Beth L Laube

Professor

1978 …2020

Research output per year

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Research Output

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2020

Aerosol deposition in 3D models of the upper airways and trachea of rhesus macaques

Kesavan, J. S., Alstadt, V. J. & Laube, B. L., 2020, (Accepted/In press) In : Aerosol Science and Technology.

Research output: Contribution to journalArticle

Changes in mucociliary clearance over time in children with cystic fibrosis

Laube, B. L., Carson, K. A., Evans, C. M., Richardson, V. L., Sharpless, G., Zeitlin, P. L. & Mogayzel, P. J., Sep 1 2020, In : Pediatric pulmonology. 55, 9, p. 2307-2314 8 p.

Research output: Contribution to journalArticle

2019
2018

Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR

Donaldson, S. H., Laube, B. L., Corcoran, T. E., Bhambhvani, P., Zeman, K., Ceppe, A., Zeitlin, P. L., Mogayzel, P. J., Boyle, M. P., Locke, L. W., Myerburg, M. M., Pilewski, J. M., Flanagan, B., Rowe, S. M. & Bennett, W. D., Dec 20 2018, In : JCI insight. 3, 24

Research output: Contribution to journalArticle

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force, Nov 1 2018, In : The European respiratory journal. 52, 5

Research output: Contribution to journalArticle

Homogeneity of Aerosol Deposition and Mucociliary Clearance are Improved Following Ivacaftor Treatment in Cystic Fibrosis

Bennett, W. D., Zeman, K. L., Laube, B. L., Wu, J., Sharpless, G., Mogayzel, P. & Donaldson, S. H., Aug 1 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 31, 4, p. 204-211 8 p.

Research output: Contribution to journalArticle

Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis

Trimble, A. T., Whitney Brown, A., Laube, B. L., Lechtzin, N., Zeman, K. L., Wu, J., Ceppe, A., Waltz, D., Bennett, W. D. & Donaldson, S. H., Sep 2018, In : Journal of Cystic Fibrosis. 17, 5, p. 650-656 7 p.

Research output: Contribution to journalArticle

2017

ERS technical standard on bronchial challenge testing: General considerations and performance of methacholine challenge tests

Coates, A. L., Wanger, J., Cockcroft, D. W., Culver, B. H., Carlsen, K. H., Diamant, Z., Gauvreau, G., Hall, G. L., Hallstrand, T. S., Horvath, I., De Jongh, F. H. C., Joos, G., Kaminsky, D. A., Laube, B. L., Leuppi, J. D. & Sterk, P. J., May 1 2017, In : European Respiratory Journal. 49, 5, 1601526.

Research output: Contribution to journalArticle

2015

Aerosolized medications for gene and peptide therapy

Laube, B. L., Jun 1 2015, In : Respiratory care. 60, 6, p. 806-821 16 p.

Research output: Contribution to journalArticle

Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children

Laube, B. L., Sharpless, G., Vikani, A. R., Harrand, V., Zinreich, S. J., Sedberry, K., Knaus, D., Barry, J. & Papania, M., Oct 1 2015, In : Journal of aerosol medicine and pulmonary drug delivery. 28, 5, p. 320-333 14 p.

Research output: Contribution to journalArticle

2014

Mucus removal is impaired in children with cystic fibrosis who have been infected by pseudomonas aeruginosa

Laube, B. L., Sharpless, G., Benson, J., Carson, K. A. & Mogayzel, P. J., Apr 2014, In : Journal of Pediatrics. 164, 4, p. 839-845 7 p.

Research output: Contribution to journalArticle

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA

Lin, W. H. W., Pan, C. H., Adams, R. J., Laube, B. L. & Griffin, D. E., Apr 15 2014, In : mBio. 5, 2, e01047-14.

Research output: Contribution to journalArticle

2013

Multisite comparison of mucociliary and cough clearance measures using standardized methods

Bennett, W. D., Laube, B. L., Corcoran, T., Zeman, K., Sharpless, G., Thomas, K., Wu, J., Mogayzel, P. J., Pilewski, J. & Donaldson, S., Jun 1 2013, In : Journal of aerosol medicine and pulmonary drug delivery. 26, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques

Rosenberg, Y. J., Laube, B., Mao, L., Jiang, X., Hernandez-Abanto, S., Lee, K. D. & Adams, R., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

2012

Deposition of dry powder generated by solovent in Sophia Anatomical Infant Nose-Throat (SAINT) model

Laube, B. L., Sharpless, G., Shermer, C., Sullivan, V. & Powell, K., May 1 2012, In : Aerosol Science and Technology. 46, 5, p. 514-520 7 p.

Research output: Contribution to journalArticle

Editorial: Standards for lung imaging techniques.

Laube, B. L., Corcoran, T. E., Devadason, S. G., Dolovich, M. B., Fleming, J. & Newman, S., Dec 2012, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 25 Suppl 1

Research output: Contribution to journalArticle

Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products

Newman, S., Bennett, W. D., Biddiscombe, M., Devadason, S. G., Dolovich, M. B., Fleming, J., Haeussermann, S., Kietzig, C., Kuehl, P. J., Laube, B. L., Sommerer, K., Taylor, G., Usmani, O. S. & Zeman, K. L., Dec 1 2012, In : Journal of aerosol medicine and pulmonary drug delivery. 25, SUPPL.1, p. S10-S28

Research output: Contribution to journalArticle

Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products

Fleming, J., Bailey, D. L., Chan, H. K., Conway, J., Kuehl, P. J., Laube, B. L. & Newman, S., Dec 1 2012, In : Journal of aerosol medicine and pulmonary drug delivery. 25, SUPPL.1, p. S29-S51

Research output: Contribution to journalArticle

2011
2010

Demonstrating bioequivalence of locally acting orally inhaled drug products (OIPs): Workshop summary report

Adams, W. P., Ahrens, R. C., Chen, M. L., Christopher, D., Chowdhury, B. A., Conner, D. P., Dalby, R., Fitzgerald, K., Hendeles, L., Hickey, A. J., Hochhaus, G., Laube, B. L., Lucas, P., Lee, S. L., Lyapustina, S., Li, B., O'Connor, D., Parikh, N., Parkins, D. A., Peri, P. & 10 others, Pitcairn, G. R., Riebe, M., Roy, P., Shah, T., Singh, G. J. P., Sharp, S. S., Suman, J. D., Weda, M., Woodcock, J. & Yu, L., Feb 1 2010, In : Journal of aerosol medicine and pulmonary drug delivery. 23, 1, p. 1-29 29 p.

Research output: Contribution to journalArticle

Deposition of albuterol aerosol generated by pneumatic nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) model

Laube, B. L., Sharpless, G., Shermer, C., Nasir, O., Sullivan, V. & Powell, K., Aug 1 2010, In : Pharmaceutical Research. 27, 8, p. 1722-1729 8 p.

Research output: Contribution to journalArticle

Vagal control of mucociliary clearance in murine lungs: A study in a chronic preparation

Bhashyam, A. R., Mogayzel, P. J., Cleary, J. C., Undem, B. J., Kollarik, M., Fox, J. & Laube, B. L., Apr 19 2010, In : Autonomic Neuroscience: Basic and Clinical. 154, 1-2, p. 74-78 5 p.

Research output: Contribution to journalArticle

2008

Chronic inhalation of nebulized levalbuterol does not increase mucociliary clearance in healthy subjects

Cleary, J. C., Karmazyn, Y., Mogayzel, P. J. & Laube, B. L., Feb 1 2008, In : Pulmonary Pharmacology and Therapeutics. 21, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

2007

Albuterol Improves Impaired Mucociliary Clearance After Lung Transplantation

Laube, B. L., Karmazyn, Y. J., Orens, J. B. & Mogayzel, P. J., Feb 1 2007, In : Journal of Heart and Lung Transplantation. 26, 2, p. 138-144 7 p.

Research output: Contribution to journalArticle

Mucociliary clearance as an outcome measure for cystic fibrosis clinical research

Donaldson, S. H., Corcoran, T. E., Laube, B. L. & Bennett, W. D., Aug 1 2007, In : Proceedings of the American Thoracic Society. 4, 4, p. 399-405 7 p.

Research output: Contribution to journalArticle

2006

IL-12 overexpression in mice as a model for Sjögren lung disease

McGrath-Morrow, S., Laube, B., Tzou, S. C., Cho, C., Cleary, J., Kimura, H., Rose, N. R. & Caturegli, P., Oct 9 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 291, 4, p. L837-L846

Research output: Contribution to journalArticle

2005

Positive expiratory pressure changes aerosol distribution in patients with cystic fibrosis

Laube, B. L., Geller, D. E., Lin, T. C., Dalby, R. N., Diener-West, M. & Zeitlin, P. L., Nov 1 2005, In : Respiratory care. 50, 11, p. 1438-1444 7 p.

Research output: Contribution to journalArticle

The effect of formulation variables and breathing patterns on the site of nasal deposition in an anatomically correct model

Guo, Y., Laube, B. & Dalby, R., Nov 1 2005, In : Pharmaceutical Research. 22, 11, p. 1871-1878 8 p.

Research output: Contribution to journalArticle

The expanding role of aerosols in systemic drug delivery, gene therapy, and vaccination

Laube, B. L., Sep 1 2005, In : Respiratory care. 50, 9, p. 1161-1174 14 p.

Research output: Contribution to journalArticle

2003

Early pulmonary response to allergen is attenuated during acute emotional stress in females with asthma

Laube, B. L., Curbow, B. A., Fitzgerald, S. T. & Spratt, K., Oct 1 2003, In : European Respiratory Journal. 22, 4, p. 613-618 6 p.

Research output: Contribution to journalArticle

Open Access

Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques

Fischer, A. C., Beck, S. E., Smith, C. I., Laube, B. L., Askin, F. B., Guggino, S. E., Adams, R. J., Flotte, T. B. & Guggino, W. B., Dec 2003, In : Molecular Therapy. 8, 6, p. 918-926 9 p.

Research output: Contribution to journalArticle

2002

Allergen challenge and deposition of nedocromil sodium in asthma

Laube, B. L., Lin, T. C., Valleteau, A., Dalby, R. N., Diemer, F. B. & Togias, A. G., Dec 1 2002, In : Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 15, 4, p. 415-425 11 p.

Research output: Contribution to journalArticle

A pilot study examining the relationship between stress and serum cortisol concentrations in women with asthma

Laube, B. L., Curbow, B. A., Costello, R. W. & Fitzgerald, S. T., Oct 2002, In : Respiratory Medicine. 96, 10, p. 823-828 6 p.

Research output: Contribution to journalArticle

Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques

Beck, S. E., Laube, B. L., Barberena, C. I., Fischer, A. C., Adams, R. J., Chesnut, K., Flotte, T. R. & Guggino, W. B., Oct 1 2002, In : Molecular Therapy. 6, 4, p. 546-554 9 p.

Research output: Contribution to journalArticle

Validity of in vitro tests on aqueous spray pumps as surrogates for nasal deposition

Suman, J. D., Laube, B. L., Lin, T. C., Brouet, G. & Dalby, R., Jan 29 2002, In : Pharmaceutical Research. 19, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

2001

Gene therapy in cystic fibrosis

Flotte, T. R. & Laube, B. L., Jan 1 2001, In : CHEST. 120, 3 SUPPL., p. 124S-131S

Research output: Contribution to journalArticle

Treating diabetes with aerosolized insulin

Laube, B. L., Jan 1 2001, In : CHEST. 120, 3 SUPPL., p. 99S-106S

Research output: Contribution to journalArticle

2000

Potent bronchoprotective effect of deep inspiration and its absence in asthma

Kapsali, T., Permutt, S., Laube, B., Scichilone, N. & Togias, A., 2000, In : Journal of applied physiology. 89, 2, p. 711-720 10 p.

Research output: Contribution to journalArticle

Targeting aerosol deposition in patients with cystic fibrosis: Effects of alterations in particle size and inspiratory flow rate

Laube, B. L., Jashnani, R., Dalby, R. N. & Zeitlin, P. L., Jan 1 2000, In : CHEST. 118, 4, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

The relationship between particle deposition in the anterior nasal passage and nasal passage characteristics

Kesavan, J., Bascom, R., Laube, B. & Swift, D. L., Jan 1 2000, In : Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 13, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

1999

Comparison of nasal deposition and clearance of aerosol generated by a nebulizer and an aqueous spray pump

Suman, J. D., Laube, B. L. & Dalby, R., Nov 11 1999, In : Pharmaceutical Research. 16, 10, p. 1648-1652 5 p.

Research output: Contribution to journalArticle

1998

Measurement of aerosol deposition in CF

Laube, B. L., Oct 1 1998, In : Pediatric pulmonology. 26, 3 SUPPL. 17, p. 181-182 2 p.

Research output: Contribution to journalArticle

Predicting in vivo lung deposition of cromolyn sodium from in vitro estimates

Laube, B. L., Jashnani, R. & Dalby, R. N., Jul 1 1998, In : Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 11, SUPPL. 1, p. S35-S42

Research output: Contribution to journalArticle

The Lung As an Alternative Route of Delivery for Insulin in Controlling Postprandial Glucose Levels in Patients with Diabetes

Laube, B. L., Benedict, G. W. & Dobs, A. S., 1998, In : CHEST. 114, 6, p. 1734-1739 6 p.

Research output: Contribution to journalArticle