Anthony Kar Lun Leung

Associate Professor

19982020

Research output per year

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Research Output

2020

Both ADP-ribosyl-binding and hydrolase activities of the alphavirus nsp3 macrodomain affect neurovirulence in mice

Abraham, R., McPherson, R. L., Dasovich, M., Badiee, M., Leung, A. K. L. & Griffin, D. E., Jan 1 2020, In : mBio. 11, 1, e03253-19.

Research output: Contribution to journalArticle

Open Access

Ion-Pairing with Triethylammonium Acetate Improves Solid-Phase Extraction of ADP-Ribosylated Peptides

McPherson, R. L., Ong, S. E. & Leung, A. K. L., Feb 7 2020, In : Journal of proteome research. 19, 2, p. 984-990 7 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation

Leung, A. K. L., May 2020, In : Trends in Cell Biology. 30, 5, p. 370-383 14 p.

Research output: Contribution to journalReview article

Structure-Mediated RNA Decay by UPF1 and G3BP1

Fischer, J. W., Busa, V. F., Shao, Y. & Leung, A. K. L., Apr 2 2020, In : Molecular cell. 78, 1, p. 70-84.e6

Research output: Contribution to journalArticle

Open Access
2019

An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation

Kalesh, K., Lukauskas, S., Borg, A. J., Snijders, A. P., Ayyappan, V., Leung, A. K. L., Haskard, D. O. & DiMaggio, P. A., Dec 1 2019, In : Scientific reports. 9, 1, 6655.

Research output: Contribution to journalArticle

Open Access

A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors

Dasovich, M. & Leung, A. K. L., Sep 19 2019, In : Molecular cell. 75, 6, p. 1089-1091 3 p.

Research output: Contribution to journalShort survey

ELTA: Enzymatic Labeling of Terminal ADP-Ribose

Ando, Y., Elkayam, E., McPherson, R. L., Dasovich, M., Cheng, S. J., Voorneveld, J., Filippov, D. V., Ong, S. E., Joshua-Tor, L. & Leung, A. K. L., Feb 21 2019, In : Molecular cell. 73, 4, p. 845-856.e5

Research output: Contribution to journalArticle

Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy

Park, Y., Chui, M. H., Suryo Rahmanto, Y., Yu, Z. C., Shamanna, R. A., Bellani, M. A., Gaillard, S., Ayhan, A., Viswanathan, A., Seidman, M. M., Franco, S., Leung, A. K. L., Bohr, V. A., Shih, I. M. & Wang, T. L., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5584-5593 10 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose)-dependent ubiquitination and its clinical implications

Vivelo, C. A., Ayyappan, V. & Leung, A. K. L., Sep 2019, In : Biochemical Pharmacology. 167, p. 3-12 10 p.

Research output: Contribution to journalReview article

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

Thirawatananond, P., McPherson, R. L., Malhi, J., Nathan, S., Lambrecht, M. J., Brichacek, M., Hergenrother, P. J., Leung, A. K. L. & Gabelli, S. B., Dec 1 2019, In : Scientific reports. 9, 1, 5940.

Research output: Contribution to journalArticle

Open Access
2018

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M. S., Merits, A., Leung, A. K. L. & Griffin, D., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. E10457-E10466

Research output: Contribution to journalArticle

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing

Zhang, T., Wu, Y. C., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H-Y., Alessi, A. F., Niaki, A. G., Periz, G., Guo, L., Wang, H., Elkayam, E., Joshua-Tor, L., Myong, S., Kim, J. K., Shorter, J., Ong, S. E., Leung, A. K. L. & 1 others, Wang, J., Mar 1 2018, In : Molecular Cell. 69, 5, p. 802-819.e1

Research output: Contribution to journalArticle

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases

Leung, A. K. L., McPherson, R. L. & Griffin, D. E., Mar 2018, In : PLoS pathogens. 14, 3, e1006864.

Research output: Contribution to journalArticle

Preparation of recombinant alphaviruses for functional studies of ADP-ribosylation

Abraham, R., McPherson, R. L., Sreekumar, E., Leung, A. K. L. & Griffin, D. E., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 297-316 20 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantitative determination of mar hydrolase residue specificity in vitro by tandem mass spectrometry

McPherson, R. L., Ong, S. E. & Leung, A. K. L., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 271-283 13 p. (Methods in Molecular Biology; vol. 1813).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

ADPriboDB: The database of ADP-ribosylated proteins

Vivelo, C. A., Wat, R., Agrawal, C., Tee, H. Y. & Leung, A. K. L., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D204-D209

Research output: Contribution to journalArticle

ADP-ribosylated peptide enrichment and site identification: The phosphodiesterase-based method

Daniels, C. M., Ong, S. E. & Leung, A. K. L., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1608. p. 79-93 15 p. (Methods in Molecular Biology; vol. 1608).

Research output: Chapter in Book/Report/Conference proceedingChapter

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

McPherson, R. L., Abraham, R., Sreekumar, E., Ong, S. E., Cheng, S. J., Baxter, V. K., Kistemaker, H. A. V., Filippov, D. V., Griffin, D. E. & Leung, A. K. L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

CircRNAs: a regulator of cellular stress

Fischer, J. W. & Leung, A. K. L., Mar 4 2017, In : Critical Reviews in Biochemistry and Molecular Biology. 52, 2, p. 220-233 14 p.

Research output: Contribution to journalReview article

Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets

Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C., 2017, In : Journal of the American Heart Association. 6, 3, e004694.

Research output: Contribution to journalArticle

Erratum: ADPriboDB: The database of ADP-ribosylated proteins (Nucleic acids research (2017) 45 D1 (D204-D209))

Vivelo, C. A., Wat, R., Agrawal, C., Tee, H. Y. & Leung, A. K. L., Jun 2 2017, In : Nucleic acids research. 45, 10, 1 p.

Research output: Contribution to journalComment/debate

PARPs

Leung, A. K. L., Dec 4 2017, In : Current Biology. 27, 23, p. R1256-R1258

Research output: Contribution to journalShort survey

SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues

Leung, A. K. L., Mar 2 2017, In : Molecular Cell. 65, 5, p. 777-778 2 p.

Research output: Contribution to journalShort survey

2016

ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome

McPherson, R. L. & Leung, A. K. L., Feb 4 2016, In : Molecular cell. 61, 3, p. 327-328 2 p.

Research output: Contribution to journalShort survey

Dynamic regulation of RNA editing in human brain development and disease

Hwang, T., Park, C. K., Leung, A. K. L., Gao, Y., Hyde, T., Kleinman, J., Rajpurohit, A., Tao, R., Shin, J. H. & Weinberger, D., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

ENPP1 processes protein ADP-ribosylation in vitro

Palazzo, L., Daniels, C. M., Nettleship, J. E., Rahman, N., McPherson, R. L., Ong, S. E., Kato, K., Nureki, O., Leung, A. K. L. & Ahel, I., Sep 1 2016, In : FEBS Journal. p. 3371-3388 18 p.

Research output: Contribution to journalArticle

RNA granules and diseases: A case study of stress granules in ALS and FTLD

Fan, A. C. & Leung, A. K. L., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 907. p. 263-296 34 p. (Advances in Experimental Medicine and Biology; vol. 907).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Methods for studying microRNA functions during stress

Ando, Y. & Leung, A. K. L., Jan 1 2015, In : Methods in Molecular Biology. 1292, 1 p.

Research output: Contribution to journalArticle

Nudix hydrolases degrade protein-conjugated ADP-ribose

Daniels, C. M., Thirawatananond, P., Ong, S. E., Gabelli, S. B. & Leung, A. K. L., Dec 16 2015, In : Scientific reports. 5, 18271.

Research output: Contribution to journalArticle

Proteomics approaches to identify mono-(ADP-ribosyl)ated and poly(ADP-ribosyl)ated proteins

Vivelo, C. A. & Leung, A. K. L., Jan 1 2015, In : Proteomics. 15, 2-3, p. 203-217 15 p.

Research output: Contribution to journalReview article

The Promise of Proteomics for the Study of ADP-Ribosylation

Daniels, C. M., Ong, S. E. & Leung, A. K. L., Jun 18 2015, In : Molecular cell. 58, 6, p. 911-924 14 p.

Research output: Contribution to journalReview article

The Whereabouts of microRNA Actions: Cytoplasm and Beyond

Leung, A. K. L., Oct 1 2015, In : Trends in Cell Biology. 25, 10, p. 601-610 10 p., 1164.

Research output: Contribution to journalReview article

2014

Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells

Daniels, C. M., Ong, S. E. & Leung, A. K. L., Aug 1 2014, In : Journal of proteome research. 13, 8, p. 3510-3522 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose): An organizer of cellular architecture

Leung, A. K. L., 2014, In : Journal of Cell Biology. 205, 5, p. 613-619 7 p.

Research output: Contribution to journalComment/debate

2013

Does an Emergency Visit to the ER Make MicroRNAs Stronger during Stress?

Ando, Y. & Leung, A. K. L., Oct 10 2013, In : Molecular cell. 52, 1, p. 1-3 3 p.

Research output: Contribution to journalShort survey

Quantifying argonaute proteins in and out of GW/P-bodies: Implications in microRNA activities

Leung, A. K. L. & Sharp, P. A., Feb 14 2013, Ten Years of Progress in GW/P Body Research. Chan, E. & Fritzler, M. (eds.). p. 165-182 18 p. (Advances in Experimental Medicine and Biology; vol. 768).

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm

Leung, A. K. L., Todorova, T., Ando, Y. & Chang, P., May 2012, In : RNA Biology. 9, 5, p. 542-548 7 p.

Research output: Contribution to journalReview article

2011

Erratum: Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs (Nature Structural and Molecular Biology (2011) 18 (237-244))

Leung, A. K. L., Young, A. G., Bhutkar, A., Zheng, G. X., Bosson, A. D., Nielsen, C. B. & Sharp, P. A., Sep 1 2011, In : Nature Structural and Molecular Biology. 18, 9, 1 p.

Research output: Contribution to journalComment/debate

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

Leung, A. K. L., Young, A. G., Bhutkar, A., Zheng, G. X., Bosson, A. D., Nielsen, C. B. & Sharp, P. A., Feb 1 2011, In : Nature Structural and Molecular Biology. 18, 2, p. 237-245 9 p.

Research output: Contribution to journalArticle

Methods for purification of proteins associated with cellular poly(ADP-Ribose) and pARP-Specific poly(ADP-Ribose)

Rood, J. E., Leung, A. K. L. & Chang, P., Oct 24 2011, Poly(ADP-ribose) Polymerase: Methods and Protocols. Tulin, A. V. (ed.). p. 153-164 12 p. (Methods in Molecular Biology; vol. 780).

Research output: Chapter in Book/Report/Conference proceedingChapter

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

Leung, A. K. L., Vyas, S., Rood, J. E., Bhutkar, A., Sharp, P. A. & Chang, P., May 20 2011, In : Molecular cell. 42, 4, p. 489-499 11 p.

Research output: Contribution to journalArticle

2010

Effect of nanoparticle conjugation on gene silencing by RNA interference

Singh, N., Agrawal, A., Leung, A. K. L., Sharp, P. A. & Bhatia, S. N., Jun 23 2010, In : Journal of the American Chemical Society. 132, 24, p. 8241-8243 3 p.

Research output: Contribution to journalArticle

MicroRNA Functions in Stress Responses

Leung, A. K. L. & Sharp, P. A., Oct 1 2010, In : Molecular cell. 40, 2, p. 205-215 11 p.

Research output: Contribution to journalReview article

2009

Fluorinated lipid constructs permit facile passage of molecular cargo into living cells

Dafik, L., Kalsani, V., Leung, A. K. L. & Kumar, K., Sep 2 2009, In : Journal of the American Chemical Society. 131, 34, p. 12091-12093 3 p.

Research output: Contribution to journalArticle

2007

microRNAs: A Safeguard against Turmoil?

Leung, A. K. L. & Sharp, P. A., Aug 24 2007, In : Cell. 130, 4, p. 581-585 5 p.

Research output: Contribution to journalShort survey

2006

Function and localization of microRNAs in mammalian cells

Leung, A. K. L. & Sharp, P. A., Dec 1 2006, In : Cold Spring Harbor symposia on quantitative biology. 71, p. 29-38 10 p.

Research output: Contribution to journalArticle

NOPdb: Nucleolar Proteome Database.

Leung, A. K. L., Trinkle-Mulcahy, L., Lam, Y. W., Andersen, J. S., Mann, M. & Lamond, A. I., Jan 1 2006, In : Nucleic acids research. 34, Database issue, p. D218-220

Research output: Contribution to journalArticle

Open Access

Quantitative analysis of argonaute protein reveals microRNA-dependent localization to stress granules

Leung, A. K. L., Calabrese, J. M. & Sharp, P. A., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18125-18130 6 p.

Research output: Contribution to journalArticle

2005

Condensed mitotic chromatin is accessible to transcription factors and chromatin structural protiens

Chen, D., Dundr, M., Wang, C., Leung, A., Lamond, A., Misteli, T. & Huang, S., Jan 3 2005, In : Journal of Cell Biology. 168, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

Nucleolar proteome dynamics

Andersen, J. S., Lam, Y. W., Leung, A. K. L., Ong, S. E., Lyon, C. E., Lamond, A. I. & Mann, M., Jan 6 2005, In : Nature. 433, 7021, p. 77-83 7 p.

Research output: Contribution to journalArticle