Angelika Doetzlhofer

Associate Professor

19982019
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Research Output 1998 2019

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Article
2019

A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

Prajapati-DiNubila, M., Benito-Gonzalez, A., Golden, E. J., Zhang, S. & Doetzlhofer, A., Jun 12 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Follistatin
Cochlea
Cell Differentiation
Epithelium
Cells
2016

Canonical Notch signaling plays an instructive role in auditory supporting cell development

Campbell, D. P., Chrysostomou, E. & Doetzlhofer, A., Jan 20 2016, In : Scientific Reports. 6, 19484.

Research output: Contribution to journalArticle

Cell Differentiation
Cochlea
Amyloid Precursor Protein Secretases
Neuroglia
Genes

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

Basch, M. L., Brown, R. M., Jen, H. I., Semerci, F., Depreux, F., Edlund, R. K., Zhang, H., Norton, C. R., Gridley, T., Cole, S. E., Doetzlhofer, A., Maletic-Savatic, M., Segil, N. & Groves, A. K., Dec 14 2016, In : eLife. 5, DECEMBER2016, e19921.

Research output: Contribution to journalArticle

Organ of Corti
Inner Auditory Hair Cells
Tuning
Cells
Cochlea

Gene transfer into the chicken auditory organ by in ovo microelectroporation

Evsen, L. & Doetzlhofer, A., Apr 1 2016, In : Journal of Visualized Experiments. 2016, 110, e53864.

Research output: Contribution to journalArticle

Gene transfer
Electroporation
Cell proliferation
Chickens
Assays
Untranslated RNA
Inner Ear
Epigenomics
Regeneration
Genes
2015

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea

Golden, E. J., Benito-Gonzalez, A. & Doetzlhofer, A., Jul 21 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. E3864-E3873

Research output: Contribution to journalArticle

RNA-Binding Proteins
Cochlea
Cell Differentiation
MicroRNAs
Cell Cycle
2014

Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of hedgehog signaling

Benito-Gonzalez, A. & Doetzlhofer, A., Sep 17 2014, In : Journal of Neuroscience. 34, 38, p. 12865-12876 12 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Cell Differentiation
Cochlea
Peripheral Nervous System
Inner Ear
2013

Notch Signaling Limits Supporting Cell Plasticity in the Hair Cell-Damaged Early Postnatal Murine Cochlea

Korrapati, S., Roux, I., Glowatzki, E. B. & Doetzlhofer, A., Aug 30 2013, In : PLoS One. 8, 8, e73276.

Research output: Contribution to journalArticle

Cochlea
hairs
Plasticity
Cells
mice
2009

Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

Doetzlhofer, A., Basch, M. L., Ohyama, T., Gessler, M., Groves, A. K. & Segil, N., Jan 20 2009, In : Developmental Cell. 16, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

Organ of Corti
Cells
Inner Ear
Transcription Factors
Cell Differentiation
2007

p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis

Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., Feb 7 2007, In : Journal of Neuroscience. 27, 6, p. 1434-1444 11 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
DNA Damage
Apoptosis
Cyclin-Dependent Kinases
Cell Cycle
2006

Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells

White, P. M., Doetzlhofer, A., Lee, Y. S., Groves, A. K. & Segil, N., Jun 22 2006, In : Nature. 441, 7096, p. 984-987 4 p.

Research output: Contribution to journalArticle

Cochlea
Organ of Corti
Cyclin-Dependent Kinases
Deafness
Inner Ear

Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea

Doetzlhofer, A., White, P., Lee, Y. S., Groves, A. & Segil, N., May 26 2006, In : Brain Research. 1091, 1, p. 282-288 7 p.

Research output: Contribution to journalArticle

Cochlea
Stem Cells
Organ of Corti
Cyclin-Dependent Kinases
Population
2004

In vitro growth and differentiation of mammalian sensory hair cell progenitors: A requirement for EGF and periotic mesenchyme

Doetzlhofer, A., White, P. M., Johnson, J. E., Segil, N. & Groves, A. K., Aug 15 2004, In : Developmental Biology. 272, 2, p. 432-447 16 p.

Research output: Contribution to journalArticle

Mesoderm
Epidermal Growth Factor
Stem Cells
Growth
Organ of Corti
2003

Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification

Schuettengruber, B., Doetzlhofer, A., Kroboth, K., Wintersberger, E. & Seiser, C., Jan 17 2003, In : Journal of Biological Chemistry. 278, 3, p. 1784-1793 10 p.

Research output: Contribution to journalArticle

Histone Code
Arylformamidase
Thymidine Kinase
Histones
Genes

Math1-driven GFP expression in the developing nervous system of transgenic mice

Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N. & Johnson, J. E., Aug 2003, In : Gene Expression Patterns. 3, 4, p. 389-395 7 p.

Research output: Contribution to journalArticle

Nervous System
Transgenic Mice
Spinal Cord
Stem Cells
Merkel Cells

The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene

Lagger, G., Doetzlhofer, A., Schuettengruber, B., Haidweger, E., Simboeck, E., Tischler, J., Chiocca, S., Suske, G., Rotheneder, H., Wintersberger, E. & Seiser, C., Apr 2003, In : Molecular and Cellular Biology. 23, 8, p. 2669-2679 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Cyclin-Dependent Kinase Inhibitor p21
Genes
Neoplasms
DNA Damage
1999

Histone deacetylase 1 can repress transcription by binding to Sp1

Doetzlhofer, A., Rotheneder, H., Lagger, G., Koranda, M., Kurtev, V., Brosch, G., Wintersberger, E. & Seiser, C., Aug 1999, In : Molecular and Cellular Biology. 19, 8, p. 5504-5511 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
trichostatin A
E2F1 Transcription Factor
Sp1 Transcription Factor
Histone Deacetylase Inhibitors
1998

Growth-regulated antisense transcription of the mouse thymidine kinase gene

Sutterluety, H., Bartl, S., Doetzlhofer, A., Khier, H., Wintersberger, E. & Seiser, C., Nov 1 1998, In : Nucleic Acids Research. 26, 21, p. 4989-4995 7 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Growth
Genes
Introns
Messenger RNA