Brian O'Rourke

Professor

1984 …2018
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Research Output 1984 2018

Assessing spatiotemporal and functional organization of mitochondrial networks

Kurz, F. T., Aon, M. A., O’Rourke, B. & Armoundas, A. A., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 383-402 20 p. (Methods in Molecular Biology; vol. 1782)

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiac Myocytes
Oxidation-Reduction
Mitochondrial Dynamics
Neurons
Mitochondrial Membrane Potential

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model

Limpitikul, W. B., Viswanathan, M. C., O'Rourke, B., Yue, D. T. & Cammarato, A., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 64-74 11 p.

Research output: Contribution to journalArticle

Diptera
Drosophila
Cardiac Myocytes
Channelopathies
Colforsin

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S. B., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinases
Phosphorylation
Phosphotransferases
Heart Failure
Sudden Cardiac Death

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O'Rourke, B. & Abraham, M. R., Oct 1 2017, In : JACC: Basic to Translational Science. 2, 5, p. 543-560 18 p.

Research output: Contribution to journalArticle

Glycolysis
Cell Adhesion
Adenosine Triphosphate
Phosphorylation
Glucose

Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling

Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D. I., Solhjoo, S., O'Rourke, B., Tomaselli, G. F., Jeong, D. S., Cho, H. & Kang, J. S., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1345-E1354

Research output: Contribution to journalArticle

beta Catenin
Connexin 43
Fibrosis
Cardiac Myocytes
Up-Regulation