20052020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

C3a is required for ILC2 function in allergic airway inflammation

Gour, N., Smole, U., Yong, H. M., Lewkowich, I. P., Yao, N., Singh, A., Gabrielson, E., Wills-Karp, M. & Lajoie, S., Jan 1 2018, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R. M. & Biswal, S., Sep 15 2008, In : American journal of respiratory and critical care medicine. 178, 6, p. 592-604 13 p.

Research output: Contribution to journalArticle

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation

Blake, D. J., Singh, A., Kombairaju, P., Malhotra, D., Mariani, T. J., Tuder, R. M., Gabrielson, E. & Biswal, S., May 1 2010, In : American journal of respiratory cell and molecular biology. 42, 5, p. 524-536 13 p.

Research output: Contribution to journalArticle

De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer

Singh, A., Ruiz, C., Bhalla, K., Haley, J. A., Li, Q. K., Acquaah-Mensah, G., Montal, E., Sudini, K. R., Skoulidis, F., Wistuba, I. I., Papadimitrakopoulou, V., Heymach, J. V., Boros, L. G., Gabrielson, E., Carretero, J., Wong, K. K., Haley, J. D., Biswal, S. & Girnun, G. D., Dec 1 2018, In : FASEB Journal. 32, 12, p. 7018-7027 10 p.

Research output: Contribution to journalArticle

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N. & Biswal, S., Jul 4 2005, In : Journal of Experimental Medicine. 202, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., Brock, M. V. & Biswal, S., Oct 1 2006, In : PLoS medicine. 3, 10, p. 1865-1876 12 p.

Research output: Contribution to journalArticle

Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases

Gour, N., Lajoie, S., Smole, U., White, M., Hu, D., Goddard, P., Huntsman, S., Eng, C., Mak, A., Oh, S., Kim, J. H., Sharma, A., Plante, S., Salem, I. H., Resch, Y., Xiao, X., Yao, N., Singh, A., Vrtala, S., Chakir, J. & 3 others, Burchard, E. G., Lane, A. P. & Wills-Karp, M., Feb 23 2018, In : Science immunology. 3, 20

Research output: Contribution to journalArticle

Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

Kong, X., Thimmulappa, R., Craciun, F., Harvey, C., Singh, A., Kombairaju, P., Reddy, S. P., Remick, D. & Biswal, S., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 928-938 11 p.

Research output: Contribution to journalArticle

Erratum: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1 (American Journal of Respiratory and Critical Care Medicine (2008) 178 (592-604))

Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J. & Pare, P., Apr 1 2009, In : American journal of respiratory and critical care medicine. 179, 7, 1 p.

Research output: Contribution to journalComment/debate

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype

Singh, A., Wu, H., Zhang, P., Happel, C., Ma, J. & Biswal, S., Aug 1 2010, In : Molecular cancer therapeutics. 9, 8, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance

Singh, A., Bodas, M., Wakabayashi, N., Bunz, F. & Biswal, S., Dec 1 2010, In : Antioxidants and Redox Signaling. 13, 11, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes

Misra, V., Lee, H., Singh, A., Huang, K., Thimmulappa, R. K., Mitzner, W., Biswal, S. & Tankersley, C. G., Nov 14 2007, In : Physiological Genomics. 31, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis

Malhotra, D., Portales-Casamar, E., Singh, A., Srivastava, S., Arenillas, D., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W. & Biswal, S., May 11 2010, In : Nucleic acids research. 38, 17, p. 5718-5734 17 p., gkq212.

Research output: Contribution to journalArticle

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O., Brigelius-Flohé, R., Kensler, T. W., Yamamoto, M. & Biswal, S., Dec 1 2006, In : American journal of respiratory cell and molecular biology. 35, 6, p. 639-650 12 p.

Research output: Contribution to journalArticle

Histone deacetylase 6-mediated selective autophagy regulates copd-associated cilia dysfunction

Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., An, C. H., Shan, B., Franks, J. M., Haley, K. J., Owen, C. A., Tesfaigzi, Y., Washko, G. R., Quackenbush, J., Silverman, E. K., Rahman, I. & 5 others, Kim, H. P., Mahmood, A., Biswal, S. S., Ryter, S. W. & Choi, A. M. K., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5212-5230 19 p.

Research output: Contribution to journalArticle

Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial

Wise, R. A., Holbrook, J. T., Criner, G., Sethi, S., Rayapudi, S., Sudini, K. R., Sugar, E., Burke, A., Thimmulappa, R., Singh, A., Talalay, P., Fahey, J. W., Berenson, C. S., Jacobs, M. R., Biswal, S., Leatherman, G., Daniel, M., Thurman, A., Marchetti, N., Kim, V. & 25 others, Shenoy, K., Smith, H., Rosario, M., Bolla, S., Mandapati, C., Eberhardt, E., Kruzel, R., Kumar, S., Noel, S., Beselman, A., Amend-Libercci, D., Ewing, C., Hart, A., Lears, A., Nowakowski, D., Prusakowski, N., Shade, D., Yasin, R., Brown, E., Wang, L., O'Connor, G., Strange, C., Wendt, C., Punturieri, A. & Viviano, L. W., Nov 1 2016, In : PLoS One. 11, 11, e0163716.

Research output: Contribution to journalArticle

Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G. & Biswal, S., Feb 1 2010, In : Molecular cancer therapeutics. 9, 2, p. 336-346 11 p.

Research output: Contribution to journalArticle

NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy

Ramesh, P. S., Devegowda, D., Singh, A. & Thimmulappa, R. K., Apr 2020, In : Critical Reviews in Oncology/Hematology. 148, 102885.

Research output: Contribution to journalReview article

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

Walker, A., Singh, A., Tully, E., Woo, J., Le Thi, Q. H., Nguyen, T., Biswal, S., Sharma, D. & Gabrielson, E., May 20 2018, In : Free Radical Biology and Medicine. 120, p. 407-413 7 p.

Research output: Contribution to journalArticle

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Kombairaju, P., Ma, J., Thimmulappa, R., Yan, G., Gabrielson, E., Singh, A. & Biswal, S., Dec 1 2012, In : Journal of Carcinogenesis. 11, 8.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors

Singh, A., Venkannagari, S., Oh, K. H., Zhang, Y. Q., Rohde, J. M., Liu, L., Nimmagadda, S., Sudini, K., Brimacombe, K. R., Gajghate, S., Ma, J., Wang, A., Xu, X., Shahane, S. A., Xia, M., Woo, J., Mensah, G. A., Wang, Z., Ferrer, M., Gabrielson, E. & 5 others, Li, Z., Rastinejad, F., Shen, M., Boxer, M. B. & Biswal, S., Nov 18 2016, In : ACS chemical biology. 11, 11, p. 3214-3225 12 p.

Research output: Contribution to journalArticle

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

Merchant, A. A., Singh, A., Matsui, W. & Biswal, S., Dec 15 2011, In : Blood. 118, 25, p. 6572-6579 8 p.

Research output: Contribution to journalArticle

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

Singh, A., Happel, C., Manna, S. K., Acquaah-Mensah, G., Carrerero, J., Kumar, S., Nasipuri, P., Krausz, K. W., Wakabayashi, N., Dewi, R., Boros, L. G., Gonzalez, F. J., Gabrielson, E., Wong, K. K., Girnun, G. & Biswal, S., Jul 1 2013, In : Journal of Clinical Investigation. 123, 7, p. 2921-2934 14 p.

Research output: Contribution to journalArticle