Atul Bedi

Associate Professor

1993 …2019
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Research Output 1993 2019

2019

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

Neoplasms
Regulatory T-Lymphocytes
Mutation
Macrophages
Carcinoma, squamous cell of head and neck
2018

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., Artemov, A. V., Wysocki, P. T., Mehra, R., Nimmagadda, S., Marchionni, L., Sidransky, D., Borrello, I. M., Izumchenko, E. & Bedi, A., Dec 1 2018, In : Nature Communications. 9, 1, 741.

Research output: Contribution to journalArticle

Transforming Growth Factors
CTLA-4 Antigen
antibodies
Immunotherapy
cancer
2017

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L. H., Hoque, M., Rodriguez-Galindo, C., Pass, H., Peled, N. & 4 others, Davies, A., Morris, R., Hidalgo, M. & Sidransky, D., 2017, In : Annals of Oncology. 28, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Therapeutics
Exome
Translational Medical Research

SMAD4 loss is associated with cetuximab resistance and induction of MAPK/JNK activation in head and neck cancer cells

Ozawa, H., Ranaweera, R. S., Izumchenko, E., Makarev, E., Zhavoronkov, A., Fertig, E., Howard, J. D., Markovic, A., Bedi, A., Ravi, R., Perez, J., Le, Q. T., Kong, C. S., Jordan, R. C., Wang, H., Kang, H., Quon, H., Sidransky, D. & Chung, C. H., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5162-5175 14 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Gene Knockdown Techniques
Phenotype
Cell Line
Cetuximab
2016

Patient-derived xenografts as tools in pharmaceutical development

Izumchenko, E., Meir, J., Bedi, A., Wysocki, P. T., Hoque, M. & Sidransky, D., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Heterografts
Pharmaceutical Preparations
Neoplasms
Decision Making
Therapeutics
2015

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma

Gilbert, J., Schell, M. J., Zhao, X., Murphy, B., Tanvetyanon, T., Leon, M. E., Hayes, D. N., Haigentz, M., Saba, N., Nieva, J., Bishop, J., Sidransky, D., Ravi, R., Bedi, A. & Chung, C. H., 2015, In : Oral Oncology. 51, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Neoplasms
Cytokines
Human papillomavirus 6
sorafenib
neoplasms
sequencing
Ports and harbors
progressions
lungs
2014
Phosphotransferases
Research
Neoplasms

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors

Izumchenko, E., Chang, X., Michailidi, C., Tsukamoto Kagohara, L., Ravi, R., Paz, K., Brait Rodrigues De Oliveira, M., Hoque, M., Ling, S., Bedi, A. & Sidransky, D., Jul 15 2014, In : Cancer Research. 74, 14, p. 3995-4005 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transforming Growth Factors
MicroRNAs
Mitogens
Epidermal Growth Factor Receptor
2013

The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors

Chang, X., Izumchenko, E., Solis, L. M., Kim, M. S., Chatterjee, A., Ling, S., Monitto, C. L., Harari, P. M., Hidalgo, M., Goodman, S. N., Wistuba, I. I., Bedi, A. & Sidransky, D., Jul 31 2013, In : PLoS One. 8, 7, e68966.

Research output: Contribution to journalArticle

erbB-1 Genes
Mitogens
Protein-Tyrosine Kinases
tyrosine
phosphotransferases (kinases)
2012

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

Bedi, A., Chang, X., Noonan, K., Pham, V., Bedi, R., Fertig, E., Considine, M., Califano, J. A., Borrello, I. M., Chung, C. H., Sidransky, D. & Ravi, R., Nov 2012, In : Molecular Cancer Therapeutics. 11, 11, p. 2429-2439 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Neoplasms
Therapeutics
Antibody-Dependent Cell Cytotoxicity
Granzymes
2011

Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance

Chang, X., Ravi, R., Pham, V., Bedi, A., Chatterjee, A. & Sidransky, D., 2011, In : PLoS One. 6, 6, e20806.

Research output: Contribution to journalArticle

adenylate kinase
Adenylate Kinase
cisplatin
cigarettes
smoke
2010

Regulation of p53 family member isoform ΔNp63α by the nuclear factor-κB targeting kinase IκB kinase β

Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A. & Sidransky, D., Feb 15 2010, In : Cancer Research. 70, 4, p. 1419-1429 11 p.

Research output: Contribution to journalArticle

DNA Damage
Protein Isoforms
Phosphotransferases
Cytokines
Drug Therapy
2006

Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling

Ravi, R., Fuchs, E. J., Jain, A., Pham, V., Yoshimura, K., Prouser, T., Jalla, S., Zhou, X., Garrett-Mayer, E., Kaufmann, S. H., Schulick, R. D., Pardoll, A. M. & Bedi, A., Feb 1 2006, In : Cancer Research. 66, 3, p. 1730-1739 10 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
X-Linked Inhibitor of Apoptosis Protein
Adoptive Immunotherapy
Neoplasms
Ligands
2004

Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL

Ravi, R., Jain, A. J., Schulick, R. D., Pham, V., Prouser, T. S., Allen, H., Mayer, E. G., Yu, H., Pardoll, A. M., Ashkenazi, A. & Bedi, A., Dec 15 2004, In : Cancer Research. 64, 24, p. 9105-9114 10 p.

Research output: Contribution to journalArticle

irinotecan
Colonic Neoplasms
Neoplasm Metastasis
Ligands
Apoptosis

NF-κB in cancer - A friend turned foe

Ravi, R. & Bedi, A., Feb 2004, In : Drug Resistance Updates. 7, 1, p. 53-67 15 p.

Research output: Contribution to journalArticle

Neoplasms
Phosphotransferases
Apoptosis
Tumor Escape
Casein Kinase II
2002

On the TRAIL from death receptors to prostate cancer therapy

Bedi, A., Nov 2002, In : Cancer Biology and Therapy. 1, 6, p. 638-639 2 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Hormone-Dependent Neoplasms
Neoplasm Drug Resistance
Proto-Oncogene Proteins
Fas-Associated Death Domain Protein

Potential methods to circumvent blocks in apoptosis in lymphomas

Ravi, R. & Bedi, A., Sep 2002, In : Current Opinion in Oncology. 14, 5, p. 490-503 14 p.

Research output: Contribution to journalArticle

Lymphoma
Apoptosis
Lymphocytes
Therapeutics
Sulindac
Colorectal Neoplasms
Apoptosis
Caspase 9
Fluorouracil

Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II

Ravi, R. & Bedi, A., Aug 1 2002, In : Cancer Research. 62, 15, p. 4180-4185 6 p.

Research output: Contribution to journalArticle

Casein Kinase II
Apoptosis
Ligands
Neoplasms
Tumor Necrosis Factor-alpha
2001

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest

Niu, G., Shain, K. H., Huang, M., Ravi, R., Bedi, A., Dalton, W. S., Jove, R. & Yu, H., Apr 15 2001, In : Cancer Research. 61, 8, p. 3276-3280 5 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cell Cycle Checkpoints
Apoptosis
Neoplasms
Bystander Effect

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

Ravi, R., Bedi, G. C., Engstrom, L. W., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J. & Bedi, A., 2001, In : Nature Cell Biology. 3, 4, p. 409-416 8 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Apoptosis
Mutant Proteins
Transcriptional Activation
Cell Death

'The metabolism of tumours': 70 years later

Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z. M., Chiles, K., Feldser, D., Laughner, E., Ravi, R., Simons, J., Taghavi, P. & Zhong, H., 2001, Novartis Foundation Symposium. Vol. 240. p. 251-260 10 p. (Novartis Foundation Symposium; vol. 240).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypoxia-Inducible Factor 1
Neoplasms
Brain Neoplasms
Mutation
Breast Neoplasms
2000

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L. & Bedi, A., Jan 1 2000, In : Genes & development. 14, 1, p. 34-44 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Neoplasms
Heterografts
Vascular Endothelial Growth Factor A
Growth
1999
Philadelphia Chromosome
Autologous Transplantation
Granulocyte-Macrophage Colony-Stimulating Factor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bone Marrow Transplantation
1998

Biological significance and molecular mechanisms of p53-induced apoptosis

Bedi, A., 1998, In : Apoptosis. 3, 4, p. 237-244 8 p.

Research output: Contribution to journalArticle

Dynamic mechanical analysis
Apoptosis
Tumors
Genes
Cells

CD95 (Fas)-induced caspase-mediated proteolysis of NF-κB

Ravi, R., Bedi, A., Fuchs, E. J. & Bedi, A., Mar 1 1998, In : Cancer Research. 58, 5, p. 882-886 5 p.

Research output: Contribution to journalArticle

Caspases
Proteolysis
T-Lymphocytes
Jurkat Cells
Caspase 3

p53-mediated repression of nuclear factor-κB RelA via the transcriptional integrator p300

Ravi, R., Mookerjee, B., Van Hensbergen, Y., Bedi, G. C., Giordano, A., El-Deiry, W. S., Fuchs, E. J. & Bedi, A., Oct 15 1998, In : Cancer Research. 58, 20, p. 4531-4536 6 p.

Research output: Contribution to journalArticle

Transcriptional Activation
p300-CBP Transcription Factors
B-Form DNA
Tumor Suppressor Genes
Genes
1997

Conversion of Bcl-2 to a bax-like death effector by caspases

Cheng, E. H. Y., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K. & Hardwick, J. M., Dec 12 1997, In : Science. 278, 5345, p. 1966-1968 3 p.

Research output: Contribution to journalArticle

Effector Caspases
Caspases
Apoptosis
Sindbis Virus
Cell Death

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1- independent activation of CPP32β

Fuchs, E. J., McKenna, K. A. & Bedi, A., Jul 1 1997, In : Cancer Research. 57, 13, p. 2550-2554 5 p.

Research output: Contribution to journalArticle

DNA Damage
Apoptosis
Thymocytes
Ligation
T-Lymphocytes
1996

Are growth factors leukemogenic?

Brodsky, R. A., Bedi, A. & Jones, R. J., Jan 1996, In : Leukemia. 10, 1, p. 175-177 3 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Intercellular Signaling Peptides and Proteins
Doxorubicin
Cyclophosphamide
National Cancer Institute (U.S.)

Requirement of p34(cdc2) kinase for apoptosis mediated by the Fas/APO-1 receptor and interleukin 1β-converting enzyme-related proteases

Yao, S. L., McKenna, K. A., Sharkis, S. J. & Bedi, A., Oct 15 1996, In : Cancer Research. 56, 20, p. 4551-4555 5 p.

Research output: Contribution to journalArticle

Caspase 1
Peptide Hydrolases
Phosphotransferases
Apoptosis
Cell Death

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34(cdc2) kinase

Yao, S. L., Akhtar, A. J., Mckenna, K. A., Bedi, G. C., Sidransky, D., Mabry, M., Ravi, R., Collector, M. I., Jones, R. J., Sharkis, S. J., Fuchs, E. J. & Bedi, A., Oct 1996, In : Nature Medicine. 2, 10, p. 1140-1143 4 p.

Research output: Contribution to journalArticle

Caffeine
Phosphotransferases
Chemical activation
DNA Damage
Tumors
1995

Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation

Bedi, A., Miller, C. B., Hanson, J. L., Goodman, S., Ambinder, R. F., Charache, P., Arthur, R. R. & Jones, R. J., May 1995, In : Journal of Clinical Oncology. 13, 5, p. 1103-1109 7 p.

Research output: Contribution to journalArticle

BK Virus
Cystitis
Bone Marrow Transplantation
Mesna
Diuresis

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents

Bedi, A., Barber, J. P., Bedi, G. C., El-Deiry, W. S., Sidransky, D., Vala, M. S., Akhtar, A. J., Hilton, J. & Jones, R. J., 1995, In : Blood. 86, 3, p. 1148-1158 11 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
DNA Damage
Apoptosis
DNA
Genes

Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis

Fuchs, E. J., Bedi, A., Jones, R. J. & Hess, A. D., 1995, In : Cancer Research. 55, 3, p. 463-466 4 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptosis
T-Lymphocytes
Radiation

Inhibition of apoptosis during development of colorectal cancer

Bedi, A., Pasricha, P. J., Akhtar, A. J., Barber, J. P., Jones, R. J., Pasricha, P. J., Giardiello, F. M., Hamilton, S. R. & Jones, R. J., 1995, In : Cancer Research. 55, 9, p. 1811-1816 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Apoptosis
Adenoma
Carcinogenesis
Epithelium

Mechanisms of cell commitment in myeloid cell differentiation.

Bedi, A. & Sharkis, S. J., Jan 1995, In : Current Opinion in Hematology. 2, 1, p. 12-21 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Myeloid Cells
Cell Differentiation
Stem Cells
Hematopoiesis

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

Pasricha, P. J., Bedi, A., O'Connor, K., Rashid, A., Akhtar, A. J., Zahurak, M. L., Piantadosi, S., Hamilton, S. R. & Giardiello, F. M., 1995, In : Gastroenterology. 109, 3, p. 994-998 5 p.

Research output: Contribution to journalArticle

Sulindac
Adenomatous Polyposis Coli
Apoptosis
Cell Cycle
Proliferating Cell Nuclear Antigen
1994
Autologous Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bone Marrow Transplantation
Homologous Transplantation
Bone Marrow

Growth factor-mediated terminal differentiation of chronic myeloid leukemia

Bedi, A., Griffin, C. A., Barber, J. P., Vala, M. S., Hawkins, A. L., Sharkis, S. J., Zehnbauer, B. A. & Jones, R. J., Nov 1 1994, In : Cancer Research. 54, 21, p. 5535-5538 4 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Intercellular Signaling Peptides and Proteins
Hematopoietic Cell Growth Factors
Apoptosis
Cytotoxins

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

Bedi, A., Zehnbauer, B. A., Barber, J. P., Sharkis, S. J. & Jones, R. J., Apr 15 1994, In : Blood. 83, 8, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

Cell death
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cell proliferation
Apoptosis
Intercellular Signaling Peptides and Proteins
1993

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia

Bedi, A., Zehnbauer, B. A., Collector, M. I., Barber, J. P., Zicha, M. S., Sharkis, S. J. & Jones, R. J., Jun 1 1993, In : Blood. 81, 11, p. 2898-2902 5 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genes
Gene Expression
Messenger RNA