Atsushi Kamiya

Associate Professor

19982019

Research output per year

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Research Output

2019

Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment: A resting-state fMRI study

Xu, Z., Zhang, J., Wang, D., Wang, T., Zhang, S., Ren, X., Zhu, X., Kamiya, A., Fang, J. & Qu, M., Jan 1 2019, In : Frontiers in Psychiatry. 10, APR, 255.

Research output: Contribution to journalArticle

Open Access

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Itoh, K., Murata, D., Kato, T., Yamada, T., Araki, Y., Saito, A., Adachi, Y., Igarashi, A., Li, S., Pletnikov, M., Huganir, R. L., Watanabe, S., Kamiya, A., Iijima, M. & Sesaki, H., Oct 2019, In : eLife. 8, e44739.

Research output: Contribution to journalArticle

Open Access

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress (Neuropsychopharmacology, (2019), 44, 4, (683-694), 10.1038/s41386-018-0177-7)

Zhu, X., Nedelcovych, M. T., Thomas, A. G., Hasegawa, Y., Moreno-Megui, A., Coomer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., Alt, J., Prchalova, E., Tenora, L., Majer, P., Rais, R., Rojas, C., Slusher, B. & Kamiya, A., Jan 1 2019, In : Neuropsychopharmacology.

Research output: Contribution to journalComment/debate

Open Access

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders

Nedelcovych, M. T., Kim, B. H., Zhu, X., Lovell, L. E., Manning, A. A., Kelschenbach, J., Hadas, E., Chao, W., Prchalová, E., Dash, R. P., Wu, Y., Alt, J., Thomas, A. G., Rais, R., Kamiya, A., Volsky, D. J. & Slusher, B., Jan 1 2019, In : Journal of Neuroimmune Pharmacology.

Research output: Contribution to journalArticle

In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

Peter, C. J., Saito, A., Hasegawa, Y., Tanaka, Y., Nagpal, M., Perez, G., Alway, E., Espeso-Gil, S., Fayyad, T., Ratner, C., Dincer, A., Gupta, A., Devi, L., Pappas, J. G., Lalonde, F. M., Butman, J. A., Han, J. C., Akbarian, S. & Kamiya, A., Sep 11 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders

Teng, X., Aouacheria, A., Lionnard, L., Metz, K. A., Soane, L., Kamiya, A. & Hardwick, J. M., Jul 1 2019, In : CNS Neuroscience and Therapeutics. 25, 7, p. 887-902 16 p.

Research output: Contribution to journalReview article

Open Access

NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling

Hasegawa, Y., Zhu, X. & Kamiya, A., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2207-2209 3 p.

Research output: Contribution to journalReview article

2018

Altered resting-state brain activities in drug-naïve major depressive disorder assessed by fMRI: Associations with somatic symptoms defined by Yin-Yang theory of the traditional Chinese Medicine

Xu, Z., Zhang, S., Huang, L., Zhu, X., Zhao, Q., Zeng, Y., Zhou, D., Wang, D., Kuga, H., Kamiya, A. & Qu, M., May 15 2018, In : Frontiers in Psychiatry. 9, MAY, 195.

Research output: Contribution to journalArticle

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

Zhu, X., Nedelcovych, M. T., Thomas, A. G., Hasegawa, Y., Moreno-Megui, A., Coomer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., Alt, J., Prchalova, E., Tenora, L., Majer, P., Rais, R., Rojas, C., Slusher, B. & Kamiya, A., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances

Fukudome, D., Hayes, L., Faust, T. E., Foss, C., Kondo, M. A., Lee, B. J., Saito, A., Kano, S., Coughlin, J. M., Kamiya, A., Pomper, M. G., Sawa, A. & Niwa, M., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

2017

Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium

Yoshimura, A., Goodson, C., Johns, J. T., Towe, M. M., Irvine, E. S., Rendradjaja, N. A., Max, L. K., Laflam, A., Ledford, E. C., Probert, J., Tieges, Z., Edwin, D. H., MacLullich, A. M. J., Hogue, C. W., Lindquist, M., Gurakar, A., Neufeld, K. J. & Kamiya, A., Dec 1 2017, In : Scientific Reports. 7, 1, 9258.

Research output: Contribution to journalArticle

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction

Segal-Gavish, H., Gazit, N., Barhum, Y., Ben-Zur, T., Taler, M., Hornfeld, S. H., Gil-Ad, I., Weizman, A., Slutsky, I., Niwa, M., Kamiya, A., Sawa, A., Offen, D. & Barzilay, R., 2017, In : Human Molecular Genetics. 26, 13, p. 2462-2471 10 p.

Research output: Contribution to journalArticle

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity

Nishi, A., Numata, S., Tajima, A., Zhu, X., Ito, K., Saito, A., Kato, Y., Kinoshita, M., Shimodera, S., Ono, S., Ochi, S., Imamura, A., Kurotaki, N., Ueno, S. I., Iwata, N., Fukui, K., Imoto, I., Kamiya, A. & Ohmori, T., Dec 1 2017, In : Scientific Reports. 7, 1, 2887.

Research output: Contribution to journalArticle

Developmental alcohol exposure impairs activity-dependent S-nitrosylation of NDEL1 for neuronal maturation

Saito, A., Taniguchi, Y., Kim, S-H., Selvakumar, B., Perez, G., Ballinger, M. D., Zhu, X., Sabra, J., Jallow, M., Yan, P., Ito, K., Rajendran, S., Hirotsune, S., Wynshaw-Boris, A., Snyder, S. H., Sawa, A. & Kamiya, A., Aug 1 2017, In : Cerebral Cortex. 27, 8, p. 3918-3929 12 p.

Research output: Contribution to journalArticle

2016

Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis

Kondo, M. A., Fukudome, D., Smith, D. R., Gallagher, M., Kamiya, A. & Sawa, A., Jun 1 2016, In : Neuroscience Research. 107, p. 70-74 5 p.

Research output: Contribution to journalArticle

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1

Niwa, M., Cash-Padgett, T., Kubo, K. I., Saito, A., Ishii, K., Sumitomo, A., Taniguchi, Y., Ishizuka, K., Jaaro-Peled, H., Tomoda, T., Nakajima, K., Sawa, A. & Kamiya, A., Nov 1 2016, In : Molecular Psychiatry. 21, 11, p. 1488-1489 2 p.

Research output: Contribution to journalComment/debate

DISC1 causes associative memory and neurodevelopmental defects in fruit flies

Furukubo-Tokunaga, K., Kurita, K., Honjo, K., Pandey, H., Ando, T., Takayama, K., Arai, Y., Mochizuki, H., Ando, M., Kamiya, A. & Sawa, A., Sep 1 2016, In : Molecular psychiatry. 21, 9, p. 1232-1243 12 p.

Research output: Contribution to journalArticle

DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity

Gancarz, A., Jouroukhin, Y., Saito, A., Shevelkin, A., Mueller, L. E., Kamiya, A., Dietz, D. M. & Pletnikov, M. V., Apr 1 2016, In : Neuroscience Research. 105, p. 70-74 5 p.

Research output: Contribution to journalArticle

Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

Saito, A., Taniguchi, Y., Rannals, M. D., Merfeld, E. B., Ballinger, M. D., Koga, M., Ohtani, Y., Gurley, D. A., Sedlak, T. W., Cross, A., Moss, S. J., Brandon, N. J., Maher, B. J. & Kamiya, A., Oct 1 2016, In : Molecular psychiatry. 21, 10, p. 1449-1459 11 p.

Research output: Contribution to journalArticle

Role for neonatal D-serine signaling: Prevention of physiological and behavioral deficits in adult Pick1 knockout mice

Nomura, J., Jaaro-Peled, H., Lewis, E., Nuñez-Abades, P., Huppe-Gourgues, F., Cash-Padgett, T., Emiliani, F., Kondo, M. A., Furuya, A., Landek-Salgado, M. A., Ayhan, Y., Kamiya, A., Takumi, T., Huganir, R., Pletnikov, M., O'Donnell, P. & Sawa, A., Mar 1 2016, In : Molecular psychiatry. 21, 3, p. 386-393 8 p.

Research output: Contribution to journalArticle

Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies

Furukubo-Tokunaga, K., Kurita, K., Honjo, K., Pandey, H., Ando, T., Takayama, K., Arai, Y., Mochizuki, H., Ando, M., Kamiya, A. & Sawa, A., Sep 1 2016, In : Molecular Psychiatry. 21, 9, p. 1157 1 p.

Research output: Contribution to journalComment/debate

2015

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory

Ballinger, M. D., Saito, A., Abazyan, B., Taniguchi, Y., Huang, C. H., Ito, K., Zhu, X., Segal, H., Jaaro-Peled, H., Sawa, A., Mackie, K., Pletnikov, M. V. & Kamiya, A., Oct 1 2015, In : Neurobiology of Disease. 82, p. 176-184 9 p.

Research output: Contribution to journalArticle

DISC1 regulates trafficking and processing of APP and Aβ generation

Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T. W., Korth, C., Brandon, N. J., Kamiya, A., Subramaniam, S., Tomoda, T. & Sawa, A., Jul 24 2015, In : Molecular psychiatry. 20, 7, p. 874-879 6 p.

Research output: Contribution to journalArticle

Half-life of DISC1 protein and its pathological significance under hypoxia stress

Barodia, S. K., Park, S. K., Ishizuka, K., Sawa, A. & Kamiya, A., Aug 1 2015, In : Neuroscience Research. 97, p. 1-6 6 p.

Research output: Contribution to journalArticle

Nuclear-translocated glyceraldehyde-3-phosphate dehydrogenase promotes Poly(ADP-ribose) polymerase-1 activation during oxidative/nitrosative stress in stroke

Nakajima, H., Kubo, T., Ihara, H., Hikida, T., Danjo, T., Nakatsuji, M., Shahani, N., Itakura, M., Ono, Y., Azuma, Y. T., Inui, T., Kamiya, A., Sawa, A. & Takeuchi, T., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14493-14503 11 p.

Research output: Contribution to journalArticle

Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

Peng, H., Ishida, M., Li, L., Saito, A., Kamiya, A., Hamilton, J. P., Fu, R., Olaru, A. V., An, F., Popescu, I., Iacob, R., Dima, S., Alexandrescu, S. T., Grigorie, R., Nastase, A., Berindan-Neagoe, I., Tomuleasa, C., Graur, F., Zaharia, F., Torbenson, M. S. & 3 others, Mezey, E., Lu, M. & Selaru, F. M., Jan 1 2015, In : Oncotarget. 6, 8, p. 5666-5677 12 p.

Research output: Contribution to journalArticle

Open Access
2014

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: Response to Sullivan

Porteous, D. J., Thomson, P. A., Millar, J. K., Evans, K. L., Hennah, W., Soares, D. C., McCarthy, S., McCombie, W. R., Clapcote, S. J., Korth, C., Brandon, N. J., Sawa, A., Kamiya, A., Roder, J. C., Lawrie, S. M., McIntosh, A. M., St Clair, D. & Blackwood, D. H., Feb 1 2014, In : Molecular psychiatry. 19, 2, p. 141-143 3 p.

Research output: Contribution to journalReview article

2013

Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF

Hurley, L. L., Akinfiresoye, L., Nwulia, E., Kamiya, A., Kulkarni, A. A. & Tizabi, Y., Feb 15 2013, In : Behavioural Brain Research. 239, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

Endocannabinoid system: Potential novel targets for treatment of schizophrenia

Saito, A., Ballinger, M. D. L., Pletnikov, M. V., Wong, D. F. & Kamiya, A., May 1 2013, In : Neurobiology of Disease. 53, p. 10-17 8 p.

Research output: Contribution to journalReview article

Subcortical dopaminergic deficits in a DISC1 mutant model: A study in direct reference to human molecular brain imaging

Jaaro-Peled, H., Niwa, M., Foss, C. A., Murai, R., Reyes, S. D. L., Kamiya, A., Mateo, Y., O'Donnell, P., Cascella, N. G., Nabeshima, T., Guilarte, T. R., Pomper, M. G. & Sawa, A., Apr 1 2013, In : Human molecular genetics. 22, 8, p. 1574-1580 7 p.

Research output: Contribution to journalArticle

2012

In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: From genes to circuits and behaviors

Taniguchi, Y., Young-Pearse, T., Sawa, A. & Kamiya, A., Apr 1 2012, In : Neuroscientist. 18, 2, p. 169-179 11 p.

Research output: Contribution to journalReview article

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

Golzio, C., Willer, J., Talkowski, M. E., Oh, E. C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J. F., Kamiya, A., Beckmann, J. S. & Katsanis, N., May 17 2012, In : Nature. 485, 7398, p. 363-367 5 p.

Research output: Contribution to journalArticle

Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: A comorbidity model

Pogorelov, V. M., Nomura, J., Kim, J., Kannan, G., Ayhan, Y., Yang, C., Taniguchi, Y., Abazyan, B., Valentine, H., Krasnova, I. N., Kamiya, A., Cadet, J. L., Wong, D. F. & Pletnikov, M. V., Mar 1 2012, In : Neuropharmacology. 62, 3, p. 1242-1251 10 p.

Research output: Contribution to journalArticle

2011

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

Ishizuka, K., Kamiya, A., Oh, E. C., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K. I., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M. D., Katsanis, N. & Sawa, A., May 5 2011, In : Nature. 473, 7345, p. 92-96 5 p.

Research output: Contribution to journalArticle

Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function

Zoubovsky, S. P., Pogorelov, V. M., Taniguchi, Y., Kim, S. H., Yoon, P., Nwulia, E., Sawa, A., Pletnikov, M. V. & Kamiya, A., May 20 2011, In : Biochemical and Biophysical Research Communications. 408, 4, p. 707-712 6 p.

Research output: Contribution to journalArticle

2010

Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth

Hayashi, M. A. F., Guerreiro, J. R., Charych, E., Kamiya, A., Barbosa, R. L., Machado, M. F., Campeiro, J. D., Oliveira, V., Sawa, A., Camargo, A. C. M. & Brandon, N. J., Aug 1 2010, In : Molecular and Cellular Neuroscience. 44, 4, p. 353-361 9 p.

Research output: Contribution to journalArticle

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., Xie, Z., Baraban, J. M., Houslay, M. D., Tomoda, T., Brandon, N. J., Kamiya, A., Yan, Z., Penzes, P. & Sawa, A., Mar 1 2010, In : Nature neuroscience. 13, 3, p. 327-332 6 p.

Research output: Contribution to journalArticle

Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

Seshadri, S., Kamiya, A., Yokota, Y., Prikulis, I., Kano, S. I., Hayashi-Takagi, A., Stanco, A., Eom, T. Y., Rao, S., Ishizuka, K., Wong, P., Korth, C., Anton, E. S. & Sawa, A., Mar 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5622-5627 6 p.

Research output: Contribution to journalArticle

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

Niwa, M., Kamiya, A., Murai, R., Kubo, K. I., Gruber, A. J., Tomita, K., Lu, L., Tomisato, S., Jaaro-Peled, H., Seshadri, S., Hiyama, H., Huang, B., Kohda, K., Noda, Y., O'Donnell, P., Nakajima, K., Sawa, A. & Nabeshima, T., Feb 25 2010, In : Neuron. 65, 4, p. 480-489 10 p.

Research output: Contribution to journalArticle

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi

Kubo, K. I., Tomita, K., Uto, A., Kuroda, K., Seshadri, S., Cohen, J., Kaibuchi, K., Kamiya, A. & Nakajima, K., Oct 1 2010, In : Biochemical and Biophysical Research Communications. 400, 4, p. 631-637 7 p.

Research output: Contribution to journalArticle

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., Cadet, J. L., Pardo, C., Mori, S., Kamiya, A., Vogel, M. W., Sawa, A., Ross, C. A. & Pletnikov, M. V., Dec 15 2010, In : Biological psychiatry. 68, 12, p. 1172-1181 10 p.

Research output: Contribution to journalArticle

2009

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation (DOI:10.1016/j.neuron.2009.05.024)

Sen, N., Hara, M. R., Ahmad, A. S., Cascio, M. B., Kamiya, A., Ehmsen, J. T., Agrawal, N., Hester, L., Doré, S., Snyder, S. H. & Sawa, A., Sep 10 2009, In : Neuron. 63, 5, 1 p.

Research output: Contribution to journalComment/debate

GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.

Sen, N., Hara, M. R., Ahmad, A. S., Cascio, M. B., Kamiya, A., Ehmsen, J. T., Aggrawal, N., Hester, L., Doré, S., Snyder, S. H. & Sawa, A., Jul 16 2009, In : Neuron. 63, 1, p. 81-91 11 p.

Research output: Contribution to journalArticle

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1

Jaaro-Peled, H., Hayashi-Takagi, A., Seshadri, S., Kamiya, A., Brandon, N. J. & Sawa, A., Sep 1 2009, In : Trends in Neurosciences. 32, 9, p. 485-495 11 p.

Research output: Contribution to journalReview article

2008

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

Burdick, K. E., Kamiya, A., Hodgkinson, C. A., Lencz, T., Derosse, P., Ishizuka, K., Elashvili, S., Arai, H., Goldman, D., Sawa, A. & Malhotra, A. K., Aug 1 2008, In : Human molecular genetics. 17, 16, p. 2462-2473 12 p.

Research output: Contribution to journalArticle