Brian O'Rourke

Professor

1984 …2020
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Research Output 1984 2020

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2020

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP

Papanicolaou, K. N., Ashok, D., Liu, T., Bauer, T. M., Sun, J., Li, Z., da Costa, E., D'Orleans, C. C., Nathan, S., Lefer, D. J., Murphy, E., Paolocci, N., Foster, D. B. & O'Rourke, B., Feb 2020, In : Journal of Molecular and Cellular Cardiology. 139, p. 176-189 14 p.

Research output: Contribution to journalArticle

Potassium Channels
Reperfusion Injury
Cardiac Myocytes
Ischemic Preconditioning
Kidney

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., O'Rourke, B. & He, L., Nov 5 2019, In : Cell Reports. 29, 6, p. 1511-1523.e5

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Metformin
Chemical activation
Respiration
Pharmacology

miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Banavath, H. N., Roman, B., Mackowski, N., Biswas, D., Afzal, J., Nomura, Y., Solhjoo, S., O'Rourke, B., Kohr, M., Murphy, E., Steenbergen, C. & Das, S., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e012919

Research output: Contribution to journalArticle

Open Access
Calcium
Reperfusion Injury
Mitochondria
Muscle Cells
Small Interfering RNA

Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice

Rovira Gonzalez, Y. I., Moyer, A. L., LeTexier, N. J., Bratti, A. D., Feng, S., Sun, C., Liu, T., Mula, J., Jha, P., Iyer, S. R., Lovering, R., O’Rourke, B., Noh, H. L., Suk, S., Kim, J. K., Essien Umanah, G. K. & Wagner, K. R., Sep 17 2019, In : JCI Insight. 4, 20, e122247.

Research output: Contribution to journalArticle

Open Access
Homeostasis
Glucose
Muscles
Skeletal Muscle
Myostatin

Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision

Ernst, P., Xu, N., Qu, J., Chen, H., Goldberg, M. S., Darley-Usmar, V., Zhang, J. J., O'Rourke, B., Liu, X. & Zhou, L., Aug 20 2019, In : Biophysical journal. 117, 4, p. 631-645 15 p.

Research output: Contribution to journalArticle

Optogenetics
Mitochondria
Light
Mitochondrial Membranes
Lighting

Single-channel properties of the ROMK-pore-forming subunit of the mitochondrial ATP-sensitive potassium channel

Laskowski, M., Augustynek, B., Bednarczyk, P., Żochowska, M., Kalisz, J., O’rourke, B., Szewczyk, A. & Kulawiak, B., Nov 1 2019, In : International journal of molecular sciences. 20, 21, 5323.

Research output: Contribution to journalArticle

Open Access
KATP Channels
adenosine triphosphate
Adenosinetriphosphate
Potassium
porosity
2018

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models

Vakrou, S., Fukunaga, R., Foster, D. B., Sorensen, L., Liu, Y., Guan, Y., Woldemichael, K., Pineda-Reyes, R., Liu, T., Tardiff, J. C., Leinwand, L. A., Tocchetti, C. G., Abraham, T. P., O'Rourke, B., Aon, M. A. & Abraham, M. R., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Hypertrophic Cardiomyopathy
Transcriptome
Alleles
Mutation
Antioxidants

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model

Limpitikul, W. B., Viswanathan, M. C., O'Rourke, B., Yue, D. T. & Cammarato, A. R., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 64-74 11 p.

Research output: Contribution to journalArticle

Diptera
Drosophila
Cardiac Myocytes
Channelopathies
Colforsin

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

Dey, S., DeMazumder, D., Sidor, A., Foster, D. B. & O'Rourke, B., Jul 20 2018, In : Circulation Research. 123, 3, p. 356-371 16 p.

Research output: Contribution to journalArticle

Sudden Cardiac Death
Proteome
Reactive Oxygen Species
Heart Failure
Cardiac Arrhythmias

Mitochondrial transplantation in humans: “magical” cure or cause for concern?

Bertero, E., Maack, C. & O'Rourke, B., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5191-5194 4 p.

Research output: Contribution to journalArticle

Transplantation

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Phosphotransferases
Heart Failure
Sudden Cardiac Death
2017

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M. G., Foster, D. B., Aon, M. A., Tsui, B., O'Rourke, B. & Abraham, M. R., Oct 1 2017, In : JACC: Basic to Translational Science. 2, 5, p. 543-560 18 p.

Research output: Contribution to journalArticle

Glycolysis
Cell Adhesion
Adenosine Triphosphate
Phosphorylation
Glucose

Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling

Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D., Solhjoo, S., O'Rourke, B., Tomaselli, G. F., Jeong, D. S., Cho, H. & Kang, J. S., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1345-E1354

Research output: Contribution to journalArticle

Catenins
Connexin 43
Fibrosis
Cardiac Myocytes
Up-Regulation

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Cardiomyopathies
Cardiac Myocytes
Transplantation
2016

Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts

Ma, J., Banerjee, P., Whelan, S. A., Liu, T., Wei, A. C., Ramirez-Correa, G., McComb, M. E., Costello, C. E., O'Rourke, B., Murphy, A. M. & Hart, G. W., Jul 1 2016, In : Journal of Proteome Research. 15, 7, p. 2254-2264 11 p.

Research output: Contribution to journalArticle

Proteomics
Medical problems
Diabetic Cardiomyopathies
Proteins
Acetylglucosamine

Compartment-specific control of reactive oxygen species scavenging by antioxidant pathway enzymes

Dey, S., Sidor, A. & O'Rourke, B., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11185-11197 13 p.

Research output: Contribution to journalArticle

Scavenging
Reactive Oxygen Species
Antioxidants
Enzymes
Oxidation-Reduction

Hibernating squirrels: SIRTin clues for organ protection after ischemia-reperfusion

Berkowitz, D. E., Steenbergen, C. J. & O'Rourke, B., Jun 1 2016, In : Anesthesiology. 124, 6, p. 1215-1217 3 p.

Research output: Contribution to journalArticle

Sciuridae
Reperfusion
Ischemia

Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytes

Goh, K. Y., Qu, J., Hong, H., Liu, T., Dell'italia, L. J., Wu, Y., O'Rourke, B. & Zhou, L., Jan 1 2016, In : Cardiovascular Research. 109, 1, p. 79-89 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Reactive Oxygen Species
Guinea Pigs
Lasers
Mitochondria

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death

Foster, D. B., Liu, T., Kammers, K., O'Meally, R., Yang, N., Papanicolaou, K., Conover Talbot, C., Cole, R. N. & O'Rourke, B., Sep 2 2016, In : Journal of Proteome Research. 15, 9, p. 3009-3028 20 p.

Research output: Contribution to journalArticle

Sudden Cardiac Death
Guinea Pigs
Heart Failure
Hypertrophy
Proteome

Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters

Breckwoldt, M. O., Armoundas, A. A., Aon, M. A., Bendszus, M., O'Rourke, B., Schwarzländer, M., Dick, T. P. & Kurz, F. T., Mar 22 2016, In : Scientific Reports. 6, 23251.

Research output: Contribution to journalArticle

Organelles
Oxidation-Reduction
Mitochondria
Axons
Nerve Crush
2015
Cardiac Resynchronization Therapy
Cholinergic Agents
Heart Failure
Muscarinic Receptors
Adrenergic Agents

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Burks, T. N., Marx-Rattner, R., Powell, L., Rucker, J., Bedja, D., Heacock, E., Smith, B. J., Foster, D. B., Kass, D. A., O'Rourke, B., Walston, J. D. & Abadir, P., 2015, In : Oncotarget. 6, 14, p. 11979-11993 15 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Cardiomyopathies
Inflammation
Myocardium
Premature Aging

Deranged sodium to sudden death

Clancy, C. E., Chen-Izu, Y., Bers, D. M., Belardinelli, L., Boyden, P. A., Csernoch, L., Despa, S., Fermini, B., Hool, L. C., Izu, L., Kass, R. S., Lederer, W. J., Louch, W. E., Maack, C., Matiazzi, A., Qu, Z., Rajamani, S., Rippinger, C. M., Sejersted, O. M., O'Rourke, B. & 3 others, Weiss, J. N., Varró, A. & Zaza, A., Mar 15 2015, In : Journal of Physiology. 593, 6, p. 1331-1345 15 p.

Research output: Contribution to journalArticle

Sudden Death
Sodium
Homeostasis
Sodium Channels
Mechanics

Dual effect of phosphate transport on mitochondrial Ca2+ dynamics

Wei, A. C., Liu, T. & O'Rourke, B., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 16088-16098 11 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Anions
Phosphates
Adenylyl Imidodiphosphate
Adenosine Triphosphate

From metabolomics to fluxomics: A computational procedure to translate metabolite profiles into metabolic fluxes

Cortassa, S., Caceres, V., Bell, L. N., O'Rourke, B., Paolocci, N. & Aon, M. A., Jan 6 2015, In : Biophysical Journal. 108, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolome
Pentoses
Glycogenolysis
Glucose

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

Ping, P., Gustafsson, Å. B., Bers, D. M., Blatter, L. A., Cai, H., Jahangir, A., Kelly, D., Muoio, D., O'Rourke, B., Rabinovitch, P., Trayanova, N., Van Eyk, J., Weiss, J. N., Wong, R. & Longacre, L. S., Jul 17 2015, In : Circulation Research. 117, 3, p. 234-238 5 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Heart Diseases
Mitochondria
Systems Integration
National Institutes of Health (U.S.)

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Tocchetti, C. G., Stanley, B. A., Sivakumaran, V., Bedja, D., O'Rourke, B., Paolocci, N., Cortassa, S. & Aon, M. A., 2015, In : Clinical Science. 129, 7, p. 561-574 14 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Oxidation-Reduction
Isoproterenol
Glucose
Muscle Cells
Cardiac Myocytes
Mitochondria
Guinea Pigs
Theoretical Models
Reactive Oxygen Species
Cardiac Myocytes
Reperfusion
Cardiac Arrhythmias
Ischemia
Muscle Cells

Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior

Kurz, F. T., Derungs, T., Aon, M. A., O'Rourke, B. & Armoundas, A. A., Apr 21 2015, In : Biophysical Journal. 108, 8, p. 1922-1933 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Reactive Oxygen Species
Oxidative Stress
Cardiac Electrophysiology
Mitochondrial Size
Acetylglucosamine
Oxidative Phosphorylation
Mitochondria
Mitochondrial Proteins
Rats

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

Bhatt, N. M., Aon, M. A., Tocchetti, C. G., Shen, X., Dey, S., Ramirez-Correa, G., O'Rourke, B., Gao, W. D. & Cortassa, S., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H291-H302

Research output: Contribution to journalArticle

Myocardial Contraction
Palmitates
Oxidation-Reduction
Glucose
Thioredoxins
2014

Cardiac mitochondria exhibit dynamic functional clustering

Kurz, F. T., Aon, M. A., O'Rourke, B. & Armoundas, A. A., 2014, In : Frontiers in Physiology. 5 AUG, Article 329.

Research output: Contribution to journalArticle

Cluster Analysis
Mitochondria
Cardiac Myocytes
Spatio-Temporal Analysis
Physiological Stress

Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat

Shen, X., Bhatt, N., Xu, J., Meng, T., Aon, M. A., O'Rourke, B., Berkowitz, D. E., Cortassa, S. & Gao, W. D., 2014, In : Journal of Pharmacology and Experimental Therapeutics. 349, 4, p. 21-28 8 p.

Research output: Contribution to journalArticle

Isoflurane
Myocardium
Oxidative Stress
Muscles
Myocardial Contraction

Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesis

Zhou, L., Solhjoo, S., Millare, B., Plank, G., Abraham, M. R., Cortassa, S., Trayanova, N. & O'Rourke, B., 2014, In : Circulation: Arrhythmia and Electrophysiology. 7, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Action Potentials
Mitochondria
Adenosine Triphosphate
Excitation Contraction Coupling

Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure

Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., Sidor, A., Abraham, T. P. & O'Rourke, B., Jun 20 2014, In : Circulation Research. 115, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

Sudden Cardiac Death
Sudden Death
Guinea Pigs
Heart Failure
NAD
Post Translational Protein Processing
Lysine
Mitochondria
Acetylation
Sirtuins

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

Cortassa, S., O'Rourke, B. & Aon, M. A., Feb 2014, In : Biochimica et Biophysica Acta - Bioenergetics. 1837, 2, p. 287-295 9 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Reactive Oxygen Species
Respiration
Mitochondria
Adenosine Diphosphate
2013

A Computational model of reactive oxygen species and redox balance in cardiac mitochondria

Gauthier, L. D., Greenstein, J. L., Cortassa, S., O'Rourke, B. & Winslow, R., Aug 20 2013, In : Biophysical Journal. 105, 4, p. 1045-1056 12 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Reactive Oxygen Species
Mitochondria
Ubiquinone
Electron Transport Complex III

An integrated mitochondrial ROS production and scavenging model: Implications for heart failure

Gauthier, L. D., Greenstein, J. L., O'Rourke, B. & Winslow, R., Dec 17 2013, In : Biophysical Journal. 105, 12, p. 2832-2842 11 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Heart Failure
Workload
NADP
Glutathione Disulfide

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

Watts, V. L., Sepulveda, F. M., Cingolani, O., Ho, A. S., Niu, X., Kim, R., Miller, K. L., Vandegaer, K., Bedja, D., Gabrielson, K. L., Rameau, G., O'Rourke, B., Kass, D. A. & Barouch, L., Sep 2013, In : Journal of Molecular and Cellular Cardiology. 62, p. 8-17 10 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Adrenergic Agents
Muscle Cells
Antioxidants
Phosphorylation

Cellular bioenergetics is an important determinant of the molecular imaging signal derived from luciferase and the sodium-iodide symporter

Chang, C., Chan, A., Lin, X., Higuchi, T., Terrovitis, J., Afzal, J. M., Rittenbach, A., Sun, D., Vakrou, S., Woldemichael, K., O'Rourke, B., Wahl, R., Pomper, M. G., Tsui, B. & Abraham, M. R., Feb 1 2013, In : Circulation Research. 112, 3, p. 441-450 10 p.

Research output: Contribution to journalArticle

Molecular Imaging
Luciferases
Energy Metabolism
Cell Transplantation
Suspensions

Enhanced tissue production through redox control in stem cell-laden hydrogels

Reid, B., Afzal, J. M., Mccartney, A. M., Abraham, M. R., O'Rourke, B. & Elisseeff, J. H., Sep 1 2013, In : Tissue Engineering - Part A. 19, 17-18, p. 2014-2023 10 p.

Research output: Contribution to journalArticle

Hydrogels
Stem cells
Reactive Oxygen Species
Stem Cells
Polyethylene glycols

HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization

Sivakumaran, V., Stanley, B. A., Tocchetti, C. G., Ballin, J. D., Caceres, V., Zhou, L., Keceli, G., Rainer, P. P., Lee, D., Huke, S., Ziolo, M. T., Kranias, E. G., Toscano, J. P., Wilson, G. M., O'Rourke, B., Kass, D. A., Mahaney, J. E. & Paolocci, N., Oct 10 2013, In : Antioxidants and Redox Signaling. 19, 11, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

Oligomerization
Cardiac Myocytes
Oxidation-Reduction
Muscle Cells
Sarcoplasmic Reticulum

Integrating mitochondrial energetics, redox and ROS metabolic networks: A two-compartment model

Kembro, J. M., Aon, M. A., Winslow, R., O'Rourke, B. & Cortassa, S., Jan 22 2013, In : Biophysical Journal. 104, 2, p. 332-343 12 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Oxidation-Reduction
Reactive Oxygen Species
NAD
NADP

Regulation of the Na+/Ca2+ exchanger by pyridine nucleotide redox potential in ventricular myocytes

Liu, T. & O'Rourke, B., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31984-31992 9 p.

Research output: Contribution to journalArticle

NAD
Muscle Cells
Oxidation-Reduction
Nucleotides
Reactive Oxygen Species

Structural and functional plasticity in long-term cultures of adult ventricular myocytes

Joshi-Mukherjee, R., Dick, I. E., Liu, T., O'Rourke, B., Yue, D. T. & Tung, L., Dec 2013, In : Journal of Molecular and Cellular Cardiology. 65, p. 76-87 12 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Muscle Cells
Guinea Pigs
Heart Failure
Excitation Contraction Coupling

The Cardiac Acetyl-Lysine Proteome

Foster, D. B., Liu, T., Rucker, J., O'Meally, R. N., Devine, L. R., Cole, R. N. & O'Rourke, B., Jul 2 2013, In : PLoS One. 8, 7, e67513.

Research output: Contribution to journalArticle

Acetylation
acetylation
Proteome
proteome
Lysine
2012

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Necrosis
Mitochondria
Mitochondrial Membranes
Apoptosis