Research output per year
Research output per year
- 1 - 50 out of 256 results
Search results
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2023
Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
Pearah, A., Ramatchandirin, B., Liu, T., Wolf, R. M., Ikeda, A., Radovick, S., Sesaki, H., Wondisford, F. E., O'Rourke, B. & He, L., Dec 21 2023, In: Cell Chemical Biology. 30, 12, p. 1585-1600.e6Research output: Contribution to journal › Article › peer-review
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Decoding Angiotensin Receptors: TOMAHAQ-Based Detection and Quantification of Angiotensin Type-1 and Type-2 Receptors
Cosarderelioglu, C., Kreimer, S., Plaza-Rodriguez, A. I., Iglesias, P. A., Talbot, C. C., Siragy, H. M., Carey, R. M., Ubaida-Mohien, C., O’rourke, B., Ferrucci, L., Bennett, D. A., Walston, J. & Abadir, P., Sep 19 2023, In: Journal of the American Heart Association. 12, 18, e030791.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats
Velmurugan, S., Liu, T., Chen, K. C., Despa, F., O’rourke, B. & Despa, S., 2023, In: Journal of the American Heart Association. 12, 14, e029997.Research output: Contribution to journal › Article › peer-review
Open Access -
Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling
Kurz, F. T., Aon, M. A., Schlemmer, H. P., Jende, J. M. E., O'Rourke, B. & Armoundas, A. A., Apr 18 2023, In: Biophysical journal. 122, 8, p. 1459-1469 11 p.Research output: Contribution to journal › Article › peer-review
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Growth Differentiation Factor-15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy
Binder, M. S., Yanek, L. R., Yang, W., Butcher, B., Norgard, S., Marine, J. E., Kolandaivelu, A., Chrispin, J., Fedarko, N. S., Calkins, H., O’rourke, B., Wu, K. C., Tomaselli, G. F. & Barth, A. S., Feb 7 2023, In: Journal of the American Heart Association. 12, 3, e8023.Research output: Contribution to journal › Article › peer-review
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Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy
Papanicolaou, K. N., Jung, J., Ashok, D., Zhang, W., Modaressanavi, A., Avila, E., Foster, D. B., Zachara, N. E. & O'Rourke, B., Mar 2023, In: Journal of Biological Chemistry. 299, 3, 102907.Research output: Contribution to journal › Article › peer-review
Open Access -
Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotection
Wang, J., Papanicolaou, K., Tryon, R., Sangalang, J., Salazar, B., Suarez-Pierre, A., Dong, J., Lee, A., Larson, E., Holmes, S., O'Rourke, B., Nichols, C. & Lawton, J., Sep 2023, In: JTCVS Open. 15, p. 231-241 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+ uptake
Ashok, D., Papanicolaou, K., Sidor, A., Wang, M., Solhjoo, S., Liu, T. & O'Rourke, B., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104708.Research output: Contribution to journal › Article › peer-review
Open Access -
Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1
Yang, X., Zhang, M., Xie, B., Peng, Z., Manning, J. R., Zimmerman, R., Wang, Q., Wei, A. C., Khalifa, M., Reynolds, M., Jin, J., Om, M., Zhu, G., Bedja, D., Jiang, H., Jurczak, M., Shiva, S., Scott, I., O'Rourke, B., Kass, D. A., & 2 others, Feb 1 2023, In: Cardiovascular research. 119, 2, p. 571-586 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability
Solhjoo, S., Liu, T., Sidor, A., Lee, D., O'Rourke, B. & Steenbergen, C., Jan 2023, In: Journal of Biological Chemistry. 299, 1, 102780.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia–Reperfusion Injury in the Isolated Mouse Heart
Pharoah, B. M., Khodade, V. S., Eremiev, A., Bao, E., Liu, T., O’rourke, B., Paolocci, N. & Toscano, J. P., May 2022, In: Antioxidants. 11, 5, 1010.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Keceli, G., Gupta, A., Sourdon, J., Gabr, R., Schä R, M., Dey, S., Tocchetti, C. G., Stuber, A., Agrimi, J., Zhang, Y., Leppo, M., Steenbergen, C., Lai, S., Yanek, L. R., O'Rourke, B., Gerstenblith, G., Bottomley, P. A., Wang, Y., Paolocci, N. & Weiss, R. G., Mar 4 2022, In: Circulation research. 130, 5, p. 741-759 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias
Sohljoo, S., Kim, S., Plank, G., O’Rourke, B. & Zhou, L., 2022, Methods in Molecular Biology. Humana Press Inc., p. 247-259 13 p. (Methods in Molecular Biology; vol. 2399).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access -
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure
Zhu, G., Ueda, K., Hashimoto, M., Zhang, M., Sasaki, M., Kariya, T., Sasaki, H., Kaludercic, N., Lee, D. I., Bedja, D., Gabrielson, M., Yuan, Y., Paolocci, N., Blanton, R. M., Karas, R. H., Mendelsohn, M. E., O’Rourke, B., Kass, D. A. & Takimoto, E., Jan 2022, In: FEBS Letters. 596, 1, p. 17-28 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease
Yang, S. Y., Castellani, C. A., Longchamps, R. J., Pillalamarri, V. K., O'Rourke, B., Guallar, E. & Arking, D. E., Jan 2021, In: Genome research. 31, 3, p. 349-358 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cardiac retinoic acid levels decline in heart failure
Yang, N., Parker, L. E., Yu, J., Jones, J. W., Liu, T., Papanicolaou, K. N., Talbot, C. C., Margulies, K. B., O’Rourke, B., Kane, M. A. & Foster, D. B., Apr 1 2021, In: JCI Insight. 6, 8, e137593.Research output: Contribution to journal › Article › peer-review
Open Access -
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
Chelko, S. P., Keceli, G., Carpi, A., Doti, N., Agrimi, J., Asimaki, A., Beti, C. B., Miyamoto, M., Amat-Codina, N., Bedja, D., Wei, A. C., Murray, B., Tichnell, C., Kwon, C., Calkins, H., James, C. A., O'Rourke, B., Halushka, M. K., Melloni, E., Saffitz, J. E., & 6 others, Feb 17 2021, In: Science translational medicine. 13, 581, eabf0891.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice
Mishra, S., Sadagopan, N., Dunkerly-Eyring, B., Rodriguez, S., Sarver, D. C., Ceddia, R. P., Murphy, S. A., Knutsdottir, H., Jani, V. P., Ashok, D., Oeing, C. U., O’Rourke, B., Gangoiti, J. A., Sears, D. D., Wong, G. W., Collins, S. & Kass, D. A., Nov 2021, In: Journal of Clinical Investigation. 131, 21, e148798.Research output: Contribution to journal › Article › peer-review
Open Access -
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+Leak
Liu, T., Yang, N., Sidor, A. & O'Rourke, B., Apr 16 2021, In: Circulation research. 128, 8, p. 1191-1204 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitochondrial Ca2+ in heart failure: Not enough or too much?
O'Rourke, B., Ashok, D. & Liu, T., Feb 2021, In: Journal of Molecular and Cellular Cardiology. 151, p. 126-134 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
MitoWave: Spatiotemporal analysis of mitochondrial membrane potential fluctuations during I/R
Ashok, D. & O'Rourke, B., Aug 17 2021, In: Biophysical journal. 120, 16, p. 3261-3271 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy
Rovira Gonzalez, Y. I., Moyer, A. L., LeTexier, N. J., Bratti, A. D., Feng, S., Peña, V., Sun, C., Pulcastro, H., Liu, T., Iyer, S. R., Lovering, R. M., O'Rourke, B. & Wagner, K. R., Feb 2021, In: FASEB Journal. 35, 2, e21276.Research output: Contribution to journal › Article › peer-review
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Pde1 inhibition modulates cav1.2 channel to stimulate cardiomyocyte contraction
Muller, G. K., Song, J., Jani, V., Wu, Y., Liu, T., Jeffreys, W. P. D., O'Rourke, B., Anderson, M. E. & Kass, D. A., Oct 15 2021, In: Circulation research. 129, 9, p. 872-886 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality
Vetter, L., Cortassa, S., O’Rourke, B., Armoundas, A. A., Bedja, D., Jende, J. M. E., Bendszus, M., Paolocci, N., Sollot, S. J., Aon, M. A. & Kurz, F. T., Mar 10 2020, In: Frontiers in Physiology. 11, 175.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP
Papanicolaou, K. N., Ashok, D., Liu, T., Bauer, T. M., Sun, J., Li, Z., da Costa, E., D'Orleans, C. C., Nathan, S., Lefer, D. J., Murphy, E., Paolocci, N., Foster, D. B. & O'Rourke, B., Feb 2020, In: Journal of Molecular and Cellular Cardiology. 139, p. 176-189 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Hydrogen peroxide diffusion and scavenging shapes mitochondrial network instability and failure by sensitizing ROS-induced ROS release
Millare, B., O’Rourke, B. & Trayanova, N., Dec 1 2020, In: Scientific reports. 10, 1, 15758.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitochondria Do Not Survive Calcium Overload During Transplantation
Bertero, E., O'Rourke, B. & Maack, C., Mar 13 2020, In: Circulation research. 126, 6, p. 784-786 3 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Mitochondrial DNA copy number and incident atrial fibrillation
Zhao, D., Bartz, T. M., Sotoodehnia, N., Post, W. S., Heckbert, S. R., Alonso, A., Longchamps, R. J., Castellani, C. A., Hong, Y. S., Rotter, J. I., Lin, H. J., O'Rourke, B., Pankratz, N., Lane, J. A., Yang, S. Y., Guallar, E. & Arking, D. E., Sep 16 2020, In: BMC medicine. 18, 1, 246.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
Castellani, C. A., Longchamps, R. J., Sumpter, J. A., Newcomb, C. E., Lane, J. A., Grove, M. L., Bressler, J., Brody, J. A., Floyd, J. S., Bartz, T. M., Taylor, K. D., Wang, P., Tin, A., Coresh, J., Pankow, J. S., Fornage, M., Guallar, E., O'Rourke, B., Pankratz, N., Liu, C., & 4 others, Sep 28 2020, In: Genome Medicine. 12, 1, 84.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity
Roman, B., Kaur, P., Ashok, D., Kohr, M., Biswas, R., O'Rourke, B., Steenbergen, C. & Das, S., Jul 2020, In: Journal of Molecular and Cellular Cardiology. 144, p. 87-96 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Response by Bertero et al to letter regarding article, "Mitochondria do not survive calcium overload"
Bertero, E., O'Rourke, B. & Maack, C., 2020, (Accepted/In press) In: Circulation research. p. E58-E59Research output: Contribution to journal › Letter › peer-review
3 Scopus citations -
TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction
Madan, A., Viswanathan, M. C., Woulfe, K. C., Schmidt, W., Sidor, A., Liu, T., Nguyen, T. H., Trinh, B., Wilson, C., Madathil, S., Vogler, G., O'Rourke, B., Biesiadecki, B. J., Tobacman, L. S. & Cammarato, A., Aug 4 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 31, p. 18822-18831 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2019
Building Leadership Capacity for Mission Execution in a Large Academic Department of Medicine
Golden, S. H., Bass, E., Berry, S., Biddison, L. D., Cayea, D., Crews, D., Desai, S., Ghanem, K. G., Herzke, C., Kirk, G., Kisuule, F., Levine, R., Marr, K., O'Rourke, B., Pasricha, P., Peairs, K., Ray, S., Durso, S. C., Hellmann, D. & Anderson, M. E., Apr 2019, In: American Journal of Medicine. 132, 4, p. 535-543 9 p.Research output: Contribution to journal › Comment/debate › peer-review
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Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., O'Rourke, B. & He, L., Nov 5 2019, In: Cell Reports. 29, 6, p. 1511-1523.e5Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Mir-181c activates mitochondrial calcium uptake by regulating micu1 in the heart
Banavath, H. N., Roman, B., Mackowski, N., Biswas, D., Afzal, J., Nomura, Y., Solhjoo, S., O’Rourke, B., Kohr, M., Murphy, E., Steenbergen, C. & Das, S., 2019, In: Journal of the American Heart Association. 8, 24, e012919.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice
Rovira Gonzalez, Y. I., Moyer, A. L., LeTexier, N. J., Bratti, A. D., Feng, S., Sun, C., Liu, T., Mula, J., Jha, P., Iyer, S. R., Lovering, R., O’Rourke, B., Noh, H. L., Suk, S., Kim, J. K., Essien Umanah, G. K. & Wagner, K. R., Sep 17 2019, In: JCI Insight. 4, 20, e122247.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision
Ernst, P., Xu, N., Qu, J., Chen, H., Goldberg, M. S., Darley-Usmar, V., Zhang, J. J., O'Rourke, B., Liu, X. & Zhou, L., Aug 20 2019, In: Biophysical journal. 117, 4, p. 631-645 15 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Single-channel properties of the ROMK-pore-forming subunit of the mitochondrial ATP-sensitive potassium channel
Laskowski, M., Augustynek, B., Bednarczyk, P., Żochowska, M., Kalisz, J., O’rourke, B., Szewczyk, A. & Kulawiak, B., Nov 1 2019, In: International journal of molecular sciences. 20, 21, 5323.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop
Tian, R., Colucci, W. S., Arany, Z., Bachschmid, M. M., Ballinger, S. W., Boudina, S., Bruce, J. E., Busija, D. W., Dikalov, S., Dorn, G. W., Galis, Z. S., Gottlieb, R. A., Kelly, D. P., Kitsis, R. N., Kohr, M. J., Levy, D., Lewandowski, E. D., McClung, J. M., Mochly-Rosen, D., O'Brien, K. D., & 12 others, Oct 1 2019, In: Circulation. 140, 14, p. 1205-1216 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations -
2018
Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models
Vakrou, S., Fukunaga, R., Foster, D. B., Sorensen, L., Liu, Y., Guan, Y., Woldemichael, K., Pineda-Reyes, R., Liu, T., Tardiff, J. C., Leinwand, L. A., Tocchetti, C. G., Abraham, T. P., O'Rourke, B., Aon, M. A. & Abraham, M. R., Mar 22 2018, In: JCI Insight. 3, 6Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Assessing spatiotemporal and functional organization of mitochondrial networks
Kurz, F. T., Aon, M. A., O’Rourke, B. & Armoundas, A. A., 2018, Methods in Molecular Biology. Humana Press Inc., p. 383-402 20 p. (Methods in Molecular Biology; vol. 1782).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access5 Scopus citations -
Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model
Limpitikul, W. B., Viswanathan, M. C., O'Rourke, B., Yue, D. T. & Cammarato, A., Jun 2018, In: Journal of Molecular and Cellular Cardiology. 119, p. 64-74 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure
Dey, S., DeMazumder, D., Sidor, A., Brian Foster, D. & O'Rourke, B., 2018, In: Circulation research. 123, 3, p. 356-371 16 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
Mitochondrial transplantation in humans: “magical” cure or cause for concern?
Bertero, E., Maack, C. & O’Rourke, B., Dec 3 2018, In: Journal of Clinical Investigation. 128, 12, p. 5191-5194 4 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State
Wang, S. B., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In: Circulation research. 122, 11, p. 1517-1531 15 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2017
Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status
Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O'Rourke, B. & Abraham, M. R., Oct 2017, In: JACC: Basic to Translational Science. 2, 5, p. 543-560 18 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D. I., Solhjoo, S., O'Rourke, B., Tomaselli, G. F., Jeong, D. S., Cho, H. & Kang, J. S., Feb 21 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1345-E1354Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Functional implications of cardiac mitochondria clustering
Kurz, F. T., Aon, M. A., O’Rourke, B. & Armoundas, A. A., May 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, (Advances in Experimental Medicine and Biology; vol. 982).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access6 Scopus citations -
Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis
Haileselassie, B., Su, E., Pozios, I., Niño, D. F., Liu, H., Lu, D. Y., Ventoulis, I., Fulton, W. B., Sodhi, C. P., Hackam, D., O’Rourke, B. & Abraham, T., Dec 1 2017, In: Intensive Care Medicine Experimental. 5, 1, 21.Research output: Contribution to journal › Article › peer-review
Open Access -
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
Cho, G. S., Lee, D. I., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In: Cell Reports. 18, 2, p. 571-582 12 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations