1993 …2019

Research output per year

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Research Output

2019

IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury following Zika virus infection

Lei, J., Vermillion, M. S., Jia, B., Xie, H., Xie, L., McLane, M. W., Sheffield, J. S., Pekosz, A., Brown, A., Klein, S. L. & Burd, I., Jan 1 2019, In : JCI Insight. 4, 7, e122678.

Research output: Contribution to journalArticle

Open Access
Open Access
2018

Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication

Wohlgemuth, N., Lane, A. P. & Pekosz, A., Nov 15 2018, In : Journal of Virology. 92, 22

Research output: Contribution to journalArticle

Moving forward: Recent developments for the ferret biomedical research model

Albrecht, R. A., Liu, W. C., Sant, A. J., Tompkins, S. M., Pekosz, A., Meliopoulos, V., Cherry, S., Thomas, P. G. & Schultz-Cherry, S., Jul 1 2018, In : mBio. 9, 4, e01113-18.

Research output: Contribution to journalShort survey

Mutations in the influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail

Liu, H., Grantham, M. L. & Pekosz, A., Jan 1 2018, In : Journal of Virology. 92, 1, e00858-17.

Research output: Contribution to journalArticle

Production of amphiregulin and recovery from influenza is greater in males than females

Vermillion, M. S., Ursin, R. L., Kuok, D. I. T., Vom Steeg, L. G., Wohlgemuth, N., Hall, O. J., Fink, A. L., Sasse, E., Nelson, A., Ndeh, R., McGrath-Morrow, S. A., Mitzner, W. A., Chan, M. C. W., Pekosz, A. & Klein, S. L., Jul 17 2018, In : Biology of Sex Differences. 9, 1, 24.

Research output: Contribution to journalArticle

Stability of the influenza virus hemagglutinin protein correlates with evolutionary dynamics

Klein, E., Blumenkrantz, D., Serohijos, A., Shakhnovich, E., Choi, J. M., Rodrigues, J. V., Smith, B. D., Lane, A. P., Feldman, A. & Pekosz, A., Jan 1 2018, In : mSphere. 3, 1, e00554-17.

Research output: Contribution to journalArticle

2017

A novel real-time RT-PCR assay for influenza C tested in Peruvian children

for the RESPIRA-PERU Group, Nov 2017, In : Journal of Clinical Virology. 96, p. 12-16 5 p.

Research output: Contribution to journalArticle

Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells

Forero, A., Fenstermacher, K., Wohlgemuth, N., Nishida, A., Carter, V., Smith, E. A., Peng, X., Hayes, M., Francis, D., Treanor, J., Morrison, J., Klein, S. L., Lane, A. P., Katze, M. G. & Pekosz, A., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D., Pekosz, A., Klein, S. L. & Burd, I., Feb 21 2017, In : Nature Communications. 8, 14575.

Research output: Contribution to journalArticle

The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells

Wohlgemuth, N., Ye, Y., Fenstermacher, K. J., Liu, H., Lane, A. P. & Pekosz, A., Dec 4 2017, In : Vaccine. 35, 48, p. 6691-6699 9 p.

Research output: Contribution to journalArticle

2016

Epizootics in Industrial Livestock Production: Preventable Gaps in Biosecurity and Biocontainment

Leibler, J. H., Dalton, K., Pekosz, A., Gray, G. C. & Silbergeld, E., 2016, (Accepted/In press) In : Zoonoses and Public Health.

Research output: Contribution to journalArticle

Pathogenesis and Molecular Mechanisms of Zika Virus

Nayak, S., Lei, J., Pekosz, A., Klein, S. L. & Burd, I., Sep 1 2016, In : Seminars in Reproductive Medicine. 34, 5, p. 266-272 7 p.

Research output: Contribution to journalArticle

Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females

Hall, O. J., Limjunyawong, N., Vermillion, M. S., Robinson, D. P., Wohlgemuth, N., Pekosz, A., Mitzner, W. A. & Klein, S. L., Sep 1 2016, In : PLoS Pathogens. 12, 9, e1005840.

Research output: Contribution to journalArticle

2015

Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model

Sussan, T. E., Gajghate, S., Thimmulappa, R. K., Ma, J., Kim, J. H., Sudini, K., Consolini, N., Cormier, S. A., Lomnicki, S., Hasan, F., Pekosz, A. & Biswal, S., Feb 4 2015, In : PloS one. 10, 2, 0116861.

Research output: Contribution to journalArticle

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

Ketscher, L., Hannß, R., Moralese, D. J., Basters, A., Guerra, S., Goldmann, T., Hausmann, A., Prinz, M., Naumann, R., Pekosz, A., Utermöhlen, O., Lenschow, D. J. & Knobeloch, K. P., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1577-1582 6 p.

Research output: Contribution to journalArticle

2014

Influenza a H1N1 pandemic strain evolution - Divergence and the potential for antigenic drift variants

Klein, E. Y., Serohijos, A. W. R., Choi, J. M., Shakhnovich, E. I. & Pekosz, A., Apr 3 2014, In : PloS one. 9, 4, e93632.

Research output: Contribution to journalArticle

Mind the gap: Social media engagement by public health researchers

Keller, B., Labrique, A., Jain, K. M., Pekosz, A. & Levine, O., Jan 1 2014, In : Journal of medical Internet research. 16, 1, e8.

Research output: Contribution to journalArticle

Sex-based biology and the rational design of influenza vaccination strategies

Klein, S. L. & Pekosz, A., Jan 1 2014, In : Journal of Infectious Diseases. 209, SUPPL. 3, p. S114-S119

Research output: Contribution to journalArticle

Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes

Espitia, C. M., Saldarriaga, O. A., Travi, B. L., Osorio, E. Y., Hernandez, A., Band, M., Patel, M. J., Medina, A. A., Cappello, M., Pekosz, A. & Melby, P. C., Nov 26 2014, In : BMC Immunology. 15, 1, 51.

Research output: Contribution to journalArticle

2013

Prospects for oral replicating adenovirus-vectored vaccines

Deal, C., Pekosz, A. & Ketner, G., Jun 10 2013, In : Vaccine. 31, 32, p. 3236-3243 8 p.

Research output: Contribution to journalReview article

Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures

Zeng, H., Goldsmith, C. S., Maines, T. R., Belser, J. A., Gustin, K. M., Pekosz, A., Zaki, S. R., Katz, J. M. & Tumpey, T. M., Mar 2013, In : Journal of virology. 87, 5, p. 2597-2607 11 p.

Research output: Contribution to journalArticle

Open Access
2012
2011

Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

Lorenzo, M. E., Hodgson, A., Robinson, D. P., Kaplan, J. B., Pekosz, A. & Klein, S. L., Nov 15 2011, In : Vaccine. 29, 49, p. 9246-9255 10 p.

Research output: Contribution to journalArticle

Influenza virus-like particles containing M2 induce broadly cross protective immunity

Song, J. M., Wang, B. Z., Park, K. M., van Rooijen, N., Quan, F. S., Kim, M. C., Jin, H. T., Pekosz, A., Compans, R. W. & Kang, S. M., Feb 2 2011, In : PloS one. 6, 1, e14538.

Research output: Contribution to journalArticle

Mutations in the membrane-proximal region of the influenza a virus M2 protein cytoplasmic tail have modest effects on virus replication

Stewart, S. M. & Pekosz, A., Dec 1 2011, In : Journal of virology. 85, 23, p. 12179-12187 9 p.

Research output: Contribution to journalArticle

No evidence of infection with avian influenza viruses among US poultry workers in the Delmarva Peninsula, Maryland and Virginia, USA

Leibler, J. H., Silbergeld, E. K., Pekosz, A. & Gray, G. C., Jan 1 2011, In : Journal of Agromedicine. 16, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

2010

Delivery of woodchuck hepatitis virus-like particle presented influenza M2e by recombinant attenuated Salmonella displaying a delayed lysis phenotype

Ameiss, K., Ashraf, S., Kong, W., Pekosz, A., Wu, W. H., Milich, D., Billaud, J. N. & Curtiss, R., Sep 1 2010, In : Vaccine. 28, 41, p. 6704-6713 10 p.

Research output: Contribution to journalArticle

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses

Grandea, A. G., Olsen, O. A., Cox, T. C., Renshaw, M., Hammond, P. W., Chan-Hui, P. Y., Mitcham, J. L., Cieplak, W., Stewart, S. M., Grantham, M. L., Pekosz, A., Kiso, M., Shinya, K., Hatta, M., Kawaoka, Y. & Moyle, M., Jul 13 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 28, p. 12658-12663 6 p.

Research output: Contribution to journalArticle

SARS coronavirus accessory gene expression and function

Schaecher, S. R. & Pekosz, A., Dec 1 2010, Molecular Biology of the SARS-Coronavirus. Springer Berlin Heidelberg, p. 153-166 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Seoul virus suppresses NF-κB-mediated inflammatory responses of antigen presenting cells from Norway rats

Au, R. Y., Jedlicka, A. E., Li, W., Pekosz, A. & Klein, S. L., Apr 25 2010, In : Virology. 400, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

The cholesterol recognition/interaction amino acid consensus motif of the influenza A virus M2 protein is not required for virus replication but contributes to virulence

Stewart, S. M., Wu, W. H., Lalime, E. N. & Pekosz, A., Sep 30 2010, In : Virology. 405, 2, p. 530-538 9 p.

Research output: Contribution to journalArticle

The impact of sex, gender and pregnancy on 2009 H1N1 disease

Klein, S. L., Passaretti, C., Anker, M., Olukoya, P. & Pekosz, A., Dec 1 2010, In : Biology of Sex Differences. 1, 1, 5.

Research output: Contribution to journalReview article

The Xs and Y of immune responses to viral vaccines

Klein, S. L., Jedlicka, A. & Pekosz, A., May 1 2010, In : The Lancet Infectious Diseases. 10, 5, p. 338-349 12 p.

Research output: Contribution to journalReview article

Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles

Grantham, M. L., Stewart, S. M., Lalime, E. N. & Pekosz, A., Sep 1 2010, In : Journal of virology. 84, 17, p. 8765-8776 12 p.

Research output: Contribution to journalArticle

2009

Influenza virus assays based on virus-inducible reporter cell lines

Li, Y., Larrimer, A., Curtiss, T., Kim, J., Jones, A., Baird-Tomlinson, H., Pekosz, A. & Olivo, P. D., Aug 31 2009, In : Influenza and other Respiratory Viruses. 3, 5, p. 241-251 11 p.

Research output: Contribution to journalArticle

Palmitoylation of the influenza A virus M2 protein is not required for virus replication in vitro but contributes to virus virulence

Grantham, M. L., Wu, W. H., Lalime, E. N., Lorenzo, M. E., Klein, S. L. & Pekosz, A., Sep 22 2009, In : Journal of virology. 83, 17, p. 8655-8661 7 p.

Research output: Contribution to journalArticle

Sialic acid recognition is a key determinant of influenza A virus tropism in murine trachea epithelial cell cultures

Pekosz, A., Newby, C., Bose, P. S. & Lutz, A., Mar 30 2009, In : Virology. 386, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

2008

An immunosuppressed Syrian golden hamster model for SARS-CoV infection

Schaecher, S. R., Stabenow, J., Oberle, C., Schriewer, J., Buller, R. M., Sagartz, J. E. & Pekosz, A., Oct 25 2008, In : Virology. 380, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

Emerging viral diseases.

Pekosz, A. & Glass, G. E., Jan 1 2008, In : Maryland medicine : MM : a publication of MEDCHI, the Maryland State Medical Society. 9, 1, p. 11, 13-16

Research output: Contribution to journalReview article

Extending the cytoplasmic tail of the influenza A virus M2 protein leads to reduced virus replication in vivo but not in vitro

Wu, W. H. & Pekosz, A., Jan 1 2008, In : Journal of virology. 82, 2, p. 1059-1063 5 p.

Research output: Contribution to journalArticle

Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells

Rowe, R. K., Suszko, J. W. & Pekosz, A., Dec 20 2008, In : Virology. 382, 2, p. 239-249 11 p.

Research output: Contribution to journalArticle

The transmembrane domain of the severe acute respiratory syndrome coronavirus ORF7b protein is necessary and sufficient for its retention in the Golgi complex

Schaecher, S. R., Diamond, M. S. & Pekosz, A., Oct 1 2008, In : Journal of virology. 82, 19, p. 9477-9491 15 p.

Research output: Contribution to journalArticle

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses

Lenschow, D. J., Lai, C., Frias-Staheli, N., Giannakopoulos, N. V., Lutz, A., Wolff, T., Osiak, A., Levine, B., Schmidt, R. E., García-Sastre, A., Leib, D. A., Pekosz, A., Knobeloch, K. P., Horak, I. & Virgin IV, H. W., Jan 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 4, p. 1371-1376 6 p.

Research output: Contribution to journalArticle

Severe acute respiratory syndrome coronavirus gene 7 products contribute to virus-induced apoptosis

Schaecher, S. R., Touchette, E., Schriewer, J., Buller, R. M. & Pekosz, A., Oct 1 2007, In : Journal of virology. 81, 20, p. 11054-11068 15 p.

Research output: Contribution to journalArticle

The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles

Schaecher, S. R., Mackenzie, J. M. & Pekosz, A., Jan 1 2007, In : Journal of virology. 81, 2, p. 718-731 14 p.

Research output: Contribution to journalArticle