi, E., Ssali, J., Kambugu, A., Musick, B. S., Cohen, C., Williams, C., Diero, L., Padian, N. & Wools-Kaloustian, K. K., Jan 2018, In : PloS one. 13, 1, e0190828.

Research output: Contribution to journalArticle

Rethinking retention: Mapping interactions between multiple factors that influence long-term engagement in HIV care

Topp, S. M., Mwamba, C., Sharma, A., Mukamba, N., Beres, L. K., Geng, E., Holmes, C. B. & Sikazwe, I., Mar 2018, In : PloS one. 13, 3, e0193641.

Research output: Contribution to journalArticle

Understanding preferences for HIV care and treatment in Zambia: Evidence from a discrete choice experiment among patients who have been lost to follow-up

Zanolini, A., Sikombe, K., Sikazwe, I., Eshun-Wilson, I., Somwe, P., Bolton Moore, C., Topp, S. M., Czaicki, N., Beres, L. K., Mwamba, C. P., Padian, N., Holmes, C. B. & Geng, E. H., Aug 2018, In : PLoS medicine. 15, 8, e1002636.

Research output: Contribution to journalArticle

‘They care rudely!’: Resourcing and relational health system factors that influence retention in care for people living with HIV in Zambia

Mwamba, C., Sharma, A., Mukamba, N., Beres, L., Geng, E., Holmes, C. B., Sikazwe, I. & Topp, S. M., Nov 2018, In : BMJ Global Health. 3, 5, e001007.

Research output: Contribution to journalArticle

2017

Awareness and management of elevated blood pressure among human immunodeficiency virus–infected adults receiving antiretroviral therapy in urban Zambia: A call to action

Bauer, S., Mwanza, M. W., Chilengi, R., Holmes, C., Zyambo, Z., Furrer, H., Egger, M., Wandeler, G. & Vinikoor, M. J., 2017, In : Global Health Action. 10, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Client uptake of safer conception strategies: Implementation outcomes from the Sakh'umndeni safer conception clinic in South Africa

Schwartz, S. R., Bassett, J., Holmes, C. B., Yende, N., Phofa, R., Sanne, I. & Van Rie, A., Mar 8 2017, In : Journal of the International AIDS Society. 20, 21291.

Research output: Contribution to journalArticle

Nonadherence to antiretroviral therapy among HIVinfected patients in Zambia is concentrated among a minority of patients and is highly variable across clinics

Czaicki, N. L., Holmes, C., Sikazwe, I., Bolton, C., Savory, T., Wa Mwanza, M., Moyo, C., Padian, N. S. & Geng, E. H., Mar 13 2017, In : AIDS. 31, 5, p. 689-696 8 p.

Research output: Contribution to journalArticle

Understanding linkage to care with HIV self-test approach in Lusaka, Zambia - A mixed method approach

Chipungu, J., Bosomprah, S., Zanolini, A., Thimurthy, H., Chilengi, R., Sharma, A. & Holmes, C. B., Nov 2017, In : PloS one. 12, 11, e0187998.

Research output: Contribution to journalArticle

2016

Understanding Sustained Retention in HIV/AIDS Care and Treatment: a Synthetic Review

Roy, M., Czaicki, N., Holmes, C., Chavan, S., Tsitsi, A., Odeny, T., Sikazwe, I., Padian, N. & Geng, E., May 17 2016, (Accepted/In press) In : Current HIV/AIDS Reports. p. 1-9 9 p.

Research output: Contribution to journalArticle

2015

Changing models of care to improve progression through the HIV treatment cascade in different populations

Holmes, C. B. & Sanne, I., Jan 1 2015, In : Current opinion in HIV and AIDS. 10, 6, p. 447-450 4 p.

Research output: Contribution to journalReview article

Reframing HIV care: Putting people at the centre of antiretroviral delivery

Duncombe, C., Rosenblum, S., Hellmann, N., Holmes, C., Wilkinson, L., Biot, M., Bygrave, H., Hoos, D. & Garnett, G., Apr 1 2015, In : Tropical Medicine and International Health. 20, 4, p. 430-447 18 p.

Research output: Contribution to journalReview article

Sustainable HIV treatment in Africa through viral-load-informed differentiated care

Phillips, A., Shroufi, A., Vojnov, L., Cohn, J., Roberts, T., Ellman, T., Bonner, K., Rousseau, C., Garnett, G., Cambiano, V., Nakagawa, F., Ford, D., Bansi-Matharu, L., Miners, A., Lundgren, J. D., Eaton, J. W., Parkes-Ratanshi, R., Katz, Z., Maman, D., Ford, N. & 29 others, Vitoria, M., Doherty, M., Dowdy, D., Nichols, B., Murtagh, M., Wareham, M., Palamountain, K. M., Chakanyuka Musanhu, C., Stevens, W., Katzenstein, D., Ciaranello, A., Barnabas, R., Braithwaite, R. S., Bendavid, E., Nathoo, K. J., Van De Vijver, D., Wilson, D. P., Holmes, C., Bershteyn, A., Walker, S., Raizes, E., Jani, I., Nelson, L. J., Peeling, R., Terris-Prestholt, F., Murungu, J., Mutasa-Apollo, T., Hallett, T. B. & Revill, P., Dec 2 2015, In : Nature. 528, 7580, p. S68-S76

Research output: Contribution to journalArticle

Where have all the patients gone?

Padian, N. S. & Holmes, C. B., Mar 1 2015, In : The Lancet HIV. 2, 3, p. e78-e79

Research output: Contribution to journalComment/debate

2014

Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations

Doherty, K., Essajee, S., Penazzato, M., Holmes, C., Resch, S. & Ciaranello, A., May 2 2014, In : BMC health services research. 14, 1, 201.

Research output: Contribution to journalArticle

Health systems implications of the 2013 WHO consolidated antiretroviral guidelines and strategies for successful implementation

Holmes, C., Pillay, Y., Mwango, A., Perriens, J., Ball, A., Barreneche, O., Wignall, S., Hirnschall, G. & Doherty, M. C., Mar 2014, In : AIDS. 28, SUPPL. 2, p. S231-S239

Research output: Contribution to journalArticle

How can we get close to zero? The potential contribution of biomedical prevention and the investment Framework towards an effective response to HIV

On behalf of the New Prevention Technology Study Group, 2014, In : PloS one. 9, 11, e111956.

Research output: Contribution to journalArticle

Managing multiple funding streams and agendas to achieve local and global health and research objectives: Lessons from the field

Holmes, C. B., Sikazwe, I., Raelly, R. L., Freeman, B. L., Wambulawae, I., Silwizya, G., Topp, S. M., Chilengi, R., Henostroza, G., Kapambwe, S., Simbeye, D., Sibajene, S., Chi, H., Godfrey, K., Chi, B. & Moore, C. B., Jan 1 2014, In : Journal of acquired immune deficiency syndromes. 65, SUPPL.1, p. S32-S35

Research output: Contribution to journalArticle

2013

Impact of an innovative approach to prevent mother-to-child transmission of HIV - Malawi, July 2011-September 2012

Chimbwandira, F., Mhango, E., Makombe, S., Midiani, D., Mwansambo, C., Njala, J., Chirwa, Z., Jahn, A., Schouten, E., Phelps, B. R., Gieselman, A., Holmes, C. B., Maida, A., Gupta, S., Barr, B. A. T., Modi, S., Dale, H., Aberle-Grasse, J., Davis, M., Bell, D. & 1 others, Houston, J., Mar 1 2013, In : Morbidity and Mortality Weekly Report. 62, 8, p. 148-151 4 p.

Research output: Contribution to journalArticle

Predictors of delay in the diagnosis and treatment of suspected tuberculosis in HIV co-infected patients in South Africa

Otwombe, K. N., Variava, E., Holmes, C. B., Chaisson, R. E. & Martinson, N., Sep 1 2013, In : International Journal of Tuberculosis and Lung Disease. 17, 9, p. 1199-1205 7 p.

Research output: Contribution to journalArticle

Prevention of mother-to-child HIV transmission within the continuum of maternal, newborn, and child health services

Chi, B. H., Bolton-Moore, C. & Holmes, C. B., Sep 1 2013, In : Current opinion in HIV and AIDS. 8, 5, p. 498-503 6 p.

Research output: Contribution to journalReview article

2012

Expanding ART for treatment and prevention of HIV in South Africa: Estimated cost and cost-effectiveness 2011-2050

Granich, R., Kahn, J. G., Bennett, R., Holmes, C. B., Garg, N., Serenata, C., Sabin, M. L., Makhlouf-Obermeyer, C., de Filippo Mack, C., Williams, P., Jones, L., Smyth, C., Kutch, K. A., Ying-Ru, L., Vitoria, M., Souteyrand, Y., Crowley, S., Korenromp, E. L. & Williams, B. G., Feb 13 2012, In : PloS one. 7, 2, e30216.

Research output: Contribution to journalArticle

HIV development assistance and adult mortality in Africa

Bendavid, E., Holmes, C. B., Bhattacharya, J. & Miller, G., May 16 2012, In : JAMA - Journal of the American Medical Association. 307, 19, p. 2060-2067 8 p.

Research output: Contribution to journalArticle