Research Output 2003 2018

2018
Cyclooxygenase 2
Dextrans
Small Interfering RNA
Down-Regulation
Acids

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts

Goggins, E., Kakkad, S., Mironchik, Y., Jacob, D., Wildes, F., Krishnamachary, B. & Bhujwalla, Z. M. Feb 1 2018 In : Neoplasia (United States). 20, 2, p. 131-139 9 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Heterografts
Collagen
Hypoxia
Neoplasms
2017

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

Krishnamachary, B., Stasinopoulos, I., Kakkad, S., Penet, M. F., Jacob, D., Wildes, F., Mironchik, Y., Pathak, A. P., Solaiyappan, M. & Bhujwalla, Z. M. 2017 In : Oncotarget. 8, 11, p. 17981-17994 14 p.

Research output: Research - peer-reviewArticle

Cyclooxygenase 2
Extracellular Matrix
Breast Neoplasms
Cancer-Associated Fibroblasts
Neoplasms

Delayed progression of lung metastases following delivery of a prodrug-activating enzyme

Dore-Savard, L., Chen, Z., Winnard, P. T., Krishnamachary, B., Raman, V., Black, M. E. & Bhujwalla, Z. M. May 1 2017 In : Anticancer Research. 37, 5, p. 2195-2200 6 p.

Research output: Research - peer-reviewArticle

Prodrugs
Neoplasm Metastasis
Lung
Enzymes
Neoplasms
Extracellular Matrix
Prostatic Neoplasms
Neoplasms
Collagen
Albumins
2016

Choline metabolism alteration: A focus on ovarian cancer

Bagnoli, M., Granata, A., Nicoletti, R., Krishnamachary, B., Bhujwalla, Z. M., Canese, R., Podo, F., Canevari, S., Iorio, E. & Mezzanzanica, D. Jun 22 2016 In : Frontiers in Oncology. 6, JUN, 153

Research output: Research - peer-reviewShort survey

Choline
Ovarian Neoplasms
Neoplasms
Ovarian epithelial cancer
Phenotype

Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers

Kakkad, S., Zhang, J., Akhbardeh, A., Jacob, D., Krishnamachary, B., Solaiyappan, M., Jacobs, M. A., Raman, V., Leibfritz, D., Glunde, K. & Bhujwalla, Z. M. Oct 1 2016 In : Neoplasia (United States). 18, 10, p. 585-593 9 p.

Research output: Research - peer-reviewArticle

Anisotropy
Collagen
Breast Neoplasms
Water
Neoplasms
Choline Kinase
Dextrans
Small Interfering RNA
Dextran
RNA

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, M. F., Krishnamachary, B., Wildes, F., Mironchik, Y., Mezzanzanica, D., Podo, F., De Reggi, M., Gharib, B. & Bhujwalla, Z. M. Nov 16 2016 In : Frontiers in Oncology. 6, NOV, 244

Research output: Research - peer-reviewArticle

Choline
Neoplasms
pantethine
Therapeutics
Ovarian Neoplasms

Phototheranostics of CD44-positive cell populations in triple negative breast cancer

Jin, J., Krishnamachary, B., Mironchik, Y., Kobayashi, H. & Bhujwalla, Z. M. Jun 15 2016 In : Scientific Reports. 6, 27871

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
Population
Breast Neoplasms
Neoplastic Stem Cells
Neoplasms
Flucytosine
Prodrugs
Prostatic Neoplasms
Tumor Necrosis Factor-alpha
Apoptosis

Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Cao, M. D., Cheng, M., Rizwan, A., Jiang, L., Krishnamachary, B., Bhujwalla, Z. M., Bathen, T. F. & Glunde, K. Aug 1 2016 In : NMR in Biomedicine. 29, 8, p. 1098-1107 10 p.

Research output: Research - peer-reviewArticle

Choline
Small Interfering RNA
Cell Movement
Phospholipids
Cell Proliferation
2015

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

Danhier, P., Krishnamachary, B., Bharti, S., Kakkad, S., Mironchik, Y. & Bhujwalla, Z. M. Dec 1 2015 In : Neoplasia (New York, N.Y.). 17, 12, p. 871-881 11 p.

Research output: Research - peer-reviewArticle

Neoplasms
Proteins
Hypoxia
enhanced green fluorescent protein
Luciferases

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Granata, A., Nicoletti, R., Perego, P., Iorio, E., Krishnamachary, B., Benigni, F., Ricci, A., Podo, F., Bhujwalla, Z. M., Canevari, S., Bagnoli, M. & Mezzanzanica, D. 2015 In : Oncotarget. 6, 13, p. 11216-11230 15 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Metabolome
Glutathione
Antioxidants
Carcinoma

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

Shah, T., Krishnamachary, B., Wildes, F., Mironchik, Y., Kakkad, S. M., Jacob, D., Artemov, D. & Bhujwalla, Z. M. 2015 In : Oncotarget. 6, 29, p. 28104-28119 16 p.

Research output: Research - peer-reviewArticle

Protein Isoforms
Neoplasm Metastasis
Hypoxia
Lipid Droplets
Cell Line

Imaging transplanted stem cells in real time using an MRI dual-contrast method

Ngen, E. J., Wang, L., Kato, Y., Krishnamachary, B., Zhu, W., Gandhi, N., Smith, B., Armour, M., Wong, J., Gabrielson, K. & Artemov, D. Sep 2 2015 In : Scientific Reports. 5, 13628

Research output: Research - peer-reviewArticle

Stem Cells
Magnetic Resonance Imaging
Cell Death
Stem Cell Transplantation
Cell- and Tissue-Based Therapy

Magnetic resonance spectroscopy of siRNA-based cancer therapy

Penet, M. F., Chen, Z., Mori, N., Krishnamachary, B. & Bhujwalla, Z. M. 2015 Methods in Molecular Biology. Humana Press Inc., Vol. 1372, p. 37-47 11 p. (Methods in Molecular Biology; vol. 1372)

Research output: ResearchChapter

Small Interfering RNA
Magnetic Resonance Spectroscopy
Neoplasms
Therapeutics
Down-Regulation

Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism

Penet, M. F., Shah, T., Bharti, S., Krishnamachary, B., Artemov, D., Mironchik, Y., Wildes, F., Maitra, A. & Bhujwalla, Z. M. Jan 15 2015 In : Clinical Cancer Research. 21, 2, p. 386-395 10 p.

Research output: Research - peer-reviewArticle

Choline
Adenocarcinoma
choline transporter
Biomarkers
Choline Kinase

Metastatic breast cancer cells in lymph nodes increase nodal collagen density

Rizwan, A., Bulte, C., Kalaichelvan, A., Cheng, M., Krishnamachary, B., Bhujwalla, Z. M., Jiang, L. & Glunde, K. May 7 2015 In : Scientific Reports. 5, 10002

Research output: Research - peer-reviewArticle

Collagen
Lymph Nodes
Breast Neoplasms
Neoplasms
Heterografts
2014
Precision Medicine
Molecular Imaging
Tumor Microenvironment
Neoplasms
Theranostic Nanomedicine

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer

Gadiya, M., Mori, N., Cao, M. D., Mironchik, Y., Kakkad, S., Gribbestad, I. S., Glunde, K., Krishnamachary, B. & Bhujwalla, Z. M. 2014 In : Cancer Biology and Therapy. 15, 5, p. 593-601 9 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Choline
Breast Neoplasms
phospholipase D1
Phospholipids

Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by 31P MRS

Wijnen, J. P., Jiang, L., Greenwood, T. R., Cheng, M., Döpkens, M., Cao, M. D., Bhujwalla, Z. M., Krishnamachary, B., Klomp, D. W. J. & Glunde, K. 2014 In : NMR in Biomedicine. 27, 6, p. 692-699 8 p.

Research output: Research - peer-reviewArticle

Metabolites
Tumors
Phospholipids
glycerophosphocholine phosphodiesterase
Breast Neoplasms
2013

Characterization of choline kinase in human endothelial cells

Mori, N., Gadiya, M., Wildes, F., Krishnamachary, B., Glunde, K. & Bhujwalla, Z. M. Nov 2013 In : NMR in Biomedicine. 26, 11, p. 1501-1507 7 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Endothelial Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
Down-Regulation

COX-2 in cancer: Gordian knot or achilles heel?

Stasinopoulos, I., Shah, T., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M. 2013 In : Frontiers in Pharmacology. 4 MAR, Article 34

Research output: Research - peer-reviewArticle

Cyclooxygenase 2
Neoplasms
Neoplasm Metastasis
Lymphatic Vessels
Tumor Microenvironment
2012

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer

Cao, M. D., Döpkens, M., Krishnamachary, B., Vesuna, F., Gadiya, M. M., Lønning, P. E., Bhujwalla, Z. M., Gribbestad, I. S. & Glunde, K. Sep 2012 In : NMR in Biomedicine. 25, 9, p. 1033-1042 10 p.

Research output: Research - peer-reviewArticle

Metabolites
Choline
Phospholipids
glycerophosphodiester phosphodiesterase
Breast Neoplasms

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S. & Semenza, G. L. Apr 5 2012 In : Oncogene. 31, 14, p. 1757-1770 14 p.

Research output: Research - peer-reviewArticle

Neural Cell Adhesion Molecule L1
Hypoxia-Inducible Factor 1
Blood Vessels
Breast Neoplasms
Neoplasm Metastasis
breast neoplasms
hypoxia
Protein Isoforms
Cells
Triple Negative Breast Neoplasms
2011

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P. T., Bol, G. M., Patel, A. H. & Raman, V. 2011 In : PLoS One. 6, 3, e17563

Research output: Research - peer-reviewArticle

breasts
epithelial cells
hypoxia-inducible factor 1
Hypoxia-Inducible Factor 1
Breast

Metabolic signatures imaged in cancer-induced cachexia

Penet, M. F., Gadiya, M. M., Krishnamachary, B., Nimmagadda, S., Pomper, M. G., Artemov, D. & Bhujwalla, Z. M. Nov 15 2011 In : Cancer Research. 71, 22, p. 6948-6956 9 p.

Research output: Research - peer-reviewArticle

Cachexia
Neoplasms
Choline
Therapeutics
Weight Loss
2010

Applications of molecular MRI and optical imaging in cancer

Penet, M. F., Mikhaylova, M., Li, C., Krishnamachary, B., Glunde, K., Pathak, A. P. & Bhujwalla, Z. M. Jun 2010 In : Future Medicinal Chemistry. 2, 6, p. 975-988 14 p.

Research output: Research - peer-reviewArticle

Molecular Imaging
Optical Imaging
Neoplasms
Pharmaceutical Preparations
Nanoparticles

Hypoxia inducible-factor1α regulates the metabolic shift of pulmonary hypertensive endothelial cells

Fijalkowska, I., Xu, W., Comhair, S. A. A., Janocha, A. J., Mavrakis, L. A., Krishnamachary, B., Zhen, L., Mao, T., Richter, A., Erzurum, S. C. & Tuder, R. M. Mar 2010 In : American Journal of Pathology. 176, 3, p. 1130-1138 9 p.

Research output: Research - peer-reviewArticle

Endothelial Cells
Lung
Hypoxia
Superoxide Dismutase
Mitochondria

Molecular and functional imaging of invasion and metastasis: Windows into the metastatic cascade

Stasinopoulos, I., Penet, M. F., Krishnamachary, B. & Bhujwalla, Z. M. 2010 In : Cancer Biomarkers. 7, 4-5, p. 173-188 16 p.

Research output: Research - peer-reviewArticle

Molecular Imaging
Neoplasm Metastasis
Neoplasms
Cellular Microenvironment
Tumor Microenvironment
2009

Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xe nog raft

Krishnamachary, B., Glunde, K., Wildes, H., Mori, N., Takagi, T., Raman, V. & Bhujwalla, Z. M. Apr 15 2009 In : Cancer Research. 69, 8, p. 3464-3471 8 p.

Research output: Research - peer-reviewArticle

Choline Kinase
Breast Neoplasms
Neoplasms
Phosphorylcholine
Choline
2008

Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model

Winnard, P. T., Botlagunta, M., Kluth, J. B., Mukadam, S., Krishnamachary, B., Vesuna, F. & Raman, V. Oct 2008 In : Cancer Gene Therapy. 15, 10, p. 645-654 10 p.

Research output: Research - peer-reviewArticle

Heterografts
Growth
Neoplasms
endonuclease G
Hypoxia
2007
Neoplasm Metastasis
Neoplasms
Hypoxia
Hypoxia-Inducible Factor 1
Biopsy

HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V. & Semenza, G. L. May 8 2007 In : Cancer Cell. 11, 5, p. 407-420 14 p.

Research output: Research - peer-reviewArticle

Cell Respiration
Hypoxia-Inducible Factor 1
Organelle Biogenesis
Renal Cell Carcinoma
Respiration
2006

Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1

Okuyama, H., Krishnamachary, B., Zhou, Y. F., Nagasawa, H., Bosch-Marce, M. & Semenza, G. L. Jun 2 2006 In : Journal of Biological Chemistry. 281, 22, p. 15554-15563 10 p.

Research output: Research - peer-reviewArticle

Vascular Endothelial Growth Factor Receptor-1
Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor Receptor
Mesenchymal Stromal Cells
Vascular Endothelial Growth Factor A

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H. & Semenza, G. L. Mar 1 2006 In : Cancer Research. 66, 5, p. 2725-2731 7 p.

Research output: Research - peer-reviewArticle

Hypoxia-Inducible Factor 1
Null Lymphocytes
Cadherins
Renal Cell Carcinoma
Neoplasms

Spontaneous transformation of cultured mouse bone marrow-derived stromal cells

Yi, F. Z., Bosch-Marce, M., Okuyama, H., Krishnamachary, B., Kimura, H., Zhang, L., Huso, D. L. & Semenza, G. L. Nov 15 2006 In : Cancer Research. 66, 22, p. 10849-10854 6 p.

Research output: Research - peer-reviewArticle

Mesenchymal Stromal Cells
Injections
Neoplasms
Contact Inhibition
Cell- and Tissue-Based Therapy
2005

OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J. & Semenza, G. L. Feb 18 2005 In : Molecular Cell. 17, 4, p. 503-512 10 p.

Research output: Research - peer-reviewArticle

Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Oxygen
Hypoxia
Proteins

Stromal cell-derived factor-1α and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

Zagzag, D., Krishnamachary, B., Yee, H., Okuyama, H., Chiriboga, L., Ali, M. A., Melamed, J. & Semenza, G. L. Jul 15 2005 In : Cancer Research. 65, 14, p. 6178-6188 11 p.

Research output: Research - peer-reviewArticle

Hemangioblastoma
Chemokine CXCL12
Renal Cell Carcinoma
Ligands
Hypoxia
2003

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1

Krishnamachary, B., Berg-Dixon, S., Kelly, B., Agani, F., Feldser, D., Ferreira, G., Iyer, N., LaRusch, J., Pak, B., Taghavi, P. & Semenza, G. L. Mar 1 2003 In : Cancer Research. 63, 5, p. 1138-1143 6 p.

Research output: Research - peer-reviewArticle

Hypoxia-Inducible Factor 1
Cell Hypoxia
Colon
Carcinoma
Neoplasms