Carolyn E Machamer

Professor

1978 …2019
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Research Output 1978 2019

2019

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Caspase 3
Thrombin
Caspases
Electric Impedance
Endothelial Cells
Infectious bronchitis virus
Virus Release
infectious bronchitis
Coronavirus
Coronavirinae
2018

Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins

Gilbert, C. E., Sztul, E., Machamer, C. E. & Lippincott-Schwartz, J., Apr 15 2018, In : Molecular Biology of the Cell. 29, 8, p. 937-947 11 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factors
Brefeldin A
Guanine Nucleotide Exchange Factors
Proteins
Temperature

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

Sisk, J. M., Frieman, M. B. & Machamer, C. E., May 1 2018, In : Journal of General Virology. 99, 5, p. 619-630 12 p., 001047.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Coronavirus
Protein S
Phosphotransferases
Coronavirus Infections
2016

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Shao, W., Machamer, C. E. & Espenshade, P., Aug 1 2016, In : Journal of Lipid Research. 57, 8, p. 1564-1573 10 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Cell growth
Endoplasmic Reticulum
Growth
Lipids
2015

A coronavirus E protein is present in two distinct pools with different effects on assembly and the secretory pathway

Westerbeck, J. W. & Machamer, C. E., 2015, In : Journal of Virology. 89, 18, p. 9313-9323 11 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Coronavirus
Coronavirinae
Secretory Pathway
Severe Acute Respiratory Syndrome

The Golgi complex in stress and death

Machamer, C. E., 2015, In : Frontiers in Neuroscience. 9, NOV, 421.

Research output: Contribution to journalArticle

Golgi Apparatus
Organelles
Secretory Pathway
Neurodegenerative Diseases
Apoptosis
2014

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

Damarla, M., Parniani, A. R., Johnston, L., Maredia, H., Serebreni, L., Hamdan, O., Sidhaye, V., Shimoda, L., Myers, A. C., Crow, M. T., Schmidt, E. P., Machamer, C. E., Gaestel, M., Rane, M. J., Kolb, T. M., Kim, B. S., Damico, R. L. & Hassoun, P. M., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Capillary Permeability
Mitogen-Activated Protein Kinases
Caspase 3
Protein Kinases
Apoptosis

Three basic residues of intracellular loop 3 of the beta-1 adrenergic receptor are required for golgin-160-dependent trafficking

Gilbert, C. E., Zuckerman, D. M., Currier, P. L. & Machamer, C. E., Feb 20 2014, In : International Journal of Molecular Sciences. 15, 2, p. 2929-2945 17 p.

Research output: Contribution to journalArticle

Adrenergic beta-1 Receptors
adrenergics
Adrenergic Receptors
Cell membranes
Proteins
2013

Accommodation of large cargo within Golgi cisternae

Machamer, C. E., Sep 2013, In : Histochemistry and Cell Biology. 140, 3, p. 261-269 9 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Physiological Phenomena
Exocytosis
Endoplasmic Reticulum
Organelles

Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase

Taylor, M. S., Ruch, T. R., Hsiao, P. Y., Hwang, Y. S., Zhang, P., Dai, L., Huang, C. R. L., Berndsen, C. E., Kim, M. S., Pandey, A., Wolberger, C., Marmorstein, R., Machamer, C. E., Boeke, J. D. & Cole, P. A., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32211-32228 18 p.

Research output: Contribution to journalArticle

Acyltransferases
Ghrelin
Organizations
Enzymes
Membrane Proteins

Golgi protein ACBD3 mediates neurotoxicity associated with huntington's disease

Sbodio, J., Paul, B., Machamer, C. E. & Snyder, S. H., May 12 2013, In : Cell Reports. 4, 5, p. 890-897 8 p.

Research output: Contribution to journalArticle

Diazepam Binding Inhibitor
Acyl Coenzyme A
Huntington Disease
Corpus Striatum
Cytotoxicity
2012
Coronavirus
Bronchitis
Secretory Pathway
Membranes
Proteins

Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage

Chandran, S. & Machamer, C. E., Mar 1 2012, In : Biochemical Journal. 442, 2, p. 391-401 11 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Ceramides
Caspases
Sphingomyelins
Endoplasmic Reticulum

The coronavirus E protein: Assembly and beyond

Ruch, T. R. & Machamer, C. E., Mar 2012, In : Viruses. 4, 3, p. 363-382 20 p.

Research output: Contribution to journalArticle

Coronavirus
Proteins
Virus Release
Ion Channels
Virion
2011

Differential regulation of two palmitoylation sites in the cytoplasmic tail of the β1-adrenergic receptor

Zuckerman, D. M., Hicks, S. W., Charron, G., Hang, H. C. & Machamer, C. E., May 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 19014-19023 10 p.

Research output: Contribution to journalArticle

Lipoylation
G-Protein-Coupled Receptors
Adrenergic Receptors
Palmitates
Cysteine

Golgi organization and stress sensing

Chandran, S. & Machamer, C. E., Feb 2011, Golgi Apparatus: Structure, Functions and Mechanisms. Nova Science Publishers, Inc., p. 1-41 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ceramides
Endoplasmic Reticulum
Apoptosis
Membranes
Sphingomyelins

Identification of a golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein

Cohen, J. R., Lin, L. D. & Machamer, C. E., Jun 2011, In : Journal of Virology. 85, 12, p. 5794-5803 10 p.

Research output: Contribution to journalArticle

Severe Acute Respiratory Syndrome
Coronavirus
Golgi Apparatus
Golgi apparatus
tail
Infectious bronchitis virus
Virus Release
Secretory Pathway
viruses
Proteins
2010
Severe Acute Respiratory Syndrome
Coronavirus
membrane proteins
Tyrosine
tyrosine
Lipoylation
Coronavirus
Cell Fusion
Detergents
Cell Membrane

Ultrastructure and regulation of lateralized connexin43 in the failing heart

Hesketh, G. G., Shah, M. H., Halperin, V. L., Cooke, C. A., Akar, F. G., Yen, T. E., Kass, D. A., Machamer, C. E., Van Eyk, J. E. & Tomaselli, G. F., Apr 2010, In : Circulation Research. 106, 6, p. 1153-1163 11 p.

Research output: Contribution to journalArticle

Connexin 43
Gap Junctions
Cardiac Myocytes
Membranes
Myocardium
2008

Acute perturbations in golgi organization impact de novo sphingomyelin synthesis

Chandran, S. & Machamer, C. E., 2008, In : Traffic. 9, 11, p. 1894-1904 11 p.

Research output: Contribution to journalArticle

Sphingomyelins
Ceramides
Endoplasmic Reticulum
Proteins
Golgi Apparatus

Generating antibodies to the gene 3 proteins of infectious bronchitis virus

Pendleton, A. R. & Machamer, C. E., 2008, Methods in Molecular Biology. Humana Press, Vol. 454. p. 163-189 27 p. (Methods in Molecular Biology; vol. 454).

Research output: Chapter in Book/Report/Conference proceedingChapter

Infectious bronchitis virus
Antibodies
Proteins
Viral Envelope Proteins
Virus Release

Generating antibodies to the gene 3 proteins of infectious bronchitis virus.

Pendleton, A. R. & Machamer, C. E., 2008, In : Methods in molecular biology (Clifton, N.J.). 454, p. 163-189 27 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Antibodies
Proteins
Viral Envelope Proteins
Virus Release
2007

Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with Golgin-160

Sbodio, J. & Machamer, C. E., Oct 12 2007, In : Journal of Biological Chemistry. 282, 41, p. 29874-29881 8 p.

Research output: Contribution to journalArticle

Caspases
Oxidation-Reduction
Cysteine
Head
Nuclear Localization Signals

Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway

Lai, S. K., Hida, K., Man, S. T., Chen, C., Machamer, C. E., Schroer, T. A. & Hanes, J. S., 2007, In : Biomaterials. 28, 18, p. 2876-2884 9 p.

Research output: Contribution to journalArticle

Nanoparticles
Polymers
Cholesterol
Latex
Biocompatible Materials
Coronavirus Spike Glycoproteins
Severe Acute Respiratory Syndrome
membrane proteins
Endoplasmic Reticulum
endoplasmic reticulum
2006

Differential localization and turnover of infectious bronchitis virus 3b protein in mammalian versus avian cells

Pendleton, A. R. & Machamer, C. E., Feb 20 2006, In : Virology. 345, 2, p. 337-345 9 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Proteins
Coronavirus
Vaccinia virus
Proteasome Endopeptidase Complex

GCP60 preferentially interacts with a caspase-generated golgin-160 fragment

Sbodio, J., Hicks, S. W., Simon, D. & Machamer, C. E., Sep 22 2006, In : Journal of Biological Chemistry. 281, 38, p. 27924-27931 8 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Caspases
Head
Apoptosis
Proteins

Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes

Williams, D., Hicks, S. W., Machamer, C. E. & Pessin, J. E., Dec 2006, In : Molecular Biology of the Cell. 17, 12, p. 5346-5355 10 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Adipocytes
Insulin
Membranes
Peptide Hydrolases

Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor

Hicks, S. W., Horn, T. A., Mccaffery, J. M., Zuckerman, D. M. & Machamer, C. E., Dec 2006, In : Traffic. 7, 12, p. 1666-1677 12 p.

Research output: Contribution to journalArticle

Adrenergic beta-1 Receptors
Adrenergic Receptors
RNA Interference
RNA
trans-Golgi Network

Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells

Cha, H., Dangi, S., Machamer, C. E. & Shapiro, P., Jan 2006, In : Cellular Signalling. 18, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

G2 Phase
HeLa Cells
Microtubules
Phosphotransferases
Cell Proliferation

The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release

Machamer, C. E. & Youn, S., 2006, Advances in Experimental Medicine and Biology. Springer New York, Vol. 581. p. 193-198 6 p. (Advances in Experimental Medicine and Biology; vol. 581).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Infectious bronchitis virus
Virus Release
Proteins
Infectious bronchitis virus
Viral Envelope Proteins
Virus Release
Cercopithecus aethiops
Biological Models

Transcriptional regulation of RNA3 of infectious bronchitis virus

Youn, S., Collisson, E. W. & Machamer, C. E., 2006, Advances in Experimental Medicine and Biology. Springer New York, Vol. 581. p. 109-112 4 p. (Advances in Experimental Medicine and Biology; vol. 581).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Infectious bronchitis virus

Transcriptional regulation of RNA3 of infectious bronchitis virus.

Youn, S., Collisson, E. W. & Machamer, C. E., 2006, In : Advances in Experimental Medicine and Biology. 581, p. 109-112 4 p.

Research output: Contribution to journalArticle

Viral Gene Expression Regulation
Nucleic Acid Sequence Homology
Molecular Sequence Data
Genetic Transcription
Infectious bronchitis virus

Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p

Sesaki, H., Dunn, C. D., Iijima, M., Shepard, K. A., Yaffe, M. P., Machamer, C. E. & Jensen, R. E., Jun 5 2006, In : Journal of Cell Biology. 173, 5, p. 651-658 8 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Membranes
Dynamins
GTP Phosphohydrolases
Proteolysis
2005

Caspase-resistant golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors

Maag, R. S., Mancini, M., Rosen, A. & Machamer, C. E., 2005, In : Molecular Biology of the Cell. 16, 6, p. 3019-3027 9 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Secretory Pathway
Caspases
Ligation
Apoptosis

Contribution of trafficking signals in the cytoplasmic tail of the infectious bronchitis virus spike protein to virus infection

Youn, S., Collisson, E. W. & Machamer, C. E., Nov 2005, In : Journal of Virology. 79, 21, p. 13209-13217 9 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Virus Diseases
Endocytosis
endocytosis
tail

Golgi structure in stress sensing and apoptosis

Hicks, S. W. & Machamer, C. E., Jul 10 2005, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1744, 3 SPEC. ISS., p. 406-414 9 p.

Research output: Contribution to journalArticle

Golgi Apparatus
Apoptosis
Microtubule-Organizing Center
Endoplasmic Reticulum Stress
Membranes

Infectious bronchitis virus 3a protein localizes to a novel domain of the smooth endoplasmic reticulum

Pendleton, A. R. & Machamer, C. E., May 2005, In : Journal of Virology. 79, 10, p. 6142-6151 10 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Smooth Endoplasmic Reticulum
smooth endoplasmic reticulum
Bronchitis
bronchitis

Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST

Hicks, S. W. & Machamer, C. E., Aug 12 2005, In : Journal of Biological Chemistry. 280, 32, p. 28944-28951 8 p.

Research output: Contribution to journalArticle

Protein Isoforms
Proteins
Leucine
Head
PDZ Domains

Targeting of the mitochondrial membrane proteins to the cell surface for functional studies

Ardehali, H., Xue, T., Dong, P. & Machamer, C. E., Dec 16 2005, In : Biochemical and Biophysical Research Communications. 338, 2, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Mitochondrial Membranes
Membrane Proteins
Cell membranes
Ions
2004

Intracellular targeting signals contribute to localization of coronavirus spike proteins near the virus assembly site

Lontok, E., Corse, E. & Machamer, C. E., Jun 2004, In : Journal of Virology. 78, 11, p. 5913-5922 10 p.

Research output: Contribution to journalArticle

Coronavirus Spike Glycoproteins
Virus Assembly
Coronavirus
Coronavirinae
Protein S

Phosphorylation of golgin-160 by mixed lineage kinase 3

Cha, H., Smith, B. L., Gallo, K., Machamer, C. E. & Shapiro, P., Feb 15 2004, In : Journal of Cell Science. 117, 5, p. 751-760 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Head
Caspases
Phosphotransferases
Apoptosis
2003

Death from within: Apoptosis and the secretory pathway

Maag, R. S., Hicks, S. W. & Machamer, C. E., Aug 2003, In : Current Opinion in Cell Biology. 15, 4, p. 456-461 6 p.

Research output: Contribution to journalArticle

Secretory Pathway
Apoptosis
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Organelles

Golgi disassembly in apoptosis: Cause or effect?

Machamer, C. E., Jun 1 2003, In : Trends in Cell Biology. 13, 6, p. 279-281 3 p.

Research output: Contribution to journalArticle

Apoptosis
Organelles
Transport Vesicles
Proteins
Golgi Apparatus

The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction

Corse, E. & Machamer, C. E., Jul 20 2003, In : Virology. 312, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
Virion
Proteins
Virus Release
Coronavirus
2002

The cytoplasmic tail of infectious bronchitis virus E protein directs golgi targeting

Corse, E. & Machamer, C. E., 2002, In : Journal of Virology. 76, 3, p. 1273-1284 12 p.

Research output: Contribution to journalArticle

Infectious bronchitis virus
tail
Coronavirus
Proteins
Coronavirinae