Research Output 1988 2018

2018

Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

Shi, J., Darrah, E., Sims, G. P., Mustelin, T., Sampson, K., Konig, M. F., Bingham, C. O., Rosen, A. & Andrade, F. Jan 1 2018 In : Annals of the rheumatic diseases. 77, 1, p. 141-148 8 p.

Research output: Contribution to journalArticle

Delta wing aircraft
Antibody Affinity
Cross Reactions
Autoantibodies
Disease Progression
2017

Brief Report: Anti–RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma

Shah, A. A., Xu, G., Rosen, A., Hummers, L. K., Wigley, F. M., Elledge, S. J. & Casciola-Rosen, L. Jun 1 2017 In : Arthritis and Rheumatology. 69, 6, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

RNA Polymerase III
Antibodies
Autoantibodies
Neoplasms
Cytidine Triphosphate
Myositis
Rheumatic Diseases
Autoantibodies
Dermatomyositis
Breast Neoplasms

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C. O., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A. Jan 6 2017 In : Journal of Proteome Research. 16, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Proteolysis
Granzymes
Epitopes
Rheumatoid Arthritis
T-cells

Reply

Baer, A. N., Petri, M., Sohn, J., Rosen, A. & Casciola-Rosen, L. Mar 1 2017 In : Arthritis Care and Research. 69, 3, p. 454 1 p.

Research output: Contribution to journalLetter

Reply

Shah, A. A., Rosen, A., Hummers, L. K., Wigley, F. M., Xu, G., Elledge, S. J. & Casciola-Rosen, L. Sep 1 2017 In : Arthritis and Rheumatology. 69, 9, p. 1915-1916 2 p.

Research output: Contribution to journalLetter

2016

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

Konig, M. F., Abusleme, L., Reinholdt, J., Palmer, R. J., Teles, R. P., Sampson, K., Rosen, A., Nigrovic, P. A., Sokolove, J., Giles, J. T., Moutsopoulos, N. M. & Andrade, F. Dec 14 2016 In : Science Translational Medicine. 8, 369, 369ra176

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Autoimmunity
Rheumatoid Arthritis
Infection
Periodontitis
Gangrene
Interferons
Antibodies
Proteins
Case-Control Studies

Association of Acroosteolysis with Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis

Park, J. K., Fava, A., Carrino, J., Del Grande, F., Rosen, A. & Boin, F. Jan 1 2016 In : Arthritis and Rheumatology. 68, 1, p. 201-209 9 p.

Research output: Contribution to journalArticle

Acro-Osteolysis
Systemic Scleroderma
Osteogenesis
Vascular Endothelial Growth Factor A
Osteoclasts
Sjogren's Syndrome
Interferons
Antibodies
Proteins
Salivary Glands

Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans

Navarro-Millán, I., Darrah, E., Westfall, A. O., Mikuls, T. R., Reynolds, R. J., Danila, M. I., Curtis, J. R., Rosen, A., Bridges, S. L. & CLEAR Investigators Oct 22 2016 In : Arthritis Research and Therapy. 18, 1, 241

Research output: Contribution to journalArticle

African Americans
Rheumatoid Arthritis
Antibodies
arginine deiminase
Autoantibodies

Autoantibodies as markers and possible mediators of scleroderma pathogenesis

Maurer, K. D. & Rosen, A. Jan 1 2016 Scleroderma: From Pathogenesis to Comprehensive Management. Springer International Publishing, p. 197-205 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Systemic Scleroderma
Autoantigens
Disease Management
Autoimmunity
Autoantibodies
Autoantigens
Rheumatic Diseases
Autoimmune Diseases
Autoimmunity
Immune System
Autoantigens
Vascular Diseases
Interferons
Endothelial Cells
Blood Vessels
Type I DNA Topoisomerase
Interstitial Lung Diseases
T-Lymphocytes
Tissue Donors
Phenotype

Improving the physical examination: In reply

Nelson, W. G., Rosen, A. & Pronovost, P. J. Oct 4 2016 In : JAMA - Journal of the American Medical Association. 316, 13, p. 1410-1411 2 p.

Research output: Contribution to journalLetter

Physical Examination

Reengineering the physical examination for the new millennium?

Nelson, W. G., Rosen, A. & Pronovost, P. J. Jun 14 2016 In : JAMA - Journal of the American Medical Association. 315, 22, p. 2391-2392 2 p.

Research output: Contribution to journalShort survey

Medical History Taking
Physician-Patient Relations
Biomedical Technology
Vital Signs
Physical Examination

Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer

Xu, G. J., Shah, A. A., Li, M. Z., Xu, Q., Rosen, A., Casciola-Rosen, L. & Elledge, S. J. Nov 22 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7526-E7534

Research output: Contribution to journalArticle

Autoantigens
Spliceosomes
Autoantibodies
Autoimmune Diseases
Epitopes
2015

A methodology for exploring biomarker - phenotype associations: Application to flow cytometry data and systemic sclerosis clinical manifestations

Huang, H., Fava, A., Guhr, T., Cimbro, R., Rosen, A., Boin, F. & Ellis, H. Sep 15 2015 In : BMC Bioinformatics. 16, 1, 293

Research output: Contribution to journalArticle

Systemic Sclerosis
Flow Cytometry
Pulmonary diseases
Flow cytometry
Systemic Scleroderma
Autoantibodies
RNA Polymerase III
Neoplasms
Age of Onset
Type I DNA Topoisomerase

Molecular subsetting of interferon pathways in Sjögren's syndrome

Hall, J. C., Baer, A. N., Shah, A. A., Criswell, L. A., Shiboski, C. H., Rosen, A. & Casciola-Rosen, L. Sep 1 2015 In : Arthritis and Rheumatology. 67, 9, p. 2437-2446 10 p.

Research output: Contribution to journalArticle

Sjogren's Syndrome
Interferons
Salivary Glands
Lip
Interferon-gamma

PUF60: A prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome

Fiorentino, D. F., Presby, M., Baer, A. N., Petri, M., Rieger, K. E., Soloski, M., Rosen, A., Mammen, A. L., Christopher-Stine, L. & Casciola-Rosen, L. Aug 7 2015 (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Dermatomyositis
Sjogren's Syndrome
Autoimmunity
Antibodies
Autoantigens

Review: Cancer-induced autoimmunity in the rheumatic diseases

Shah, A. A., Casciola-Rosen, L. & Rosen, A. Feb 1 2015 In : Arthritis and Rheumatology. 67, 2, p. 317-326 10 p.

Research output: Contribution to journalArticle

Dermatomyositis
Systemic Scleroderma
Rheumatic Diseases
Autoimmunity
Autoimmune Diseases
2014
arginine deiminase
Pulmonary diseases
rheumatoid arthritis
Interstitial Lung Diseases
respiratory tract diseases

Association of the autoimmune disease scleroderma with an immunologic response to cancer

Joseph, C. G., Darrah, E., Shah, A. A., Skora, A. D., Casciola-Rosen, L. A., Wigley, F. M., Boin, F., Fava, A., Thoburn, C., Kinde, I., Jiao, Y., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Rosen, A. 2014 In : Science. 343, 6167, p. 152-157 6 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Neoplasms
Antibodies
Antigens
Connective Tissue Diseases

Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B

Duan-Porter, W. D., Woods, V. L., Maurer, K. D., Li, S. & Rosen, A. Dec 9 2014 In : PLoS One. 9, 12, e115062

Research output: Contribution to journalArticle

Granzymes
Oligomers
Conformations
Monomers
deuterium
2013

Acute gout after renal transplantation with notable hypouricemia

Juraschek, S. P., Kurano, T., Rosen, A. & Gelber, A. C. Oct 2013 In : American Journal of Medicine. 126, 10

Research output: Contribution to journalArticle

Hyperuricemia
Gout
Kidney Transplantation
Chronic Kidney Failure

Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

Darrah, E., Giles, J. T., Ols, M. L., Bull, H. G., Andrade, F. & Rosen, A. May 22 2013 In : Science Translational Medicine. 5, 186, 186ra65

Research output: Contribution to journalArticle

Autoantibodies
Rheumatoid Arthritis
Calcium
Antibodies
Autoantigens

Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: Systematic analysis

Park, J. K., Rosen, A., Saffitz, J. E., Asimaki, A., Litovsky, S. H., Mackey-Bojack, S. M. & Halushka, M. K. Aug 2013 In : Rheumatology. 52, 8, p. 1529-1533 5 p., ket184

Research output: Contribution to journalArticle

Cathepsin K
Osteoclasts
Giant Cells
Crohn Disease
Myocarditis

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Romero, V., Fert-Bober, J., Nigrovic, P. A., Darrah, E., Haque, U. J., Lee, D. M., Van Eyk, J., Rosen, A. & Andrade, F. Oct 30 2013 In : Science Translational Medicine. 5, 209, 209ra150

Research output: Contribution to journalArticle

Autoantigens
Rheumatoid Arthritis
Perforin
Complement Membrane Attack Complex
Neutrophil Activation

Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ

Fiorentino, D. F., Chung, L. S., Christopher-Stine, L., Zaba, L., Li, S., Mammen, A. L., Rosen, A. & Casciola-Rosen, L. Nov 2013 In : Arthritis and Rheumatism. 65, 11, p. 2954-2962 9 p.

Research output: Contribution to journalArticle

Dermatomyositis
Transcription Factors
Antibodies
Neoplasms
Immunoprecipitation
Thyroiditis
Thyrotropin
Hepatitis C
Interferon-alpha
Thyroid Gland

Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American populations

Ferucci, E. D., Darrah, E., Smolik, I., Choromanski, T. L., Robinson, D. B., Newkirk, M. M., Fritzler, M. J., Rosen, A. & El-Gabalawy, H. S. Sep 2013 In : Journal of Rheumatology. 40, 9, p. 1523-1528 6 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Antibodies
Population
Peptides
Epitopes

The Autoimmune Myopathies

Casciola-Rosen, L. & Rosen, A. Dec 2013 The Autoimmune Diseases: Fifth Edition. Elsevier Inc., p. 547-554 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Myositis
Autoantigens
Muscular Diseases
Muscle Cells
Wounds and Injuries
2012

A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: Report of 2 cases and review of the literature

Chaisson, N. F., Paik, J., Orbai, A. M., Casciola-Rosen, L., Fiorentino, D., Danoff, S. & Rosen, A. Jul 2012 In : Medicine (United States). 91, 4, p. 220-228 9 p.

Research output: Contribution to journalArticle

Lung
Antibodies
Dermatomyositis
Interstitial Lung Diseases
Muscular Diseases

Autoantibodies in pathogenesis

Doering, K. & Rosen, A. Jan 1 2012 Scleroderma: From Pathogenesis to Comprehensive Management. Springer US, p. 199-208 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autoantibodies
Skin
Systemic Scleroderma
Autoimmunity
Pulmonary Hypertension
Molecular Pathology
Muscular Diseases
Disease Management
Muscles

Editorial introductions

Rosen, A., Casciola-Rosen, L. & Varga, J. Nov 2012 In : Current Opinion in Rheumatology. 24, 6

Research output: Contribution to journalArticle

Identification of novel autoantigens by a triangulation approach

Cottrell, T. R., Hall, J. C., Rosen, A. & Casciola-Rosen, L. Nov 30 2012 In : Journal of Immunological Methods. 385, 1-2, p. 35-44 10 p.

Research output: Contribution to journalArticle

Autoantigens
Autoantibodies
Autoimmune Diseases
Antigens
Myositis

Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis

Park, J. K., Askin, F., Giles, J. T., Halushka, M. K., Rosen, A. & Levine, S. M. Aug 8 2012 In : PLoS One. 7, 8, e42659

Research output: Contribution to journalArticle

Granulomatosis with Polyangiitis
giant cells
Giant Cells
Acid Phosphatase
Calcitonin Receptors
MM Form Creatine Kinase
Fructose-Bisphosphate Aldolase
Myositis
Muscle Cells
Biomarkers

Mechanisms of autoimmunity

Cottrell, T. & Rosen, A. Dec 12 2012 Clinical Immunology: Principles and Practice: Fourth Edition. Elsevier Inc., p. 587-594 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autoimmunity

Myocardial citrullination in rheumatoid arthritis: A correlative histopathologic study

Giles, J. T., Fert-Bober, J., Park, J. K., Bingham, C. O., Andrade, F., Fox-Talbot, K., Pappas, D., Rosen, A., van Eyk, J., Bathon, J. M. & Halushka, M. K. Feb 24 2012 In : Arthritis Research and Therapy. 14, 1, R39

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Staining and Labeling
Citrulline
Myocarditis
Heart Failure
Autoantigens
Actins
Rheumatoid Arthritis
Neutrophils
Substrates
Hepatitis C
Interferon-alpha
Thyroiditis
Thyroid Gland
Phenotype

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

Hall, J. C., Casciola-Rosen, L., Berger, A. E., Kapsogeorgou, E. K., Cheadle, C., Tzioufas, A. G., Baer, A. N. & Rosen, A. Oct 23 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17609-17614 6 p.

Research output: Contribution to journalArticle

Sjogren's Syndrome
Rheumatic Diseases
Interferons
Interferon-gamma
Dermatomyositis
2011
monocytes
Monocytes
lupus erythematosus
cytokines
Anti-Inflammatory Agents

A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4b is expressed exclusively in mature striated muscle cells

Mammen, A. L., Mahoney, J. A., Germain, A., Badders, N., Taylor, J. P., Rosen, A. & Spinette, S. Dec 9 2011 In : PLoS One. 6, 12, e28861

Research output: Contribution to journalArticle

striated muscle
Striated Muscle
Ligases
ubiquitin
Ubiquitin

Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease

Grader-Beck, T., Boin, F., Von Gunten, S., Smith, D., Rosen, A. & Bochner, B. S. Dec 2011 In : Annals of the Rheumatic Diseases. 70, 12, p. 2218-2224 7 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Vascular Diseases
Lung Diseases
Carbohydrates
Antibodies

Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase in patients with statin-associated autoimmune myopathy

Mammen, A. L., Chung, T., Christopher-Stine, L., Rosen, P., Rosen, A., Doering, K. R., Casciola-Rosen, L. A., Yalcin, A., Kilic, G. & Kantarci, M. Mar 2011 In : Arthritis and Rheumatism. 63, 3, p. 713-721 9 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coenzymes
Muscular Diseases
Autoantibodies
Oxidoreductases