Carolyn E Machamer

Professor

1978 …2019
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Research Output 1978 2019

Accommodation of large cargo within Golgi cisternae

Machamer, C. E., Sep 2013, In : Histochemistry and Cell Biology. 140, 3, p. 261-269 9 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Physiological Phenomena
Exocytosis
Endoplasmic Reticulum
Organelles

A coronavirus E protein is present in two distinct pools with different effects on assembly and the secretory pathway

Westerbeck, J. W. & Machamer, C. E., 2015, In : Journal of Virology. 89, 18, p. 9313-9323 11 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Coronavirus
Coronavirinae
Secretory Pathway
Severe Acute Respiratory Syndrome

Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens

Lefrancois, L., Puddington, L., Machamer, C. E. & Bevan, M. J., 1985, In : Journal of Experimental Medicine. 162, 4, p. 1275-1293 19 p.

Research output: Contribution to journalArticle

Differentiation Antigens
Cytotoxic T-Lymphocytes
Tunicamycin
Carbohydrates
Antigens

Acute perturbations in golgi organization impact de novo sphingomyelin synthesis

Chandran, S. & Machamer, C. E., 2008, In : Traffic. 9, 11, p. 1894-1904 11 p.

Research output: Contribution to journalArticle

Sphingomyelins
Ceramides
Endoplasmic Reticulum
Proteins
Golgi Apparatus

A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein

Swift, A. M. & Machamer, C. E., Oct 1991, In : Journal of Cell Biology. 115, 1, p. 19-30 12 p.

Research output: Contribution to journalArticle

Coronavirus
Membranes
Proteins
Golgi Apparatus
GTP-Binding Proteins

Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting

Radka, S. F., Machamer, C. E. & Cresswell, P., 1984, In : Human Immunology. 10, 3, p. 177-188 12 p.

Research output: Contribution to journalArticle

Electrophoresis
Western Blotting
Monoclonal Antibodies
Histocompatibility Antigens Class II
HLA-DR Antigens

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Caspase 3
Thrombin
Caspases
Electric Impedance
Endothelial Cells

Antibodies against the measles matrix polypeptide after clinical infection and vaccination

Machamer, C. E., Hayes, E. C., Gollobin, S. D., Westfall, L. K. & Zweerink, H. J., 1980, In : Infection and Immunity. 27, 3, p. 817-825 9 p.

Research output: Contribution to journalArticle

Measles
Vaccination
Measles virus
Peptides
Antibodies

Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase

Taylor, M. S., Ruch, T. R., Hsiao, P. Y., Hwang, Y. S., Zhang, P., Dai, L., Huang, C. R. L., Berndsen, C. E., Kim, M. S., Pandey, A., Wolberger, C., Marmorstein, R., Machamer, C. E., Boeke, J. D. & Cole, P. A., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32211-32228 18 p.

Research output: Contribution to journalArticle

Acyltransferases
Ghrelin
Organizations
Enzymes
Membrane Proteins

A single-amino-acid substitution eliminates the stringent carbohydrate requirement for intracellular transport of a viral glycoprotein

Pitta, A. M., Rose, J. K. & Machamer, C. E., 1989, In : Journal of Virology. 63, 9, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

amino acid substitution
Amino Acid Substitution
G-proteins
GTP-Binding Proteins
glycoproteins
Oligosaccharides
GTP-Binding Proteins
Glycosylation
Gastrin-Secreting Cells
Vesicular Stomatitis
Coronavirus
Bronchitis
Secretory Pathway
Membranes
Proteins
Severe Acute Respiratory Syndrome
Coronavirus
membrane proteins
Tyrosine
tyrosine

A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region

Machamer, C. E. & Rose, J. K., 1987, In : Journal of Cell Biology. 105, 3, p. 1205-1214 10 p.

Research output: Contribution to journalArticle

Coronavirus
Mutant Proteins
Glycoproteins
Infectious bronchitis virus
Intracellular Membranes

Assembly of vaccinia virus: Role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks

Sodeik, B., Doms, R. W., Ericsson, M., Hiller, G., Machamer, C. E., Van't Hof, W., Van Meer, G., Moss, B. & Griffiths, G., 1993, In : Journal of Cell Biology. 121, 3, p. 521-542 22 p.

Research output: Contribution to journalArticle

Vaccinia virus
Endoplasmic Reticulum
Viruses
Membranes
Phospholipids

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens

Machamer, C. E. & Cresswell, P., 1982, In : Journal of Immunology. 129, 6, p. 2564-2569 6 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Glycosylation
Precipitins
Cell Line
Tunicamycin

Caspase-2 is localized at the Golgi complex and cleaves Golgin-160 during apoptosis

Mancini, M., Machamer, C. E., Roy, S., Nicholson, D. W., Thornberry, N. A., Casciola Rosen, L. A. & Rosen, A., May 1 2000, In : Journal of Cell Biology. 149, 3, p. 603-612 10 p.

Research output: Contribution to journalArticle

Caspase 2
Golgi Apparatus
Caspases
Apoptosis
Cysteine Proteases

Caspase-resistant golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors

Maag, R. S., Mancini, M., Rosen, A. & Machamer, C. E., 2005, In : Molecular Biology of the Cell. 16, 6, p. 3019-3027 9 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Secretory Pathway
Caspases
Ligation
Apoptosis

Cells infected with a cell-associated subacute sclerosing panencephalitis virus do not express M protein

Machamer, C. E., Hayes, E. C. Z. & Zweerink, H. J., Jan 30 1981, In : Virology. 108, 2, p. 515-520 6 p.

Research output: Contribution to journalArticle

Subacute Sclerosing Panencephalitis
Viruses
Cerebrospinal Fluid
Antibodies
Measles

Cell surface display and intracellular trafficking of free glycosylphosphatidylinositols in mammalian cells

Baumann, N. A., Vidugiriene, J., Machamer, C. E. & Menon, A. K., Mar 10 2000, In : Journal of Biological Chemistry. 275, 10, p. 7378-7389 12 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Display devices
Cells
Cell membranes
Cell Membrane

Ceramide accumulation uncovers a cycling pathway for the cis-Golgi network marker, infectious bronchitis virus M protein

Maceyka, M. & Machamer, C. E., Dec 15 1997, In : Journal of Cell Biology. 139, 6, p. 1411-1418 8 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Ceramides
Sphingolipids
Proteins
Golgi Apparatus

Cholesterol-independent targeting of Golgi membrane proteins in insect cells

Rolls, M. M., Marquardt, M. T., Kielian, M. & Machamer, C. E., 1997, In : Molecular Biology of the Cell. 8, 11, p. 2111-2118 8 p.

Research output: Contribution to journalArticle

Insects
Membrane Proteins
Cholesterol
Golgi Apparatus
Aedes

Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics

Breitwieser, G. E., McLenithan, J. C., Cortese, J. F., Shields, J. M., Oliva-Hemker, M., Majewski, J. L., Machamer, C. E. & Yang, V. W., Mar 1997, In : American Journal of Physiology - Cell Physiology. 272, 3 41-3

Research output: Contribution to journalArticle

Proteolipids
Ion Channels
Endoplasmic Reticulum
Epithelium
Xenopus laevis

Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins

Gilbert, C. E., Sztul, E., Machamer, C. E. & Lippincott-Schwartz, J., Apr 15 2018, In : Molecular Biology of the Cell. 29, 8, p. 937-947 11 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factors
Brefeldin A
Guanine Nucleotide Exchange Factors
Proteins
Temperature

Contribution of trafficking signals in the cytoplasmic tail of the infectious bronchitis virus spike protein to virus infection

Youn, S., Collisson, E. W. & Machamer, C. E., Nov 2005, In : Journal of Virology. 79, 21, p. 13209-13217 9 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Virus Diseases
Endocytosis
endocytosis
tail

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

Sisk, J. M., Frieman, M. B. & Machamer, C. E., May 1 2018, In : Journal of General Virology. 99, 5, p. 619-630 12 p., 001047.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Coronavirus
Protein S
Phosphotransferases
Coronavirus Infections
Viral Matrix Proteins
Vesicular Stomatitis
GTP-Binding Proteins
Glycoproteins
Membrane Proteins

Death from within: Apoptosis and the secretory pathway

Maag, R. S., Hicks, S. W. & Machamer, C. E., Aug 2003, In : Current Opinion in Cell Biology. 15, 4, p. 456-461 6 p.

Research output: Contribution to journalArticle

Secretory Pathway
Apoptosis
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Organelles

Differential effects of mutations in three domains on folding, quaternary structure, and intracellular transport of vesicular stomatitis virus G protein

Doms, R. W., Ruusala, A., Machamer, C. E., Helenius, J., Helenius, A. & Rose, J. K., 1988, In : Journal of Cell Biology. 107, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

Vesicular Stomatitis
Mutant Proteins
Glycoproteins
Viruses
Mutation

Differential localization and turnover of infectious bronchitis virus 3b protein in mammalian versus avian cells

Pendleton, A. R. & Machamer, C. E., Feb 20 2006, In : Virology. 345, 2, p. 337-345 9 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Proteins
Coronavirus
Vaccinia virus
Proteasome Endopeptidase Complex

Differential regulation of two palmitoylation sites in the cytoplasmic tail of the β1-adrenergic receptor

Zuckerman, D. M., Hicks, S. W., Charron, G., Hang, H. C. & Machamer, C. E., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 19014-19023 10 p.

Research output: Contribution to journalArticle

Lipoylation
G-Protein-Coupled Receptors
Adrenergic Receptors
Palmitates
Cysteine

Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease?

Larrick, J. W., Buckley, C. E., Machamer, C. E., Schlagel, G. D., Yost, J. A., Blessing-Moore, J. & Levy, D., 1983, In : The Journal of Allergy and Clinical Immunology. 71, 2, p. 184-188 5 p.

Research output: Contribution to journalArticle

Hypergammaglobulinemia
Immunoglobulin E
Pollen
Population
IgE Receptors

Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway

Rosenwald, A. G., Machamer, C. E. & Machamer, C. E., 1992, In : Biochemistry®. 31, 14, p. 3581-3590 10 p.

Research output: Contribution to journalArticle

Sphingolipids
Secretory Pathway
Membranes
Golgi Apparatus
RV 538
Endoplasmic Reticulum
Tyrosine
Tail
Vesicular Stomatitis
Viruses

Either N-linked oligosaccharide of VSV G protein is sufficient for cell surface expression

Machamer, C. E., Florkiewicz, R. & Rose, J. K., 1985, In : Federation proceedings. 44, 4

Research output: Contribution to journalArticle

Oligosaccharides
GTP-Binding Proteins

Elimination of mycoplasma from human B-lymphoblastoid cell lines

Howell, D. N., Machamer, C. E. & Cresswell, P., 1982, In : Human Immunology. 5, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Mycoplasma
Nude Mice
Feeder Cells
Foreskin
Cell Line

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Shao, W., Machamer, C. E. & Espenshade, P., Aug 1 2016, In : Journal of Lipid Research. 57, 8, p. 1564-1573 10 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Cell growth
Endoplasmic Reticulum
Growth
Lipids
Detergents
Conformations
Proteins
Oligomers
Viruses

GCP60 preferentially interacts with a caspase-generated golgin-160 fragment

Sbodio, J., Hicks, S. W., Simon, D. & Machamer, C. E., Sep 22 2006, In : Journal of Biological Chemistry. 281, 38, p. 27924-27931 8 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Caspases
Head
Apoptosis
Proteins

Generating antibodies to the gene 3 proteins of infectious bronchitis virus

Pendleton, A. R. & Machamer, C. E., 2008, Methods in Molecular Biology. Humana Press, Vol. 454. p. 163-189 27 p. (Methods in Molecular Biology; vol. 454).

Research output: Chapter in Book/Report/Conference proceedingChapter

Infectious bronchitis virus
Antibodies
Proteins
Viral Envelope Proteins
Virus Release

Generating antibodies to the gene 3 proteins of infectious bronchitis virus.

Pendleton, A. R. & Machamer, C. E., 2008, In : Methods in molecular biology (Clifton, N.J.). 454, p. 163-189 27 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Antibodies
Proteins
Viral Envelope Proteins
Virus Release

Glycosylation allows cell-surface transport of an anchored secretory protein

Guan, J. L., Machamer, C. E. & Rose, J. K., 1985, In : Cell. 42, 2, p. 489-496 8 p.

Research output: Contribution to journalArticle

Glycosylation
Protein Transport
Mutant Proteins
Growth Hormone
Proteins

Golgi disassembly in apoptosis: Cause or effect?

Machamer, C. E., Jun 1 2003, In : Trends in Cell Biology. 13, 6, p. 279-281 3 p.

Research output: Contribution to journalArticle

Apoptosis
Organelles
Transport Vesicles
Proteins
Golgi Apparatus

Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes

Williams, D., Hicks, S. W., Machamer, C. E. & Pessin, J. E., Dec 2006, In : Molecular Biology of the Cell. 17, 12, p. 5346-5355 10 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Adipocytes
Insulin
Membranes
Peptide Hydrolases

Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor

Hicks, S. W., Horn, T. A., Mccaffery, J. M., Zuckerman, D. M. & Machamer, C. E., Dec 2006, In : Traffic. 7, 12, p. 1666-1677 12 p.

Research output: Contribution to journalArticle

Adrenergic beta-1 Receptors
Adrenergic Receptors
RNA Interference
RNA
trans-Golgi Network

Golgi organization and stress sensing

Chandran, S. & Machamer, C. E., Feb 2011, Golgi Apparatus: Structure, Functions and Mechanisms. Nova Science Publishers, Inc., p. 1-41 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ceramides
Endoplasmic Reticulum
Apoptosis
Membranes
Sphingomyelins

Golgi protein ACBD3 mediates neurotoxicity associated with huntington's disease

Sbodio, J., Paul, B., Machamer, C. E. & Snyder, S. H., May 12 2013, In : Cell Reports. 4, 5, p. 890-897 8 p.

Research output: Contribution to journalArticle

Diazepam Binding Inhibitor
Acyl Coenzyme A
Huntington Disease
Corpus Striatum
Cytotoxicity

Golgi retention signals: do membranes hold the key?

Machamer, C. E., 1991, In : Trends in Cell Biology. 1, 6, p. 141-144 4 p.

Research output: Contribution to journalArticle

Membranes
Golgi Apparatus
Proteins
Endoplasmic Reticulum
Organelles

Golgi structure in stress sensing and apoptosis

Hicks, S. W. & Machamer, C. E., Jul 10 2005, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 3 SPEC. ISS., p. 406-414 9 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Apoptosis
Microtubule-Organizing Center
Endoplasmic Reticulum Stress
Membranes

Heavy chain binding protein recognizes incompletely disulfidebonded forms of vesicular stomatitis virus G protein

Machamer, C. E., Doms, R. W., Bolel, D. G., Helenius, A. & Rose, J. K., 1990, In : Journal of Biological Chemistry. 265, 12, p. 6879-6883 5 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Carrier Proteins
Mutant Proteins
Endoplasmic Reticulum
Disulfides