Caren L Meyers

Associate Professor

20002019
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Research Output 2000 2019

2019

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

Hobson, J. J., Curley, P., Savage, A. C., Al-Khouja, A., Siccardi, M., Flexner, C., Meyers, C. F., Owen, A. & Rannard, S. P., Jan 1 2019, In : Nanoscale Advances. 1, 11, p. 4301-4307 7 p.

Research output: Contribution to journalArticle

Open Access
Tenofovir
Oils
drugs
oils
Nanoparticles

Enamide Prodrugs of Acetyl Phosphonate Deoxy- d -xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents

Bartee, D., Sanders, S., Phillips, P. D., Harrison, M. J., Koppisch, A. T. & Meyers, C. L., Mar 8 2019, In : ACS Infectious Diseases. 5, 3, p. 406-417 12 p.

Research output: Contribution to journalArticle

Organophosphonates
Prodrugs
Anti-Bacterial Agents
Bacterial Physiological Phenomena
Thiamine Pyrophosphate

Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Hobson, J. J., Al-khouja, A., Curley, P., Meyers, D. J., Flexner, C. W., Siccardi, M., Owen, A., Meyers, C. L. & Rannard, S. P., Dec 1 2019, In : Nature communications. 10, 1, 1413.

Research output: Contribution to journalArticle

human immunodeficiency virus
Prodrugs
Drug Combinations
Viruses
Nanoparticles

X-ray crystallography–based structural elucidation of enzyme-bound intermediates along the 1-deoxy-D-xylulose 5-phosphate synthase reaction coordinate

Chen, P. Y. T., DeColli, A. A., Meyers, C. L. & Drennan, C. L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 33, p. 12405-12414 10 p.

Research output: Contribution to journalArticle

Decarboxylation
X-Rays
X rays
Xylulose
Glyceraldehyde 3-Phosphate
2018

Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors

Sanders, S., Bartee, D., Harrison, M. J., Phillips, P. D., Koppisch, A. T. & Meyers, C. L., May 1 2018, In : PLoS One. 13, 5, e0197638.

Research output: Contribution to journalArticle

Nutrients
culture media
anti-infective agents
Phosphates
phosphates

Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria

DeColli, A. A., Nemeria, N. S., Majumdar, A., Gerfen, G. J., Jordan, F. & Meyers, C. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 28, p. 10857-10869 13 p.

Research output: Contribution to journalArticle

Decarboxylation
Pyruvic Acid
Bacteria
Phosphates
Thiamine Pyrophosphate
Pathogens
Phosphates
Escherichia coli
Substrates
Antimetabolites

Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase

Bartee, D. & Meyers, C. L., May 14 2018, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

Glyceraldehyde 3-Phosphate
Thiamine Pyrophosphate
Diphosphates
Pyruvic Acid
Triazoles
Metabolism
Thiamine Pyrophosphate
Anti-Bacterial Agents
Enzymes
Phosphates
2017

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

Afanador, G. A., Guerra, A. J., Swift, R. P., Rodriguez, R. E., Bartee, D., Matthews, K. A., Schön, A., Freire, E. I., Meyers, C. L. & Prigge, S. T., Nov 1 2017, In : Molecular Microbiology. 106, 3, p. 439-451 13 p.

Research output: Contribution to journalArticle

Plasmodium
Chlamydia
Lipoylation
Oxidation-Reduction
Enzymes

Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy- d -xylulose 5-Phosphate Synthase

Sanders, S., Vierling, R. J., Bartee, D., Decolli, A. A., Harrison, M. J., Aklinski, J. L., Koppisch, A. T. & Meyers, C. L., Jul 14 2017, In : ACS Infectious Diseases. 3, 7, p. 467-478 12 p.

Research output: Contribution to journalArticle

Thiamine Pyrophosphate
Glyceraldehyde 3-Phosphate
Bacteria
xylulose-5-phosphate
Growth Inhibitors

Conformational dynamics of 1-deoxy-D-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS

Zhou, J., Yang, L., DeColli, A., Meyers, C. L., Nemeria, N. S. & Jordan, F., Aug 29 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 35, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

Ligands
Thiamine Pyrophosphate
Glyceraldehyde 3-Phosphate
Enzymes
Decarboxylation

In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents

Rajoli, R. K. R., Back, D. J., Rannard, S., Meyers, C. L., Flexner, C. W., Owen, A. & Siccardi, M., May 24 2017, (Accepted/In press) In : Clinical Pharmacokinetics. p. 1-12 12 p.

Research output: Contribution to journalArticle

Rilpivirine
Computer Simulation
Pharmacokinetics
Injections
Physiological Phenomena
2016

Competence of Thiamin Diphosphate-Dependent Enzymes with 2′-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin

Nemeria, N. S., Shome, B., Decolli, A. A., Heflin, K., Begley, T. P., Meyers, C. L. & Jordan, F., Mar 1 2016, In : Biochemistry®. 55, 7, p. 1135-1148 14 p.

Research output: Contribution to journalArticle

Thiamine Pyrophosphate
Diphosphates
Thiamine
Vitamins
Mental Competency
2015

Hydroxybenzaldoximes Are D -GAP-Competitive Inhibitors of E. coli 1-Deoxy- D -Xylulose-5-Phosphate Synthase

Bartee, D., Morris, F., Al-Khouja, A. & Meyers, C. L., Aug 1 2015, In : ChemBioChem. 16, 12, p. 1771-1781 11 p.

Research output: Contribution to journalArticle

Escherichia coli
Glyceraldehyde 3-Phosphate
Biosynthesis
Terpenes
Vitamin B 6

Pharmacological activation of myosin ii paralogs to correct cell mechanics defects

Surcel, A., Ng, W. P., West-Foyle, H., Zhu, Q., Ren, Y., Avery, L. B., Krenc, A. K., Meyers, D. J., Rock, R. S., Anders, R. A., Meyers, C. L. & Robinson, D., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1428-1433 6 p.

Research output: Contribution to journalArticle

Myosins
Mechanics
Pharmacology
Myosin Type II
Nonmuscle Myosin Type IIB

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV

Rajoli, R. K. R., Back, D. J., Rannard, S., Meyers, C. L., Flexner, C. W., Owen, A. & Siccardi, M., Dec 19 2015, In : Clinical Pharmacokinetics. 54, 6, p. 639-650 12 p.

Research output: Contribution to journalArticle

Pharmacokinetics
HIV
Rilpivirine
Tenofovir
efavirenz

Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr)

Armstrong, C. M., Meyers, D. J., Imlay, L. S., Meyers, C. L. & Odom, A. R., Sep 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5511-5519 9 p.

Research output: Contribution to journalArticle

Prodrugs
Anti-Infective Agents
Mutation
Genes
Polyisoprenyl Phosphates
2014

Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines

Webster, M. R., Kamat, C., Connis, N., Zhao, M., Weeraratna, A. T., Rudek, M. A., Hann, C. L. & Meyers, C. L. F., Feb 2014, In : Molecular Cancer Therapeutics. 13, 2, p. 297-306 10 p.

Research output: Contribution to journalArticle

Clodronic Acid
Prodrugs
Melanoma
Cell Line
Diphosphonates

Defining critical residues for substrate binding to 1-deoxy- d -xylulose 5-phosphate synthase - Active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

Brammer Basta, L. A., Patel, H., Kakalis, L., Jordan, F. & Meyers, C. L., 2014, In : FEBS Journal. 281, 12, p. 2820-2837 18 p.

Research output: Contribution to journalArticle

Glyceraldehyde 3-Phosphate
Diphosphates
Decarboxylation
Catalytic Domain
Substitution reactions

Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for malaria venture malaria box active in blood and liver stage plasmodium falciparum parasites

Hain, A. U. P., Bartee, D., Sanders, N. G., Miller, A. S., Sullivan, D. J., Levitskaya, J., Meyers, C. L. & Bosch, J., Jun 12 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4521-4531 11 p.

Research output: Contribution to journalArticle

Autophagy
Plasmodium falciparum
Malaria
Parasites
Liver

Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

Afanador, G. A., Matthews, K. A., Bartee, D., Gisselberg, J. E., Walters, M. S., Meyers, C. L. & Prigge, S. T., Oct 1 2014, In : Molecular Microbiology. 94, 1, p. 156-171 16 p.

Research output: Contribution to journalArticle

Lipoylation
Mitochondrial Proteins
Plasmodium falciparum
Oxidation-Reduction
Oxidoreductases

Targeting DXP synthase in human pathogens: Enzyme inhibition and antimicrobial activity of butylacetylphosphonate

Smith, J. M., Warrington, N. V., Vierling, R. J., Kuhn, M. L., Anderson, W. F., Koppisch, A. T. & Meyers, C. L., Jan 2014, In : Journal of Antibiotics. 67, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

Thiamine Pyrophosphate
Salmonella enterica
Enzymes
Polyisoprenyl Phosphates
Glyceraldehyde 3-Phosphate
2013

DXP synthase-catalyzed c-n bond formation: Nitroso substrate specificity studies guide selective inhibitor design

Morris, F., Vierling, R., Boucher, L., Bosch, J. & Meyers, C. L., Jul 2013, In : ChemBioChem. 14, 11, p. 1309-1315 7 p.

Research output: Contribution to journalArticle

Substrate Specificity
Substrates
Glyceraldehyde 3-Phosphate
Pyruvic Acid
Thiamine Pyrophosphate

GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK

Park, S., Lee, C., Sabharwal, P., Zhang, M., Meyers, C. L. & Sockanathan, S., Jan 18 2013, In : Science. 339, 6117, p. 324-328 5 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Neurogenesis
Motor Neurons
glycerophosphodiester phosphodiesterase
Disintegrins

Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF

Kipchirchir Bitok, J. & Meyers, C. L., 2013, In : MedChemComm. 4, 1, p. 130-134 5 p.

Research output: Contribution to journalArticle

Diphosphonates
Modulators
Diphosphates
Substrates
Escherichia coli
2012

2 C-methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity

Kipchirchir Bitok, J. & Meyers, C. L., Oct 19 2012, In : ACS Chemical Biology. 7, 10, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

Terpenes
Biosynthesis
Erythritol
Feedback
Diphosphates
Glyceraldehyde 3-Phosphate
Decarboxylation
Thiamine Pyrophosphate
Thiamine
Pyruvic Acid

Selective inhibition of E. coli 1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

Smith, J. M., Vierling, R. J. & Meyers, C. L., 2012, In : MedChemComm. 3, 1, p. 65-67 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Terpenes
Escherichia coli
Pathogens
Anti-Infective Agents
2011

1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism

Brammer, L. A., Smith, J. M., Wade, H. & Meyers, C. L., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36522-36531 10 p.

Research output: Contribution to journalArticle

Pathogens
Kinetics
Glyceraldehyde 3-Phosphate
Thiamine Pyrophosphate
Biosynthetic Pathways

Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells

Webster, M. R., Zhao, M., Rudek-Renaut, M., Hann, C. & Meyers, C. L., Oct 13 2011, In : Journal of Medicinal Chemistry. 54, 19, p. 6647-6656 10 p.

Research output: Contribution to journalArticle

Clodronic Acid
Prodrugs
Diphosphonates
Non-Small Cell Lung Carcinoma
Calcium Metabolism Disorders

IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications

Xiao, Y., Rooker, D., You, Q., Meyers, C. L. & Liu, P., Mar 7 2011, In : ChemBioChem. 12, 4, p. 527-530 4 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Hydroxyl Radical
Oxygen
deoxyxylulose phosphate
2010

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: Synthesis from an epoxide and mechanisms

Xiao, Y., Nyland, R. L., Meyers, C. L. & Liu, P., Oct 14 2010, In : Chemical Communications. 46, 38, p. 7220-7222 3 p.

Research output: Contribution to journalArticle

Diphosphates
Epoxy Compounds
Reducing Agents
Phosphates
Communication

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

Gómez García, I., Stevenson, C. E. M., Usón, I., Meyers, C. L., Walsh, C. T. & Lawson, D. M., Jan 15 2010, In : Journal of Molecular Biology. 395, 2, p. 390-407 18 p.

Research output: Contribution to journalArticle

Novobiocin
Methyltransferases
Anti-Bacterial Agents
Aminocoumarins
Enzymes

Versatile 1H-31P-31P COSY 2D NMR Techniques for the Characterization of Polyphosphorylated Small Molecules

Majumdar, A., Sun, Y., Shah, M. & Meyers, C. L., May 21 2010, In : Journal of Organic Chemistry. 75, 10, p. 3214-3223 10 p.

Research output: Contribution to journalArticle

Diphosphates
Nuclear magnetic resonance
Molecules
Polyisoprenyl Phosphates
Bearings (structural)
2009
Epoxy Compounds
Biosynthesis
Terpenes
Catalysis
Enzymes

Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using 1H-31P-31P correlation NMR spectroscopy

Majumdar, A., Shah, M. H., Bitok, J. K., Hassis-Lebeau, M. E. & Meyers, C. L., 2009, In : Molecular BioSystems. 5, 9, p. 935-944 10 p.

Research output: Contribution to journalArticle

Terpenes
Magnetic Resonance Spectroscopy
Phosphorylation
Diphosphates
Enzymes

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase

Brammer, L. A. & Meyers, C. L., Oct 15 2009, In : Organic Letters. 11, 20, p. 4748-4751 4 p.

Research output: Contribution to journalArticle

Pyruvic Acid
phosphates
Substrates
pyruvates
flexibility
2008
Aminocoumarins
DNA Gyrase
Novobiocin
Bacterial DNA
Synchrotrons

Thin-layer chromatography

Meyers, C. L. & Meyers, D. J., 2008, In : Current Protocols in Nucleic Acid Chemistry. SUPPL. 34

Research output: Contribution to journalArticle

Thin layer chromatography
Column chromatography
Thin Layer Chromatography
Chromatography
Metrorrhagia
2007
Aminocoumarins
DNA Gyrase
Novobiocin
methionine
Bacterial DNA
2006

Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase

Tello, M., Jakimowicz, P., Errey, J. C., Meyers, C. L., Walsh, C. T., Buttner, M. J., Lawson, D. M. & Field, R. A., 2006, In : Chemical Communications. 10, p. 1079-1081 3 p.

Research output: Contribution to journalArticle

Racemases and Epimerases
thymidine diphosphate-6-deoxy-xylo-4-hexulose

The 1.6-Å resolution crystal structure of NovW: A 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

Jakimowicz, P., Tello, M., Meyers, C. L., Walsh, C. T., Buttner, M. J., Field, R. A. & Lawson, D. M., Apr 1 2006, In : Proteins. 63, 1, p. 261-265 5 p.

Research output: Contribution to journalArticle

Carbohydrate Epimerases
Nucleoside Diphosphate Sugars
Deoxy Sugars
Novobiocin
Racemases and Epimerases
2005

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway

Pacholec, M., Meyers, C. L., Oberthür, M., Kahne, D. & Walsh, C. T., Mar 29 2005, In : Biochemistry®. 44, 12, p. 4949-4956 8 p.

Research output: Contribution to journalArticle

Aminocoumarins
Novobiocin
Ligases
Streptomyces antibioticus
DNA Gyrase
2004

A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Wu, W., Meyers, C. L. & Borch, R. F., Jun 24 2004, In : Organic Letters. 6, 13, p. 2257-2260 4 p.

Research output: Contribution to journalArticle

nucleosides
Nucleosides
preparation
zwitterions
Hydrogen

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN

Meyers, C. L., Oberthür, M., Heide, L., Kahne, D. & Walsh, C. T., Nov 30 2004, In : Biochemistry®. 43, 47, p. 15022-15036 15 p.

Research output: Contribution to journalArticle

Aminocoumarins
Scaffolds
Novobiocin
Enzymes
DNA Gyrase

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring

Meyers, C. L., Oberthür, M., Xu, H., Heide, L., Kahne, D. & Walsh, C. T., Dec 22 2004, In : Angewandte Chemie - International Edition. 43, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

Novobiocin
Biosynthesis
Antibiotics
Sugars
Escherichia coli

Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton

Pi, N., Meyers, C. L., Pacholec, M., Walsh, C. T. & Leary, J. A., Jul 6 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 27, p. 10036-10041 6 p.

Research output: Contribution to journalArticle

Novobiocin
Skeleton
Ligases
Enzymes
Anti-Bacterial Agents
2003

Antibiotic glycosyltransferases

Walsh, C. T., Losey, H. C. & Meyers, C. L., Jun 2003, In : Biochemical Society Transactions. 31, 3, p. 487-492 6 p.

Research output: Contribution to journalArticle

Glycosyltransferases
Anti-Bacterial Agents
Novobiocin
Biosynthesis
Vancomycin

Antibiotic glycosyltransferases: Antibiotic maturation and prospects for reprogramming

Walsh, C., Meyers, C. L. & Losey, H. C., Jul 31 2003, In : Journal of Medicinal Chemistry. 46, 16, p. 3425-3436 12 p.

Research output: Contribution to journalArticle

Coumarins
Glycosyltransferases
Molecular Models
Hexoses
Glycopeptides