Changxue Lu

Instructor

20072019
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Research Output 2007 2019

2019

Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

Sharp, A., Welti, J. C., Lambros, M. B. K., Dolling, D., Rodrigues, D. N., Pope, L., Aversa, C., Figueiredo, I., Fraser, J., Ahmad, Z., Lu, C., Rescigno, P., Kolinsky, M., Bertan, C., Seed, G., Riisnaes, R., Miranda, S., Crespo, M., Pereira, R., Ferreira, A. & 15 others, Fowler, G., Ebbs, B., Flohr, P., Neeb, A., Bianchini, D., Petremolo, A., Sumanasuriya, S., Paschalis, A., Mateo, J., Tunariu, N., Yuan, W., Carreira, S., Plymate, S. R., Luo, J. & de Bono, J. S., Jan 1 2019, In : European Urology.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Cell Count

Expression pattern of androgen receptor and AR-V7 in androgen-deprivation therapy–naïve salivary duct carcinomas

Yang, R. K., Zhao, P., Lu, C., Luo, J. & Hu, R., Feb 1 2019, In : Human Pathology. 84, p. 173-182 10 p.

Research output: Contribution to journalArticle

Salivary Ducts
Androgen Receptors
Androgens
Carcinoma
Immunohistochemistry

Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: The PROPHECY study

Armstrong, A. J., Halabi, S., Luo, J., Nanus, D. M., Giannakakou, P., Szmulewitz, R. Z., Danila, D. C., Healy, P., Anand, M., Rothwell, C. J., Rasmussen, J., Thornburg, B., Berry, W. R., Wilder, R. S., Lu, C., Chen, Y., Silberstein, J. L., Kemeny, G., Galletti, G., Somarelli, J. A. & 7 others, Gupta, S., Gregory, S. G., Scher, H. I., Dittamore, R., Tagawa, S. T., Antonarakis, E. & George, D. J., Jan 1 2019, In : Journal of Clinical Oncology. 37, 13, p. 1120-1129 10 p.

Research output: Contribution to journalArticle

Open Access
Castration
Androgen Receptors
Prostatic Neoplasms
Hormones
Circulating Neoplastic Cells

Re: Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Geraghty, C., Yan, P. S., Hankey, W., Sunkel, B., Cheng, X., Antonarakis, E. S., Wang, Q. E., Liu, Z., Huang, T. H., Jin, V. X., Clinton, S. K., Luo, J., Huang, J. & Wang, Q., Mar 1 2019, In : Journal of Urology. 201, 3, p. 446-447 2 p.

Research output: Contribution to journalComment/debate

Castration-Resistant Prostatic Neoplasms
Homeodomain Proteins
Castration
Prostatic Neoplasms
2018

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Geraghty, C., Yan, P. S., Hankey, W., Sunkel, B., Cheng, X., Antonarakis, E., Wang, Q. E., Liu, Z., Huang, T. H. M., Jin, V. X., Clinton, S. K., Luo, J., Huang, J. & Wang, Q., Jun 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. 6810-6815 6 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Circulating Neoplastic Cells
Oncogenes

Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

Antonarakis, E., Lu, C., Luber, B., Liang, C., Wang, H., Chen, Y., Silberstein, J. L., Piana, D., Lai, Z., Chen, Y., Isaacs, W. B. & Luo, J., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Castration
DNA Repair
Prostatic Neoplasms
Mutation
Germ-Line Mutation

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms

Chalfin, H. J., Glavaris, S. A., Malihi, P. D., Sperger, J. M., Gorin, M., Lu, C., Goodwin, C. R., Chen, Y., Caruso, E. A., Dumpit, R., Kuhn, P., Lang, J. M., Nelson, P. S., Luo, J. & Pienta, K., Jan 1 2018, (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Bone Marrow
Prostate
Neoplasms
2017

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting

Lokhandwala, P., Riel, S. L., Haley, L., Lu, C., Chen, Y., Silberstein, J., Zhu, Y., Zheng, G., Lin, M-T., Gocke, C., Partin, A. W., Antonarakis, E., Luo, J. & Eshleman, J., Jan 1 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Circulating Neoplastic Cells
Prostatic Neoplasms
Castration
Ligands

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: An open-label, phase 2, multicohort study

Teply, B. A., Wang, H., Luber, B., Sullivan, R., Rifkind, I., Bruns, A., Spitz, A., DeCarli, M., Sinibaldi, V., Pratz, C. F., Lu, C., Silberstein, J. L., Luo, J., Schweizer, M. T., Drake, C. G., Carducci, M. A., Paller, C., Antonarakis, E., Eisenberger, M. & Denmeade, S. R., Jan 1 2017, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Castration
Androgens
Prostatic Neoplasms
Therapeutics
MDV 3100
Circulating Neoplastic Cells
Castration
Androgen Receptors
Prostatic Neoplasms
Messenger RNA

Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer

Zhu, Y., Sharp, A., Anderson, C. M., Silberstein, J. L., Taylor, M., Lu, C., Zhao, P., Demarzo, A. M., Antonarakis, E., Wang, M., Wu, X., Luo, Y., Su, N., Nava Rodrigues, D., Figueiredo, I., Welti, J., Park, E., Ma, X. J., Coleman, I., Morrissey, C. & 4 others, Plymate, S. R., Nelson, P. S., de Bono, J. S. & Luo, J., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Biopsy
Disease-Free Survival
2016

Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer

Guedes, L. B., Morais, C. L., Almutairi, F., Haffner, M. C., Zheng, Q., Isaacs, J. T., Antonarakis, E., Lu, C., Tsai, H., Luo, J., Demarzo, A. M. & Lotan, T., Sep 15 2016, In : Clinical Cancer Research. 22, 18, p. 4651-4663 13 p.

Research output: Contribution to journalArticle

In Situ Hybridization
Prostatic Neoplasms
RNA
Paraffin
Formaldehyde
2015
Castration
Androgen Receptors
Prostatic Neoplasms
Drug Therapy
Prostate-Specific Antigen

Serial blood-based analysis of AR-V7 in men with advanced prostate cancer

Nakazawa, M., Lu, C., Chen, Y., Paller, C., Carducci, M. A., Eisenberger, M., Luo, J. & Antonarakis, E., Sep 1 2015, In : Annals of Oncology. 26, 9, p. 1859-1865 7 p., mdv282.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Circulating Neoplastic Cells
docetaxel
Therapeutics
2014

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

Antonarakis, E., Lu, C., Wang, H., Luber, B., Nakazawa, M., Roeser, J. C., Chen, Y., Mohammad, T. A., Chen, Y., Fedor, H. L., Lotan, T., Zheng, Q., Demarzo, A. M., Isaacs, J. T., Isaacs, W. B., Nadal, R., Paller, C., Denmeade, S. R., Carducci, M. A., Eisenberger, M. & 1 others, Luo, J., Sep 11 2014, In : New England Journal of Medicine. 371, 11, p. 1028-1038 11 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Prostatic Neoplasms
Disease-Free Survival
Circulating Neoplastic Cells
Androgen Receptors
2013

Decoding the androgen receptor splice variants

Lu, C. & Luo, J., 2013, In : Translational Andrology and Urology. 2, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
Hormones
Therapeutics
2012

Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma

Lu, C., Zhu, X., Willingham, M. C. & Cheng, S. Y., Apr 19 2012, In : Oncogene. 31, 16, p. 2007-2016 10 p.

Research output: Contribution to journalArticle

Follicular Adenocarcinoma
Thyroid Hormones
Cell Proliferation
Neoplasms
Thyroid Gland

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer

Hu, R., Lu, C., Mostaghel, E. A., Yegnasubramanian, S., Gurel, M., Tannahill, C., Edwards, J., Isaacs, W. B., Nelson, P. S., Bluemn, E., Plymate, S. R. & Luo, J., Jul 15 2012, In : Cancer Research. 72, 14, p. 3457-3462 6 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Ligands
Therapeutics

SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer

Kim, W. G., Guigon, C. J., Fozzatti, L., Park, J. W., Lu, C., Willingham, M. C. & Cheng, S. Y., Mar 1 2012, In : Clinical Cancer Research. 18, 5, p. 1281-1290 10 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Epithelial-Mesenchymal Transition
2011

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

Saji, M., Narahara, K., McCarty, S. K., Vasko, V. V., La Perle, K. M., Porter, K., Jarjoura, D., Lu, C., Cheng, S. Y. & Ringel, M. D., Oct 20 2011, In : Oncogene. 30, 42, p. 4307-4315 9 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Blood Vessels
Neoplasm Metastasis
Thyroid Hormone Receptors
Neoplasms

Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors

Fozzatti, L., Lu, C., Kim, D. W. & Cheng, S. Y., Jun 2011, In : Molecular Endocrinology. 25, 6, p. 908-921 14 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
Protein Isoforms
Nuclear Proteins
Phenotype
Liver

Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesis

Lu, C. & Cheng, S. Y., Aug 2011, In : Steroids. 76, 9, p. 885-891 7 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
Thyroid Gland
Carcinogenesis
Gene expression
Thyroid Hormone Resistance Syndrome

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)

Fozzatti, L., Lu, C., Kim, D. W., Park, J. W., Astapova, I., Gavrilova, O., Willingham, M. C., Hollenberg, A. N. & Cheng, S. Y., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17462-17467 6 p.

Research output: Contribution to journalArticle

Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Co-Repressor Proteins
Thyroid Hormones
Thyroid Gland
2010

Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma

Lu, C., Zhao, L., Ying, H., Willingham, M. C. & Cheng, S. Y., Apr 2010, In : Endocrinology. 151, 4, p. 1929-1939 11 p.

Research output: Contribution to journalArticle

Follicular Adenocarcinoma
Thyroid Neoplasms
Growth
Thyroid Gland
Thyrotropin Receptors

Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer

Guigon, C. J., Fozzatti, L., Lu, C., Willingham, M. C. & Cheng, S. Y., Mar 18 2010, In : Carcinogenesis. 31, 7, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Growth
Eukaryotic Initiation Factors
Neoplasms
Thyroid Gland
Thyroid Hormone Receptors
Adipogenesis
Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Carcinogenesis
2009

Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors

Furuya, F., Lu, C., Guigon, C. J. & Cheng, S. Y., Jul 2009, In : Steroids. 74, 7, p. 628-634 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Thyroid Hormone Receptors
Co-Repressor Proteins
Chemical activation
Tumors
2008

Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors

Lu, C., Willingham, M. C., Furuya, F. & Cheng, S. Y., Jul 2008, In : Endocrinology. 149, 7, p. 3339-3345 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Pituitary Neoplasms
Thyrotropin
70-kDa Ribosomal Protein S6 Kinases
Growth

Regulation of β-catenin by a novel nongenomic action of thyroid hormone β receptor

Guigon, C. J., Zhao, L., Lu, C., Willingham, M. C. & Cheng, S. Y., Jul 2008, In : Molecular and Cellular Biology. 28, 14, p. 4598-4608 11 p.

Research output: Contribution to journalArticle

Catenins
Thyroid Hormone Receptors
Thyroid Gland
Carcinogenesis
Follicular Adenocarcinoma
2007

Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer

Furuya, F., Lu, C., Willingham, M. C. & Cheng, S. Y., Dec 2007, In : Carcinogenesis. 28, 12, p. 2451-2458 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Thyroid Neoplasms
Neoplasms
Thyroid Gland

Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling

Furuya, F., Guigon, C. J., Zhao, L., Lu, C., Hanover, J. A. & Cheng, S. Y., Sep 2007, In : Molecular and Cellular Biology. 27, 17, p. 6116-6126 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Co-Repressor Proteins
Thyroid Gland
Neoplasms
Follicular Adenocarcinoma