Brady Maher

Associate Professor

20052019
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Research Output 2005 2019

2019

Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities

Li, H., Zhu, Y., Morozov, Y. M., Chen, X., Page, S. C., Rannals, M. D., Maher, B. & Rakic, P., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Genes
Haploinsufficiency
Neocortex
Neurogenesis
Locomotion
2018

Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability

Hill, J. L., Jimenez, D. V., Mai, Y., Ren, M., Hallock, H. L., Maynard, K. R., Chen, H. Y., Hardy, N. F., Schloesser, R. J., Maher, B., Yang, F. & Martinowich, K., Jan 1 2018, (Accepted/In press) In : Brain Structure and Function.

Research output: Contribution to journalArticle

Interneurons
Brain-Derived Neurotrophic Factor
Seizures
tropomyosin kinase
cortistatin

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

The BrainSeq Consortium, Aug 1 2018, In : Nature Neuroscience. 21, 8, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

Medical Genetics
Transcriptome
Schizophrenia
Quantitative Trait Loci
RNA Sequence Analysis
2017

The intellectual disability and schizophrenia associated transcription factor TCF4 is regulated by neuronal activity and protein kinase A

Sepp, M., Vihma, H., Nurm, K., Urb, M., Page, S. C., Roots, K., Hark, A., Maher, B., Pruunsild, P. & Timmusk, T., Oct 25 2017, In : Journal of Neuroscience. 37, 43, p. 10516-10527 12 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Intellectual Disability
Schizophrenia
Transcription Factors
Neurons

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

Page, S. C., Hamersky, G. R., Gallo, R. A., Rannals, M. D., Calcaterra, N. E., Campbell, M. N., Mayfield, B., Briley, A., Phan, B. N., Jaffe, A. & Maher, B., Mar 14 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Pyramidal Cells
Autistic Disorder
Schizophrenia
Transcription Factors
Psychiatry
2016

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

Li, M., Jaffe, A., Straub, R. E., Tao, R., Shin, J. H., Wang, Y., Chen, Q., Li, C., Jia, Y., Ohi, K., Maher, B., Brandon, N. J., Cross, A., Chenoweth, J. G., Hoeppner, D. J., Wei, H., Hyde, T., McKay, R., Kleinman, J. & Weinberger, D., Jun 1 2016, In : Nature Medicine. 22, 6, p. 649-656 8 p.

Research output: Contribution to journalArticle

Schizophrenia
Protein Isoforms
Genes
Polymorphism
Minisatellite Repeats

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In : Cell. 165, 5, p. 1238-1254 17 p.

Research output: Contribution to journalArticle

Organoids
Bioreactors
Viruses
Brain
Human Development

Crucial roles of the Arp2/3 complex during mammalian corticogenesis

Wang, P. S., Chou, F. S., Ramachandran, S., Xia, S., Chen, H. Y., Guo, F., Suraneni, P., Maher, B. & Li, R., Aug 1 2016, In : Development. 143, 15, p. 2741-2752 12 p.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Ependymoglial Cells
Actins
Cell Polarity
Adherens Junctions

Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

Saito, A., Taniguchi, Y., Rannals, M. D., Merfeld, E. B., Ballinger, M. D., Koga, M., Ohtani, Y., Gurley, D. A., Sedlak, T. W., Cross, A., Moss, S. J., Brandon, N. J., Maher, B. J. & Kamiya, A., Jan 5 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

GABA-A Receptors
Prefrontal Cortex
Psychiatry
Sensory Gating
Electroporation
Ants
Proteasome Endopeptidase Complex
Drug Discovery
Schizophrenia
Electrophysiological Phenomena
2015

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

Jaffe, A., Shin, J. H., Collado-Torres, L., Leek, J. T., Tao, R., Li, C., Gao, Y., Jia, Y., Maher, B., Hyde, T., Kleinman, J. & Weinberger, D., Jan 1 2015, In : Nature Neuroscience. 18, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Brain
Transcriptome
Gene Expression Profiling
Prefrontal Cortex
Chromatin

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

Rannals, M. D., Hamersky, G. R., Page, S. C., Campbell, M. N., Briley, A., Gallo, R. A., Phan, B. N., Hyde, T., Kleinman, J., Shin, J. H., Jaffe, A., Weinberger, D. & Maher, B., Mar 19 2015, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

Psychiatry
Transcription Factors
Ion Channels
Neurons
Genes
2014

Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder a novel transcript fetally regulated by the psychosis risk variant rs1344706

Tao, R., Cousijn, H., Jaffe, A., Burnet, P. W. J., Edwards, F., Eastwood, S. L., Shin, J. H., Lane, T. A., Walker, M. A., Maher, B., Weinberger, D., Harrison, P. J., Hyde, T. & Kleinman, J., Oct 1 2014, In : JAMA Psychiatry. 71, 10, p. 1112-1120 9 p.

Research output: Contribution to journalArticle

Zinc Fingers
Major Depressive Disorder
Bipolar Disorder
Psychotic Disorders
Schizophrenia

Knockdown of the dyslexia-associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex

Centanni, T. M., Booker, A. B., Sloan, A. M., Chen, F., Maher, B., Carraway, R. S., Khodaparast, N., Rennaker, R., LoTurco, J. J. & Kilgard, M. P., 2014, In : Cerebral Cortex. 24, 7, p. 1753-1766 14 p.

Research output: Contribution to journalArticle

Dyslexia
Auditory Cortex
Phonetics
Aptitude
RNA Interference

PiggyBac transposon-mediated cellular transgenesis in mammalian forebrain by in utero electroporation

Chen, F., Maher, B. & Loturco, J. J., Jul 1 2014, In : Cold Spring Harbor Protocols. 2014, 7, p. 741-749 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Electroporation
Prosencephalon
Plasmids
Cells
2012

Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses

Maher, B. & LoTurco, J. J., Mar 30 2012, In : PLoS One. 7, 3, e34053.

Research output: Contribution to journalArticle

synapse
Synapses
Schizophrenia
RNA Interference
glutamates

Olig2-dependent developmental fate switch of NG2 cells

Zhu, X., Zuo, H., Maher, B., Serwanski, D. R., LoTurco, J. J., Richard Lu, Q. & Nishiyama, A., Jul 1 2012, In : Development (Cambridge). 139, 13, p. 2299-2309 11 p.

Research output: Contribution to journalArticle

Astrocytes
Oligodendroglia
Prosencephalon
Basic Helix-Loop-Helix Transcription Factors
Corpus Callosum

ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2

Girgenti, M. J., LoTurco, J. J. & Maher, B., Feb 27 2012, In : PLoS One. 7, 2, e32404.

Research output: Contribution to journalArticle

Schizophrenia
Genes
chromatin
transcription (genetics)
promoter regions
2009

Direct actions of carbenoxolone on synaptic transmission and neuronal membrane properties

Tovar, K. R., Maher, B. & Westbrook, G. L., Aug 2009, In : Journal of Neurophysiology. 102, 2, p. 974-978 5 p.

Research output: Contribution to journalArticle

Carbenoxolone
Synaptic Transmission
Membranes
Excitatory Postsynaptic Potentials
Gap Junctions

Experience-dependent maturation of the glomerular microcircuit

Maher, B., McGinley, M. J. & Westbrook, G. L., Sep 29 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 39, p. 16865-16870 6 p.

Research output: Contribution to journalArticle

Gap Junctions
Dendrites
Sensory Deprivation
Membranes
Excitatory Postsynaptic Potentials

Stop and go GABA

Maher, B. & Loturco, J. J., Jul 2009, In : Nature Neuroscience. 12, 7, p. 817-818 2 p.

Research output: Contribution to journalShort survey

Interneurons
gamma-Aminobutyric Acid
Chlorides
2008

Co-transmission of dopamine and GABA in periglomerular cells

Maher, B. & Westbrook, G. L., Mar 2008, In : Journal of Neurophysiology. 99, 3, p. 1559-1564 6 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Dopamine
Olfactory Receptor Neurons
Tyrosine
Excitatory Postsynaptic Potentials
2005

Activation of postsynaptic Ca2+ stores modulates glutamate receptor cycling in hippocampal neurons

Maher, B., MacKinnon, R. L., Bai, J., Chapman, E. R. & Kelly, P. T., Jan 2005, In : Journal of Neurophysiology. 93, 1, p. 178-188 11 p.

Research output: Contribution to journalArticle

AMPA Receptors
Synaptotagmins
Excitatory Postsynaptic Potentials
Glutamate Receptors
SNARE Proteins

Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons

Kelly, P. T., MacKinnon, R. L., Dietz, R. V., Maher, B. & Wang, J., Apr 27 2005, In : Molecular Brain Research. 135, 1-2, p. 232-248 17 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Excitatory Postsynaptic Potentials
Synaptic Transmission
Perfusion
Neurons

SK channel regulation of dendritic excitability and dendrodendritic inhibition in the olfactory bulb

Maher, B. & Westbrook, G. L., Dec 2005, In : Journal of Neurophysiology. 94, 6, p. 3743-3750 8 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Apamin
N-Methylaspartate
Dendrites
Action Potentials