Anthony Kar Lun Leung

Associate Professor

19982020

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2020

Both ADP-ribosyl-binding and hydrolase activities of the alphavirus nsp3 macrodomain affect neurovirulence in mice

Abraham, R., McPherson, R. L., Dasovich, M., Badiee, M., Leung, A. K. L. & Griffin, D. E., Jan 1 2020, In : mBio. 11, 1, e03253-19.

Research output: Contribution to journalArticle

Open Access

Ion-Pairing with Triethylammonium Acetate Improves Solid-Phase Extraction of ADP-Ribosylated Peptides

McPherson, R. L., Ong, S. E. & Leung, A. K. L., Feb 7 2020, In : Journal of proteome research. 19, 2, p. 984-990 7 p.

Research output: Contribution to journalArticle

Structure-Mediated RNA Decay by UPF1 and G3BP1

Fischer, J. W., Busa, V. F., Shao, Y. & Leung, A. K. L., Apr 2 2020, In : Molecular cell. 78, 1, p. 70-84.e6

Research output: Contribution to journalArticle

Open Access
2019

An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation

Kalesh, K., Lukauskas, S., Borg, A. J., Snijders, A. P., Ayyappan, V., Leung, A. K. L., Haskard, D. O. & DiMaggio, P. A., Dec 1 2019, In : Scientific reports. 9, 1, 6655.

Research output: Contribution to journalArticle

Open Access

ELTA: Enzymatic Labeling of Terminal ADP-Ribose

Ando, Y., Elkayam, E., McPherson, R. L., Dasovich, M., Cheng, S. J., Voorneveld, J., Filippov, D. V., Ong, S. E., Joshua-Tor, L. & Leung, A. K. L., Feb 21 2019, In : Molecular cell. 73, 4, p. 845-856.e5

Research output: Contribution to journalArticle

Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy

Park, Y., Chui, M. H., Suryo Rahmanto, Y., Yu, Z. C., Shamanna, R. A., Bellani, M. A., Gaillard, S., Ayhan, A., Viswanathan, A., Seidman, M. M., Franco, S., Leung, A. K. L., Bohr, V. A., Shih, I. M. & Wang, T. L., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5584-5593 10 p.

Research output: Contribution to journalArticle

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

Thirawatananond, P., McPherson, R. L., Malhi, J., Nathan, S., Lambrecht, M. J., Brichacek, M., Hergenrother, P. J., Leung, A. K. L. & Gabelli, S. B., Dec 1 2019, In : Scientific reports. 9, 1, 5940.

Research output: Contribution to journalArticle

Open Access
2018

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M. S., Merits, A., Leung, A. K. L. & Griffin, D., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing

Zhang, T., Wu, Y. C., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H-Y., Alessi, A. F., Niaki, A. G., Periz, G., Guo, L., Wang, H., Elkayam, E., Joshua-Tor, L., Myong, S., Kim, J. K., Shorter, J., Ong, S. E., Leung, A. K. L. & 1 others, Wang, J., Mar 1 2018, In : Molecular Cell. 69, 5, p. 802-819.e1

Research output: Contribution to journalArticle

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases

Leung, A. K. L., McPherson, R. L. & Griffin, D. E., Mar 2018, In : PLoS pathogens. 14, 3, e1006864.

Research output: Contribution to journalArticle

2017

ADPriboDB: The database of ADP-ribosylated proteins

Vivelo, C. A., Wat, R., Agrawal, C., Tee, H. Y. & Leung, A. K. L., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D204-D209

Research output: Contribution to journalArticle

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

McPherson, R. L., Abraham, R., Sreekumar, E., Ong, S. E., Cheng, S. J., Baxter, V. K., Kistemaker, H. A. V., Filippov, D. V., Griffin, D. E. & Leung, A. K. L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets

Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C., 2017, In : Journal of the American Heart Association. 6, 3, e004694.

Research output: Contribution to journalArticle

2016

Dynamic regulation of RNA editing in human brain development and disease

Hwang, T., Park, C. K., Leung, A. K. L., Gao, Y., Hyde, T., Kleinman, J., Rajpurohit, A., Tao, R., Shin, J. H. & Weinberger, D., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

ENPP1 processes protein ADP-ribosylation in vitro

Palazzo, L., Daniels, C. M., Nettleship, J. E., Rahman, N., McPherson, R. L., Ong, S. E., Kato, K., Nureki, O., Leung, A. K. L. & Ahel, I., Sep 1 2016, In : FEBS Journal. p. 3371-3388 18 p.

Research output: Contribution to journalArticle

2015

Methods for studying microRNA functions during stress

Ando, Y. & Leung, A. K. L., Jan 1 2015, In : Methods in Molecular Biology. 1292, 1 p.

Research output: Contribution to journalArticle

Nudix hydrolases degrade protein-conjugated ADP-ribose

Daniels, C. M., Thirawatananond, P., Ong, S. E., Gabelli, S. B. & Leung, A. K. L., Dec 16 2015, In : Scientific reports. 5, 18271.

Research output: Contribution to journalArticle

2014

Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells

Daniels, C. M., Ong, S. E. & Leung, A. K. L., Aug 1 2014, In : Journal of proteome research. 13, 8, p. 3510-3522 13 p.

Research output: Contribution to journalArticle

2011

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

Leung, A. K. L., Young, A. G., Bhutkar, A., Zheng, G. X., Bosson, A. D., Nielsen, C. B. & Sharp, P. A., Feb 1 2011, In : Nature Structural and Molecular Biology. 18, 2, p. 237-245 9 p.

Research output: Contribution to journalArticle

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

Leung, A. K. L., Vyas, S., Rood, J. E., Bhutkar, A., Sharp, P. A. & Chang, P., May 20 2011, In : Molecular cell. 42, 4, p. 489-499 11 p.

Research output: Contribution to journalArticle

2010

Effect of nanoparticle conjugation on gene silencing by RNA interference

Singh, N., Agrawal, A., Leung, A. K. L., Sharp, P. A. & Bhatia, S. N., Jun 23 2010, In : Journal of the American Chemical Society. 132, 24, p. 8241-8243 3 p.

Research output: Contribution to journalArticle

2009

Fluorinated lipid constructs permit facile passage of molecular cargo into living cells

Dafik, L., Kalsani, V., Leung, A. K. L. & Kumar, K., Sep 2 2009, In : Journal of the American Chemical Society. 131, 34, p. 12091-12093 3 p.

Research output: Contribution to journalArticle

2006

Function and localization of microRNAs in mammalian cells

Leung, A. K. L. & Sharp, P. A., Dec 1 2006, In : Cold Spring Harbor symposia on quantitative biology. 71, p. 29-38 10 p.

Research output: Contribution to journalArticle

NOPdb: Nucleolar Proteome Database.

Leung, A. K. L., Trinkle-Mulcahy, L., Lam, Y. W., Andersen, J. S., Mann, M. & Lamond, A. I., Jan 1 2006, In : Nucleic acids research. 34, Database issue, p. D218-220

Research output: Contribution to journalArticle

Open Access

Quantitative analysis of argonaute protein reveals microRNA-dependent localization to stress granules

Leung, A. K. L., Calabrese, J. M. & Sharp, P. A., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18125-18130 6 p.

Research output: Contribution to journalArticle

2005

Condensed mitotic chromatin is accessible to transcription factors and chromatin structural protiens

Chen, D., Dundr, M., Wang, C., Leung, A., Lamond, A., Misteli, T. & Huang, S., Jan 3 2005, In : Journal of Cell Biology. 168, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

Nucleolar proteome dynamics

Andersen, J. S., Lam, Y. W., Leung, A. K. L., Ong, S. E., Lyon, C. E., Lamond, A. I. & Mann, M., Jan 6 2005, In : Nature. 433, 7021, p. 77-83 7 p.

Research output: Contribution to journalArticle

2004

Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells

Leung, A. K. L., Gerlich, D., Miller, G., Lyon, C., Lam, Y. W., Lleres, D., Daigle, N., Zomerdijk, J., Ellenberg, J. & Lamond, A. I., Sep 13 2004, In : Journal of Cell Biology. 166, 6, p. 787-800 14 p.

Research output: Contribution to journalArticle

2002

Directed proteomic analysis of the human nucleolus

Andersen, J. S., Lyon, C. E., Fox, A. H., Leung, A. K. L., Lam, Y. W., Steen, H., Mann, M. & Lamond, A. I., Jan 8 2002, In : Current Biology. 12, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles

Leung, A. K. L. & Lamond, A. I., May 13 2002, In : Journal of Cell Biology. 157, 4, p. 615-629 15 p.

Research output: Contribution to journalArticle

Paraspeckles: A novel nuclear domain

Fox, A. H., Lam, Y. W., Leung, A. K. L., Lyon, C. E., Andersen, J., Mann, M. & Lamond, A. I., Jan 8 2002, In : Current Biology. 12, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

Yeast Pescadillo is required for multiple activities during 60s ribosomal subunit synthesis

Oeffinger, M., Lueng, A., Lamond, A. & Tollervey, D., 2002, In : RNA. 8, 5, p. 626-636 11 p.

Research output: Contribution to journalArticle

1998

Mechanism of N-acetylgalactosamine binding to a C-type animal lectin carbohydrate-recognition domain

Kolatkart, A. R., Leung, A. K., Isecke, R., Brossmer, R., Drickamer, K. & Weis, W. I., Jul 31 1998, In : Journal of Biological Chemistry. 273, 31, p. 19502-19508 7 p.

Research output: Contribution to journalArticle