Andrew P Lane

Professor

1992 …2019
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Research Output 1992 2019

2019

Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel, Jan 1 2019, In : Chest. 155, 1, p. 155-167 13 p.

Research output: Contribution to journalArticle

Cough
Human Influenza
Pneumonia
Outpatients
Guidelines

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Chen, M., Reed, R. R. & Lane, A. P., Oct 3 2019, In : Cell stem cell. 25, 4, p. 501-513.e5

Research output: Contribution to journalArticle

Stem Cells
Inflammation
Chemokines
Macrophages
Cytokines

Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel, Jan 1 2019, In : Chest. 155, 1, p. 147-154 8 p.

Research output: Contribution to journalArticle

Whooping Cough
Cough
Guidelines
Vomiting
Fever

Endonasal endoscopic resection of olfactory neuroblastoma: An 11-year experience

Gallia, G. L., Asemota, A. O., Blitz, A. M., Lane, A. P., Koch, W. M., Reh, D. D. & Ishii, M., Jan 1 2019, In : Journal of neurosurgery. 131, 1, p. 238-244 7 p.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
Neoplasms
Frozen Sections
Recurrence

Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation

London, N., Tharakan, A., Mendiola, M., Chen, M., Dobzanski, A., Sussan, T. E., Zaykaner, M., Han, A. H., Lane, A. P., Sidhaye, V., Biswal, S. & Ramanathan, M., Jan 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalLetter

Ovum
Inflammation
sulforafan

Otolaryngology Aspects of Chronic Cough

Altman, K. W., Lane, A. P. & Irwin, R. S., Jul 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice. 7, 6, p. 1750-1755 6 p.

Research output: Contribution to journalReview article

Otolaryngology
Cough
Practice Guidelines
Respiratory Physiological Phenomena
Evidence-Based Practice

Response

CHEST Expert Cough Panel, May 2019, In : CHEST. 155, 5, p. 1082-1083 2 p.

Research output: Contribution to journalLetter

Open Access
2018

Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis

Tharakan, A., Dobzanski, A., London, N., Khalil, S. M., Surya, N., Lane, A. P. & Ramanathan, M., Jan 1 2018, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Papain
Nasal Lavage Fluid
Cytokines
Goblet Cells
Cysteine Proteases

Chronic Cough Related to Acute Viral Bronchiolitis in Children: CHEST Expert Panel Report

CHEST Expert Cough Panel, Aug 1 2018, In : Chest. 154, 2, p. 378-382 5 p.

Research output: Contribution to journalArticle

Viral Bronchiolitis
Cough
Bronchiolitis
montelukast
Patient Preference

Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel*, Jan 1 2018, In : Chest. 153, 1, p. 196-209 14 p.

Research output: Contribution to journalArticle

Cough
Guidelines
Patient Preference
Bronchitis
South America

Clinical Consensus Statement: Balloon Dilation of the Sinuses

Piccirillo, J. F., Payne, S. C., Rosenfeld, R. M., Baroody, F. M., Batra, P. S., DelGaudio, J. M., Edelstein, D. R., Lane, A. P., Luong, A. U., Manes, R. P., McCoul, E. D., Platt, M. P., Reh, D. D. & Corrigan, M. D., Feb 1 2018, In : Otolaryngology - Head and Neck Surgery (United States). 158, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

Dilatation
Sinusitis
Tomography
Sphenoid Sinus
Nasal Polyps

Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel, Feb 1 2018, In : Chest. 153, 2, p. 339-348 10 p.

Research output: Contribution to journalArticle

Cough
Guidelines
Lung
Infection
Costs and Cost Analysis

Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis

London, N., Tharakan, A., Mendiola, M., Sussan, T. E., Chen, M., Dobzanski, A., Lane, A. P., Sidhaye, V., Biswal, S. & Ramanathan, M., Jan 1 2018, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Inflammation
Ovalbumin
Nasal Lavage Fluid
Cytokines
Goblet Cells

Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size

Laidlaw, T. M., Prussin, C., Panettieri, R. A., Lee, S., Ferguson, B. J., Adappa, N. D., Lane, A. P., Palumbo, M. L., Sullivan, M., Archibald, D., Dworetzky, S. I., Hebrank, G. T. & Bozik, M. E., Jan 1 2018, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Nasal Polyps
Polyps
Eosinophils
Eosinophilia
pramipexole

Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases

Gour, N., Lajoie, S., Smole, U., White, M., Hu, D., Goddard, P., Huntsman, S., Eng, C., Mak, A., Oh, S., Kim, J. H., Sharma, A., Plante, S., Salem, I. H., Resch, Y., Xiao, X., Yao, N., Singh, A., Vrtala, S., Chakir, J. & 3 others, Burchard, E. G., Lane, A. P. & Wills-Karp, M., Feb 23 2018, In : Science immunology. 3, 20

Research output: Contribution to journalArticle

Tropomyosin
Invertebrates
Single Nucleotide Polymorphism
Immunity
Epithelial Cells

Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication

Wohlgemuth, N., Lane, A. P. & Pekosz, A., Nov 15 2018, In : Journal of Virology. 92, 22

Research output: Contribution to journalArticle

Protein Transport
Virus Replication
virus replication
virion
Influenza A virus

Nasal polyp fibroblasts modulate epithelial characteristics via Wnt signaling

Dobzanski, A., Khalil, S. M. & Lane, A. P., Jan 1 2018, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Nasal Polyps
Fibroblasts
Epithelial Cells
Organoids
Coculture Techniques

Stability of the influenza virus hemagglutinin protein correlates with evolutionary dynamics

Klein, E., Blumenkrantz, D., Serohijos, A., Shakhnovich, E., Choi, J. M., Rodrigues, J. V., Smith, B. D., Lane, A. P., Feldman, A. & Pekosz, A., Jan 1 2018, In : mSphere. 3, 1, e00554-17.

Research output: Contribution to journalArticle

Hemagglutinins
Orthomyxoviridae
Protein Stability
Influenza A virus
Proteins

Temporal instability of the post-surgical maxillary sinus microbiota

Koutsourelakis, I., Halderman, A., Khalil, S., Hittle, L. E., Mongodin, E. F. & Lane, A. P., Aug 30 2018, In : BMC Infectious Diseases. 18, 1, 441.

Research output: Contribution to journalArticle

Maxillary Sinus
Microbiota
Dysbiosis
Bacteria
rRNA Genes

Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance: CHEST Expert Panel Report

Hill, A. T., Barker, A. F., Bolser, D. C., Davenport, P., Ireland, B., Chang, A. B., Mazzone, S. B., McGarvey, L., Adams, T. M., Altman, K. W., Azoulay, E., Birring, S. S., Blackhall, F., Boulet, L. P., Brightling, C., Callahan-Lyon, P., Cowley, T., El Solh, A. A., Escalante, P., Field, S. K. & 33 others, Fisher, D., French, C. T., Gibson, P., Harding, S. M., Harnden, A., Irwin, R. S., Kahrilas, P. J., Kavanagh, J., Keogh, K. A., Lai, K., Lane, A. P., Lim, K., Madison, J. M., Malesker, M. A., Metlay, J. P., Molasoitis, A., Moore, A., Murad, M. H., Narasimhan, M., Nguyen, H. Q., Newcombe, P., Oppenheimer, J., Restrepo, M. I., Rosen, M., Rubin, B., Ryu, J. H., Singh, S., Smith, M. P., Tarlo, S. M., Turmel, J., Vertigan, A. E., Wang, G. & Weinberger, M., Apr 1 2018, In : Chest. 153, 4, p. 986-993 8 p.

Research output: Contribution to journalArticle

Bronchiectasis
Cough
Cystic Fibrosis
Fibrosis
Hospitalization

Treatment of Interstitial Lung Disease Associated Cough: CHEST Guideline and Expert Panel Report

Collaborators, Oct 1 2018, In : Chest. 154, 4, p. 904-917 14 p.

Research output: Contribution to journalArticle

Interstitial Lung Diseases
Cough
Guidelines
Therapeutics
Idiopathic Pulmonary Fibrosis
2017
Olfactory Mucosa
Inflammation
Neural Stem Cells
Tumor Necrosis Factor Receptors
Adult Stem Cells

Bactericidal antibiotics promote oxidative damage and programmed cell death in sinonasal epithelial cells

Kohanski, M. A., Tharakan, A., London, N., Lane, A. P. & Ramanathan, M., Apr 1 2017, In : International Forum of Allergy and Rhinology. 7, 4, p. 359-364 6 p.

Research output: Contribution to journalArticle

Levofloxacin
Cell Death
Epithelial Cells
Reactive Oxygen Species
Anti-Bacterial Agents

Combined endonasal and eyelid approach for management of extensive frontal sinus inverting papilloma

Albathi, M., Ramanathan, M., Lane, A. P. & Boahene, D. O., 2017, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Frontal Sinus
Papilloma
Eyelids
Transverse Sinuses
Neoplasms

Complete surgical resection and short-term survival in acute invasive fungal rhinosinusitis

Roxbury, C. R., Smith, D. F., Higgins, T. S., Lee, S. E., Gallia, G. L., Ishii, M., Lane, A. P. & Reh, D. D., Mar 1 2017, In : American Journal of Rhinology and Allergy. 31, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Survival
Mycoses
Paranasal Sinuses
Nasal Cavity
Skull Base

Cough in the Athlete: CHEST Guideline and Expert Panel Report

Boulet, L. P., Turmel, J., Irwin, R. S., Altman, K. W., Barker, A. F., Birring, S. S., Blackhall, F., Bolser, D. C., Boulet, L. P., Braman, S. S., Brightling, C., Callahan-Lyon, P., Chang, A. B., Cowley, T., Davenport, P., Ebihara, S., El Solh, A. A., Escalante, P., Feinstein, A., Field, S. K. & 30 others, Fisher, D., French, C. T., Gibson, P., Gold, P., Grant, C., Harding, S. M., Harnden, A., Hill, A. T., Irwin, R. S., Kahrilas, P. J., Keogh, K. A., Lai, K., Lane, A. P., Lim, K., Malesker, M. A., Mazzone, P., McGarvey, L., Murad, M. H., Newcombe, P., Nguyen, H. Q., Oppenheimer, J., Rosen, M., Rubin, B., Ryu, J. H., Smith, J., Tarlo, S. M., Vertigan, A. E., Wang, G., Weinberger, M. & Weir, K., Feb 1 2017, In : Chest. 151, 2, p. 441-454 14 p.

Research output: Contribution to journalArticle

Cough
Athletes
Guidelines
Exercise
Population

Etiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel, Sep 1 2017, In : Chest. 152, 3, p. 607-617 11 p.

Research output: Contribution to journalArticle

Cough
Guidelines
Pediatrics
Sleep
Patient Preference

Evaluation of the innate immune responses to influenza and live-attenuated influenza vaccine infection in primary differentiated human nasal epithelial cells

Forero, A., Fenstermacher, K., Wohlgemuth, N., Nishida, A., Carter, V., Smith, E. A., Peng, X., Hayes, M., Francis, D., Treanor, J., Morrison, J., Klein, S. L., Lane, A. P., Katze, M. G. & Pekosz, A., 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Attenuated Vaccines
Influenza Vaccines
live vaccines
Orthomyxoviridae
Nose

Genetic and Immune Dysregulation in Chronic Rhinosinusitis

Halderman, A. & Lane, A. P., Feb 1 2017, In : Otolaryngologic Clinics of North America. 50, 1, p. 13-28 16 p.

Research output: Contribution to journalReview article

Inborn Genetic Diseases
Immune System
Inflammation
Therapeutics
Pyroglyphidae
Epithelial Cells
Electric Impedance
Zonula Occludens-1 Protein
Permeability

Olfactory loss in chronic rhinosinusitis is associated with neuronal activation of c-Jun N-terminal kinase

Victores, A. J., Chen, M., Smith, A. & Lane, A. P., Jan 1 2017, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Inflammation
Apoptosis
Olfactory Receptor Neurons
Cytokines

Organism and Microbiome Analysis. Techniques and Implications for Chronic Rhinosinusitis

Halderman, A. A. & Lane, A. P., 2017, (Accepted/In press) In : Otolaryngologic Clinics of North America.

Research output: Contribution to journalArticle

Culture Techniques
Microbiota
DNA Sequence Analysis
Bacteria
Therapeutics

Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report

CHEST Expert Cough Panel, Nov 1 2017, In : Chest. 152, 5, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

Common Cold
Cough
Therapeutics
Guidelines
Randomized Controlled Trials

Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer: CHEST Guideline and Expert Panel Report

CHEST Expert Cough Panel, Apr 1 2017, In : Chest. 151, 4, p. 861-874 14 p.

Research output: Contribution to journalArticle

Cough
Lung Neoplasms
Guidelines
Antitussive Agents
Therapeutics

The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells

Wohlgemuth, N., Ye, Y., Fenstermacher, K. J., Liu, H., Lane, A. P. & Pekosz, A., Dec 4 2017, In : Vaccine. 35, 48, p. 6691-6699 9 p.

Research output: Contribution to journalArticle

Attenuated Vaccines
Influenza Vaccines
Nose
influenza
epithelial cells

Bactericidal antibiotics promote reactive oxygen species formation and inflammation in human sinonasal epithelial cells

Kohanski, M. A., Tharakan, A., Lane, A. P. & Ramanathan, M., Feb 1 2016, In : International Forum of Allergy and Rhinology. 6, 2, p. 191-200 10 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Epithelial Cells
Anti-Bacterial Agents
Inflammation
Levofloxacin

Characterization of a novel high-dose ovalbumin-induced murine model of allergic sinonasal inflammation

Mendiola, M., Tharakan, A., Chen, M., Asempa, T., Lane, A. P. & Ramanathan, M., Sep 1 2016, In : International Forum of Allergy and Rhinology. 6, 9, p. 964-972 9 p.

Research output: Contribution to journalArticle

Ovalbumin
Inflammation
Eosinophilia
Anti-Inflammatory Agents
Inbred C57BL Mouse

Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report

Kahrilas, P. J., Altman, K. W., Chang, A. B., Field, S. K., Harding, S. M., Lane, A. P., Lim, K., McGarvey, L., Smith, J., Irwin, R. S., Adams, T. M., Altman, K. W., Azoulay, E., Barker, A. F., Blackhall, F., Bolser, D. C., Boulet, L. P., Brightling, C., Callahan-Lyon, P., Canning, B. J. & 38 others, Chang, A. B., Cowley, T., Ebihara, S., El Solh, A. A., Escalante, P., Field, S. K., Feinstein, A., Fisher, D., French, C. T., Gibson, P., Gold, P., Gould, M. K., Grant, C., Harding, S. M., Harnden, A., Hill, A. T., Irwin, R. S., Kahrilas, P. J., Keogh, K. A., Lai, K., Lane, A. P., Lim, K., Malesker, M. A., Mazzone, S., McGarvey, L., Murad, M. H., Nguyen, H. Q., Newcombe, P., Oppenheimer, J., Rosen, M., Rubin, B., Ryu, J. H., Smith, J., Tarlo, S. M., Vertigan, A. E., Wang, G., Weinberger, M. & Weir, K., Dec 1 2016, In : Chest. 150, 6, p. 1341-1360 20 p.

Research output: Contribution to journalArticle

Gastroesophageal Reflux
Cough
Guidelines
Proton Pump Inhibitors
Weight Loss

CNS complications of frontal sinus disease

Liang, J. & Lane, A. P., Jan 1 2016, The Frontal Sinus, Second Edition. Springer Berlin Heidelberg, p. 121-132 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Frontal Sinusitis
Frontal Sinus
Anti-Bacterial Agents
Influenza A virus
Virus Replication
Orthomyxoviridae
Nose
Estrogens

Immunomodulators in the Treatment of Nasal Polyposis

Halderman, A. A. & Lane, A. P., 2016, In : Advances in Oto-Rhino-Laryngology. 79, p. 103-113 11 p.

Research output: Contribution to journalArticle

Nasal Polyps
Immunologic Factors
Nose
Leukotrienes
Interleukin-5
Inflammation
Tumor Necrosis Factor-alpha
Transgenic Mice
Olfactory Mucosa
Tumor Necrosis Factor Receptors

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi, R. R., Kingdom, T. T., Hwang, P. H., Smith, T. L., Alt, J. A., Baroody, F. M., Batra, P. S., Bernal-Sprekelsen, M., Bhattacharyya, N., Chandra, R. K., Chiu, A., Citardi, M. J., Cohen, N. A., Delgaudio, J., Desrosiers, M., Dhong, H. J., Douglas, R., Ferguson, B., Fokkens, W. J., Georgalas, C. & 55 others, Goldberg, A., Gosepath, J., Hamilos, D. L., Han, J. K., Harvey, R., Hellings, P., Hopkins, C., Jankowski, R., Javer, A. R., Kern, R., Kountakis, S., Kowalski, M. L., Lane, A. P., Lanza, D. C., Lebowitz, R., Lee, H. M., Lin, S. Y., Lund, V., Luong, A., Mann, W., Marple, B. F., Mcmains, K. C., Metson, R., Naclerio, R., Nayak, J. V., Otori, N., Palmer, J. N., Parikh, S. R., Passali, D., Peters, A., Piccirillo, J., Poetker, D. M., Psaltis, A. J., Ramadan, H. H., Ramakrishnan, V. R., Riechelmann, H., Roh, H. J., Rudmik, L., Sacks, R., Schlosser, R. J., Senior, B. A., Sindwani, R., Stankiewicz, J. A., Stewart, M., Tan, B. K., Toskala, E., Voegels, R., Wang, D. Y., Weitzel, E. K., Wise, S., Woodworth, B. A., Wormald, P. J., Wright, E. D., Zhou, B. & Kennedy, D. W., Feb 1 2016, In : International Forum of Allergy and Rhinology. 6, p. S22-S209

Research output: Contribution to journalArticle

Hypersensitivity
Nasal Polyps
Manuscripts
Publications
Pediatrics

Occupational and Environmental Contributions to Chronic Cough in Adults: Chest Expert Panel Report

Tarlo, S. M., Altman, K. W., Oppenheimer, J., Lim, K., Vertigan, A., Prezant, D., Irwin, R. S., Adams, T. M., Altman, K. W., Azoulay, E., Barker, A. F., Birring, S. S., Blackhall, F., Bolser, D. C., Boulet, L. P., Braman, S. S., Brightling, C., Callahan-Lyon, P., Chang, A. B., Ebihara, S. & 35 others, El Solh, A. A., Escalante, P., Feinstein, A., Field, S. K., Fisher, D., French, C. T., Gibson, P., Gold, P., Gould, M. K., Grant, C., Harding, S. M., Harnden, A., Hill, A. T., Irwin, R. S., Kahrilas, P. J., Keogh, K. A., Lai, K., Lane, A. P., Lim, K., Malesker, M. A., Mazzone, S., McGarvey, L., Molasiotis, A., Murad, M. H., Oppenheimer, J., Prezant, D., Restrepo, M. I., Rosen, M., Rubin, B., Ryu, J. H., Tarlo, S. M., Vertigan, A. E., Wang, G., Weinberger, M. & Weir, K., Oct 1 2016, In : Chest. 150, 4, p. 894-907 14 p.

Research output: Contribution to journalArticle

Cough
Thorax
Guidelines
Occupational Exposure
Occupational Diseases
NF-E2-Related Factor 2
Smoke
Tobacco Products
Epithelial Cells
Junctional Adhesion Molecule A

Role of the type I tumor necrosis factor receptor in inflammation-associated olfactory dysfunction

Sousa Garcia, D., Chen, M., Smith, A. K., Lazarini, P. R. & Lane, A. P., 2016, (Accepted/In press) In : International Forum of Allergy and Rhinology.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Inflammation
Knockout Mice
Allergens
Receptors, Tumor Necrosis Factor, Type II

Sinonasal innate immunity in the pathophysiology of chronic rhinosinusitis

Donatelli, L. A. & Lane, A. P., Dec 1 2016, In : Otorinolaringologia. 66, 4, p. 107-119 13 p.

Research output: Contribution to journalReview article

Innate Immunity
Immune System
Nose
Mucous Membrane
Epithelium
2015

Dysregulated Macrophages Are Present in Bleomycin-Induced Murine Laryngotracheal Stenosis

Hillel, A. T., Samad, I., Ma, G., Ding, D., Sadtler, K., Powell, J., Lane, A. P. & Horton, M., Aug 25 2015, In : Otolaryngology - Head and Neck Surgery. 153, 2, p. 244-250 7 p.

Research output: Contribution to journalArticle

Pathologic Constriction
Macrophages
Wounds and Injuries
Fibrosis
Bleomycin

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota

Liu, C. M., Kohanski, M. A., Mendiola, M., Soldanova, K., Dwan, M. G., Lester, R., Nordstrom, L., Price, L. B. & Lane, A. P., Mar 1 2015, In : International Forum of Allergy and Rhinology. 5, 3, p. 185-190 6 p.

Research output: Contribution to journalArticle

Microbiota
Adrenal Cortex Hormones
Nose
Nasal Lavage
Corynebacterium