Brian Ladle

Assistant Professor


Research output per year

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Research Output

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

Li, K. P., Ladle, B. H., Kurtulus, S., Sholl, A., Shanmuganad, S. & Hildeman, D. A., Jan 1 2019, (Accepted/In press) In : Cell death and differentiation.

Research output: Contribution to journalArticle

Open Access
  • De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

    Ladle, B., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J., Jaffee, E., Hildeman, D. A. & Gamper, C., Sep 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

    Research output: Contribution to journalArticle

  • De Novo DNA methylation is required to restrict T helper lineage plasticity

    Thomas, R. M., Gamper, C. J., Ladle, B. H., Powell, J. D. & Wells, A. D., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22900-22909 10 p.

    Research output: Contribution to journalArticle

  • CD8+Foxp3+ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response

    Le, D. T., Ladle, B. H., Lee, T., Weiss, V., Yao, X., Leubner, A., Armstrong, T. D. & Jaffee, E. M., Aug 1 2011, In : International Journal of Cancer. 129, 3, p. 636-647 12 p.

    Research output: Contribution to journalArticle

  • OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen

    Murata, S., Ladle, B. H., Kim, P. S., Lutz, E. R., Wolpoe, M. E., Ivie, S. E., Smith, H. M., Armstrong, T. D., Emens, L. A., Jaffee, E. M. & Reilly, R. T., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 974-983 10 p.

    Research output: Contribution to journalArticle

    Open Access