Brian Ladle

Assistant Professor

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Fingerprint Dive into the research topics where Brian Ladle is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
T-Lymphocytes Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Neoplasm Antigens Medicine & Life Sciences
Tumor-Infiltrating Lymphocytes Medicine & Life Sciences
T-cells Chemical Compounds
Granulocyte-Macrophage Colony-Stimulating Factor Medicine & Life Sciences
Vaccination Medicine & Life Sciences
T-Cell Antigen Receptor Medicine & Life Sciences

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Research Output 2005 2019

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

Li, K. P., Ladle, B. H., Kurtulus, S., Sholl, A., Shanmuganad, S. & Hildeman, D. A., Jan 1 2019, (Accepted/In press) In : Cell death and differentiation.

Research output: Contribution to journalArticle

Open Access
T-Cell Antigen Receptor
DNA Methylation

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J., Jaffee, E., Hildeman, D. A. & Gamper, C., Sep 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Contribution to journalArticle

DNA Methylation
Wild Animals
DNA methyltransferase 3A

De Novo DNA methylation is required to restrict T helper lineage plasticity

Thomas, R. M., Gamper, C., Ladle, B., Powell, J. & Wells, A. D., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22900-22909 10 p.

Research output: Contribution to journalArticle

DNA Methylation

CD8+Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response

Le, D., Ladle, B., Lee, T., Weiss, V., Yao, X., Leubner, A., Armstrong, T. D. & Jaffee, E., Aug 1 2011, In : International Journal of Cancer. 129, 3, p. 636-647 12 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Tumor Microenvironment
Neoplasm Antigens

OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen

Murata, S., Ladle, B., Kim, P. S., Lutz, E. R., Wolpoe, M. E., Ivie, S. E., Smith, H. M., Armstrong, T. D., Emens, L. A., Jaffee, E. & Reilly, R. T., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 974-983 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Granulocyte-Macrophage Colony-Stimulating Factor