Research Output 1983 2018

2018

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

Oyinlade, O., Wei, S., Lal, B., Laterra, J., Zhu, H., Goodwin, C. R., Wang, S., Ma, D., Wan, J. & Xia, S. Feb 26 2018 (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucose Dehydrogenase
Glucose 1-Dehydrogenase
Uridine Diphosphate
Glioblastoma
Growth
2016

A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis

Sun, H., Luo, L., Lal, B., Ma, X., Chen, L., Hann, C. L., Fulton, A. M., Leahy, D. J., Laterra, J. & Li, M. Feb 4 2016 In : Nature Communications. 7, 10339

Research output: Contribution to journalArticle

metastasis
antibodies
Tumors
tumors
cancer

Epigenetic modulation of a miR-296-5p: HMGA1 axis regulates Sox2 expression and glioblastoma stem cells

Lopez-Bertoni, H., Lal, B., Michelson, N., Guerrero-Cázares, H., Quiñones-Hinojosa, A., Li, Y. & Laterra, J. Feb 22 2016 (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Glioblastoma
Epigenomics
Stem Cells
Neoplastic Stem Cells
Neoplasms

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Tilghman, J., Schiapparelli, P., Lal, B., Ying, M., Quinones-Hinojosa, A., Xia, S. & Laterra, J. 2016 In : Neoplasia. 18, 3, p. 185-198 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Integrins
Stem Cells
Neoplasms
Cell Movement
Salicylic acid
Dendrimers
Salicylic Acid
dendrimers
Magnetic resonance imaging

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

Xia, S., Lal, B., Tung, B., Wang, S., Goodwin, C. R. & Laterra, J. Apr 1 2016 In : Neuro-Oncology. 18, 4, p. 507-517 11 p.

Research output: Contribution to journalArticle

Tenascin
Tumor Microenvironment
Glioblastoma
Neoplasms
Brain Neoplasms
2015

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. & Li, Y. Jul 23 2015 In : Oncogene. 34, 30, p. 3994-4004 11 p.

Research output: Contribution to journalArticle

Transferases
MicroRNAs
Phenotype
DNA
Neoplasms
Blood Volume
Blood-Brain Barrier
Brain Neoplasms
Glucose
Area Under Curve
Noise
Glioblastoma
Principal Component Analysis
Protons
Neoplasms
2014

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models

Grossman, R., Brastianos, H., Blakeley, J. O., Mangraviti, A., Lal, B., Zadnik, P., Hwang, L., Wicks, R. T., Goodwin, R. C., Brem, H. & Tyler, B. Jan 2014 In : Journal of Neuro-Oncology. 116, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Vascular Endothelial Growth Factor A
Survival
Therapeutics

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J. Jun 4 2014 In : BMC Cancer. 14, 1, 401

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance

Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model

Hong, X., Liu, L., Wang, M., Ding, K., Fan, Y., Ma, B., Lal, B., Tyler, B., Mangraviti, A., Wang, S., Wong, J., Laterra, J. & Zhou, J. 2014 In : Neuro-Oncology. 16, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

Glioma
Radiotherapy
Neoplasms
Amides
Protons
2013

In vivo c-Met pathway inhibition depletes human glioma xenografts of tumor-propagating stem-like cells

Rath, P., Lal, B., Ajala, O., Li, Y., Xia, S., Kim, J. & Laterra, J. Apr 2013 In : Translational Oncology. 6, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Stem Cells
Neoplasms
Neoplastic Stem Cells
2012

Collagen IV and CXC chemokine-derived antiangiogenic peptides suppress glioma xenograft growth

Rosca, E. V., Lal, B., Koskimaki, J. E., Popel, A. S. & Laterra, J. Aug 2012 In : Anti-Cancer Drugs. 23, 7, p. 706-712 7 p.

Research output: Contribution to journalArticle

CXC Chemokines
Heterografts
Glioma
Collagen
Peptides

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Wang, S. D., Rath, P., Lal, B., Richard, J. P., Li, Y., Goodwin, C. R., Laterra, J. & Xia, S. Dec 13 2012 In : Oncogene. 31, 50, p. 5132-5143 12 p.

Research output: Contribution to journalArticle

EphB2 Receptors
Focal Adhesion Protein-Tyrosine Kinases
Glioblastoma
Cell Movement
Cell Proliferation

Evaluation of radiation necrosis and malignant glioma in rat models using diffusion tensor MR imaging

Wang, S., Chen, Y., Lal, B., Ford, E., Tryggestad, E., Armour, M., Yan, K., Laterra, J. & Zhou, J. Mar 2012 In : Journal of Neuro-Oncology. 107, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Glioma
Necrosis
Radiation
Gliosarcoma
2011

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

Li, Y., Li, A., Glas, M., Lal, B., Ying, M., Sang, Y., Xia, S., Trageser, D., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Scheffler, B. & Laterra, J. Jun 14 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 24, p. 9951-9956 6 p.

Research output: Contribution to journalArticle

Glioblastoma
Phenotype
Neoplastic Stem Cells
Transcription Factors
Stem Cells

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

Zhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D. X., Ford, E., Tyler, B., Blakeley, J., Laterra, J. & Van Zijl, P. C. M. Jan 2011 In : Nature Medicine. 17, 1, p. 130-134 5 p.

Research output: Contribution to journalArticle

Magnetic resonance
Amides
Glioma
Proton transfer
Protons

Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin: Laboratory investigation

Grossman, R., Tyler, B., Hwang, L., Zadnik, P., Lal, B., Javaherian, K. & Brem, H. Dec 2011 In : Journal of Neurosurgery. 115, 6, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Endostatins
temozolomide
Glioma
Antibodies
Survival

PTEN reconstitution alters glioma responses to c-Met pathway inhibition

Rory Goodwin, C., Lal, B., Ho, S., Woodard, C. L., Zhou, X., Taeger, A., Xia, S. & Laterra, J. Oct 2011 In : Anti-Cancer Drugs. 22, 9, p. 905-912 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Glioma
Heterografts
Growth
Receptor Protein-Tyrosine Kinases

Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition

Ying, M., Wang, S., Sang, Y., Sun, P., Lal, B., Goodwin, C. R., Guerrero-Cazares, H., Quinones-Hinojosa, A., Laterra, J. & Xia, S. Aug 4 2011 In : Oncogene. 30, 31, p. 3454-3467 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Tretinoin
Stem Cells
Neoplastic Stem Cells
Down-Regulation
2010

Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation

Goodwin, C. R., Lal, B., Zhou, X., Ho, S., Xia, S., Taeger, A., Murray, J. & Laterra, J. Apr 1 2010 In : Cancer Research. 70, 7, p. 2932-2941 10 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Cell Movement
Glioma
Growth
Small Interfering RNA
2009

Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity

Pei, Z., Sun, P., Huang, P., Lal, B., Laterra, J. & Watkins, P. A. Dec 15 2009 In : Cancer Research. 69, 24, p. 9175-9182 8 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioma
Cell Proliferation
Heterografts
Growth

DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation

Sun, P., Xia, S., Lal, B., Eberhart, C. G., Quinones-Hinojosa, A., Maciaczyk, J., Matsui, W., DiMeco, F., Piccirillo, S. M., Vescovi, A. L. & Laterra, J. Jul 2009 In : Stem Cells. 27, 7, p. 1473-1486 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Differentiation
Neoplastic Stem Cells
Genes
Neoplasms

EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts

Lal, B., Goodwin, C. R., Sang, Y., Foss, C. A., Cornet, K., Muzamil, S., Pomper, M. G., Kim, J. & Laterra, J. Jul 1 2009 In : Molecular Cancer Therapeutics. 8, 7, p. 1751-1760 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Hepatocyte Growth Factor
Receptor Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinases
2008

Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts

Salhotra, A., Lal, B., Laterra, J., Zhe Sun, P., van Zijl, P. C. M. & Zhou, J. Jun 2008 In : NMR in Biomedicine. 21, 5, p. 489-497 9 p.

Research output: Contribution to journalArticle

Gliosarcoma
Proton transfer
Glioblastoma
Heterografts
Amides

Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma

Li, Y., Guessous, F., Johnson, E. B., Eberhart, C. G., Li, X. N., Shu, Q., Fan, S., Lal, B., Laterra, J., Schiff, D. & Abounader, R. Feb 2008 In : Laboratory Investigation. 88, 2, p. 98-111 14 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hepatocyte Growth Factor
Proto-Oncogene Proteins c-myc
Heterografts
Cell Cycle

Hepatocyte growth factor and Sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth

Binning, M. J., Niazi, T., Pedone, C. A., Lal, B., Eberhart, C. G., Kim, K. J., Laterra, O. & Fults, D. W. Oct 1 2008 In : Cancer Research. 68, 19, p. 7838-7845 8 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hepatocyte Growth Factor
Hedgehogs
Stem Cells
Growth

PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

Li, Y., Guessous, F., Kwon, S., Kumar, M., Ibidapo, O., Fuller, L., Johnson, E., Lal, B., Hussaini, I., Bao, Y., Laterra, J., Schiff, D. & Abounader, R. Mar 15 2008 In : Cancer Research. 68, 6, p. 1723-1731 9 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Mutant Proteins
Cell Proliferation
Mutation Rate
2007

ABCG2/BCRP expression modulates D-luciferin-based bioluminescence imaging

Zhang, Y., Bressler, J. P., Neal, J., Lal, B., Bhang, H. E. C., Laterra, J. & Pomper, M. G. Oct 1 2007 In : Cancer Research. 67, 19, p. 9389-9397 9 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
P-Glycoprotein
Heterografts
Firefly Luciferases
Preclinical Drug Evaluations
Diffusion Magnetic Resonance Imaging
Brain Neoplasms
Diffusion Tensor Imaging
Anisotropy
Glioblastoma
2006

Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts

Kim, K. J., Wang, L., Su, Y. C., Gillespie, G. Y., Salhotra, A., Lal, B. & Laterra, J. Feb 15 2006 In : Clinical Cancer Research. 12, 4, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Heterografts
Glioma
Monoclonal Antibodies
Neoplasms
2005

Targeting the c-Met pathway potentiates glioblastoma responses to γ-radiation

Lal, B., Xia, S., Abounader, R. & Laterra, J. Jun 15 2005 In : Clinical Cancer Research. 11, 12, p. 4479-4486 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Gamma Rays
Glioblastoma
Catalytic RNA
Heterografts

The scatter factor/hepatocyte growth factor: c-Met pathway in human embryonal central nervous system tumor malignancy

Li, Y., Lal, B., Kwon, S., Fan, X., Saldanha, U., Reznik, T. E., Kuchner, E. B., Eberhart, C., Laterra, J. & Abounader, R. Oct 15 2005 In : Cancer Research. 65, 20, p. 9355-9362 8 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Hepatocyte Growth Factor
Neoplasms
Medulloblastoma
Heterografts
2004

Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity

Song, X., Pope, C., Murthy, R., Shaikh, J., Lal, B. & Bressler, J. P. Apr 2004 In : Toxicological Sciences. 78, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Paraoxon
Blood-Brain Barrier
Cholinergic Agents
Toxicity

Vascular Endothelial Growth Factor Mediates Vasogenic Edema in Acute Lead Encephalopathy

Hossain, M. A., Russell, J. C., Miknyoczki, S., Ruggeri, B., Lal, B. & Laterra, J. May 2004 In : Annals of Neurology. 55, 5, p. 660-667 8 p.

Research output: Contribution to journalArticle

Brain Diseases
Vascular Endothelial Growth Factor A
Edema
Capillary Permeability
Blood-Brain Barrier
2003

Amide Proton Transfer (APT) Contrast for Imaging of Brain Tumors

Zhou, J., Lal, B., Wilson, D. A., Laterra, J. & Van Zijl, P. C. M. Dec 2003 In : Magnetic Resonance in Medicine. 50, 6, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

Amides
Brain Neoplasms
Protons
Water
Gliosarcoma
2002

In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis.

Abounader, R., Lal, B., Luddy, C., Koe, G., Davidson, B., Rosen, E. M. & Laterra, J. 2002 In : FASEB Journal. 16, 1, p. 108-110 3 p.

Research output: Contribution to journalArticle

Catalytic RNA
Hepatocyte Growth Factor
Glioma
Apoptosis
Growth
2000

Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor

Guerin, C., Luddy, C., Abounader, R., Lal, B. & Laterra, J. Jun 24 2000 In : Biochemical and Biophysical Research Communications. 273, 1, p. 287-293 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Glioma
Gene transfer
Tumors
Cells
1999

Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression

Abounader, R., Ranganathan, S., Lal, B., Fielding, K., Book, A., Dietz, H., Burger, P. & Laterra, J. Sep 15 1999 In : Journal of the National Cancer Institute. 91, 18, p. 1548-1556 9 p.

Research output: Contribution to journalArticle

Catalytic RNA
Hepatocyte Growth Factor
Glioblastoma
Neoplasms
U1 small nuclear RNA
1996

Endothelial cell-based cytokine gene delivery inhibits 9L glioma growth in vivo

Nam, M., Johnston, P., Lal, B., Indurti, R., Wilson, M. A. & Laterra, J. Aug 26 1996 In : Brain Research. 731, 1-2, p. 161-170 10 p.

Research output: Contribution to journalArticle

Glioma
Endothelial Cells
Cytokines
Interleukin-2
Growth
Sulfhydryl Compounds
Anions
Potassium
Erythrocytes
Sulfhydryl Reagents
1994
Cell Tracking
beta-Galactosidase
Microvessels
Lac Operon
Staining and Labeling

Endothelial cell implantation and survival within experimental gliomas

Lal, B., Indurti, R. R., Couraud, P. O., Goldstein, G. W. & Laterra, J. Oct 11 1994 In : Proceedings of the National Academy of Sciences of the United States of America. 91, 21, p. 9695-9699 5 p.

Research output: Contribution to journalArticle

Glioma
Cell Survival
Endothelial Cells
Brain Neoplasms
Neoplasms
1993

Aluminum ingestion alters behaviour and some neurochemicals in rats.

Lal, B., Gupta, A., Gupta, A., Murthy, R. C., Ali, M. M. & Chandra, S. V. Jan 1993 In : Indian Journal of Experimental Biology. 31, 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

Aluminum
Rats
Eating
Brain
Metals
1991

Behavioral toxicity of cadmium in rats in relation to the level of protein nutrition

Ali, M. M., Lal, B., Mathur, N. & Chandra, S. V. 1991 In : Nutrition Research. 11, 4, p. 325-335 11 p.

Research output: Contribution to journalArticle

Cadmium
Diet
Aptitude
Learning
Locomotion

Cardiotoxicity and hypertension in rats after oral lead exposure

Lai, B., Murthy, R. C., Anand, M., Chandra, S. V., Kumar, R., Tripathi, O. & Srimal, R. C. 1991 In : Drug and Chemical Toxicology. 14, 3, p. 305-318 14 p.

Research output: Contribution to journalArticle

Rats
Lead
Blood pressure
Hypertension
Potable water
1990

Effect of hexavalent chromium on testicular maturation in the rat

Saxena, D. K., Murthy, R. C., Lal, B., Srivastava, R. S. & Chandra, S. V. 1990 In : Reproductive Toxicology. 4, 3, p. 223-228 6 p.

Research output: Contribution to journalArticle

Rats
Testis
L-Iditol 2-Dehydrogenase
Potassium Dichromate
gamma-Glutamyltransferase

Lead induced testicular hypersensitivity in stressed rats

Saxena, D. K., Lal, B., Srivastava, R. S. & Chandra, S. V. 1990 In : Experimental Pathology. 39, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

Rats
Hypersensitivity
Immobilization
Sperm Count
Androgens
1989

Chronic cadmium-ethanol administration alters metal distribution and some biochemicals in rat brain

Murthy, R. C., Saxena, D. K., Lal, B. & Chandra, S. V. 1989 In : Biochemistry International. 19, 1, p. 135-143 9 p.

Research output: Contribution to journalArticle

Inbred Strains Rats
Biogenic Amines
Adders
Monoamine Oxidase
Tissue Distribution