Research output per year
Research output per year
- 1 - 50 out of 117 results
Search results
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2020
A Phase I Study of Dinaciclib in Combination With MK-2206 in Patients With Advanced Pancreatic Cancer
for the ETCTN-9231 Study Team, Nov 2020, In: Clinical and translational science. 13, 6, p. 1178-1188 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Epigenetic therapy inhibits metastases by disrupting premetastatic niches
Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., Li, H., Cai, Y., Xia, L., Huang, P., Rodgers, K., Lee, B., Riemer, J. B., Day, C. P., Yen, R. W. C., Cui, Y., & 28 others, Mar 12 2020, In: Nature. 579, 7798, p. 284-290 7 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
2019
A phase i trial of the VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced solid tumors and differentiated thyroid cancers
Kurzrock, R., Ball, D. W., Zahurak, M. L., Nelkin, B. D., Subbiah, V., Ahmed, S., O'Connor, A., Karunsena, E., Parkinson, R. M., Bishop, J. A., Ha, Y., Sharma, R., Gocke, C. D., Zinner, R., Rudek, M. A., Sherman, S. I. & Azad, N. S., Sep 15 2019, In: Clinical Cancer Research. 25, 18, p. 5475-5484 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2018
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis
Taparra, K., Wang, H., Malek, R., Lafargue, A., Barbhuiya, M. A., Wang, X., Simons, B. W., Ballew, M., Nugent, K., Groves, J., Williams, R. D., Shiraishi, T., Verdone, J., Yildirir, G., Henry, R., Zhang, B., Wong, J., Wang, K. K. H., Nelkin, B. D., Pienta, K. J., & 3 others, Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4924-4937 14 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2017
Overall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma
Schlumberger, M., Elisei, R., Müller, S., Schöffski, P., Brose, M., Shah, M., Licitra, L., Krajewska, J., Kreissl, M. C., Niederle, B., Cohen, E. E. W., Wirth, L., Ali, H., Clary, D. O., Yaron, Y., Mangeshkar, M., Ball, D., Nelkin, B. & Sherman, S., Nov 2017, In: Annals of Oncology. 28, 11, p. 2813-2819 7 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
Recent advances in the biology and therapy of medullary thyroid carcinoma
Nelkin, B., 2017, In: F1000Research. 6, 2184.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
2016
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H., & 4 others, Jan 11 2016, In: Cancer cell. 29, 1, p. 75-89 15 p.Research output: Contribution to journal › Article › peer-review
Open Access120 Scopus citations -
2015
A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours
Wilky, B. A., Rudek, M. A., Ahmed, S., Laheru, D. A., Cosgrove, D., Donehower, R. C., Nelkin, B., Ball, D., Doyle, L. A., Chen, H., Ye, X., Bigley, G., Womack, C. & Azad, N. S., Jan 6 2015, In: British journal of cancer. 112, 1, p. 24-31 8 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Combined inhibition of cyclin-dependent kinases (dinaciclib) and AKT(MK-2206) blocks pancreatic tumor growth and metastases in patient-derived xenograft models
Hu, C., Dadon, T., Chenna, V., Yabuuchi, S., Bannerji, R., Booher, R., Strack, P., Azad, N., Nelkin, B. D. & Maitra, A., Jul 1 2015, In: Molecular cancer therapeutics. 14, 7, p. 1532-1539 8 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Trametinib with and without pazopanib has potent preclinical activity in thyroid cancer
Ball, D. W., Jin, N., Xue, P., Bhan, S., Ahmed, S. R., Rosen, D. M., Schayowit Z, A., Clark, D. P. & Nelkin, B. D., Nov 1 2015, In: Oncology reports. 34, 5, p. 2319-2324 6 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2014
Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression
Wissing, M. D., Dadon, T., Kim, E., Piontek, K. B., Shim, J. S., Kaelber, N. S., Liu, J. O., Kachhap, S. K. & Nelkin, B. D., Jul 2014, In: Oncology reports. 32, 1, p. 419-424 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2013
Cabozantinib in progressive medullary thyroid cancer
Elisei, R., Schlumberger, M. J., Müller, S. P., Schöffski, P., Brose, M. S., Shah, M. H., Licitra, L., Jarzab, B., Medvedev, V., Kreissl, M. C., Niederle, B., Cohen, E. E. W., Wirth, L. J., Ali, H., Hessel, C., Yaron, Y., Ball, D., Nelkin, B. & Sherman, S. I., Oct 10 2013, In: Journal of Clinical Oncology. 31, 29, p. 3639-3646 8 p.Research output: Contribution to journal › Article › peer-review
Open Access613 Scopus citations -
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS
Agrawal, N., Jiao, Y., Sausen, M., Leary, R., Bettegowda, C., Roberts, N. J., Bhan, S., Ho, A. S., Khan, Z., Bishop, J., Westra, W. H., Wood, L. D., Hruban, R. H., Tufano, R. P., Robinson, B., Dralle, H., Toledo, S. P. A., Toledo, R. A., Morris, L. G. T., Ghossein, R. A., & 8 others, Feb 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 2, p. E364-E369Research output: Contribution to journal › Article › peer-review
Open Access139 Scopus citations -
Misidentification of putative medullary thyroid cancer cell lines RO-H85-1 and RO-D81-1
Dadon, T., Ball, D. & Nelkin, B. D., Mar 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 3, p. 954-955 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access5 Scopus citations -
2011
Cyclin-dependent kinase inhibitor dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
Feldmann, G., Mishra, A., Bisht, S., Karikari, C., Garrido-Laguna, I., Rasheed, Z., Ottenhof, N. A., Dadon, T., Alvarez, H., Fendrich, V., Rajeshkumar, N. V., Matsui, W., Brossart, P., Hidalgo, M., Bannerji, R., Maitra, A. & Nelkin, B. D., Oct 1 2011, In: Cancer Biology and Therapy. 12, 7, p. 598-609 12 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
Jin, N., Jiang, T., Rosen, D. M., Nelkin, B. D. & Ball, D. W., Oct 15 2011, In: Clinical Cancer Research. 17, 20, p. 6482-6489 8 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2010
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
Feldmann, G., Mishra, A., Hong, S. M., Bisht, S., Strock, C. J., Ball, D. W., Goggins, M., Maitra, A. & Nelkin, B. D., Jun 1 2010, In: Cancer Research. 70, 11, p. 4460-4469 10 p.Research output: Contribution to journal › Article › peer-review
Open Access117 Scopus citations -
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
Alvarez, H., Montgomery, E. A., Karikari, C., Canto, M., Dunbar, K. B., Wang, J. S., Feldmann, G., Hong, S. M., Haffner, M. C., Meeker, A. K., Holland, S. J., Yu, J., Heckrodt, T. J., Zhang, J., Ding, P., Goff, D., Singh, R., Roa, J. C., Marimuthu, A., Riggins, G. J., & 4 others, Nov 15 2010, In: Cancer Biology and Therapy. 10, 10, p. 1009-1018 10 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2009
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer
Jiang, T., Collins, B. J., Jin, N., Watkins, D. N., Brock, M. V., Matsui, W., Nelkin, B. D. & Ball, D. W., Feb 1 2009, In: Cancer Research. 69, 3, p. 845-854 10 p.Research output: Contribution to journal › Article › peer-review
Open Access127 Scopus citations -
Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer
Jin, N., Jiang, T., Rosen, D. M., Nelkin, B. D. & Ball, D. W., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 10, p. 4107-4112 6 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2007
Characterization of membrane potential-dependent uptake of the novel PET tracer 18F-fluorobenzyl triphenylphosphonium cation
Madar, I., Ravert, H., Nelkin, B., Abro, M., Pomper, M., Dannals, R. & Frost, J. J., Dec 2007, In: European Journal of Nuclear Medicine and Molecular Imaging. 34, 12, p. 2057-2065 9 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244
Ball, D. W., Jin, N., Rosen, D. M., Dackiw, A., Sidransky, D., Xing, M. & Nelkin, B. D., Dec 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 12, p. 4712-4718 7 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
2006
Activity of irinotecan and the tyrosine kinase inhibitor CEP-751 in medullary thyroid cancer
Strock, C. J., Park, J. I., Rosen, D. M., Ruggeri, B., Denmeade, S. R., Ball, D. W. & Nelkin, B. D., Jan 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 1, p. 79-84 6 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
Strock, C. J., Park, J. I., Nakakura, E. K., Bova, G. S., Isaacs, J. T., Ball, D. W. & Nelkin, B. D., Aug 1 2006, In: Cancer Research. 66, 15, p. 7509-7515 7 p.Research output: Contribution to journal › Article › peer-review
119 Scopus citations -
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells
Arany, I., Megyesi, J. K., Nelkin, B. D. & Safirstein, R. L., Aug 28 2006, In: Kidney international. 70, 4, p. 669-674 6 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
ΔNp63α overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
Sommer, M., Poliak, N., Upadhyay, S., Ratovitski, E., Nelkin, B. D., Donehower, L. A. & Sidransky, D., Sep 1 2006, In: Cell Cycle. 5, 17, p. 2005-2011 7 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
2005
GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice
Park, J. I., Powers, J. F., Tischler, A. S., Strock, C. J., Ball, D. W. & Nelkin, B. D., Feb 1 2005, In: Experimental cell research. 303, 1, p. 79-88 10 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
Kim, E. J., Park, J. I. & Nelkin, B. D., Feb 11 2005, In: Journal of Biological Chemistry. 280, 6, p. 4913-4920 8 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Interleukin-1β can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
Park, J. I., Strock, C. J., Ball, D. W. & Nelkin, B. D., Feb 7 2005, In: Cytokine. 29, 3, p. 125-134 10 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling
Nakakura, E. K., Sriuranpong, V. R., Kunnimalaiyaan, M., Hsiao, E. C., Schuebel, K. E., Borges, M. W., Jin, N., Collins, B. J., Nelkin, B. D., Chen, H. & Ball, D. W., Jul 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4350-4356 7 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
2003
Assays for raf-1 kinase phosphorylation and activity in human small cell lung cancer cells.
Ravi, R. K. & Nelkin, B. D., 2003, In: Methods in Molecular Medicine. 74, p. 201-210 10 p.Research output: Contribution to journal › Article › peer-review
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CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth
Strock, C. J., Park, J. I., Rosen, M., Dionne, C., Ruggeri, B., Jones-Bolin, S., Denmeade, S. R., Ball, D. W. & Nelkin, B. D., Sep 1 2003, In: Cancer Research. 63, 17, p. 5559-5563 5 p.Research output: Contribution to journal › Article › peer-review
86 Scopus citations -
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
Sriuranpong, V., Park, J. I., Amornphimoltham, P., Patel, V., Nelkin, B. D. & Gutkind, J. S., Jun 1 2003, In: Cancer Research. 63, 11, p. 2948-2956 9 p.Research output: Contribution to journal › Article › peer-review
226 Scopus citations -
The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway
Park, J. I., Strock, C. J., Ball, D. W. & Nelkin, B. D., Jan 2003, In: Molecular and cellular biology. 23, 2, p. 543-554 12 p.Research output: Contribution to journal › Article › peer-review
Open Access103 Scopus citations -
2002
Notch signaling induces rapid degradation of achaete-scute homolog 1
Sriuranpong, V., Borges, M. W., Strock, C. L., Nakakura, E. K., Watkins, D. N., Blaumueller, C. M., Nelkin, B. D. & Ball, D. W., 2002, In: Molecular and cellular biology. 22, 9, p. 3129-3139 11 p.Research output: Contribution to journal › Article › peer-review
Open Access130 Scopus citations -
The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer.
Sellar, G. C., Watt, K. P., Li, L., Nelkin, B. D., Rabiasz, G. J., Porteous, D. J., Smyth, J. F. & Gabra, H., Nov 2002, In: International journal of oncology. 21, 5, p. 929-933 5 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2001
BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression
Sellar, G. C., Li, L., Watt, K. P., Nelkin, B. D., Rabiasz, G. J., Stronach, E. A., Miller, E. P., Porteous, D. J., Smyth, J. F. & Gabra, H., Oct 1 2001, In: Cancer Research. 61, 19, p. 6977-6981 5 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma
Nelkin, B. D. & Ball, D. W., 2001, In: Oncology reports. 8, 1, p. 157-160 4 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Mammalian scratch: A neural-specific Snail family transcriptional repressor
Nakakura, E. K., Watkins, D. N., Schuebel, K. E., Sriuranpong, V., Borges, M. W., Nelkin, B. D. & Ball, D. W., Mar 27 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 7, p. 4010-4015 6 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells
Nakakura, E. K., Watkins, D. N., Sriuranpong, V., Borges, M. W., Nelkin, B. D. & Ball, D. W., Nov 1 2001, In: Molecular Brain Research. 95, 1-2, p. 162-166 5 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Notch signaling induces cell cycle arrest in small cell lung cancer cells
Sriuranpong, V., Borges, M. W., Ravi, R. K., Arnold, D. R., Nelkin, B. D., Baylin, S. B. & Ball, D. W., Apr 1 2001, In: Cancer Research. 61, 7, p. 3200-3205 6 p.Research output: Contribution to journal › Article › peer-review
362 Scopus citations -
2000
Cloning and chromosomal localization of the human BARX2 homeobox protein gene
Krasner, A., Wallace, L., Thiagalingam, A., Jones, C., Lengauer, C., Minahan, L., Ma, Y., Kalikin, L., Feinberg, A. P., Jabs, E. W., Tunnacliffe, A., Baylin, S. B., Ball, D. W. & Nelkin, B. D., May 30 2000, In: Gene. 250, 1-2, p. 171-180 10 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice
Linnoila, R. I., Zhao, B., DeMayo, J. L., Nelkin, B. D., Baylin, S. B., DeMayo, F. J. & Ball, D. W., 2000, In: Cancer Research. 60, 15, p. 4005-4009 5 p.Research output: Contribution to journal › Article › peer-review
102 Scopus citations -
Reactive oxygen species are critical for the growth and differentiation of medullary thyroid carcinoma cells
Ha, H. C., Thiagalingam, A., Nelkin, B. D. & Casero, J., 2000, In: Clinical Cancer Research. 6, 9, p. 3783-3787 5 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
1999
Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells
Ravi, R., Thiagalingam, A., Weber, E., McMahon, M., Nelkin, B. D. & Mabry, M., 1999, In: American journal of respiratory cell and molecular biology. 20, 4, p. 543-549 7 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells
Ravi, R. K., McMahon, M., Yangang, Z., Williams, J. R., Dillehay, L. E., Nelkin, B. D. & Mabry, M., Mar 15 1999, In: Journal of cellular biochemistry. 72, 4, p. 458-469 12 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27(Kip1) expression
Weber, E., Ravi, R. K., Knudsen, E. S., Williams, J. R., Dillehay, L. E., Nelkin, B. D., Kalemkerian, G. P., Feramisco, J. R. & Mabry, M., Mar 15 1999, In: International Journal of Cancer. 80, 6, p. 935-943 9 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression
Mcgregor, L. M., Mccune, B. K., Graff, J. R., Mcdowell, P. R., Romans, K. E., Yancopoulos, G. D., Ball, D. W., Baylin, S. B. & Nelkin, B. D., Apr 13 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 8, p. 4540-4545 6 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
1998
Activated Raf-1 causes growth arrest in human small cell lung cancer cells
Ravi, R. K., Weber, E., McMahon, M., Williams, J. R., Baylin, S., Mal, A., Harter, M. L., Dillehay, L. E., Claudio, P. P., Giordano, A., Nelkin, B. D. & Mabry, M., Jan 1 1998, In: Journal of Clinical Investigation. 101, 1, p. 153-159 7 p.Research output: Contribution to journal › Article › peer-review
Open Access127 Scopus citations -
Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells
Ravi, R. K., Scott, F. M., Cuttitta, F., Weber, E., Kalemkerian, G. P., Nelkin, B. D. & Mabry, M., 1998, In: Oncology reports. 5, 2, p. 497-501 5 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations