C John Sperati

Associate Professor

19972019
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Research Output 1997 2019

2019

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease

CureGN Consortium, Feb 1 2019, In : American Journal of Kidney Diseases. 73, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Observational Studies
Prospective Studies
Chronic Kidney Failure
IGA Glomerulonephritis
Lipoid Nephrosis

Drug-Induced Hypertension

Foy, M. C., Vaishnav, J. & Sperati, C. J., Jan 1 2019, (Accepted/In press) In : Endocrinology and metabolism clinics of North America.

Research output: Contribution to journalReview article

Blood Pressure
Hypertension
Polypharmacy
Renin-Angiotensin System
Drug-Related Side Effects and Adverse Reactions

Egad!

Platt, L., Deboer, S. R., Shenderov, K., Probasco, J. C., Guterman, E. L., Manesh, R. & Sperati, C. J., Mar 1 2019, In : Journal of hospital medicine. 14, 3, p. 181-185 5 p.

Research output: Contribution to journalArticle

Open Access

Primary Care Physicians’ Perceived Barriers to Nephrology Referral and Co-management of Patients with CKD: a Qualitative Study

On behalf of the National Kidney Foundation Education Committee, Jan 1 2019, In : Journal of general internal medicine.

Research output: Contribution to journalArticle

Nephrology
Primary Care Physicians
Chronic Renal Insufficiency
Referral and Consultation
Baltimore

Primary care physicians’ perceptions of barriers and facilitators to management of chronic kidney disease: A mixed methods study

on behalf of the National Kidney Foundation Education Committee¶, Jan 1 2019, In : PloS one. 14, 8, e0221325.

Research output: Contribution to journalArticle

Open Access
Primary Care Physicians
kidney diseases
Chronic Renal Insufficiency
physicians
methodology

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Upreti, H., Kasmani, J., Dane, K., Braunstein, E., Streiff, M. B., Shanbhag, S. P., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S. & Chaturvedi, S., Sep 26 2019, In : Blood. 134, 13, p. 1037-1045 9 p.

Research output: Contribution to journalArticle

Thrombotic Thrombocytopenic Purpura
Survivors
Stroke
Recovery
Patient treatment
2018
Vasculitis
Immunoglobulin A
Therapeutics
Immunosuppressive Agents
Biopsy

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

Vaught, A., Braunstein, E., Jasem, J., Yuan, X., Makhlin, I., Eloundou, S., Baines, A. C., Merrill, S., Chaturvedi, S., Blakemore, K., Sperati, C. J. & Brodsky, R. A., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Alternative Complement Pathway
Germ-Line Mutation
Hemolysis
Blood Platelets
Liver

Hydroxychloroquine-induced mimic of renal Fabry disease

Sperati, C. J. & Rosenberg, A., Sep 1 2018, In : Kidney International. 94, 3, 1 p.

Research output: Contribution to journalArticle

Hydroxychloroquine
Fabry Disease
Kidney

Raman Spectroscopy for the Diagnosis of Intratubular Triamterene Crystallization

Sperati, C. J., Zhang, C., Delsante, M., Gupta, R., Bagnasco, S. M. & Barman, I., Jan 1 2018, (Accepted/In press) In : Kidney International Reports.

Research output: Contribution to journalArticle

Triamterene
Raman Spectrum Analysis
Crystallization

Renal vein thrombosis and pulmonary embolism

Chedid, A., Hanouneh, M. & Sperati, C. J., Nov 1 2018, In : Cleveland Clinic Journal of Medicine. 85, 11, p. 833-834 2 p.

Research output: Contribution to journalArticle

Renal Veins
Pulmonary Embolism
Thrombosis

What the non-nephrologist needs to know about dialysis

Foy, M. & Sperati, C. J., Mar 1 2018, In : Seminars in Dialysis. 31, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

Dialysis
Peritoneal Dialysis
Chronic Kidney Failure
Renal Dialysis
Home Hemodialysis
2017
medicine
curriculum
examination
confidence
physician-patient relationship

Eculizumab cessation in atypical hemolytic uremic syndrome

Merrill, S., Brittingham, Z. D., Yuan, X., Moliterno, A. R., Sperati, C. J. & Brodsky, R. A., Jul 20 2017, In : Blood. 130, 3, p. 368-372 5 p.

Research output: Contribution to journalLetter

Antibodies, Monoclonal, Humanized
eculizumab

Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors

Muzaale, A., Althoff, K., Sperati, C. J., Abraham, A. G., Kucirka, L. M., Massie, A. B., Kitahata, M. M., Horberg, M. A., Justice, A. C., Fischer, M. J., Silverberg, M. J., Butt, A. A., Boswell, S. L., Rachlis, A. R., Mayor, A. M., Gill, M. J., Eron, J. J., Napravnik, S., Drozd, D. R., Martin, J. N. & 6 others, Bosch, R. J., Durand, C., Locke, J. E., Moore, R. D., Lucas, G. M. & Segev, D., 2017, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

Chronic Kidney Failure
Tissue Donors
HIV
Kidney
Incidence

The Hyperlipidemia Effect: Pseudohyponatremia in Pancreatic Cancer

Adashek, M. L., Clark, B. W., Sperati, C. J. & Massey, C. J., 2017, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

Hyperlipidemias
Pancreatic Neoplasms
2016

Feasibility and safety of physical therapy during continuous renal replacement therapy in the intensive care unit

Toonstra, A. L., Zanni, J. M., Sperati, C. J., Nelliot, A., Mantheiy, E., Skinner, E. H. & Needham, D., May 1 2016, In : Annals of the American Thoracic Society. 13, 5, p. 699-704 6 p.

Research output: Contribution to journalArticle

Renal Replacement Therapy
Intensive Care Units
Safety
Therapeutics
Rehabilitation

Renal Thrombotic Microangiopathy, Podocytopathy, and Chylous Ascites: A Hard-Nosed Diagnosis

McMahon, B. A., Moran, R. A., Sperati, C. J., Bagnasco, S. M., Novick, T. & Atta, M., Oct 1 2016, In : American Journal of Medicine. 129, 10, p. e227-e231

Research output: Contribution to journalComment/debate

Urinary fractional excretion indices in the evaluation of acute kidney injury

Pahwa, A. K. & Sperati, C. J., Jan 1 2016, In : Journal of Hospital Medicine. 11, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Urea
Biomarkers
Sodium
2015

Modified Ham test for atypical hemolytic uremic syndrome

Gavriilaki, E., Yuan, X., Ye, Z., Ambinder, A. J., Shanbhag, S. P., Streiff, M. B., Kickler, T. S., Moliterno, A. R., Sperati, C. J. & Brodsky, R. A., Jun 4 2015, In : Blood. 125, 23, p. 3637-3646 10 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Assays
Cells
Phosphoinositide Phospholipase C
Complement Membrane Attack Complex

Novel therapeutics in hypertension and kidney disease

Sperati, C. J. & Whaley-Connell, A., Sep 1 2015, In : Current Opinion in Nephrology and Hypertension. 24, 5, p. 401-402 2 p.

Research output: Contribution to journalArticle

Secondary hypertension: Beginnings and transitions

Sperati, C. J. & Whaley-Connell, A., May 1 2015, In : Advances in Chronic Kidney Disease. 22, 3, p. 177-178 2 p.

Research output: Contribution to journalArticle

Hypertension

Thrombotic Microangiopathy. Focus on Atypical Hemolytic Uremic Syndrome

Sperati, C. J. & Moliterno, A. R., Jun 1 2015, In : Hematology/Oncology Clinics of North America. 29, 3, p. 541-559 19 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Genetic Testing
Acute Disease
Registries
Chronic Disease
2014
Methylmalonic Acid
Liver Transplantation
Kidney Transplantation
Renal Dialysis
Transplants

Cachexia, urinary tract infection, nephromegaly, and kidney failure

Storm, A., Bhasin, B., Rangachari, D. & Sperati, C. J., 2014, In : American Journal of Kidney Diseases. 63, 1

Research output: Contribution to journalArticle

Kidney Function Tests
Malacoplakia
Bethanechol
Homeless Persons
Muscarinic Agonists

Cachexia, Urinary Tract Infection, Nephromegaly, and Kidney Failure

Storm, A., Bhasin, B., Rangachari, D. & Sperati, C. J., 2014, In : American Journal of Kidney Diseases. 63, 1, p. xviii-xxi

Research output: Contribution to journalArticle

Cachexia
Urinary Tract Infections
Renal Insufficiency

Chronic kidney disease in an adult with propionic acidemia

Vernon, H. J., Bagnasco, S. M., Hamosh, A. & Sperati, C. J., Jan 1 2014, JIMD Reports. Springer, p. 5-10 6 p. (JIMD Reports; vol. 12).

Research output: Chapter in Book/Report/Conference proceedingChapter

Propionic Acidemia
Chronic Renal Insufficiency
Kidney Diseases
Kidney
Pathology

Fibromuscular dysplasia: State of the science and critical unanswered questions: A scientific statement from the american heart association

Olin, J. W., Gornik, H. L., Bacharach, J. M., Biller, J., Fine, L. J., Gray, B. H., Gray, W. A., Gupta, R., Hamburg, N. M., Katzen, B. T., Lookstein, R. A., Lumsden, A. B., Newburger, J. W., Rundek, T., Sperati, C. J. & Stanley, J. C., Mar 4 2014, In : Circulation. 129, 9, p. 1048-1078 31 p.

Research output: Contribution to journalArticle

Fibromuscular Dysplasia
American Heart Association
Aneurysm
Dissection
Atherosclerosis

Variable clinical presentation of an MUC1 mutation causing medullary cystic kidney disease type 1

Bleyer, A. J., Kmoch, S., Antignac, C., Robins, V., Kidd, K., Kelsoe, J. R., Hladik, G., Klemmer, P., Knohl, S. J., Scheinman, S. J., Vo, N., Santi, A., Harris, A., Canaday, O., Weller, N., Hulick, P. J., Vogel, K., Rahbari-Oskoui, F. F., Tuazon, J., Deltas, C. & 14 others, Somers, D., Megarbane, A., Kimmel, P. L., Sperati, C. J., Orr-Urtreger, A., Ben-Shachar, S., Waugh, D. A., Mcginn, S., Bleyer, A. J., Hodaňová, K., Vyletal, P., Živná, M., Hart, T. C. & Hart, P. S., Mar 7 2014, In : Clinical Journal of the American Society of Nephrology. 9, 3, p. 527-535 9 p.

Research output: Contribution to journalArticle

Mucoproteins
Mutation
Chronic Kidney Failure
Age of Onset
Respiratory System
2013

Hemodialysis: Initiation and complications

Sperati, C. J., Nov 1 2013, Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer New York, p. 333-348 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Renal Dialysis
Dialysis
Catheters
Arteriovenous Fistula
Diabetic Nephropathies
Focal Segmental Glomerulosclerosis
Ribavirin
Hepacivirus
Interferons
Hepatitis
2012

All wrapped up and nowhere to flow

Naderi, A. A., Houston, B. A. & Sperati, C. J., Sep 2012, In : American Journal of Medicine. 125, 9, p. 876-879 4 p.

Research output: Contribution to journalArticle

Drug Administration Schedule
Mycophenolic Acid
Retroperitoneal Fibrosis
Surgical Decompression
Percutaneous Nephrostomy
2011

The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): A biopsy study

George, E., Nadkarni, G. N., Estrella, M. M., Lucas, G. M., Sperati, C. J., Atta, M. & Fine, D. M., Sep 2011, In : Medicine. 90, 5, p. 289-295 7 p.

Research output: Contribution to journalArticle

Kidney Diseases
Hepatitis C
Coinfection
HIV
Biopsy
2010
Idiopathic Thrombocytopenic Purpura
Antiphospholipid Syndrome
Acute Kidney Injury
Thrombocytopenia
Thrombopoietin Receptors

Genetic epidemiology of chronic kidney disease

Estrella, M. M., Sperati, C. J., Kao, W. H. L. & Parekh, R. S., May 2010, In : Current Opinion in Nephrology and Hypertension. 19, 3, p. 283-291 9 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Chronic Renal Insufficiency
Genome
Kidney Diseases
Disease Progression

Incidental Discovery of a Renal Cell Carcinoma on Native Kidney Biopsy

Sperati, C. J., Alachkar, N., Rodriguez, R., Haas, M. & Choi, M. J., Jul 2010, In : American Journal of Kidney Diseases. 56, 1, p. 175-180 6 p.

Research output: Contribution to journalArticle

Incidental Findings
Kidney Neoplasms
Renal Cell Carcinoma
Kidney
Biopsy

The Tissue's the Issue

Zeidner, J. F., Ostrin, E. J., Sydnor, E., Fine, D. M. & Sperati, C. J., May 2010, In : American Journal of Medicine. 123, 5, p. 420-422 3 p.

Research output: Contribution to journalArticle

Anti-Glomerular Basement Membrane Disease
Sinusitis
Differential Diagnosis
2009

Association of Single-Nucleotide Polymorphisms in JAK3, STAT4, and STAT6 With New Cardiovascular Events in Incident Dialysis Patients

Sperati, C. J., Parekh, R. S., Berthier-Schaad, Y., Jaar, B., Plantinga, L., Fink, N., Powe, N. R., Smith, M. W., Coresh, J. & Kao, W. H. L., May 2009, In : American Journal of Kidney Diseases. 53, 5, p. 845-855 11 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Dialysis
Janus Kinases
Cardiovascular Diseases
Transducers

Fibromuscular dysplasia

Sperati, C. J., Gilotra, N., Arepally, A. & Atta, M., Feb 2009, In : Kidney International. 75, 3, p. 333-336 4 p.

Research output: Contribution to journalArticle

Fibromuscular Dysplasia
Angiography
Kidney
Flank Pain
Polyarteritis Nodosa
Hepatitis C
Coinfection
HIV Infections
HIV
Kidney

Response to Causative vascular abnormalities for renal ischemia

Sperati, C. J., Gilotra, N., Arepally, A. & Atta, M., Jun 2009, In : Kidney International. 75, 12, p. 1354 1 p.

Research output: Contribution to journalArticle

Blood Vessels
Ischemia
Kidney
2006

Tuberculosis-associated haemophagocytic syndrome

Brastianos, P. K., Swanson, J. W., Torbenson, M., Sperati, C. J. & Karakousis, P., Jul 2006, In : Lancet Infectious Diseases. 6, 7, p. 447-454 8 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Tuberculosis
Mononuclear Phagocyte System
Macrophage Activation
Disease Management
1997

Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway

Collard, C. D., Väkevä, A., Büküsoglu, C., Zünd, G., Sperati, C. J., Colgan, S. P. & Stahl, G. L., Jul 1 1997, In : Circulation. 96, 1, p. 326-333 8 p.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Complement C3b
Complement C3
Alternative Complement Pathway
Cell Hypoxia