Caren L Meyers

Associate Professor

20002019

Research output per year

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Research Output

2019

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

Hobson, J. J., Curley, P., Savage, A. C., Al-Khouja, A., Siccardi, M., Flexner, C., Meyers, C. F., Owen, A. & Rannard, S. P., Jan 1 2019, In : Nanoscale Advances. 1, 11, p. 4301-4307 7 p.

Research output: Contribution to journalArticle

Open Access

Enamide Prodrugs of Acetyl Phosphonate Deoxy- d -xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents

Bartee, D., Sanders, S., Phillips, P. D., Harrison, M. J., Koppisch, A. T. & Meyers, C. L., Mar 8 2019, In : ACS Infectious Diseases. 5, 3, p. 406-417 12 p.

Research output: Contribution to journalArticle

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Hobson, J. J., Al-khouja, A., Curley, P., Meyers, D. J., Flexner, C. W., Siccardi, M., Owen, A., Meyers, C. L. & Rannard, S. P., Dec 1 2019, In : Nature communications. 10, 1, 1413.

Research output: Contribution to journalArticle

X-ray crystallography–based structural elucidation of enzyme-bound intermediates along the 1-deoxy-D-xylulose 5-phosphate synthase reaction coordinate

Chen, P. Y. T., DeColli, A. A., Meyers, C. L. & Drennan, C. L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 33, p. 12405-12414 10 p.

Research output: Contribution to journalArticle

2018

Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors

Sanders, S., Bartee, D., Harrison, M. J., Phillips, P. D., Koppisch, A. T. & Meyers, C. L., May 1 2018, In : PLoS One. 13, 5, e0197638.

Research output: Contribution to journalArticle

Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria

DeColli, A. A., Nemeria, N. S., Majumdar, A., Gerfen, G. J., Jordan, F. & Meyers, C. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 28, p. 10857-10869 13 p.

Research output: Contribution to journalArticle

Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase

Bartee, D. & Meyers, C. L., May 14 2018, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

2017

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

Afanador, G. A., Guerra, A. J., Swift, R. P., Rodriguez, R. E., Bartee, D., Matthews, K. A., Schön, A., Freire, E. I., Meyers, C. L. & Prigge, S. T., Nov 1 2017, In : Molecular Microbiology. 106, 3, p. 439-451 13 p.

Research output: Contribution to journalArticle

Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy- d -xylulose 5-Phosphate Synthase

Sanders, S., Vierling, R. J., Bartee, D., Decolli, A. A., Harrison, M. J., Aklinski, J. L., Koppisch, A. T. & Meyers, C. L., Jul 14 2017, In : ACS Infectious Diseases. 3, 7, p. 467-478 12 p.

Research output: Contribution to journalArticle

Conformational dynamics of 1-deoxy-D-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS

Zhou, J., Yang, L., DeColli, A., Meyers, C. L., Nemeria, N. S. & Jordan, F., Aug 29 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 35, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents

Rajoli, R. K. R., Back, D. J., Rannard, S., Meyers, C. L., Flexner, C. W., Owen, A. & Siccardi, M., May 24 2017, (Accepted/In press) In : Clinical Pharmacokinetics. p. 1-12 12 p.

Research output: Contribution to journalArticle

2016

Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Nemeria, N. S., Shome, B., Decolli, A. A., Heflin, K., Begley, T. P., Meyers, C. L. & Jordan, F., Mar 1 2016, In : Biochemistry®. 55, 7, p. 1135-1148 14 p.

Research output: Contribution to journalArticle

2015

Hydroxybenzaldoximes Are D -GAP-Competitive Inhibitors of E. coli 1-Deoxy- D -Xylulose-5-Phosphate Synthase

Bartee, D., Morris, F., Al-Khouja, A. & Meyers, C. L., Aug 1 2015, In : ChemBioChem. 16, 12, p. 1771-1781 11 p.

Research output: Contribution to journalArticle

Pharmacological activation of myosin ii paralogs to correct cell mechanics defects

Surcel, A., Ng, W. P., West-Foyle, H., Zhu, Q., Ren, Y., Avery, L. B., Krenc, A. K., Meyers, D. J., Rock, R. S., Anders, R. A., Meyers, C. L. & Robinson, D., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1428-1433 6 p.

Research output: Contribution to journalArticle

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV

Rajoli, R. K. R., Back, D. J., Rannard, S., Meyers, C. L., Flexner, C. W., Owen, A. & Siccardi, M., Dec 19 2015, In : Clinical Pharmacokinetics. 54, 6, p. 639-650 12 p.

Research output: Contribution to journalArticle

Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr)

Armstrong, C. M., Meyers, D. J., Imlay, L. S., Meyers, C. L. & Odom, A. R., Sep 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5511-5519 9 p.

Research output: Contribution to journalArticle

2014

Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines

Webster, M. R., Kamat, C., Connis, N., Zhao, M., Weeraratna, A. T., Rudek, M. A., Hann, C. L. & Meyers, C. L. F., Feb 2014, In : Molecular Cancer Therapeutics. 13, 2, p. 297-306 10 p.

Research output: Contribution to journalArticle

Defining critical residues for substrate binding to 1-deoxy- d -xylulose 5-phosphate synthase - Active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

Brammer Basta, L. A., Patel, H., Kakalis, L., Jordan, F. & Meyers, C. L., 2014, In : FEBS Journal. 281, 12, p. 2820-2837 18 p.

Research output: Contribution to journalArticle

Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for malaria venture malaria box active in blood and liver stage plasmodium falciparum parasites

Hain, A. U. P., Bartee, D., Sanders, N. G., Miller, A. S., Sullivan, D. J., Levitskaya, J., Meyers, C. L. & Bosch, J., Jun 12 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4521-4531 11 p.

Research output: Contribution to journalArticle

Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

Afanador, G. A., Matthews, K. A., Bartee, D., Gisselberg, J. E., Walters, M. S., Meyers, C. L. & Prigge, S. T., Oct 1 2014, In : Molecular Microbiology. 94, 1, p. 156-171 16 p.

Research output: Contribution to journalArticle

Targeting DXP synthase in human pathogens: Enzyme inhibition and antimicrobial activity of butylacetylphosphonate

Smith, J. M., Warrington, N. V., Vierling, R. J., Kuhn, M. L., Anderson, W. F., Koppisch, A. T. & Meyers, C. L., Jan 2014, In : Journal of Antibiotics. 67, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

2013

DXP synthase-catalyzed c-n bond formation: Nitroso substrate specificity studies guide selective inhibitor design

Morris, F., Vierling, R., Boucher, L., Bosch, J. & Meyers, C. L., Jul 2013, In : ChemBioChem. 14, 11, p. 1309-1315 7 p.

Research output: Contribution to journalArticle

GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK

Park, S., Lee, C., Sabharwal, P., Zhang, M., Meyers, C. L. & Sockanathan, S., Jan 18 2013, In : Science. 339, 6117, p. 324-328 5 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF

Kipchirchir Bitok, J. & Meyers, C. L., 2013, In : MedChemComm. 4, 1, p. 130-134 5 p.

Research output: Contribution to journalArticle

2012

2 C-methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity

Kipchirchir Bitok, J. & Meyers, C. L., Oct 19 2012, In : ACS Chemical Biology. 7, 10, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

Selective inhibition of E. coli 1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

Smith, J. M., Vierling, R. J. & Meyers, C. L., 2012, In : MedChemComm. 3, 1, p. 65-67 3 p.

Research output: Contribution to journalArticle

2011

1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism

Brammer, L. A., Smith, J. M., Wade, H. & Meyers, C. L., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36522-36531 10 p.

Research output: Contribution to journalArticle

Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells

Webster, M. R., Zhao, M., Rudek-Renaut, M., Hann, C. & Meyers, C. L., Oct 13 2011, In : Journal of Medicinal Chemistry. 54, 19, p. 6647-6656 10 p.

Research output: Contribution to journalArticle

IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications

Xiao, Y., Rooker, D., You, Q., Meyers, C. L. & Liu, P., Mar 7 2011, In : ChemBioChem. 12, 4, p. 527-530 4 p.

Research output: Contribution to journalArticle

2010

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: Synthesis from an epoxide and mechanisms

Xiao, Y., Nyland, R. L., Meyers, C. L. & Liu, P., Oct 14 2010, In : Chemical Communications. 46, 38, p. 7220-7222 3 p.

Research output: Contribution to journalArticle

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

Gómez García, I., Stevenson, C. E. M., Usón, I., Meyers, C. L., Walsh, C. T. & Lawson, D. M., Jan 15 2010, In : Journal of Molecular Biology. 395, 2, p. 390-407 18 p.

Research output: Contribution to journalArticle

Versatile 1H-31P-31P COSY 2D NMR Techniques for the Characterization of Polyphosphorylated Small Molecules

Majumdar, A., Sun, Y., Shah, M. & Meyers, C. L., May 21 2010, In : Journal of Organic Chemistry. 75, 10, p. 3214-3223 10 p.

Research output: Contribution to journalArticle

2009

Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using 1H-31P-31P correlation NMR spectroscopy

Majumdar, A., Shah, M. H., Bitok, J. K., Hassis-Lebeau, M. E. & Meyers, C. L., 2009, In : Molecular BioSystems. 5, 9, p. 935-944 10 p.

Research output: Contribution to journalArticle

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase

Brammer, L. A. & Meyers, C. L., Oct 15 2009, In : Organic Letters. 11, 20, p. 4748-4751 4 p.

Research output: Contribution to journalArticle

2008

Thin-layer chromatography

Meyers, C. L. & Meyers, D. J., 2008, In : Current Protocols in Nucleic Acid Chemistry. SUPPL. 34

Research output: Contribution to journalArticle

2007
2006

Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase

Tello, M., Jakimowicz, P., Errey, J. C., Meyers, C. L., Walsh, C. T., Buttner, M. J., Lawson, D. M. & Field, R. A., 2006, In : Chemical Communications. 10, p. 1079-1081 3 p.

Research output: Contribution to journalArticle

The 1.6-Å resolution crystal structure of NovW: A 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

Jakimowicz, P., Tello, M., Meyers, C. L., Walsh, C. T., Buttner, M. J., Field, R. A. & Lawson, D. M., Apr 1 2006, In : Proteins. 63, 1, p. 261-265 5 p.

Research output: Contribution to journalArticle

2005

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway

Pacholec, M., Meyers, C. L., Oberthür, M., Kahne, D. & Walsh, C. T., Mar 29 2005, In : Biochemistry®. 44, 12, p. 4949-4956 8 p.

Research output: Contribution to journalArticle

2004

A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Wu, W., Meyers, C. L. & Borch, R. F., Jun 24 2004, In : Organic Letters. 6, 13, p. 2257-2260 4 p.

Research output: Contribution to journalArticle

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN

Meyers, C. L., Oberthür, M., Heide, L., Kahne, D. & Walsh, C. T., Nov 30 2004, In : Biochemistry®. 43, 47, p. 15022-15036 15 p.

Research output: Contribution to journalArticle

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring

Meyers, C. L., Oberthür, M., Xu, H., Heide, L., Kahne, D. & Walsh, C. T., Dec 22 2004, In : Angewandte Chemie - International Edition. 43, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton

Pi, N., Meyers, C. L., Pacholec, M., Walsh, C. T. & Leary, J. A., Jul 6 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 27, p. 10036-10041 6 p.

Research output: Contribution to journalArticle

2003

Antibiotic glycosyltransferases: Antibiotic maturation and prospects for reprogramming

Walsh, C., Meyers, C. L. & Losey, H. C., Jul 31 2003, In : Journal of Medicinal Chemistry. 46, 16, p. 3425-3436 12 p.

Research output: Contribution to journalArticle

Antibiotic glycosyltransferases

Walsh, C. T., Losey, H. C. & Meyers, C. L., Jun 2003, In : Biochemical Society Transactions. 31, 3, p. 487-492 6 p.

Research output: Contribution to journalArticle