Brian O'Rourke

Professor

1984 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality

Vetter, L., Cortassa, S., O’Rourke, B., Armoundas, A. A., Bedja, D., Jende, J. M. E., Bendszus, M., Paolocci, N., Sollot, S. J., Aon, M. A. & Kurz, F. T., Mar 10 2020, In : Frontiers in Physiology. 11, 175.

Research output: Contribution to journalArticle

Open Access

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP

Papanicolaou, K. N., Ashok, D., Liu, T., Bauer, T. M., Sun, J., Li, Z., da Costa, E., D'Orleans, C. C., Nathan, S., Lefer, D. J., Murphy, E., Paolocci, N., Foster, D. B. & O'Rourke, B., Feb 2020, In : Journal of Molecular and Cellular Cardiology. 139, p. 176-189 14 p.

Research output: Contribution to journalArticle

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., O'Rourke, B. & He, L., Nov 5 2019, In : Cell Reports. 29, 6, p. 1511-1523.e5

Research output: Contribution to journalArticle

Open Access

miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Banavath, H. N., Roman, B., Mackowski, N., Biswas, D., Afzal, J., Nomura, Y., Solhjoo, S., O'Rourke, B., Kohr, M., Murphy, E., Steenbergen, C. & Das, S., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e012919

Research output: Contribution to journalArticle

Open Access

Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice

Rovira Gonzalez, Y. I., Moyer, A. L., LeTexier, N. J., Bratti, A. D., Feng, S., Sun, C., Liu, T., Mula, J., Jha, P., Iyer, S. R., Lovering, R., O’Rourke, B., Noh, H. L., Suk, S., Kim, J. K., Essien Umanah, G. K. & Wagner, K. R., Sep 17 2019, In : JCI Insight. 4, 20, e122247.

Research output: Contribution to journalArticle

Open Access

Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision

Ernst, P., Xu, N., Qu, J., Chen, H., Goldberg, M. S., Darley-Usmar, V., Zhang, J. J., O'Rourke, B., Liu, X. & Zhou, L., Aug 20 2019, In : Biophysical journal. 117, 4, p. 631-645 15 p.

Research output: Contribution to journalArticle

Single-channel properties of the ROMK-pore-forming subunit of the mitochondrial ATP-sensitive potassium channel

Laskowski, M., Augustynek, B., Bednarczyk, P., Żochowska, M., Kalisz, J., O’rourke, B., Szewczyk, A. & Kulawiak, B., Nov 1 2019, In : International journal of molecular sciences. 20, 21, 5323.

Research output: Contribution to journalArticle

Open Access
2018

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models

Vakrou, S., Fukunaga, R., Foster, D. B., Sorensen, L., Liu, Y., Guan, Y., Woldemichael, K., Pineda-Reyes, R., Liu, T., Tardiff, J. C., Leinwand, L. A., Tocchetti, C. G., Abraham, T. P., O'Rourke, B., Aon, M. A. & Abraham, M. R., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model

Limpitikul, W. B., Viswanathan, M. C., O'Rourke, B., Yue, D. T. & Cammarato, A. R., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 64-74 11 p.

Research output: Contribution to journalArticle

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

Dey, S., DeMazumder, D., Sidor, A., Foster, D. B. & O'Rourke, B., Jul 20 2018, In : Circulation Research. 123, 3, p. 356-371 16 p.

Research output: Contribution to journalArticle

Mitochondrial transplantation in humans: “magical” cure or cause for concern?

Bertero, E., Maack, C. & O'Rourke, B., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5191-5194 4 p.

Research output: Contribution to journalArticle

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

2017

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O'Rourke, B. & Abraham, M. R., Oct 2017, In : JACC: Basic to Translational Science. 2, 5, p. 543-560 18 p.

Research output: Contribution to journalArticle

Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling

Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D., Solhjoo, S., O'Rourke, B., Tomaselli, G. F., Jeong, D. S., Cho, H. & Kang, J. S., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1345-E1354

Research output: Contribution to journalArticle

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

2016

Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts

Ma, J., Banerjee, P., Whelan, S. A., Liu, T., Wei, A. C., Ramirez-Correa, G., McComb, M. E., Costello, C. E., O'Rourke, B., Murphy, A. M. & Hart, G. W., Jul 1 2016, In : Journal of Proteome Research. 15, 7, p. 2254-2264 11 p.

Research output: Contribution to journalArticle

Compartment-specific control of reactive oxygen species scavenging by antioxidant pathway enzymes

Dey, S., Sidor, A. & O'Rourke, B., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11185-11197 13 p.

Research output: Contribution to journalArticle

Hibernating squirrels: SIRTin clues for organ protection after ischemia-reperfusion

Berkowitz, D. E., Steenbergen, C. J. & O'Rourke, B., Jun 1 2016, In : Anesthesiology. 124, 6, p. 1215-1217 3 p.

Research output: Contribution to journalArticle

Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytes

Goh, K. Y., Qu, J., Hong, H., Liu, T., Dell'italia, L. J., Wu, Y., O'rourke, B. & Zhou, L., Jan 1 2016, In : Cardiovascular research. 109, 1, p. 79-89 11 p.

Research output: Contribution to journalArticle

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death

Foster, D. B., Liu, T., Kammers, K., O'Meally, R., Yang, N., Papanicolaou, K., Conover Talbot, C., Cole, R. N. & O'Rourke, B., Sep 2 2016, In : Journal of Proteome Research. 15, 9, p. 3009-3028 20 p.

Research output: Contribution to journalArticle

Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters

Breckwoldt, M. O., Armoundas, A. A., Aon, M. A., Bendszus, M., O'Rourke, B., Schwarzländer, M., Dick, T. P. & Kurz, F. T., Mar 22 2016, In : Scientific Reports. 6, 23251.

Research output: Contribution to journalArticle

2015

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Burks, T. N., Marx, R., Powell, L., Rucker, J., Bedja, D., Heacock, E., Smith, B. J., Brian Foster, D., Kass, D., O'Rourke, B., Walston, J. D. & Abadir, P. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 11979-11993 15 p.

Research output: Contribution to journalArticle

Open Access

Deranged sodium to sudden death

Clancy, C. E., Chen-Izu, Y., Bers, D. M., Belardinelli, L., Boyden, P. A., Csernoch, L., Despa, S., Fermini, B., Hool, L. C., Izu, L., Kass, R. S., Lederer, W. J., Louch, W. E., Maack, C., Matiazzi, A., Qu, Z., Rajamani, S., Rippinger, C. M., Sejersted, O. M., O'Rourke, B. & 3 others, Weiss, J. N., Varró, A. & Zaza, A., Mar 15 2015, In : Journal of Physiology. 593, 6, p. 1331-1345 15 p.

Research output: Contribution to journalArticle

Dual effect of phosphate transport on mitochondrial Ca2+ dynamics

Wei, A. C., Liu, T. & O'Rourke, B., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 16088-16098 11 p.

Research output: Contribution to journalArticle

From metabolomics to fluxomics: A computational procedure to translate metabolite profiles into metabolic fluxes

Cortassa, S., Caceres, V., Bell, L. N., O'Rourke, B., Paolocci, N. & Aon, M. A., Jan 6 2015, In : Biophysical journal. 108, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

Ping, P., Gustafsson, Å. B., Bers, D. M., Blatter, L. A., Cai, H., Jahangir, A., Kelly, D., Muoio, D., O'Rourke, B., Rabinovitch, P., Trayanova, N., Van Eyk, J., Weiss, J. N., Wong, R. & Longacre, L. S., Jul 17 2015, In : Circulation research. 117, 3, p. 234-238 5 p.

Research output: Contribution to journalArticle

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Tocchetti, C. G., Stanley, B. A., Sivakumaran, V., Bedja, D., O'Rourke, B., Paolocci, N., Cortassa, S. & Aon, M. A., Jan 1 2015, In : Clinical Science. 129, 7, p. 561-574 14 p.

Research output: Contribution to journalArticle

Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior

Kurz, F. T., Derungs, T., Aon, M. A., O'Rourke, B. & Armoundas, A. A., Apr 21 2015, In : Biophysical journal. 108, 8, p. 1922-1933 12 p.

Research output: Contribution to journalArticle

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

Bhatt, N. M., Aon, M. A., Tocchetti, C. G., Shen, X., Dey, S., Ramirez-Correa, G., Rourke, B., Gao, W. D. & Cortassa, S., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H291-H302

Research output: Contribution to journalArticle

2014

Cardiac mitochondria exhibit dynamic functional clustering

Kurz, F. T., Aon, M. A., O'Rourke, B. & Armoundas, A. A., Jan 1 2014, In : Frontiers in Physiology. 5 AUG, Article 329.

Research output: Contribution to journalArticle

Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat

Shen, X., Bhatt, N., Xu, J., Meng, T., Aon, M. A., O'Rourke, B., Berkowitz, D. E., Cortassa, S. & Gao, W. D., Apr 2014, In : Journal of Pharmacology and Experimental Therapeutics. 349, 4, p. 21-28 8 p.

Research output: Contribution to journalArticle

Effects of regional mitochondrial depolarization on electrical propagation: Implications for arrhythmogenesis

Zhou, L., Solhjoo, S., Millare, B., Plank, G., Abraham, M. R., Cortassa, S., Trayanova, N. & O'Rourke, B., Feb 2014, In : Circulation: Arrhythmia and Electrophysiology. 7, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure

Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., Sidor, A., Abraham, T. P. & O'Rourke, B., Jun 20 2014, In : Circulation research. 115, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

Cortassa, S., O'Rourke, B. & Aon, M. A., Feb 1 2014, In : Biochimica et Biophysica Acta - Bioenergetics. 1837, 2, p. 287-295 9 p.

Research output: Contribution to journalArticle

2013

A Computational model of reactive oxygen species and redox balance in cardiac mitochondria

Gauthier, L. D., Greenstein, J. L., Cortassa, S., O'Rourke, B. & Winslow, R. L., Aug 20 2013, In : Biophysical journal. 105, 4, p. 1045-1056 12 p.

Research output: Contribution to journalArticle

An integrated mitochondrial ROS production and scavenging model: Implications for heart failure

Gauthier, L. D., Greenstein, J. L., O'Rourke, B. & Winslow, R. L., Dec 17 2013, In : Biophysical journal. 105, 12, p. 2832-2842 11 p.

Research output: Contribution to journalArticle

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

Watts, V. L., Sepulveda, F. M., Cingolani, O. H., Ho, A. S., Niu, X., Kim, R., Miller, K. L., Vandegaer, K., Bedja, D., Gabrielson, K. L., Rameau, G., O'Rourke, B., Kass, D. A. & Barouch, L. A., Sep 1 2013, In : Journal of Molecular and Cellular Cardiology. 62, p. 8-17 10 p.

Research output: Contribution to journalArticle

Cellular bioenergetics is an important determinant of the molecular imaging signal derived from luciferase and the sodium-iodide symporter

Chang, C., Chan, A., Lin, X., Higuchi, T., Terrovitis, J., Afzal, J. M., Rittenbach, A., Sun, D., Vakrou, S., Woldemichael, K., O'Rourke, B., Wahl, R., Pomper, M., Tsui, B. & Abraham, M. R., Feb 1 2013, In : Circulation research. 112, 3, p. 441-450 10 p.

Research output: Contribution to journalArticle

Enhanced tissue production through redox control in stem cell-laden hydrogels

Reid, B., Afzal, J. M., Mccartney, A. M., Abraham, M. R., O'Rourke, B. & Elisseeff, J. H., Sep 1 2013, In : Tissue Engineering - Part A. 19, 17-18, p. 2014-2023 10 p.

Research output: Contribution to journalArticle

HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization

Sivakumaran, V., Stanley, B. A., Tocchetti, C. G., Ballin, J. D., Caceres, V., Zhou, L., Keceli, G., Rainer, P. P., Lee, D. I., Huke, S., Ziolo, M. T., Kranias, E. G., Toscano, J. P., Wilson, G. M., O'Rourke, B., Kass, D. A., Mahaney, J. E. & Paolocci, N., Oct 10 2013, In : Antioxidants and Redox Signaling. 19, 11, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

Integrating mitochondrial energetics, redox and ROS metabolic networks: A two-compartment model

Kembro, J. M., Aon, M. A., Winslow, R. L., O'Rourke, B. & Cortassa, S., Jan 22 2013, In : Biophysical journal. 104, 2, p. 332-343 12 p.

Research output: Contribution to journalArticle

Regulation of the Na+/Ca2+ exchanger by pyridine nucleotide redox potential in ventricular myocytes

Liu, T. & O'Rourke, B., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31984-31992 9 p.

Research output: Contribution to journalArticle

Structural and functional plasticity in long-term cultures of adult ventricular myocytes

Joshi-Mukherjee, R., Dick, I. E., Liu, T., O'Rourke, B., Yue, D. T. & Tung, L., Dec 1 2013, In : Journal of Molecular and Cellular Cardiology. 65, p. 76-87 12 p.

Research output: Contribution to journalArticle

The Cardiac Acetyl-Lysine Proteome

Foster, D. B., Liu, T., Rucker, J., O'Meally, R. N., Devine, L. R., Cole, R. N. & O'Rourke, B., Jul 2 2013, In : PloS one. 8, 7, e67513.

Research output: Contribution to journalArticle

2012

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle