Changxue Lu

2022

RNA profiling of circulating tumor cells systemically captured from diagnostic leukapheresis products in prostate cancer patients

Dong, L., Du, X., Lu, C., Zhang, Z., Huang, C. Y., Yang, L., Warren, S., Kuczler, M. D., Reyes, D. K., Luo, J., Amend, S. R., Xue, W. & Pienta, K. J., Dec 15 2022, In: Materials Today Bio. 17, 100474.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Ar splicing variants and resistance to ar targeting agents

Kanayama, M., Lu, C., Luo, J. & Antonarakis, E., Jun 1 2021, In: Cancers. 13, 11, 2563.

Research output: Contribution to journal › Review article › peer-review

Open Access

2020

Androgen receptor variant-driven prostate cancer II: advances in clinical investigation

Brown, L. C., Lu, C., Antonarakis, E. S., Luo, J. & Armstrong, A. J., Sep 1 2020, In: Prostate Cancer and Prostatic Diseases. 23, 3, p. 367-380 14 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Androgen receptor variant-driven prostate cancer II: advances in laboratory investigations

Lu, C., Brown, L. C., Antonarakis, E. S., Armstrong, A. J. & Luo, J., Sep 1 2020, In: Prostate Cancer and Prostatic Diseases. 23, 3, p. 381-397 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Scopus citations

Prospective multicenter study of circulating tumor cell AR-V7 and taxane versus hormonal treatment outcomes in metastatic castration-Resistant prostate cancer

Armstrong, A. J., Luo, J., Nanus, D. M., Giannakakou, P., Szmulewitz, R. Z., Danila, D. C., Healy, P., Anand, M., Berry, W. R., Zhang, T., Harrison, M. R., Lu, C., Chen, Y., Galletti, G., Schonhoft, J. D., Scher, H. I., Wenstrup, R., Tagawa, S. T., Antonarakis, E. S., George, D. J., & 1 othersHalabi, S., 2020, In: JCO Precision Oncology. 4, p. 1285-1301 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer

Wang, K., Luo, J., Yeh, S., You, B., Meng, J., Chang, P., Niu, Y., Li, G., Lu, C., Zhu, Y., Antonarakis, E. S., Luo, J., Huang, C. P., Xu, W. & Chang, C., Dec 1 2020, In: Nature communications. 11, 1, 2689.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Treatment with abiraterone and enzalutamide does not overcome poor outcome from metastatic castration-resistant prostate cancer in men with the germline homozygous HSD3B1 c.1245C genotype

Lu, C., Terbuch, A., Dolling, D., Yu, J., Wang, H., Chen, Y., Fountain, J., Bertan, C., Sharp, A., Carreira, S., Isaacs, W. B., Antonarakis, E. S., De Bono, J. S. & Luo, J., Sep 2020, In: Annals of Oncology. 31, 9, p. 1178-1185 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

Sharp, A., Welti, J. C., Lambros, M. B. K., Dolling, D., Rodrigues, D. N., Pope, L., Aversa, C., Figueiredo, I., Fraser, J., Ahmad, Z., Lu, C., Rescigno, P., Kolinsky, M., Bertan, C., Seed, G., Riisnaes, R., Miranda, S., Crespo, M., Pereira, R., Ferreira, A., & 15 othersFowler, G., Ebbs, B., Flohr, P., Neeb, A., Bianchini, D., Petremolo, A., Sumanasuriya, S., Paschalis, A., Mateo, J., Tunariu, N., Yuan, W., Carreira, S., Plymate, S. R., Luo, J. & de Bono, J. S., Nov 2019, In: European Urology. 76, 5, p. 676-685 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Expression pattern of androgen receptor and AR-V7 in androgen-deprivation therapy–naïve salivary duct carcinomas

Yang, R. K., Zhao, P., Lu, C., Luo, J. & Hu, R., Feb 2019, In: Human pathology. 84, p. 173-182 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: The PROPHECY study

Armstrong, A. J., Halabi, S., Luo, J., Nanus, D. M., Giannakakou, P., Szmulewitz, R. Z., Danila, D. C., Healy, P., Anand, M., Rothwell, C. J., Rasmussen, J., Thornburg, B., Berry, W. R., Wilder, R. S., Lu, C., Chen, Y., Silberstein, J. L., Kemeny, G., Galletti, G., Somarelli, J. A., & 7 othersGupta, S., Gregory, S. G., Scher, H. I., Dittamore, R., Tagawa, S. T., Antonarakis, E. S. & George, D. J., 2019, In: Journal of Clinical Oncology. 37, 13, p. 1120-1129 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

Re: Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Geraghty, C., Yan, P. S., Hankey, W., Sunkel, B., Cheng, X., Antonarakis, E. S., Wang, Q. E., Liu, Z., Huang, T. H., Jin, V. X., Clinton, S. K., Luo, J., Huang, J. & Wang, Q., Mar 1 2019, In: Journal of Urology. 201, 3, p. 446-447 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

2018

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study

Teply, B. A., Wang, H., Luber, B., Sullivan, R., Rifkind, I., Bruns, A., Spitz, A., DeCarli, M., Sinibaldi, V., Pratz, C. F., Lu, C., Silberstein, J. L., Luo, J., Schweizer, M. T., Drake, C. G., Carducci, M. A., Paller, C. J., Antonarakis, E. S., Eisenberger, M. A. & Denmeade, S. R., Jan 2018, In: The Lancet Oncology. 19, 1, p. 76-86 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Geraghty, C., Yan, P. S., Hankey, W., Sunkel, B., Cheng, X., Antonarakis, E. S., Wang, Q. E., Liu, Z., Huang, T. H. M., Jin, V. X., Clinton, S. K., Luo, J., Huang, J. & Wang, Q., Jun 26 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6810-6815 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

Antonarakis, E. S., Lu, C., Luber, B., Liang, C., Wang, H., Chen, Y., Silberstein, J. L., Piana, D., Lai, Z., Chen, Y., Isaacs, W. B. & Luo, J., Aug 2018, In: European Urology. 74, 2, p. 218-225 8 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer

Zhu, Y., Sharp, A., Anderson, C. M., Silberstein, J. L., Taylor, M., Lu, C., Zhao, P., De Marzo, A. M., Antonarakis, E. S., Wang, M., Wu, X., Luo, Y., Su, N., Nava Rodrigues, D., Figueiredo, I., Welti, J., Park, E., Ma, X. J., Coleman, I., Morrissey, C., & 4 othersPlymate, S. R., Nelson, P. S., de Bono, J. S. & Luo, J., May 2018, In: European Urology. 73, 5, p. 727-735 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms

Chalfin, H. J., Glavaris, S. A., Malihi, P. D., Sperger, J. M., Gorin, M. A., Lu, C., Goodwin, C. R., Chen, Y., Caruso, E. A., Dumpit, R., Kuhn, P., Lang, J. M., Nelson, P. S., Luo, J. & Pienta, K. J., Jun 2018, In: Journal of Urology. 199, 6, p. 1494-1501 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2017

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting

Lokhandwala, P. M., Riel, S. L., Haley, L., Lu, C., Chen, Y., Silberstein, J., Zhu, Y., Zheng, G., Lin, M. T., Gocke, C. D., Partin, A. W., Antonarakis, E. S., Luo, J. & Eshleman, J. R., Jan 1 2017, In: Journal of Molecular Diagnostics. 19, 1, p. 115-125 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first & second-line Abiraterone & Enzalutamide

Antonarakis, E. S., Lu, C., Luber, B., Wang, H., Chen, Y., Zhu, Y., Silberstein, J. L., Taylor, M. N., Maughan, B. L., Denmeade, S. R., Pienta, K. J., Paller, C. J., Carducci, M. A., Eisenberger, M. A. & Luo, J., Jul 1 2017, In: Journal of Clinical Oncology. 35, 19, p. 2149-2156 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

239 Scopus citations

2016

Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer

Guedes, L. B., Morais, C. L., Almutairi, F., Haffner, M. C., Zheng, Q., Isaacs, J. T., Antonarakis, E. S., Lu, C., Tsai, H., Luo, J., De Marzo, A. M. & Lotan, T. L., Sep 15 2016, In: Clinical Cancer Research. 22, 18, p. 4651-4663 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2015

Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer

Antonarakis, E. S., Lu, C., Luber, B., Wang, H., Chen, Y., Nakazawa, M., Nadal, R., Paller, C. J., Denmeade, S. R., Carducci, M. A., Eisenberger, M. A. & Luo, J., Aug 2015, In: JAMA Oncology. 1, 5, p. 582-591 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

427 Scopus citations

Serial blood-based analysis of AR-V7 in men with advanced prostate cancer

Nakazawa, M., Lu, C., Chen, Y., Paller, C. J., Carducci, M. A., Eisenberger, M. A., Luo, J. & Antonarakis, E. S., Sep 1 2015, In: Annals of Oncology. 26, 9, p. 1859-1865 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

2014

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

Antonarakis, E. S., Lu, C., Wang, H., Luber, B., Nakazawa, M., Roeser, J. C., Chen, Y., Mohammad, T. A., Chen, Y., Fedor, H. L., Lotan, T. L., Zheng, Q., De Marzo, A. M., Isaacs, J. T., Isaacs, W. B., Nadal, R., Paller, C. J., Denmeade, S. R., Carducci, M. A., Eisenberger, M. A., & 1 othersLuo, J., Sep 11 2014, In: New England Journal of Medicine. 371, 11, p. 1028-1038 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1594 Scopus citations

2013

Decoding the androgen receptor splice variants

Lu, C. & Luo, J., Sep 2013, In: Translational Andrology and Urology. 2, 3, p. 178-186 9 p.

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

2012

Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma

Lu, C., Zhu, X., Willingham, M. C. & Cheng, S. Y., Apr 19 2012, In: Oncogene. 31, 16, p. 2007-2016 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer

Hu, R., Lu, C., Mostaghel, E. A., Yegnasubramanian, S., Gurel, M., Tannahill, C., Edwards, J., Isaacs, W. B., Nelson, P. S., Bluemn, E., Plymate, S. R. & Luo, J., Jul 15 2012, In: Cancer Research. 72, 14, p. 3457-3462 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

393 Scopus citations

SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer

Kim, W. G., Guigon, C. J., Fozzatti, L., Park, J. W., Lu, C., Willingham, M. C. & Cheng, S. Y., Mar 1 2012, In: Clinical Cancer Research. 18, 5, p. 1281-1290 10 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2011

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

Saji, M., Narahara, K., McCarty, S. K., Vasko, V. V., La Perle, K. M., Porter, K., Jarjoura, D., Lu, C., Cheng, S. Y. & Ringel, M. D., Oct 20 2011, In: Oncogene. 30, 42, p. 4307-4315 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors

Fozzatti, L., Lu, C., Kim, D. W. & Cheng, S. Y., Jun 2011, In: Molecular Endocrinology. 25, 6, p. 908-921 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesis

Lu, C. & Cheng, S. Y., Aug 2011, In: Steroids. 76, 9, p. 885-891 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)

Fozzatti, L., Lu, C., Kim, D. W., Park, J. W., Astapova, I., Gavrilova, O., Willingham, M. C., Hollenberg, A. N. & Cheng, S. Y., Oct 18 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17462-17467 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2010

Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma

Lu, C., Zhao, L., Ying, H., Willingham, M. C. & Cheng, S. Y., Apr 2010, In: Endocrinology. 151, 4, p. 1929-1939 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer

Guigon, C. J., Fozzatti, L., Lu, C., Willingham, M. C. & Cheng, S. Y., Mar 18 2010, In: Carcinogenesis. 31, 7, p. 1284-1291 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors

Lu, C. & Cheng, S. Y., Mar 2010, In: Journal of Molecular Endocrinology. 44, 3, p. 143-154 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

44 Scopus citations

2009

Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors

Furuya, F., Lu, C., Guigon, C. J. & Cheng, S. Y., Jul 2009, In: Steroids. 74, 7, p. 628-634 7 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2008

Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors

Lu, C., Willingham, M. C., Furuya, F. & Cheng, S. Y., Jul 2008, In: Endocrinology. 149, 7, p. 3339-3345 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Regulation of β-catenin by a novel nongenomic action of thyroid hormone β receptor

Guigon, C. J., Zhao, L., Lu, C., Willingham, M. C. & Cheng, S. Y., Jul 2008, In: Molecular and cellular biology. 28, 14, p. 4598-4608 11 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

2007

Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer

Furuya, F., Lu, C., Willingham, M. C. & Cheng, S. Y., Dec 2007, In: Carcinogenesis. 28, 12, p. 2451-2458 8 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling

Furuya, F., Guigon, C. J., Zhao, L., Lu, C., Hanover, J. A. & Cheng, S. Y., Sep 2007, In: Molecular and cellular biology. 27, 17, p. 6116-6126 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2006

Characterization of the DNA-binding properties and the transactivation activity of Schistosoma mansoni nuclear receptor fushi tarazu-factor 1α (SmFTZ-F1α)

Lu, C., Niles, E. G. & LoVerde, P. T., Nov 2006, In: Molecular and Biochemical Parasitology. 150, 1, p. 72-82 11 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Identification and characterization of a novel fushi tarazu factor 1 (FTZ-F1) nuclear receptor in Schistosoma mansoni

Lu, C., Wu, W., Niles, E. G. & LoVerde, P. T., Nov 2006, In: Molecular and Biochemical Parasitology. 150, 1, p. 25-36 12 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Changxue Lu

Research output

Search results