Atul Bedi

Associate Professor

1993 …2019

Research output per year

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Research Output

2019

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

2017

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia

Makarev, E., Schubert, A. D., Kanherkar, R. R., London, N., Teka, M., Ozerov, I., Lezhnina, K., Bedi, A., Ravi, R., Mehra, R., Hoque, M. O., Sloma, I., Gaykalova, D. A., Csoka, A. B., Sidransky, D., Zhavoronkov, A. & Izumchenko, E., Dec 4 2017, In : Cell Death Discovery. 3, 1, 17022.

Research output: Contribution to journalArticle

Open Access

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M. O., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 others, Davies, A., Morris, R., Hidalgo, M. & Sidransky, D., Jan 1 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

Ozawa, H., Ranaweera, R. S., Izumchenko, E., Makarev, E., Zhavoronkov, A., Fertig, E., Howard, J. D., Markovic, A., Bedi, A., Ravi, R., Perez, J., Le, Q. T., Kong, C. S., Jordan, R. C., Wang, H., Kang, H., Quon, H., Sidransky, D. & Chung, C. H., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5162-5175 14 p.

Research output: Contribution to journalArticle

2016

Patient-derived xenografts as tools in pharmaceutical development

Izumchenko, E., Meir, J., Bedi, A., Wysocki, P. T., Hoque, M. O. & Sidransky, D., Jun 1 2016, In : Clinical pharmacology and therapeutics. 99, 6, p. 612-621 10 p.

Research output: Contribution to journalArticle

2015

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma

Gilbert, J., Schell, M. J., Zhao, X., Murphy, B., Tanvetyanon, T., Leon, M. E., Hayes, D. N., Haigentz, M., Saba, N., Nieva, J., Bishop, J., Sidransky, D., Ravi, R., Bedi, A. & Chung, C. H., Jan 1 2015, In : Oral Oncology. 51, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA

Izumchenko, E., Chang, X., Brait, M., Fertig, E., Kagohara, L. T., Bedi, A., Marchionni, L., Agrawal, N., Ravi, R., Jones, S., Hoque, M. O., Westra, W. H. & Sidransky, D., Sep 16 2015, In : Nature communications. 6, 8258.

Research output: Contribution to journalArticle

2014

Erratum: The TGFβ-miR200-Mig6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors (Cancer Research (2014) 74 (3995-4005))

Izumchenko, E., Chang, X., Michailidi, C., Kagohara, L., Ravi, R., Paz, K., Brait, M., Hoque, M. O., Ling, S., Bedi, A. & Sidransky, D., Sep 1 2014, In : Cancer Research. 74, 17, 1 p.

Research output: Contribution to journalComment/debate

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors

Izumchenko, E., Chang, X., Michailidi, C., Kagohara, L., Ravi, R., Paz, K., Brait, M., Hoque, M., Ling, S., Bedi, A. & Sidransky, D., Jul 15 2014, In : Cancer Research. 74, 14, p. 3995-4005 11 p.

Research output: Contribution to journalArticle

2013

The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors

Chang, X., Izumchenko, E., Solis, L. M., Kim, M. S., Chatterjee, A., Ling, S., Monitto, C. L., Harari, P. M., Hidalgo, M., Goodman, S. N., Wistuba, I. I., Bedi, A. & Sidransky, D., Jul 31 2013, In : PloS one. 8, 7, e68966.

Research output: Contribution to journalArticle

2012

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E. J., Considine, M., Califano, J. A., Borrello, I., Chung, C. H., Sidransky, D. & Ravi, R., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

2011

Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance

Chang, X., Ravi, R., Pham, V., Bedi, A., Chatterjee, A. & Sidransky, D., Jun 20 2011, In : PloS one. 6, 6, e20806.

Research output: Contribution to journalArticle

2010

Regulation of p53 family member isoform ΔNp63α by the nuclear factor-κB targeting kinase IκB kinase β

Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A. & Sidransky, D., Feb 15 2010, In : Cancer Research. 70, 4, p. 1419-1429 11 p.

Research output: Contribution to journalArticle

2006

Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling

Ravi, R., Fuchs, E. J., Jain, A., Pham, V., Yoshimura, K., Prouser, T., Jalla, S., Zhou, X., Garrett-Mayer, E., Kaufmann, S. H., Schulick, R. D., Pardoll, D. M. & Bedi, A., Feb 1 2006, In : Cancer Research. 66, 3, p. 1730-1739 10 p.

Research output: Contribution to journalArticle

2004

Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL

Ravi, R., Jain, A. J., Schulick, R. D., Pham, V., Prouser, T. S., Allen, H., Mayer, E. G., Yu, H., Pardoll, D. M., Ashkenazi, A. & Bedi, A., Dec 15 2004, In : Cancer Research. 64, 24, p. 9105-9114 10 p.

Research output: Contribution to journalArticle

NF-κB in cancer - A friend turned foe

Ravi, R. & Bedi, A., Feb 2004, In : Drug Resistance Updates. 7, 1, p. 53-67 15 p.

Research output: Contribution to journalArticle

2002

On the TRAIL from death receptors to prostate cancer therapy

Bedi, A., Jan 1 2002, In : Cancer Biology and Therapy. 1, 6, p. 638-639 2 p.

Research output: Contribution to journalComment/debate

Open Access

Potential methods to circumvent blocks in apoptosis in lymphomas

Ravi, R. & Bedi, A., Sep 1 2002, In : Current opinion in oncology. 14, 5, p. 490-503 14 p.

Research output: Contribution to journalReview article

Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II

Ravi, R. & Bedi, A., Aug 1 2002, In : Cancer Research. 62, 15, p. 4180-4185 6 p.

Research output: Contribution to journalArticle

2001

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest

Niu, G., Shain, K. H., Huang, M., Ravi, R., Bedi, A., Dalton, W. S., Jove, R. & Yu, H., Apr 15 2001, In : Cancer Research. 61, 8, p. 3276-3280 5 p.

Research output: Contribution to journalArticle

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

Ravi, R., Bedi, G. C., Engstrom, L. W., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J. & Bedi, A., Apr 23 2001, In : Nature cell biology. 3, 4, p. 409-416 8 p.

Research output: Contribution to journalArticle

'The metabolism of tumours': 70 years later

Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z., Chiles, K., Feldser, D., Laughner, E., Ravi, R., Simons, J., Taghavi, P. & Zhong, H., Dec 1 2001, In : Novartis Foundation Symposium. 240, p. 251-260 10 p.

Research output: Contribution to journalArticle

2000

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L. & Bedi, A., Jan 1 2000, In : Genes and Development. 14, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

1999

Philadelphia chromosome-negative engraftment after autologous transplantation with granulocyte-macrophage colony-stimulating factor for chronic myeloid leukemia

Gladstone, D. E., Bedi, A., Miller, C. B., Noga, S. J., Griffin, C. A., Piantadosi, S., Cagnoni, P. J., Brodsky, R. A., Smith, B. D., Douglas, T. T., Shpall, E. J. & Jones, R. J., Jan 1 1999, In : Biology of Blood and Marrow Transplantation. 5, 6, p. 394-399 6 p.

Research output: Contribution to journalArticle

Open Access
1998

Biological significance and molecular mechanisms of p53-induced apoptosis

Bedi, A., Jan 1 1998, In : Apoptosis. 3, 4, p. 237-244 8 p.

Research output: Contribution to journalArticle

CD95 (Fas)-induced caspase-mediated proteolysis of NF-κB

Ravi, R., Bedi, A., Fuchs, E. J. & Bedi, A., Mar 1 1998, In : Cancer Research. 58, 5, p. 882-886 5 p.

Research output: Contribution to journalArticle

p53-mediated repression of nuclear factor-κB RelA via the transcriptional integrator p300

Ravi, R., Mookerjee, B., Van Hensbergen, Y., Bedi, G. C., Giordano, A., El-Deiry, W. S., Fuchs, E. J. & Bedi, A., Oct 15 1998, In : Cancer Research. 58, 20, p. 4531-4536 6 p.

Research output: Contribution to journalArticle

1997

Conversion of Bcl-2 to a bax-like death effector by caspases

Cheng, E. H. Y., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K. & Hardwick, J. M., Dec 12 1997, In : Science. 278, 5345, p. 1966-1968 3 p.

Research output: Contribution to journalArticle

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1- independent activation of CPP32β

Fuchs, E. J., McKenna, K. A. & Bedi, A., Jul 1 1997, In : Cancer Research. 57, 13, p. 2550-2554 5 p.

Research output: Contribution to journalArticle

1996

Are growth factors leukemogenic?

Brodsky, R. A., Bedi, A. & Jones, R. J., Jan 1996, In : Leukemia. 10, 1, p. 175-177 3 p.

Research output: Contribution to journalArticle

Requirement of p34(cdc2) kinase for apoptosis mediated by the Fas/APO-1 receptor and interleukin 1β-converting enzyme-related proteases

Yao, S. L., McKenna, K. A., Sharkis, S. J. & Bedi, A., Oct 15 1996, In : Cancer Research. 56, 20, p. 4551-4555 5 p.

Research output: Contribution to journalArticle

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34(cdc2) kinase

Yao, S. L., Akhtar, A. J., Mckenna, K. A., Bedi, G. C., Sidransky, D., Mabry, M., Ravi, R., Collector, M. I., Jones, R. J., Sharkis, S. J., Fuchs, E. J. & Bedi, A., Oct 1 1996, In : Nature medicine. 2, 10, p. 1140-1143 4 p.

Research output: Contribution to journalArticle

1995

Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation

Bedi, A., Miller, C. B., Hanson, J. L., Goodman, S., Ambinder, R. F., Charache, P., Arthur, R. R. & Jones, R. J., May 1995, In : Journal of Clinical Oncology. 13, 5, p. 1103-1109 7 p.

Research output: Contribution to journalArticle

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents

Bedi, A., Barber, J. P., Bedi, G. C., El-Deiry, W. S., Sidransky, D., Vala, M. S., Akhtar, A. J., Hilton, J. & Jones, R. J., Jan 1 1995, In : Blood. 86, 3, p. 1148-1158 11 p.

Research output: Contribution to journalArticle

Cytotoxic T Cells Overcome BCR-ABL-mediated Resistance to Apoptosis

Fuchs, E. J., Bedi, A., Jones, R. J. & Hess, A. D., Feb 1 1995, In : Cancer Research. 55, 3, p. 463-466 4 p.

Research output: Contribution to journalArticle

Inhibition of Apoptosis during Development of Colorectal Cancer

Bedi, A., Akhtar, A. J., Barber, J. P., Hamilton, S. R., Jones, R. J., Pasricha, P. J., Giardiello, F. M., Bedi, G. C., Hamilton, S. R. & Zehnbauer, B. A., May 1 1995, In : Cancer Research. 55, 9, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Mechanisms of cell commitment in myeloid cell differentiation.

Bedi, A. & Sharkis, S. J., Jan 1995, In : Current opinion in hematology. 2, 1, p. 12-21 10 p.

Research output: Contribution to journalReview article

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

Pasricha, P. J., Bedi, A., O'Connor, K., Rashid, A., Akhtar, A. J., Zahurak, M. L., Piantadosi, S., Hamilton, S. R. & Giardiello, F. M., Sep 1995, In : Gastroenterology. 109, 3, p. 994-998 5 p.

Research output: Contribution to journalArticle

1994

Biology of chronic myeloid leukemia and its relevance to autologous bone marrow transplantation

Jones, R. J. & Bedi, A., Jan 1 1994, In : Current opinion in oncology. 6, 2, p. 122-126 5 p.

Research output: Contribution to journalReview article

Growth Factor-mediated Terminal Differentiation of Chronic Myeloid Leukemia

Bedi, A., Griffin, C. A., Barber, J. P., Vala, M. S., Hawkins, A. L., Sharkis, S. J., Zehnbauer, B. A. & Jones, R. J., Nov 1994, In : Cancer Research. 54, 21, p. 5535-5538 4 p.

Research output: Contribution to journalArticle

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

Bedi, A., Zehnbauer, B. A., Barber, J. P., Sharkis, S. J. & Jones, R. J., Apr 15 1994, In : Blood. 83, 8, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

1993

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia

Bedi, A., Zehnbauer, B. A., Collector, M. I., Barber, J. P., Zicha, M. S., Sharkis, S. J. & Jones, R. J., Jun 14 1993, In : Blood. 81, 11, p. 2898-2902 5 p.

Research output: Contribution to journalArticle