Balaji Krishnamachary

Research Associate

20032018
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Research Output 2003 2018

2018
Cyclooxygenase 2
Dextrans
Small Interfering RNA
Down-Regulation
Acids

Hypoxia-induced reporter genes with different half-lives

Krishnamachary, B., Danhier, P., Kakkad, S., Bharti, S. K. & Bhujwalla, Z. M., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-125 13 p. (Methods in Molecular Biology; vol. 1790)

Research output: Chapter in Book/Report/Conference proceedingChapter

Reporter Genes
Half-Life
Preclinical Drug Evaluations
Molecular Imaging
Optical Imaging

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts

Goggins, E., Kakkad, S., Mironchik, Y., Jacob, D., Wildes, F., Krishnamachary, B. & Bhujwalla, Z. M., Feb 1 2018, In : Neoplasia (United States). 20, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Heterografts
Collagen
Extracellular Matrix
Cell Hypoxia

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft

Bharti, S. K., Mironchik, Y., Wildes, F., Penet, M. F., Goggins, E., Krishnamachary, B. & Bhujwalla, Z. M., Jan 1 2018, In : Oncotarget. 9, 20, p. 15326-15339 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Heterografts
Magnetic Resonance Spectroscopy
Neoplasms
Hypoxia

Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells

Shah, T., Krishnamachary, B., Wildes, F., Wijnen, J. P., Glunde, K. & Bhujwalla, Z. M., Aug 1 2018, In : NMR in Biomedicine. 31, 8, e3936

Research output: Contribution to journalArticle

Cells
Ethanolamines
Cytotoxicity
Cell culture
Tumors
2017
Cyclooxygenase 2
Extracellular Matrix
Breast Neoplasms
Collagen
Down-Regulation

Delayed progression of lung metastases following delivery of a prodrug-activating enzyme

Dore-Savard, L., Chen, Z., Winnard, P. T., Krishnamachary, B., Raman, V., Black, M. E. & Bhujwalla, Z. M., May 1 2017, In : Anticancer Research. 37, 5, p. 2195-2200 6 p.

Research output: Contribution to journalArticle

Prodrugs
Cytosine Deaminase
Neoplasm Metastasis
Lung
Enzymes
Extracellular Matrix
Prostatic Neoplasms
Neoplasms
Collagen
Albumins
2016

Choline metabolism alteration: A focus on ovarian cancer

Bagnoli, M., Granata, A., Nicoletti, R., Krishnamachary, B., Bhujwalla, Z. M., Canese, R., Podo, F., Canevari, S., Iorio, E. & Mezzanzanica, D., Jun 22 2016, In : Frontiers in Oncology. 6, JUN, 153

Research output: Contribution to journalShort survey

Choline
Ovarian Neoplasms
Choline Kinase
Phenotype
Phospholipase D

Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers

Kakkad, S., Zhang, J., Akhbardeh, A., Jacob, D., Krishnamachary, B., Solaiyappan, M., Jacobs, M. A., Raman, V., Leibfritz, D., Glunde, K. & Bhujwalla, Z. M., Oct 1 2016, In : Neoplasia (United States). 18, 10, p. 585-593 9 p.

Research output: Contribution to journalArticle

Anisotropy
Collagen
Breast Neoplasms
Water
Diffusion Tensor Imaging
Choline Kinase
Dextran
Dextrans
RNA
Small Interfering RNA

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, M. F., Krishnamachary, B., Wildes, F., Mironchik, Y., Mezzanzanica, D., Podo, F., De Reggi, M., Gharib, B. & Bhujwalla, Z. M., Nov 16 2016, In : Frontiers in Oncology. 6, NOV, 244

Research output: Contribution to journalArticle

Choline
Neoplasms
Ovarian Neoplasms
Ascites
pantethine

Phototheranostics of CD44-positive cell populations in triple negative breast cancer

Jin, J., Krishnamachary, B., Mironchik, Y., Kobayashi, H. & Bhujwalla, Z. M., Jun 15 2016, In : Scientific Reports. 6, 27871

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Population
Breast Neoplasms
Aldehyde Dehydrogenase
Cytosine Deaminase
Flucytosine
Prodrugs
Cell death
Antigens

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Cao, M. D., Cheng, M., Rizwan, A., Jiang, L., Krishnamachary, B., Bhujwalla, Z. M., Bathen, T. F. & Glunde, K., Aug 1 2016, In : NMR in Biomedicine. 29, 8, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

Cell proliferation
Choline
Metabolism
Small Interfering RNA
Cell Movement
2015
Luciferases
Neoplasms
Proteins
Response Elements
Prostatic Neoplasms

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Granata, A., Nicoletti, R., Perego, P., Iorio, E., Krishnamachary, B., Benigni, F., Ricci, A., Podo, F., Bhujwalla, Z. M., Canevari, S., Bagnoli, M. & Mezzanzanica, D., 2015, In : Oncotarget. 6, 13, p. 11216-11230 15 p.

Research output: Contribution to journalArticle

Choline Kinase
Metabolome
Glutathione
Antioxidants
Carcinoma

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

Shah, T., Krishnamachary, B., Wildes, F., Mironchik, Y., Kakkad, S. M., Jacob, D., Artemov, D. & Bhujwalla, Z. M., 2015, In : Oncotarget. 6, 29, p. 28104-28119 16 p.

Research output: Contribution to journalArticle

Protein Isoforms
Neoplasm Metastasis
Hypoxia
Lipid Droplets
Cell Hypoxia

Imaging transplanted stem cells in real time using an MRI dual-contrast method

Ngen, E. J., Wang, L., Kato, Y., Krishnamachary, B., Zhu, W., Gandhi, N., Smith, B., Armour, M., Wong, J., Gabrielson, K. & Artemov, D., Sep 2 2015, In : Scientific Reports. 5, 13628

Research output: Contribution to journalArticle

Stem Cells
Magnetic Resonance Imaging
Cell Death
Stem Cell Transplantation
Cell- and Tissue-Based Therapy

Magnetic resonance spectroscopy of siRNA-based cancer therapy

Penet, M. F., Chen, Z., Mori, N., Krishnamachary, B. & Bhujwalla, Z. M., 2015, Methods in Molecular Biology. Humana Press Inc., Vol. 1372, p. 37-47 11 p. (Methods in Molecular Biology; vol. 1372)

Research output: Chapter in Book/Report/Conference proceedingChapter

Small Interfering RNA
Magnetic Resonance Spectroscopy
Neoplasms
Therapeutics
Choline Kinase

Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism

Penet, M. F., Shah, T., Bharti, S., Krishnamachary, B., Artemov, D., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M., Jan 15 2015, In : Clinical Cancer Research. 21, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Choline
Adenocarcinoma
Choline Kinase
Biomarkers
Tumor Cell Line

Metastatic breast cancer cells in lymph nodes increase nodal collagen density

Rizwan, A., Bulte, C., Kalaichelvan, A., Cheng, M., Krishnamachary, B., Bhujwalla, Z. M., Jiang, L. & Glunde, K., May 7 2015, In : Scientific Reports. 5, 10002

Research output: Contribution to journalArticle

Collagen
Lymph Nodes
Breast Neoplasms
Heterografts
Extracellular Matrix
2014
Precision Medicine
Molecular Imaging
Tumor Microenvironment
Neoplasms
Stromal Cells

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer

Gadiya, M., Mori, N., Cao, M. D., Mironchik, Y., Kakkad, S., Gribbestad, I. S., Glunde, K., Krishnamachary, B. & Bhujwalla, Z. M., 2014, In : Cancer Biology and Therapy. 15, 5, p. 593-601 9 p.

Research output: Contribution to journalArticle

Choline Kinase
Choline
Breast Neoplasms
Phosphorylcholine
Phospholipids

Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by 31P MRS

Wijnen, J. P., Jiang, L., Greenwood, T. R., Cheng, M., Döpkens, M., Cao, M. D., Bhujwalla, Z. M., Krishnamachary, B., Klomp, D. W. J. & Glunde, K., 2014, In : NMR in Biomedicine. 27, 6, p. 692-699 8 p.

Research output: Contribution to journalArticle

Metabolites
Tumors
Phospholipids
Breast Neoplasms
Choline
2013

Characterization of choline kinase in human endothelial cells

Mori, N., Gadiya, M., Wildes, F., Krishnamachary, B., Glunde, K. & Bhujwalla, Z. M., Nov 2013, In : NMR in Biomedicine. 26, 11, p. 1501-1507 7 p.

Research output: Contribution to journalArticle

Choline Kinase
Endothelial cells
Endothelial Cells
Human Umbilical Vein Endothelial Cells
Down-Regulation

COX-2 in cancer: Gordian knot or achilles heel?

Stasinopoulos, I., Shah, T., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M., 2013, In : Frontiers in Pharmacology. 4 MAR, Article 34

Research output: Contribution to journalArticle

Cyclooxygenase 2
Neoplasms
Neoplasm Metastasis
Lymphatic Vessels
Tumor Microenvironment
2012

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer

Cao, M. D., Döpkens, M., Krishnamachary, B., Vesuna, F., Gadiya, M. M., Lønning, P. E., Bhujwalla, Z. M., Gribbestad, I. S. & Glunde, K., Sep 2012, In : NMR in Biomedicine. 25, 9, p. 1033-1042 10 p.

Research output: Contribution to journalArticle

Metabolites
Choline
Phospholipids
Breast Neoplasms
Tumors

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L., Apr 5 2012, In : Oncogene. 31, 14, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecule L1
Hypoxia-Inducible Factor 1
Blood Vessels
Breast Neoplasms
Neoplasm Metastasis
Triple Negative Breast Neoplasms
breast neoplasms
hypoxia
Protein Isoforms
Cells
2011

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P. T., Bol, G. M., Patel, A. H. & Raman, V., 2011, In : PLoS One. 6, 3, e17563

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
breasts
Breast
epithelial cells
Epithelial Cells

Metabolic signatures imaged in cancer-induced cachexia

Penet, M. F., Gadiya, M. M., Krishnamachary, B., Nimmagadda, S., Pomper, M. G., Artemov, D. & Bhujwalla, Z. M., Nov 15 2011, In : Cancer Research. 71, 22, p. 6948-6956 9 p.

Research output: Contribution to journalArticle

Cachexia
Neoplasms
Choline
Weight Loss
Lipids
2010

Applications of molecular MRI and optical imaging in cancer

Penet, M. F., Mikhaylova, M., Li, C., Krishnamachary, B., Glunde, K., Pathak, A. P. & Bhujwalla, Z. M., Jun 2010, In : Future Medicinal Chemistry. 2, 6, p. 975-988 14 p.

Research output: Contribution to journalArticle

Molecular Imaging
Optical Imaging
Neoplasms
Pharmaceutical Preparations
Nanoparticles

Hypoxia inducible-factor1α regulates the metabolic shift of pulmonary hypertensive endothelial cells

Fijalkowska, I., Xu, W., Comhair, S. A. A., Janocha, A. J., Mavrakis, L. A., Krishnamachary, B., Zhen, L., Mao, T., Richter, A., Erzurum, S. C. & Tuder, R. M., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1130-1138 9 p.

Research output: Contribution to journalArticle

Endothelial Cells
Lung
Superoxide Dismutase
Mitochondria
Nitric Oxide

Molecular and functional imaging of invasion and metastasis: Windows into the metastatic cascade

Stasinopoulos, I., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M., 2010, In : Cancer Biomarkers. 7, 4-5, p. 173-188 16 p.

Research output: Contribution to journalArticle

Molecular Imaging
Neoplasm Metastasis
Neoplasms
Cellular Microenvironment
Tumor Microenvironment
2009

Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xe nog raft

Krishnamachary, B., Glunde, K., Wildes, H., Mori, N., Takagi, T., Raman, V. & Bhujwalla, Z. M., Apr 15 2009, In : Cancer Research. 69, 8, p. 3464-3471 8 p.

Research output: Contribution to journalArticle

Choline Kinase
Breast Neoplasms
Phosphorylcholine
Neoplasms
Choline
2008

Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model

Winnard, P. T., Botlagunta, M., Kluth, J. B., Mukadam, S., Krishnamachary, B., Vesuna, F. & Raman, V., Oct 2008, In : Cancer Gene Therapy. 15, 10, p. 645-654 10 p.

Research output: Contribution to journalArticle

Heterografts
Growth
Neoplasms
Genetic Therapy
Genes
2007
Hypoxia-Inducible Factor 1
Biopsy
Cells
Neoplasm Metastasis
Cell adhesion

HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, CV. & Semenza, G. L., May 8 2007, In : Cancer Cell. 11, 5, p. 407-420 14 p.

Research output: Contribution to journalArticle

Cell Respiration
Hypoxia-Inducible Factor 1
Organelle Biogenesis
Renal Cell Carcinoma
Respiration
2006

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1

Okuyama, H., Krishnamachary, B., Zhou, Y. F., Nagasawa, H., Bosch-Marce, M. & Semenza, G. L., Jun 2 2006, In : Journal of Biological Chemistry. 281, 22, p. 15554-15563 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor Receptor
Mesenchymal Stromal Cells
Vascular Endothelial Growth Factor A

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H. & Semenza, G. L., Mar 1 2006, In : Cancer Research. 66, 5, p. 2725-2731 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Null Lymphocytes
Cadherins
Renal Cell Carcinoma
Neoplasms

Spontaneous transformation of cultured mouse bone marrow-derived stromal cells

Yi, F. Z., Bosch-Marce, M., Okuyama, H., Krishnamachary, B., Kimura, H., Zhang, L., Huso, D. L. & Semenza, G. L., Nov 15 2006, In : Cancer Research. 66, 22, p. 10849-10854 6 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Contact Inhibition
Injections
Neoplasms
Cell- and Tissue-Based Therapy
2005

OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J. & Semenza, G. L., Feb 18 2005, In : Molecular Cell. 17, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Oxygen
Hydroxylation
Multiprotein Complexes

Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M. A., Melamed, J. & Semenza, G. L., Jul 15 2005, In : Cancer Research. 65, 14, p. 6178-6188 11 p.

Research output: Contribution to journalArticle

Hemangioblastoma
Chemokine CXCL12
Renal Cell Carcinoma
Ligands
Von Hippel-Lindau Tumor Suppressor Protein
2003

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1

Krishnamachary, B., Berg-Dixon, S., Kelly, B., Agani, F., Feldser, D., Ferreira, G., Iyer, N., LaRusch, J., Pak, B., Taghavi, P. & Semenza, G. L., Mar 1 2003, In : Cancer Research. 63, 5, p. 1138-1143 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Hypoxia
Colon
Carcinoma
Urokinase Plasminogen Activator Receptors