Betty Mae Tyler

Associate Professor

1994 …2020

Research output per year

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Research Output

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Article
2020

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies

Choi, J., Rui, Y., Kim, J., Gorelick, N., Wilson, D. R., Kozielski, K., Mangraviti, A., Sankey, E., Brem, H., Tyler, B., Green, J. J. & Jackson, E. M., Jan 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 23, 102115.

Research output: Contribution to journalArticle

2019

A miniature multi-contrast microscope for functional imaging in freely behaving animals

Senarathna, J., Yu, H., Deng, C., Zou, A. L., Issa, J. B., Hadjiabadi, D. H., Gil, S., Wang, Q., Tyler, B. M., Thakor, N. V. & Pathak, A., Dec 1 2019, In : Nature Communications. 10, 1, 99.

Research output: Contribution to journalArticle

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer

Shapira-Furman, T., Serra, R., Gorelick, N., Doglioli, M., Tagliaferri, V., Cecia, A., Peters, M., Kumar, A., Rottenberg, Y., Langer, R., Brem, H., Tyler, B. M. & Domb, A. J., Feb 10 2019, In : Journal of Controlled Release. 295, p. 93-101 9 p.

Research output: Contribution to journalArticle

Evaluation of an in vivo model for ventricular shunt infection: A pilot study using a novel antimicrobial-loaded polymer

Iyer, R. R., Gorelick, N., Carroll, K., Blitz, A. M., Beck, S., Garrett, C. M., Monroe, A., Tyler, B., Zuckerman, S. T., Capadona, J. R., Von Recum, H. A. & Luciano, M. G., Jan 1 2019, In : Journal of neurosurgery. 131, 2, p. 587-595 9 p.

Research output: Contribution to journalArticle

Evaluation of select biocompatible markers for labelling peripheral nerves on 11.7 T MRI

Gullotti, D., Mangraviti, A., Zhang, J., Volpin, F., Fink, G., Reiss, R., Ahlawat, S., Olivi, A., Hoke, A., Tyler, B. M. & Belzberg, A. J., Mar 1 2019, In : Journal of Neuroscience Methods. 315, p. 6-13 8 p.

Research output: Contribution to journalArticle

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor

Han, D., Serra, R., Gorelick, N., Fatima, U., Eberhart, C. G., Brem, H., Tyler, B. & Steckl, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 17936.

Research output: Contribution to journalArticle

Open Access

Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste

Smith, S. J., Tyler, B. M., Gould, T., Veal, G. J., Gorelick, N., Rowlinson, J., Serra, R., Ritchie, A., Berry, P., Otto, A., Choi, J., Skuli, N., Estevez-Cebrero, M., Shakesheff, K. M., Brem, H., Grundy, R. G. & Rahman, R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 5094-5106 13 p.

Research output: Contribution to journalArticle

Open Access
2018

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., Belcaid, Z., Ganguly, S., Tyler, B., Brem, H., Pardoll, D. M. & Lim, M., Apr 17 2018, In : Oncotarget. 9, 29, p. 20681-20697 17 p.

Research output: Contribution to journalArticle

Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

Casaos, J., Huq, S., Lott, T., Felder, R., Choi, J., Gorelick, N., Peters, M., Xia, Y., Maxwell, R., Zhao, T., Ji, C., Simon, T., Sesen, J., Scotland, S. J., Kast, R. E., Rubens, J., Raabe, E., Eberhart, C. G., Jackson, E. M., Brem, H. & 2 others, Tyler, B. & Skuli, N., Jan 1 2018, In : Oncotarget. 9, 8, p. 8054-8067 14 p.

Research output: Contribution to journalArticle

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Paldor, I., Chaichana, K. L., Brem, H. & Tyler, B. M., Jan 1 2018, In : Progress in neurological surgery. 32, p. 159-171 13 p.

Research output: Contribution to journalArticle

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

Hung, A. L., Maxwell, R., Theodros, D., Belcaid, Z., Mathios, D., Luksik, A. S., Kim, E., Wu, A., Xia, Y., Garzon-Muvdi, T., Jackson, C., Ye, X., Tyler, B. M., Selby, M., Korman, A., Barnhart, B., Park, S. M., Youn, J. I., Chowdhury, T., Park, C. K. & 3 others, Brem, H., Pardoll, A. M. & Lim, M., May 23 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

2017

Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas

Kim, J. E., Patel, M. A., Mangraviti, A., Kim, E. S., Theodros, D., Velarde, E., Liu, A., Sankey, E. W., Tam, A., Xu, H., Mathios, D., Jackson, C. M., Harris-Bookman, S., Garzon-Muvdi, T., Sheu, M., Martin, A., Tyler, B. M., Tran, P. T., Ye, X., Olivi, A. & 6 others, Taube, J. M., Burger, P. C., Drake, C. G., Brem, H., Pardoll, A. M. & Lim, M., Jan 1 2017, In : Clinical Cancer Research. 23, 1, p. 124-136 13 p.

Research output: Contribution to journalArticle

Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: An orthotopic spine model

Sarabia-Estrada, R., Ruiz-Valls, A., Shah, S. R., Ahmed, A. K., Ordonez, A. A., Rodriguez, F. J., Guerrero-Cazares, H., Jimenez-Estrada, I., Velarde, E., Tyler, B., Li, Y., Phillips, N. A., Goodwin, C. R., Petteys, R. J., Jain, S. K., Gallia, G. L., Gokaslan, Z. L., Quinones-Hinojosa, A. & Sciubba, D. M., Aug 1 2017, In : Journal of Neurosurgery: Spine. 27, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy

Mangraviti, A., Raghavan, T., Volpin, F., Skuli, N., Gullotti, D., Zhou, J., Asnaghi, L., Sankey, E., Liu, A., Wang, Y., Lee, D. H., Gorelick, N., Serra, R., Peters, M., Schriefer, D., Delaspre, F., Rodriguez, F. J., Eberhart, C. G., Brem, H., Olivi, A. & 1 others, Tyler, B. M., Dec 1 2017, In : Scientific Reports. 7, 1, 14978.

Research output: Contribution to journalArticle

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. J. & Riggins, G. J., Jan 1 2017, In : Oncotarget. 8, 46, p. 80124-80138 15 p.

Research output: Contribution to journalArticle

The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma

Paldor, I., Abbadi, S., Bonne, N., Ye, X., Rodriguez, F. J., Rowshanshad, D., Itzoe, M. L., Vigilar, V., Giovannini, M., Brem, H., Blakeley, J. & Tyler, B. M., Jul 22 2017, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., Francica, B., Nirschl, T. R., Ghasemzadeh, A., Mathios, D., Harris-Bookman, S., Jackson, C. C., Jackson, C., Ye, X., Tran, P. T., Tyler, B., Coric, V., Selby, M., Brem, H., Drake, C. G. & 2 others, Pardoll, D. M. & Lim, M., May 17 2016, In : Journal for immunotherapy of cancer. 4, 1, 28.

Research output: Contribution to journalArticle

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C. K., Jackson, C. M., Garzon-Muvdi, T., Kim, E., Theodros, D., Polanczyk, M., Martin, A., Suk, I., Ye, X., Tyler, B. M., Bettegowda, C., Brem, H., Pardoll, A. M. & Lim, M., Dec 21 2016, In : Science Translational Medicine. 8, 370, 370ra180.

Research output: Contribution to journalArticle

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

Zhang, C., Nance, E. A., Mastorakos, P., Chisholm, J., Berry, S., Eberhart, C. G., Tyler, B. M., Brem, H., Suk, J. S. & Hanes, J. S., Dec 5 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival

Mangraviti, A., Tzeng, S., Gullotti, D., Kozielski, K. L., Kim, J. E., Seng, M., Abbadi, S., Schiapparelli, P., Sarabia-Estrada, R., Vescovi, A., Brem, H., Olivi, A., Tyler, B. M., Green, J. & Quinones-Hinojosa, A., Sep 1 2016, In : Biomaterials. 100, p. 53-66 14 p.

Research output: Contribution to journalArticle

Polylactic acid (PLA) controlled delivery carriers for biomedical applications

Tyler, B. M., Gullotti, D., Mangraviti, A., Utsuki, T. & Brem, H., Apr 25 2016, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications

Chintakunta, R., Buaron, N., Kahn, N., Moriah, A., Lifshiz, R., Goldbart, R., Traitel, T., Tyler, B. M., Brem, H. & Kost, J., Oct 5 2016, In : Carbohydrate Polymers. 150, p. 308-318 11 p.

Research output: Contribution to journalArticle

The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain

Jackson, S., Anders, N. M., Mangraviti, A., Wanjiku, T. M., Sankey, E. W., Liu, A., Brem, H., Tyler, B., Rudek, M. A. & Grossman, S. A., Feb 1 2016, In : Journal of neuro-oncology. 126, 3, p. 433-439 7 p.

Research output: Contribution to journalArticle

The Johns Hopkins hunterian laboratory philosophy: Mentoring students in a scientific neurosurgical research laboratory

Tyler, B. M., Liu, A., Sankey, E. W., Mangraviti, A., Barone, M. A. & Brem, H., Jun 1 2016, In : Academic Medicine. 91, 6, p. 778-784 7 p.

Research output: Contribution to journalArticle

Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic

Volpin, F., Casaos, J., Sesen, J., Mangraviti, A., Choi, J., Gorelick, N., Frikeche, J., Lott, T., Felder, R., Scotland, S. J., Eisinger-Mathason, T. S. K., Brem, H., Tyler, B. M. & Skuli, N., Dec 12 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2015

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

Staedtke, V., Bai, R. Y., Sun, W., Huang, J., Kibler, K. K., Tyler, B. M., Gallia, G. L., Kinzler, K., Vogelstein, B., Zhou, S. & Riggins, G. J., Jan 1 2015, In : Oncotarget. 6, 8, p. 5536-5546 11 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis

Yoshida, J., Wicks, R. T., Zambrano, A. I., Tyler, B. M., Javaherian, K., Grossman, R., Daoud, Y. J., Gehlbach, P., Brem, H. & Stark, W. J., Jan 1 2015, In : Journal of Ophthalmology. 2015, 137136.

Research output: Contribution to journalArticle

Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy

Mangraviti, A., Tyler, B. & Brem, H., Jan 1 2015, In : Surgical Neurology International. 6, 2, p. S78-S84

Research output: Contribution to journalArticle

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

Wicks, R. T., Azadi, J., Mangraviti, A., Zhang, I., Hwang, L., Joshi, A., Bow, H., Hutt-Cabezas, M., Martin, K. L., Rudek, M. A., Zhao, M., Brem, H. & Tyler, B. M., Jan 1 2015, In : Neuro-oncology. 17, 1, p. 70-80 11 p.

Research output: Contribution to journalArticle

Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response

Sesen, J., Dahan, P., Scotland, S. J., Saland, E., Dang, V. T., Lemarié, A., Tyler, B. M., Brem, H., Toulas, C., Moyal, E. C. J., Sarry, J. E. & Skuli, N., Apr 13 2015, In : PloS one. 10, 4, e0123721.

Research output: Contribution to journalArticle

MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel

Grossman, R., Burger, P., Soudry, E., Tyler, B., Chaichana, K. L., Weingart, J., Olivi, A., Gallia, G. L., Sidransky, D., Quiñones-Hinojosa, A., Ye, X. & Brem, H., Dec 2015, In : Journal of Clinical Neuroscience. 22, 12, p. 1938-1942 5 p.

Research output: Contribution to journalArticle

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies

Mangraviti, A., Gullotti, D., Tyler, B. & Brem, H., Sep 18 2015, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo

Mangraviti, A., Tzeng, S. Y., Kozielski, K. L., Wang, Y., Jin, Y., Gullotti, D., Pedone, M., Buaron, N., Liu, A., Wilson, D. R., Hansen, S. K., Rodriguez, F. J., Gao, G. D., Dimeco, F., Brem, H., Olivi, A., Tyler, B. & Green, J. J., Feb 24 2015, In : ACS Nano. 9, 2, p. 1236-1249 14 p.

Research output: Contribution to journalArticle

Quantitative correlational study of microbubble-enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model

Yang, C., Lee, D. H., Mangraviti, A., Su, L., Zhang, K., Zhang, Y., Zhang, B., Li, W., Tyler, B., Wong, J., Wang, K. K. H., Velarde, E., Zhou, J. & Ding, K., Aug 1 2015, In : Medical physics. 42, 8, p. 4762-4772 11 p.

Research output: Contribution to journalArticle

Safety studies of post-surgical buprenorphine therapy for mice

Traul, K. A., Romero, J. B., Brayton, C., DeTolla, L., Forbes-McBean, N., Halquist, M. S., Karnes, H. T., Sarabia-Estrada, R., Tomlinson, M. J., Tyler, B. M., Ye, X., Zadnik, P. & Guarnieri, M., Apr 1 2015, In : Laboratory Animals. 49, 2, p. 100-110 11 p.

Research output: Contribution to journalArticle

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

Zhang, F., Mastorakos, P., Mishra, M. K., Mangraviti, A., Hwang, L., Zhou, J., Hanes, J., Brem, H., Olivi, A., Tyler, B. & Kannan, R. M., Jan 1 2015, In : Biomaterials. 52, 1, p. 507-516 10 p.

Research output: Contribution to journalArticle

2014

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models

Grossman, R., Brastianos, H., Blakeley, J. O., Mangraviti, A., Lal, B., Zadnik, P., Hwang, L., Wicks, R. T., Goodwin, R. C., Brem, H. & Tyler, B., Jan 1 2014, In : Journal of neuro-oncology. 116, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models: Laboratory investigation

Yohay, K., Tyler, B., Weaver, K. D., Pardo, A. C., Gincel, D., Blakeley, J., Brem, H. & Rothstein, J. D., Apr 2014, In : Journal of neurosurgery. 120, 4, p. 854-863 10 p.

Research output: Contribution to journalArticle

Extravascular optical coherence tomography: Evaluation of carotid atherosclerosis and pravastatin therapy

Wicks, R. T., Huang, Y., Zhang, K., Zhao, M., Tyler, B. M., Suk, I., Hwang, L., Ruzevick, J., Jallo, G., Brem, H., Pradilla, G. & Kang, J. U., Apr 2014, In : Stroke. 45, 4, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model

Belcaid, Z., Phallen, J. A., Zeng, J., See, A. P., Mathios, D., Gottschalk, C., Nicholas, S., Kellett, M., Ruzevick, J., Jackson, C., Albesiano, E., Durham, N. M., Ye, X., Tran, P. T., Tyler, B., Wong, J. W., Brem, H., Pardoll, D. M., Drake, C. G. & Lim, M., Jul 11 2014, In : PloS one. 9, 7, e101764.

Research output: Contribution to journalArticle

Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain

Upadhyay, U. M., Tyler, B., Patta, Y., Wicks, R., Spencer, K., Scott, A., Masi, B., Hwang, L., Grossman, R., Cima, M., Brem, H. & Langer, R., Nov 11 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 16071-16076 6 p.

Research output: Contribution to journalArticle

Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma: Laboratory investigation

Bow, H., Hwang, L. S., Schildhaus, N., Xing, J., Murray, L., Salditch, Q., Ye, X., Zhang, Y., Weingart, J., Brem, H. & Tyler, B., Mar 2014, In : Journal of neurosurgery. 120, 3, p. 662-669 8 p.

Research output: Contribution to journalArticle

Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model

Hong, X., Liu, L., Wang, M., Ding, K., Fan, Y., Ma, B., Lal, B., Tyler, B., Mangraviti, A., Wang, S., Wong, J., Laterra, J. & Zhou, J., Jun 2014, In : Neuro-oncology. 16, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer

Gabikian, P., Tyler, B. M., Zhang, I., Li, K. W., Brem, H. & Walter, K. A., May 2014, In : Journal of neurosurgery. 120, 5, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

Subcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs

Guarnieri, M., Tyler, B., Detolla, L., Zhao, M. & Kobrin, B., Jan 1 2014, In : Journal of Pharmacy and Bioallied Sciences. 6, 1, p. 38-42 5 p.

Research output: Contribution to journalArticle

Thermal latency studies in opiate-treated mice

Schildhaus, N., Trink, E., Polson, C., Detolla, L., Tyler, B., Jallo, G., Tok, S. & Guarnieri, M., Jan 1 2014, In : Journal of Pharmacy and Bioallied Sciences. 6, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

2013

Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas

Zeng, J., See, A. P., Phallen, J., Jackson, C. M., Belcaid, Z., Ruzevick, J., Durham, N., Meyer, C., Harris, T. J., Albesiano, E., Pradilla, G., Ford, E., Wong, J., Hammers, H. J., Mathios, D., Tyler, B., Brem, H., Tran, P. T., Pardoll, D., Drake, C. G. & 1 others, Lim, M., Jun 1 2013, In : International Journal of Radiation Oncology Biology Physics. 86, 2, p. 343-349 7 p.

Research output: Contribution to journalArticle

Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model

Vellimana, A. K., Recinos, V. R., Hwang, L., Fowers, K. D., Li, K. W., Zhang, Y., Okonma, S., Eberhart, C. G., Brem, H. & Tyler, B. M., Feb 1 2013, In : Journal of neuro-oncology. 111, 3, p. 229-236 8 p.

Research output: Contribution to journalArticle

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma

Sattler, R., Tyler, B., Hoover, B., Coddington, L. T., Recinos, V., Hwang, L., Brem, H. & Rothstein, J. D., Oct 1 2013, In : Journal of neurosurgery. 119, 4, p. 878-886 9 p.

Research output: Contribution to journalArticle