Antony Rosen

Professor

1988 …2019
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Research Output 1988 2019

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Article
2019
Autoantibodies
Rheumatoid Arthritis
Joints
Antibodies
Methotrexate

Estimating autoantibody signatures to detect autoimmune disease patient subsets

Wu, Z., Casciola Rosen, L. A., Shah, A., Rosen, A. & Zeger, S., Jan 1 2019, In : Biostatistics (Oxford, England). 20, 1, p. 30-47 18 p.

Research output: Contribution to journalArticle

Autoantibodies
Signature
Subset
Warping
Immune Response
Open Access
Precision Medicine
RNA Polymerase I
RNA Polymerase III
Antibodies
Neoplasms
Anti-Idiotypic Antibodies
2018

Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

Shi, J., Darrah, E., Sims, G. P., Mustelin, T., Sampson, K., Konig, M. F., Bingham, C., Rosen, A. & Andrade, F. A., Jan 1 2018, In : Annals of the Rheumatic Diseases. 77, 1, p. 141-148 8 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Antibodies
Autoantibodies
protein-arginine deiminase
B-Lymphocytes
Autoantibodies
Phenotype
Neoplasms
Set theory
Incidence
Open Access
Cell Shape
Epithelial Cells
Proteins
Autoantigens
Lip

Rare loss of function variants in candidate genes and risk of colorectal cancer

NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 others, Steering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In : Human Genetics. 137, 10, p. 795-806 12 p.

Research output: Contribution to journalArticle

Polyps
Colorectal Neoplasms
Genes
Penetrance
Genetic Testing
2017

Brief Report: Anti–RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma

Shah, A., Xu, G., Rosen, A., Hummers, L., Wigley, F., Elledge, S. J. & Casciola Rosen, L. A., Jun 1 2017, In : Arthritis and Rheumatology. 69, 6, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

Antibodies
Autoantibodies
Neoplasms
Cytidine Triphosphate
Odds Ratio
Open Access
Medicine
Learning
Delivery of Health Care
Safety
Health
Myositis
Rheumatic Diseases
Autoantibodies
Dermatomyositis
Breast Neoplasms

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A., Jan 6 2017, In : Journal of Proteome Research. 16, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Proteolysis
Granzymes
Epitopes
Rheumatoid Arthritis
T-cells
2016

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

Konig, M. F., Abusleme, L., Reinholdt, J., Palmer, R. J., Teles, R. P., Sampson, K., Rosen, A., Nigrovic, P. A., Sokolove, J., Giles, J. T., Moutsopoulos, N. M. & Andrade, F. A., Dec 14 2016, In : Science Translational Medicine. 8, 369, 369ra176.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Autoimmunity
Rheumatoid Arthritis
Infection
Periodontitis
Gangrene
Interferons
Antibodies
Proteins
Case-Control Studies

Association of Acroosteolysis with Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis

Park, J. K., Fava, A., Carrino, J., Del Grande, F., Rosen, A. & Boin, F., Jan 1 2016, In : Arthritis and Rheumatology. 68, 1, p. 201-209 9 p.

Research output: Contribution to journalArticle

Acro-Osteolysis
Systemic Scleroderma
Osteogenesis
Vascular Endothelial Growth Factor A
Osteoclasts
Interferons
Antibodies
Proteins
Salivary Glands
Lip
African Americans
Rheumatoid Arthritis
Antibodies
arginine deiminase
Autoantibodies
Autoantigens
Rheumatic Diseases
Autoimmune Diseases
Autoimmunity
Immune System

Enrichment of Scleroderma Vascular Disease–Associated Autoantigens in Endothelial Lineage Cells

McMahan, Z., Cottrell, T. R., Wigley, F., Antiochos, B., Zambidis, E., Park, T. S., Halushka, M. K., Gutierrez, L., Cimbro, R., Rosen, A. & Casciola Rosen, L. A., Oct 1 2016, In : Arthritis and Rheumatology. 68, 10, p. 2540-2549 10 p.

Research output: Contribution to journalArticle

Autoantigens
Interferons
Blood Vessels
Endothelial Cells
Proteins

Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma

Fava, A., Cimbro, R., Wigley, F., Liu, Q. R., Rosen, A. & Boin, F., May 4 2016, In : Arthritis Research and Therapy. 18, 1, 99.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Interstitial Lung Diseases
T-Lymphocytes
Tissue Donors
Phenotype

Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer

Xu, G. J., Shah, A., Li, M. Z., Xu, Q., Rosen, A., Casciola Rosen, L. A. & Elledge, S. J., Nov 22 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7526-E7534

Research output: Contribution to journalArticle

Autoantigens
Spliceosomes
Autoantibodies
Autoimmune Diseases
Epitopes
2015

A methodology for exploring biomarker - phenotype associations: Application to flow cytometry data and systemic sclerosis clinical manifestations

Huang, H., Fava, A., Guhr, T., Cimbro, R., Rosen, A., Boin, F. & Ellis, H., Sep 15 2015, In : BMC Bioinformatics. 16, 1, 293.

Research output: Contribution to journalArticle

Systemic Sclerosis
Flow Cytometry
Pulmonary diseases
Flow cytometry
Systemic Scleroderma
Autoantibodies
RNA Polymerase III
Neoplasms
Age of Onset
Type I DNA Topoisomerase

Molecular subsetting of interferon pathways in Sjögren's syndrome

Hall, J. C., Baer, A., Shah, A., Criswell, L. A., Shiboski, C. H., Rosen, A. & Casciola Rosen, L. A., Sep 1 2015, In : Arthritis and Rheumatology. 67, 9, p. 2437-2446 10 p.

Research output: Contribution to journalArticle

Interferons
Salivary Glands
Lip
Interferon-gamma
Lacrimal Apparatus

PUF60: A prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome

Fiorentino, D. F., Presby, M., Baer, A., Petri, M., Rieger, K. E., Soloski, M. J., Rosen, A., Mammen, A. L., Christopher-Stine, L. & Casciola Rosen, L. A., Aug 7 2015, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Dermatomyositis
Autoimmunity
Antibodies
Autoantigens
Autoantibodies

Review: Cancer-induced autoimmunity in the rheumatic diseases

Shah, A., Casciola Rosen, L. A. & Rosen, A., Feb 1 2015, In : Arthritis and Rheumatology. 67, 2, p. 317-326 10 p.

Research output: Contribution to journalArticle

Dermatomyositis
Systemic Scleroderma
Rheumatic Diseases
Autoimmunity
Autoimmune Diseases
2014

Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease

Giles, J. T., Darrah, E., Danoff, S., Johnson, C., Andrade, F. A., Rosen, A. & Bathon, J. M., Jun 5 2014, In : PLoS One. 9, 6, e98794.

Research output: Contribution to journalArticle

arginine deiminase
Pulmonary diseases
rheumatoid arthritis
Interstitial Lung Diseases
respiratory tract diseases

Association of the autoimmune disease scleroderma with an immunologic response to cancer

Joseph, C. G., Darrah, E., Shah, A., Skora, A. D., Casciola Rosen, L. A., Wigley, F., Boin, F., Fava, A., Thoburn, C., Kinde, I., Jiao, Y., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Rosen, A., 2014, In : Science. 343, 6167, p. 152-157 6 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Neoplasms
Antibodies
Antigens
Connective Tissue Diseases

Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B

Duan-Porter, W. D., Woods, V. L., Maurer, K. D., Li, S. & Rosen, A., Dec 9 2014, In : PLoS One. 9, 12, e115062.

Research output: Contribution to journalArticle

Granzymes
Oligomers
Conformations
Monomers
deuterium
2013

Acute gout after renal transplantation with notable hypouricemia

Juraschek, S. P., Kurano, T., Rosen, A. & Gelber, A., Oct 2013, In : American Journal of Medicine. 126, 10

Research output: Contribution to journalArticle

Hyperuricemia
Gout
Kidney Transplantation
Chronic Kidney Failure

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. A. & Rosen, A., May 22 2013, In : Science Translational Medicine. 5, 186, 186ra65.

Research output: Contribution to journalArticle

Autoantibodies
Rheumatoid Arthritis
Calcium
Antibodies
Autoantigens

Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: Systematic analysis

Park, J. K., Rosen, A., Saffitz, J. E., Asimaki, A., Litovsky, S. H., Mackey-Bojack, S. M. & Halushka, M. K., Aug 2013, In : Rheumatology. 52, 8, p. 1529-1533 5 p., ket184.

Research output: Contribution to journalArticle

Cathepsin K
Osteoclasts
Giant Cells
Crohn Disease
Myocarditis

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F. A., Oct 30 2013, In : Science Translational Medicine. 5, 209, 209ra150.

Research output: Contribution to journalArticle

Autoantigens
Rheumatoid Arthritis
Perforin
Complement Membrane Attack Complex
Neutrophil Activation

Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ

Fiorentino, D. F., Chung, L. S., Christopher-Stine, L., Zaba, L., Li, S., Mammen, A. L., Rosen, A. & Casciola Rosen, L. A., Nov 2013, In : Arthritis and Rheumatism. 65, 11, p. 2954-2962 9 p.

Research output: Contribution to journalArticle

Dermatomyositis
Transcription Factors
Antibodies
Neoplasms
Immunoprecipitation
Thyroiditis
Thyrotropin
Hepatitis C
Interferon-alpha
Thyroid Gland

Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations

Ferucci, E. D., Darrah, E., Smolik, I., Choromanski, T. L., Robinson, D. B., Newkirk, M. M., Fritzler, M. J., Rosen, A. & El-Gabalawy, H. S., Sep 2013, In : Journal of Rheumatology. 40, 9, p. 1523-1528 6 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Antibodies
Population
Peptides
Epitopes
2012

A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: Report of 2 cases and review of the literature

Chaisson, N. F., Paik, J., Orbai, A-M., Casciola Rosen, L. A., Fiorentino, D., Danoff, S. & Rosen, A., Jul 2012, In : Medicine (United States). 91, 4, p. 220-228 9 p.

Research output: Contribution to journalArticle

Lung
Antibodies
Dermatomyositis
Interstitial Lung Diseases
Muscular Diseases
Molecular Pathology
Muscular Diseases
Disease Management
Muscles

Editorial introductions

Rosen, A., Casciola Rosen, L. A. & Varga, J., Nov 2012, In : Current Opinion in Rheumatology. 24, 6

Research output: Contribution to journalArticle

Identification of novel autoantigens by a triangulation approach

Cottrell, T. R., Hall, J. C., Rosen, A. & Casciola Rosen, L. A., Nov 30 2012, In : Journal of Immunological Methods. 385, 1-2, p. 35-44 10 p.

Research output: Contribution to journalArticle

Autoantigens
Autoantibodies
Autoimmune Diseases
Antigens
Myositis

Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis

Park, J. K., Askin, F. B., Giles, J. T., Halushka, M. K., Rosen, A. & Levine, S. M., Aug 8 2012, In : PLoS One. 7, 8, e42659.

Research output: Contribution to journalArticle

Granulomatosis with Polyangiitis
giant cells
Giant Cells
Acid Phosphatase
Calcitonin Receptors
MM Form Creatine Kinase
Fructose-Bisphosphate Aldolase
Myositis
Muscle Cells
Biomarkers

Myocardial citrullination in rheumatoid arthritis: A correlative histopathologic study

Giles, J. T., Fert-Bober, J., Park, J. K., Bingham, C., Andrade, F. A., Fox-Talbot, K., Pappas, D., Rosen, A., van Eyk, J., Bathon, J. M. & Halushka, M. K., Feb 24 2012, In : Arthritis Research and Therapy. 14, 1, R39.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Staining and Labeling
Citrulline
Myocarditis
Heart Failure
Autoantigens
Rheumatoid Arthritis
Neutrophils
Substrates
Actins
Hepatitis C
Interferons
Thyroiditis
Thyroid Gland
Phenotype

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

Hall, J. C., Casciola Rosen, L. A., Berger, A. E., Kapsogeorgou, E. K., Cheadle, C., Tzioufas, A. G., Baer, A. & Rosen, A., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17609-17614 6 p.

Research output: Contribution to journalArticle

Rheumatic Diseases
Interferons
Interferon-gamma
Dermatomyositis
Therapeutics
2011
monocytes
Monocytes
lupus erythematosus
cytokines
Anti-Inflammatory Agents

A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4b is expressed exclusively in mature striated muscle cells

Mammen, A. L., Mahoney, J. A., Germain, A., Badders, N., Taylor, J. P., Rosen, A. & Spinette, S., Dec 9 2011, In : PLoS One. 6, 12, e28861.

Research output: Contribution to journalArticle

striated muscle
Striated Muscle
Ligases
ubiquitin
Ubiquitin

Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease

Grader Beck, T., Boin, F., Von Gunten, S., Smith, D., Rosen, A. & Bochner, B. S., Dec 2011, In : Annals of the Rheumatic Diseases. 70, 12, p. 2218-2224 7 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Vascular Diseases
Lung Diseases
Carbohydrates
Antibodies

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase in patients with statin-associated autoimmune myopathy

Mammen, A. L., Chung, T., Christopher-Stine, L., Rosen, P., Rosen, A., Doering, K. R., Casciola Rosen, L. A., Yalcin, A., Kilic, G. & Kantarci, M., Mar 2011, In : Arthritis and Rheumatism. 63, 3, p. 713-721 9 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coenzymes
Muscular Diseases
Coenzyme A
Autoantibodies