Anthony Ross Cammarato

Associate Professor

20042020

Research output per year

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Research Output

2020

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity

Lin, Y. H., Schmidt, W., Fritz, K. S., Jeong, M. Y., Cammarato, A., Foster, D. B., Biesiadecki, B. J., McKinsey, T. A. & Woulfe, K. C., Feb 2020, In : Journal of Molecular and Cellular Cardiology. 139, p. 135-147 13 p.

Research output: Contribution to journalArticle

2019

As time flies by: Investigating cardiac aging in the short-lived Drosophila model

Blice-Baum, A. C., Guida, M. C., Hartley, P. S., Adams, P. D., Bodmer, R. & Cammarato, A., Jul 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 7, p. 1831-1844 14 p.

Research output: Contribution to journalReview article

Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology in Drosophila melanogaster

Weismann, C. G., Blice-Baum, A., Tong, T., Li, J., Huang, B. K., Jonas, S. M., Cammarato, A. & Choma, M. A., Jan 1 2019, In : Biology Open. 8, 8, bio044339.

Research output: Contribution to journalArticle

Open Access

Quantifying tissue-specific overexpression of FOXO in Drosophila via mRNA fluorescence in situ hybridization using branched DNA probe technology

Blice-Baum, A. C., Vogler, G., Viswanathan, M. C., Trinh, B., Limpitikul, W. B. & Cammarato, A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 171-190 20 p. (Methods in Molecular Biology; vol. 1890).

Research output: Chapter in Book/Report/Conference proceedingChapter

The actin ‘A-triad's’ role in contractile regulation in health and disease

Schmidt, W. & Cammarato, A. R., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalReview article

2018

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy

Walls, S. M., Cammarato, A., Chatfield, D. A., Ocorr, K., Harris, G. L. & Bodmer, R., Mar 6 2018, In : Cell Reports. 22, 10, p. 2702-2715 14 p.

Research output: Contribution to journalArticle

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model

Limpitikul, W. B., Viswanathan, M. C., O'Rourke, B., Yue, D. T. & Cammarato, A. R., Jun 1 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 64-74 11 p.

Research output: Contribution to journalArticle

Fropofol decreases force development in cardiac muscle

Ren, X., Schmidt, W., Huang, Y., Lu, H., Liu, W., Bu, W., Eckenhoff, R., Cammarato, A. & Gao, W. D., Aug 2018, In : FASEB Journal. 32, 8, p. 4203-4213 11 p.

Research output: Contribution to journalArticle

Imaging neural activity in the ventral nerve cord of behaving adult Drosophila

Chen, C. L., Hermans, L., Viswanathan, M. C., Fortun, D., Aymanns, F., Unser, M., Cammarato, A. R., Dickinson, M. H. & Ramdya, P., Dec 1 2018, In : Nature Communications. 9, 1, 4390.

Research output: Contribution to journalArticle

Prolonged cross-bridge binding triggers muscle dysfunction in a drosophila model of myosin-based hypertrophic cardiomyopathy

Kronert, W. A., Bell, K. M., Viswanathan, M. C., Melkani, G. C., Trujillo, A. S., Huang, A., Melkani, A., Cammarato, A. R., Swank, D. M. & Bernstein, S. I., Aug 13 2018, In : eLife. 7, e38064.

Research output: Contribution to journalArticle

2017

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Viswanathan, M. C., Schmidt, W., Rynkiewicz, M. J., Agarwal, K., Gao, J., Katz, J., Lehman, W. & Cammarato, A., Sep 12 2017, In : Cell Reports. 20, 11, p. 2612-2625 14 p.

Research output: Contribution to journalArticle

Expression patterns of cardiac aging in Drosophila

Cannon, L., Zambon, A. C., Cammarato, A., Zhang, Z., Vogler, G., Munoz, M., Taylor, E., Cartry, J., Bernstein, S. I., Melov, S. & Bodmer, R., Feb 1 2017, In : Aging Cell. 16, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline

Blice-Baum, A. C., Zambon, A. C., Kaushik, G., Viswanathan, M. C., Engler, A. J., Bodmer, R. & Cammarato, A. R., Feb 1 2017, In : Aging Cell. 16, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo

Viswanathan, M. C., Tham, R. C., Kronert, W. A., Sarsoza, F., Trujillo, A. S., Cammarato, A. R. & Bernstein, S. I., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4799-4813 15 p.

Research output: Contribution to journalArticle

2016

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

Achal, M., Trujillo, A. S., Melkani, G. C., Farman, G. P., Ocorr, K., Viswanathan, M. C., Kaushik, G., Newhard, C. S., Glasheen, B. M., Melkani, A., Suggs, J. A., Moore, J. R., Swank, D. M., Bodmer, R., Cammarato, A. & Bernstein, S. I., Jun 5 2016, In : Journal of molecular biology. 428, 11, p. 2446-2461 16 p.

Research output: Contribution to journalArticle

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Kooij, V., Viswanathan, M. C., Lee, D., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E. & Cammarato, A. R., May 15 2016, In : Cardiovascular Research. 110, 2, p. 238-248 11 p.

Research output: Contribution to journalArticle

2015

Enhanced assessment of contractile dynamics in Drosophila hearts

Cammarato, A., Ocorr, S. & Ocorr, K., Jan 1 2015, In : BioTechniques. 58, 2, p. 77-80 4 p.

Research output: Contribution to journalArticle

Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance

Viswanathan, M. C., Blice-Baum, A. C., Schmidt, W., Foster, D. B. & Cammarato, A., Jan 1 2015, In : Frontiers in Physiology. 6, MAR, p. 1-30 30 p.

Research output: Contribution to journalArticle

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

Kaushik, G., Spenlehauer, A., Sessions, A. O., Trujillo, A. S., Fuhrmann, A., Fu, Z., Venkatraman, V., Pohl, D., Tuler, J., Wang, M., Lakatta, E. G., Ocorr, K., Bodmer, R., Bernstein, S. I., Van Eyk, J. E., Cammarato, A. & Engler, A. J., Jun 17 2015, In : Science translational medicine. 7, 292, 292ra99.

Research output: Contribution to journalArticle

2014

A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.

Viswanathan, M. C., Kaushik, G., Engler, A. J., Lehman, W. & Cammarato, A., Jan 17 2014, In : Unknown Journal. 114, 2, p. e6-17

Research output: Contribution to journalArticle

Open Access

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging

Nishimura, M., Kumsta, C., Kaushik, G., Diop, S. B., Ding, Y., Bisharat-Kernizan, J., Catan, H., Cammarato, A., Ross, R. S., Engler, A. J., Bodmer, R., Hansen, M. & Ocorr, K., Jun 2014, In : Aging Cell. 13, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

Sizing up models of heart failure: Proteomics from flies to humans

Kooij, V., Venkatraman, V., Tra, J., Kirk, J. A., Rowell, J., Blice-Baum, A., Cammarato, A. & Van Eyk, J. E., Oct 1 2014, In : Proteomics - Clinical Applications. 8, 9-10, p. 653-664 12 p.

Research output: Contribution to journalReview article

2013

The NADPH Metabolic Network Regulates Human αB-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster

Xie, H. B., Cammarato, A., Rajasekaran, N. S., Zhang, H., Suggs, J. A., Lin, H. C., Bernstein, S. I., Benjamin, I. J. & Golic, K. G., Jun 1 2013, In : PLoS genetics. 9, 6, e1003544.

Research output: Contribution to journalArticle

2012

Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness

Wang, Y., Melkani, G. C., Suggs, J. A., Melkani, A., Kronert, W. A., Cammarato, A. & Bernstein, S. I., Jun 1 2012, In : Molecular biology of the cell. 23, 11, p. 2057-2065 9 p.

Research output: Contribution to journalArticle

Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction

Kaushik, G., Zambon, A. C., Fuhrmann, A., Bernstein, S. I., Bodmer, R., Engler, A. J. & Cammarato, A., Aug 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 8, p. 1656-1662 7 p.

Research output: Contribution to journalArticle

2011

A mighty small heart: The cardiac proteome of adult Drosophila melanogaster

Cammarato, A., Ahrens, C. H., Alayari, N. N., Qeli, E., Rucker, J., Reedy, M. C., Zmasek, C. M., Gucek, M., Cole, R. N., van Eyk, J. E., Bodmer, R., O'Rourke, B., Bernstein, S. I. & Foster, D. B., May 6 2011, In : PloS one. 6, 4, e18497.

Research output: Contribution to journalArticle

In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium

Kaushik, G., Fuhrmann, A., Cammarato, A. & Engler, A. J., Dec 7 2011, In : Biophysical journal. 101, 11, p. 2629-2637 9 p.

Research output: Contribution to journalArticle

Structural basis for myopathic defects engendered by alterations in the myosin rod

Cammarato, A., Li, X., Reedy, M. C., Lee, C. F., Lehman, W. & Bernstein, S. I., Dec 9 2011, In : Journal of molecular biology. 414, 4, p. 477-484 8 p.

Research output: Contribution to journalArticle

2010

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

Neely, G. G., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, C. P., Keene, A. C., Alayari, N. N., Yamakawa, H., Elling, U., Berger, C. & 15 others, Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, J. A., Imai, Y., Pfeufer, A., Hicks, A. A., Pramstaller, P. P., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R. & Penninger, J. M., Apr 1 2010, In : Cell. 141, 1, p. 142-153 12 p.

Research output: Contribution to journalArticle

Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase

Melkani, G. C., Lee, C. F., Cammarato, A. & Bernstein, S. I., May 28 2010, In : Biochemical and Biophysical Research Communications. 396, 2, p. 317-322 6 p.

Research output: Contribution to journalArticle

Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands

Sousa, D., Cammarato, A., Jang, K., Graceffa, P., Tobacman, L. S., Li, X. & Lehman, W., Aug 4 2010, In : Biophysical journal. 99, 3, p. 862-868 7 p.

Research output: Contribution to journalArticle

In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation

Vikhorev, P. G., Vikhoreva, N. N., Cammarato, A. & Sparrow, J. C., Sep 1 2010, In : Journal of Muscle Research and Cell Motility. 31, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

2009

Fluorescent labeling of drosophila heart structures

Alayari, N. N., Vogler, G., Taghli-Lamallem, O., Ocorr, K., Bodmer, R. & Cammarato, A., Oct 2009, In : Journal of Visualized Experiments. 32, e1423.

Research output: Contribution to journalArticle

Semi-automated optical Heartbeat Analysis of small hearts

Ocorr, K., Fink, M., Cammarato, A., Bernstein, S. I. & Bodmer, R., Sep 2009, In : Journal of Visualized Experiments. 31, e1435.

Research output: Contribution to journalArticle

2008

Genetics and pathogenic mechanisms of cardiomyopathies in the Drosophila model

Taghli-Lamallem, O., Bodmer, R., Chamberlain, J. S. & Cammarato, A., Sep 1 2008, In : Drug Discovery Today: Disease Models. 5, 3, p. 125-134 10 p.

Research output: Contribution to journalReview article

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles

Cammarato, A., Dambacher, C. M., Knowles, A. F., Kronert, W. A., Bodmer, R., Ocorr, K. & Bernstein, S. I., Feb 1 2008, In : Molecular biology of the cell. 19, 2, p. 553-562 10 p.

Research output: Contribution to journalArticle

2007

Alternative S2 Hinge Regions of the Myosin Rod Differentially Affect Muscle Function, Myofibril Dimensions and Myosin Tail Length

Suggs, J. A., Cammarato, A., Kronert, W. A., Nikkhoy, M., Dambacher, C. M., Megighian, A. & Bernstein, S. I., Apr 13 2007, In : Journal of molecular biology. 367, 5, p. 1312-1329 18 p.

Research output: Contribution to journalArticle

2006

αB-Crystallin Maintains Skeletal Muscle Myosin Enzymatic Activity and Prevents its Aggregation under Heat-shock Stress

Melkani, G. C., Cammarato, A. & Bernstein, S. I., May 5 2006, In : Journal of molecular biology. 358, 3, p. 635-645 11 p.

Research output: Contribution to journalArticle

2005

E93K charge reversal on actin perturbs steric regulation of thin filaments

Cammarato, A., Craig, R., Sparrow, J. C. & Lehman, W., Apr 15 2005, In : Journal of molecular biology. 347, 5, p. 889-894 6 p.

Research output: Contribution to journalArticle

In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band

Ayme-Southgate, A., Saide, J., Southgate, R., Bounaix, C., Cammarato, A., Patel, S. & Wussler, C., Dec 1 2005, In : Journal of Muscle Research and Cell Motility. 26, 6-8, p. 467-477 11 p.

Research output: Contribution to journalArticle

2004

Drosophila, Muscle Regulation Characterized by Electron Microscopy and Three-Dimensional Reconstruction of Thin Filament Mutants

Cammarato, A., Hatch, V., Saide, J., Craig, R., Sparrow, J. C., Tobacman, L. S. & Lehman, W., Mar 2004, In : Biophysical journal. 86, 3, p. 1618-1624 7 p.

Research output: Contribution to journalArticle

Open Access