Research output per year
Research output per year
- 25 results
Search results
-
2023
Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals
Koo, H. Y., Kim, M. A., Min, H., Hwang, J. Y., Prajapati-DiNubila, M., Kim, K. S., Matzuk, M. M., Park, J. W., Doetzlhofer, A., Kim, U. K. & Bok, J., Jan 3 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 1, e2213099120.Research output: Contribution to journal › Article › peer-review
Open Access -
TRIM71 reactivation enhances the mitotic and hair cell–forming potential of cochlear supporting cells
Li, X. J., Morgan, C., Nadar-Ponniah, P. T., Kolanus, W. & Doetzlhofer, A., Sep 6 2023, In: EMBO Reports. 24, 9, e56562.Research output: Contribution to journal › Article › peer-review
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2022
Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea
Li, X. J., Morgan, C., Goff, L. A. & Doetzlhofer, A., Feb 2022, In: Science Advances. 8, 6, eabj7651.Research output: Contribution to journal › Article › peer-review
Open Access -
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Duy, P. Q., Weise, S. C., Marini, C., Li, X. J., Liang, D., Dahl, P. J., Ma, S., Spajic, A., Dong, W., Juusola, J., Kiziltug, E., Kundishora, A. J., Koundal, S., Pedram, M. Z., Torres-Fernández, L. A., Händler, K., De Domenico, E., Becker, M., Ulas, T., Juranek, S. A., & 47 others, Apr 2022, In: Nature neuroscience. 25, 4, p. 458-473 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear
Evsen, L., Li, X., Zhang, S., Razin, S. & Doetzlhofer, A., Aug 2020, In: Development (Cambridge). 147, 15, dev183384.Research output: Contribution to journal › Article › peer-review
Open Access -
LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling
Li, X. J. & Doetzlhofer, A., Sep 8 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 36, p. 22225-22236 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The notch ligand jagged1 is required for the formation, maintenance, and survival of Hensen’s cells in the mouse cochlea
Chrysostomou, E., Zhou, L., Darcy, Y. L., Graves, K. A., Doetzlhofer, A. & Cox, B. C., Dec 2 2020, In: Journal of Neuroscience. 40, 49, p. 9401-9413 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2019
A counter gradient of activin a and follistatin instructs the timing of hair cell differentiation in the murine cochlea
Prajapati-Dinubila, M., Benito-Gonzalez, A., Golden, E. J., Zhang, S. & Doetzlhofer, A., Jun 2019, In: eLife. 8, e47613.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2017
Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration
Doetzlhofer, A. & Avraham, K. B., May 2017, In: Seminars in Cell and Developmental Biology. 65, p. 69-79 11 p.Research output: Contribution to journal › Review article › peer-review
18 Scopus citations -
2016
Canonical Notch signaling plays an instructive role in auditory supporting cell development
Campbell, D. P., Chrysostomou, E. & Doetzlhofer, A., Jan 20 2016, In: Scientific reports. 6, 19484.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates
Basch, M. L., Brown, R. M., Jen, H. I., Semerci, F., Depreux, F., Edlund, R. K., Zhang, H., Norton, C. R., Gridley, T., Cole, S. E., Doetzlhofer, A., Maletic-Savatic, M., Segil, N. & Groves, A. K., Dec 14 2016, In: eLife. 5, DECEMBER2016, e19921.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Gene transfer into the chicken auditory organ by in ovo microelectroporation
Evsen, L. & Doetzlhofer, A., Apr 2016, In: Journal of Visualized Experiments. 2016, 110, e53864.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea
Golden, E. J., Benito-Gonzalez, A. & Doetzlhofer, A., Jul 21 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. E3864-E3873Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2014
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of hedgehog signaling
Benito-Gonzalez, A. & Doetzlhofer, A., Sep 17 2014, In: Journal of Neuroscience. 34, 38, p. 12865-12876 12 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
2013
Notch Signaling Limits Supporting Cell Plasticity in the Hair Cell-Damaged Early Postnatal Murine Cochlea
Korrapati, S., Roux, I., Glowatzki, E. & Doetzlhofer, A., Aug 30 2013, In: PloS one. 8, 8, e73276.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
2009
Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti
Doetzlhofer, A., Basch, M. L., Ohyama, T., Gessler, M., Groves, A. K. & Segil, N., Jan 20 2009, In: Developmental Cell. 16, 1, p. 58-69 12 p.Research output: Contribution to journal › Article › peer-review
Open Access186 Scopus citations -
2007
p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
Laine, H., Doetzlhofer, A., Mantela, J., Ylikoski, J., Laiho, M., Roussel, M. F., Segil, N. & Pirvola, U., Feb 7 2007, In: Journal of Neuroscience. 27, 6, p. 1434-1444 11 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
2006
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
White, P. M., Doetzlhofer, A., Lee, Y. S., Groves, A. K. & Segil, N., Jun 22 2006, In: Nature. 441, 7096, p. 984-987 4 p.Research output: Contribution to journal › Article › peer-review
304 Scopus citations -
Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea
Doetzlhofer, A., White, P., Lee, Y. S., Groves, A. & Segil, N., May 26 2006, In: Brain research. 1091, 1, p. 282-288 7 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
2004
In vitro growth and differentiation of mammalian sensory hair cell progenitors: A requirement for EGF and periotic mesenchyme
Doetzlhofer, A., White, P. M., Johnson, J. E., Segil, N. & Groves, A. K., Aug 15 2004, In: Developmental biology. 272, 2, p. 432-447 16 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
2003
Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification
Schuettengruber, B., Doetzlhofer, A., Kroboth, K., Wintersberger, E. & Seiser, C., Jan 17 2003, In: Journal of Biological Chemistry. 278, 3, p. 1784-1793 10 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Math1-driven GFP expression in the developing nervous system of transgenic mice
Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N. & Johnson, J. E., Aug 2003, In: Gene Expression Patterns. 3, 4, p. 389-395 7 p.Research output: Contribution to journal › Article › peer-review
210 Scopus citations -
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene
Lagger, G., Doetzlhofer, A., Schuettengruber, B., Haidweger, E., Simboeck, E., Tischler, J., Chiocca, S., Suske, G., Rotheneder, H., Wintersberger, E. & Seiser, C., Apr 2003, In: Molecular and cellular biology. 23, 8, p. 2669-2679 11 p.Research output: Contribution to journal › Article › peer-review
Open Access163 Scopus citations -
1999
Histone deacetylase 1 can repress transcription by binding to Sp1
Doetzlhofer, A., Rotheneder, H., Lagger, G., Koranda, M., Kurtev, V., Brosch, G., Wintersberger, E. & Seiser, C., Aug 1999, In: Molecular and cellular biology. 19, 8, p. 5504-5511 8 p.Research output: Contribution to journal › Article › peer-review
346 Scopus citations -
1998
Growth-regulated antisense transcription of the mouse thymidine kinase gene
Sutterluety, H., Bartl, S., Doetzlhofer, A., Khier, H., Wintersberger, E. & Seiser, C., Nov 1 1998, In: Nucleic acids research. 26, 21, p. 4989-4995 7 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations