Research Output 1988 2017

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2017

Brief Report: Anti–RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma

Shah, A. A., Xu, G., Rosen, A., Hummers, L. K., Wigley, F. M., Elledge, S. J. & Casciola-Rosen, L. Jun 1 2017 In : Arthritis and Rheumatology. 69, 6, p. 1306-1312 7 p.

Research output: Research - peer-reviewArticle

Antibodies
Neoplasms
Autoantibodies
RNA Polymerase III
Cytidine Triphosphate

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C. O., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A. Jan 6 2017 In : Journal of Proteome Research. 16, 1, p. 355-365 11 p.

Research output: Research - peer-reviewArticle

Granzymes
Proteolysis
Epitopes
Rheumatoid Arthritis
protein-arginine deiminase
2016

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

Konig, M. F., Abusleme, L., Reinholdt, J., Palmer, R. J., Teles, R. P., Sampson, K., Rosen, A., Nigrovic, P. A., Sokolove, J., Giles, J. T., Moutsopoulos, N. M. & Andrade, F. Dec 14 2016 In : Science Translational Medicine. 8, 369, 369ra176

Research output: Research - peer-reviewArticle

Aggregatibacter actinomycetemcomitans
Autoimmunity
Rheumatoid Arthritis
Infection
Periodontitis
Gangrene
Interferons
Antibodies
Proteins
Case-Control Studies

Association of Acroosteolysis with Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis

Park, J. K., Fava, A., Carrino, J., Del Grande, F., Rosen, A. & Boin, F. Jan 1 2016 In : Arthritis and Rheumatology. 68, 1, p. 201-209 9 p.

Research output: Research - peer-reviewArticle

Acro-Osteolysis
Systemic Scleroderma
Osteogenesis
Vascular Endothelial Growth Factor A
Osteoclasts
Sjogren's Syndrome
Interferons
Antibodies
Proteins
Salivary Glands

Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans

Navarro-Millán, I., Darrah, E., Westfall, A. O., Mikuls, T. R., Reynolds, R. J., Danila, M. I., Curtis, J. R., Rosen, A., Bridges, S. L. & CLEAR Investigators Oct 22 2016 In : Arthritis Research and Therapy. 18, 1, 241

Research output: Research - peer-reviewArticle

African Americans
Rheumatoid Arthritis
Antibodies
arginine deiminase
Peptides
Autoantigens
Rheumatic Diseases
Autoimmune Diseases
Autoimmunity
Immune System
Autoantigens
Vascular Diseases
Interferons
Endothelial Cells
Proteins
Type I DNA Topoisomerase
Interstitial Lung Diseases
T-Lymphocytes
Tissue Donors
Phenotype
Autoantigens
Neoplasms
Spliceosomes
Autoantibodies
Autoimmune Diseases
2015

A methodology for exploring biomarker - phenotype associations: Application to flow cytometry data and systemic sclerosis clinical manifestations

Huang, H., Fava, A., Guhr, T., Cimbro, R., Rosen, A., Boin, F. & Ellis, H. Sep 15 2015 In : BMC Bioinformatics. 16, 1, 293

Research output: Research - peer-reviewArticle

Systemic Sclerosis
Flow Cytometry
Biomarkers
Phenotype
Methodology
Autoantibodies
Neoplasms
RNA Polymerase III
Age of Onset
Odds Ratio

Molecular subsetting of interferon pathways in Sjögren's syndrome

Hall, J. C., Baer, A. N., Shah, A. A., Criswell, L. A., Shiboski, C. H., Rosen, A. & Casciola-Rosen, L. Sep 1 2015 In : Arthritis and Rheumatology. 67, 9, p. 2437-2446 10 p.

Research output: Research - peer-reviewArticle

Sjogren's Syndrome
Interferons
Salivary Glands
Lip
Interferon-gamma

PUF60: A prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome

Fiorentino, D. F., Presby, M., Baer, A. N., Petri, M., Rieger, K. E., Soloski, M., Rosen, A., Mammen, A. L., Christopher-Stine, L. & Casciola-Rosen, L. Aug 7 2015 (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Research - peer-reviewArticle

Dermatomyositis
Sjogren's Syndrome
Autoimmunity
Antibodies
Autoantigens

Review: Cancer-induced autoimmunity in the rheumatic diseases

Shah, A. A., Casciola-Rosen, L. & Rosen, A. Feb 1 2015 In : Arthritis and Rheumatology. 67, 2, p. 317-326 10 p.

Research output: Research - peer-reviewArticle

2014
Interstitial Lung Diseases
Rheumatoid Arthritis
Antibodies
arginine deiminase
rheumatoid arthritis

Association of the autoimmune disease scleroderma with an immunologic response to cancer

Joseph, C. G., Darrah, E., Shah, A. A., Skora, A. D., Casciola-Rosen, L. A., Wigley, F. M., Boin, F., Fava, A., Thoburn, C., Kinde, I., Jiao, Y., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Rosen, A. 2014 In : Science. 343, 6167, p. 152-157 6 p.

Research output: Research - peer-reviewArticle

Autoimmune Diseases
Neoplasms
Antibodies
Antigens
Genes

Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B

Duan-Porter, W. D., Woods, V. L., Maurer, K. D., Li, S. & Rosen, A. Dec 9 2014 In : PLoS One. 9, 12, e115062

Research output: Research - peer-reviewArticle

proteins
Granzymes
Oligomers
Conformations
Monomers
2013

Acute gout after renal transplantation with notable hypouricemia

Juraschek, S. P., Kurano, T., Rosen, A. & Gelber, A. C. Oct 2013 In : American Journal of Medicine. 126, 10

Research output: Research - peer-reviewArticle

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. & Rosen, A. May 22 2013 In : Science Translational Medicine. 5, 186, 186ra65

Research output: Research - peer-reviewArticle

Autoantibodies
Rheumatoid Arthritis
Calcium
Antibodies
Enzymes

Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: Systematic analysis

Park, J. K., Rosen, A., Saffitz, J. E., Asimaki, A., Litovsky, S. H., Mackey-Bojack, S. M. & Halushka, M. K. Aug 2013 In : Rheumatology. 52, 8, p. 1529-1533 5 p., ket184

Research output: Research - peer-reviewArticle

Cathepsin K
Osteoclasts
Giant Cells
Tartrate-Resistant Acid Phosphatase
Crohn Disease

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F. Oct 30 2013 In : Science Translational Medicine. 5, 209, 209ra150

Research output: Research - peer-reviewArticle

Autoantigens
Rheumatoid Arthritis
Perforin
Proteins
Complement Membrane Attack Complex

Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ

Fiorentino, D. F., Chung, L. S., Christopher-Stine, L., Zaba, L., Li, S., Mammen, A. L., Rosen, A. & Casciola-Rosen, L. Nov 2013 In : Arthritis and Rheumatism. 65, 11, p. 2954-2962 9 p.

Research output: Research - peer-reviewArticle

Dermatomyositis
Transcription Factors
Antibodies
Neoplasms
nuclear matrix protein 2

Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations

Ferucci, E. D., Darrah, E., Smolik, I., Choromanski, T. L., Robinson, D. B., Newkirk, M. M., Fritzler, M. J., Rosen, A. & El-Gabalawy, H. S. Sep 2013 In : Journal of Rheumatology. 40, 9, p. 1523-1528 6 p.

Research output: Research - peer-reviewArticle

Rheumatoid Arthritis
Antibodies
Population
protein-arginine deiminase
Peptides
2012
Lung
Antibodies
IFIH1 Interferon-Induced Helicase
Dermatomyositis
Interstitial Lung Diseases

Editorial introductions

Rosen, A., Casciola-Rosen, L. & Varga, J. Nov 2012 In : Current Opinion in Rheumatology. 24, 6

Research output: Research - peer-reviewArticle

Identification of novel autoantigens by a triangulation approach

Cottrell, T. R., Hall, J. C., Rosen, A. & Casciola-Rosen, L. Nov 30 2012 In : Journal of Immunological Methods. 385, 1-2, p. 35-44 10 p.

Research output: Research - peer-reviewArticle

Autoantigens
Autoantibodies
Autoimmune Diseases
Antigens
Myositis

Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis

Park, J. K., Askin, F., Giles, J. T., Halushka, M. K., Rosen, A. & Levine, S. M. Aug 8 2012 In : PLoS One. 7, 8, e42659

Research output: Research - peer-reviewArticle

giant cells
acid phosphatase
Acid Phosphatase
tartaric acid
Granulomatosis with Polyangiitis
Fructose-Bisphosphate Aldolase
Myositis
Muscle Cells
Biomarkers
Serum

Myocardial citrullination in rheumatoid arthritis: A correlative histopathologic study

Giles, J. T., Fert-Bober, J., Park, J. K., Bingham, C. O., Andrade, F., Fox-Talbot, K., Pappas, D., Rosen, A., van Eyk, J., Bathon, J. M. & Halushka, M. K. Feb 24 2012 In : Arthritis Research and Therapy. 14, 1, R39

Research output: Research - peer-reviewArticle

Rheumatoid Arthritis
Staining and Labeling
Citrulline
Myocarditis
Heart Failure
Autoantigens
Actins
Rheumatoid Arthritis
protein-arginine deiminase
Substrates
Hepatitis C
Interferon-alpha
Thyroid Gland
Phenotype
Serum

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

Hall, J. C., Casciola-Rosen, L., Berger, A. E., Kapsogeorgou, E. K., Cheadle, C., Tzioufas, A. G., Baer, A. N. & Rosen, A. Oct 23 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17609-17614 6 p.

Research output: Research - peer-reviewArticle

Sjogren's Syndrome
Rheumatic Diseases
Interferons
Interferon-gamma
Therapeutics
2011
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Cells
Cytokines
monocytes

A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4b is expressed exclusively in mature striated muscle cells

Mammen, A. L., Mahoney, J. A., Germain, A., Badders, N., Taylor, J. P., Rosen, A. & Spinette, S. Dec 9 2011 In : PLoS One. 6, 12, e28861

Research output: Research - peer-reviewArticle

Striated Muscle
Ligases
Ubiquitin
Muscle Cells
Exons

Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease

Grader-Beck, T., Boin, F., Von Gunten, S., Smith, D., Rosen, A. & Bochner, B. S. Dec 2011 In : Annals of the Rheumatic Diseases. 70, 12, p. 2218-2224 7 p.

Research output: Research - peer-reviewArticle

Systemic Scleroderma
Vascular Diseases
Lung Diseases
Carbohydrates
Antibodies

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase in patients with statin-associated autoimmune myopathy

Mammen, A. L., Chung, T., Christopher-Stine, L., Rosen, P., Rosen, A., Doering, K. R., Casciola-Rosen, L. A., Yalcin, A., Kilic, G. & Kantarci, M. Mar 2011 In : Arthritis and Rheumatism. 63, 3, p. 713-721 9 p.

Research output: Research - peer-reviewArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coenzymes
Muscular Diseases
Autoantibodies
Oxidoreductases
Systemic Scleroderma
Neoplasms
Autoantigens
RNA Polymerase III
Autoantibodies
Dermatomyositis
Melanoma
Retrospective Studies
Phenotype
Antibodies
2010

Arthritis & rheumatism

Rosen, A. & Diamond, J. S. Jun 2010 In : Arthritis and Rheumatism. 62, 6, p. 1563 1 p.

Research output: Research - peer-reviewArticle

arginine deiminase
peptidylarginine deiminase type IV
Cell Line
Rheumatoid Arthritis
Enzymes

Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis

Kolfenbach, J. R., Deane, K. D., Derber, L. A., O'Donnell, C. I., Gilliland, W. R., Edison, J. D., Rosen, A., Darrah, E., Norris, J. M. & Holers, V. M. 2010 In : Arthritis and Rheumatism. 62, 9, p. 2633-2639 7 p.

Research output: Research - peer-reviewArticle

Autoimmunity
Rheumatoid Arthritis
arginine deiminase
cyclic citrullinated peptide
Antibodies

Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients

Niland, B., Miklossy, G., Banki, K., Biddison, W. E., Casciola-Rosen, L., Rosen, A., Martinvalet, D., Lieberman, J. & Perl, A. Apr 1 2010 In : Journal of Immunology. 184, 7, p. 4025-4032 8 p.

Research output: Research - peer-reviewArticle

Transaldolase
Granzymes
Multiple Sclerosis
Oligodendroglia
T-Lymphocytes
RNA Polymerase I
RNA Polymerase III
Antibodies
Neoplasms
Autoantibodies

Granzyme B cleavage of autoantigens in autoimmunity

Darrah, E. & Rosen, A. Apr 2010 In : Cell Death and Differentiation. 17, 4, p. 624-632 9 p.

Research output: Research - peer-reviewArticle

Granzymes
Autoantigens
Autoimmunity
Autoimmune Diseases
Epitopes
Regulatory T-Lymphocytes
Autoimmunity
Interferon-alpha
Antiviral Agents
T-Lymphocytes

Type i interferons: Crucial participants in disease amplification in autoimmunity

Hall, J. C. & Rosen, A. Jan 2010 In : Nature Reviews Rheumatology. 6, 1, p. 40-49 10 p.

Research output: Research - peer-reviewArticle

Interferon Type I
Autoimmunity
Interferons
Antiviral Agents
Adaptive Immunity