Research Output 1976 2017

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2017

Autologous reconstitution of human cancer and immune system in vivo

Fu, J., Sen, R., Masica, D. L., Karchin, R., Pardoll, D., Walter, V., Hayes, D. N., Chung, C. H. & Kim, Y. J. 2017 In : Oncotarget. 8, 2, p. 2053-2068 16 p.

Research output: Research - peer-reviewArticle

Immune System
Neoplasms
Tumor Microenvironment
Human Trafficking
Tumor-Infiltrating Lymphocytes

Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas

Kim, J. E. , Patel, M. A. , Mangraviti, A. , Kim, E. S. , Theodros, D. , Velarde, E. , Liu, A. , Sankey, E. W. , Tam, A. , Xu, H. , Mathios, D. , Jackson, C. M. , Harris-Bookman, S. , Garzon-Muvdi, T. , Sheu, M. , Martin, A. M. , Tyler, B. M. , Tran, P. T. , Ye, X. , Olivi, A. & 6 others Taube, J. M., Burger, P. C., Drake, C. G., Brem, H., Pardoll, D. M. & Lim, M. Jan 1 2017 In : Clinical Cancer Research. 23, 1, p. 124-136 13 p.

Research output: Research - peer-reviewArticle

Mucin-3
Glioma
Immunoglobulins
Radiation
T-Lymphocytes

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V. , Smith, K. N. , Forde, P. M. , Niknafs, N. , Bhattacharya, R. , White, J. , Zhang, T. , Adleff, V. , Phallen, J. , Wali, N. , Hruban, C. , Guthrie, V. B. , Rodgers, K. , Naidoo, J. , Kang, H. , Sharfman, W. , Georgiades, C. , Verde, F. , Illei, P. , Li, Q. K. & 9 others Gabrielson, E., Brock, M. V., Zahnow, C. A., Baylin, S. B., Scharpf, R. B., Brahmer, J. R., Karchin, R., Pardoll, D. M. & Velculescu, V. E. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Research - peer-reviewArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
Therapeutics

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T. , Durham, J. N. , Smith, K. N. , Wang, H. , Bartlett, B. R. , Aulakh, L. K. , Lu, S. , Kemberling, H. , Wilt, C. , Luber, B. S. , Wong, F. , Azad, N. S. , Rucki, A. A. , Laheru, D. , Donehower, R. , Zaheer, A. , Fisher, G. A. , Crocenzi, T. S. , Lee, J. J. , Greten, T. F. & 26 others Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K. M., Fader, A. N., Taube, J., Housseau, F., Spetzler, D., Xiao, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J. R., Vogelstein, B., Anders, R. A. & Diaz, L. A. Jul 28 2017 In : Science. 357, 6349, p. 409-413 5 p.

Research output: Research - peer-reviewArticle

Death Domain Receptors
Neoplasms
Turcot syndrome
DNA Mismatch Repair
Disease-Free Survival

Prediction of response to immune checkpoint inhibitor therapy using early-time-point 18F-FDG PET/CT imaging in patients with advanced melanoma

Cho, S. Y., Lipson, E. J., Im, H. J., Rowe, S. P., Gonzalez, E. M., Blackford, A., Chirindel, A., Pardoll, D. M., Topalian, S. L. & Wahl, R. L. Sep 1 2017 In : Journal of Nuclear Medicine. 58, 9, p. 1421-1428 8 p.

Research output: Research - peer-reviewArticle

Melanoma
Therapeutics
Neoplasms
Organizations
Research

Primary resistance to PD-1 blockade mediated by JAK1/2 mutations

Shin, D. S. , Zaretsky, J. M. , Escuin-Ordinas, H. , Garcia-Diaz, A. , Hu-Lieskovan, S. , Kalbasi, A. , Grasso, C. S. , Hugo, W. , Sandoval, S. , Torrejon, D. Y. , Palaskas, N. , Abril-Rodriguez, G. , Parisi, G. , Azhdam, A. , Chmielowski, B. , Cherry, G. , Seja, E. , Berent-Maoz, B. , Shintaku, I. P. , Le, D. T. & 7 others Pardoll, D. M., Diaz, L. A., Tumeh, P. C., Graeber, T. G., Lo, R. S., Comin-Anduix, B. & Ribas, A. Feb 1 2017 In : Cancer Discovery. 7, 2, p. 188-201 14 p.

Research output: Research - peer-reviewArticle

Mutation
Therapeutics
Neoplasms
Interferon-gamma
Melanoma

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Thiele Orberg, E., Fan, H., Tam, A. J., Dejea, C. M., Destefano Shields, C. E., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., Ganguly, S., Fu, J., Pardoll, D. M., Sears, C. L. & Housseau, F. Mar 1 2017 In : Mucosal Immunology. 10, 2, p. 421-433 13 p.

Research output: Research - peer-reviewArticle

Bacteroides fragilis
Colon
Carcinogenesis
Interleukin-17
Myeloid-Derived Suppressor Cells

Transcriptional mechanisms of resistance to anti-PD-1 therapy

Ascierto, M. L. , Makohon-Moore, A. , Lipson, E. J. , Taube, J. M. , McMiller, T. L. , Berger, A. E. , Fan, J. , Kaunitz, G. J. , Cottrell, T. R. , Kohutek, Z. A. , Favorov, A. , Makarov, V. , Riaz, N. , Chan, T. A. , Cope, L. , Hruban, R. H. , Pardoll, D. M. , Taylor, B. S. , Solit, D. B. , Iacobuzio-Donahue, C. A. & 1 others Topalian, S. L. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3168-3180 13 p.

Research output: Research - peer-reviewArticle

Melanoma
Therapeutics
Biomarkers
Neoplasm Metastasis
Skin
2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Patel, M. A. , Kim, J. E. , Theodros, D. , Tam, A. , Velarde, E. , Kochel, C. M. , Francica, B. , Nirschl, T. R. , Ghasemzadeh, A. , Mathios, D. , Harris-Bookman, S. , Jackson, C. C. , Jackson, C. , Ye, X. , Tran, P. T. , Tyler, B. , Coric, V. , Selby, M. , Brem, H. , Drake, C. G. & 2 others Pardoll, D. M. & Lim, M. May 17 2016 In : Journal for ImmunoTherapy of Cancer. 4, 1, 28

Research output: Research - peer-reviewArticle

Radiosurgery
Glioma
Monoclonal Antibodies
Radiation
Neoplasms

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C. K., Jackson, C. M., Garzon-Muvdi, T., Kim, E., Theodros, D., Polanczyk, M., Martin, A. M., Suk, I., Ye, X., Tyler, B., Bettegowda, C., Brem, H., Pardoll, D. M. & Lim, M. Dec 21 2016 In : Science Translational Medicine. 8, 370, 370ra180

Research output: Research - peer-reviewArticle

Immunity
Drug Therapy
Neoplasms
Glioblastoma
Immunotherapy

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Danilova, L., Wang, H., Sunshine, J., Kaunitz, G. J., Cottrell, T. R., Xu, H., Esandrio, J., Anders, R. A., Cope, L., Pardoll, D. M., Drake, C. G. & Taube, J. M. Nov 29 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. E7769-E7777

Research output: Research - peer-reviewArticle

Melanoma
Neoplasms
Ligands
Programmed Cell Death 1 Ligand 2 Protein
Biomarkers

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., Powell, J. D., Housseau, F., Pardoll, D. M. & Elisseeff, J. H. Apr 15 2016 In : Science. 352, 6283, p. 366-370 5 p.

Research output: Research - peer-reviewArticle

Th2 Cells
Biocompatible Materials
Regeneration
Muscles
Interleukin-4

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 152 (974-986))

Chiappinelli, K. B. , Strissel, P. L. , Desrichard, A. , Li, H. , Henke, C. , Akman, B. , Hein, A. , Rote, N. S. , Cope, L. M. , Snyder, A. , Makarov, V. , Budhu, S. , Slamon, D. J. , Wolchok, J. D. , Pardoll, D. M. , Beckmann, M. W. , Zahnow, C. A. , Merghoub, T. , Chan, T. A. , Baylin, S. B. & 1 others Strick, R. Feb 25 2016 In : Cell. 164, 5, p. 1073 1 p.

Research output: Research - peer-reviewArticle

Erratum to: PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

Mathios, D., Ruzevick, J., Jackson, C. M., Xu, H., Shah, S. R., Taube, J. M., Burger, P. C., McCarthy, E. F., Quinones-Hinojosa, A., Pardoll, D. M. & Lim, M. May 9 2016 (Accepted/In press) In : Journal of Neuro-Oncology. p. 1 1 p.

Research output: Research - peer-reviewArticle

Biomarkers
Neoplasms
Therapeutics
CTLA-4 Antigen
Kidney Neoplasms

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, D. M., Li, H. & Pan, F. Jul 19 2016 In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

PD-1 blockade with pembrolizumab in advanced merkel-cell carcinoma

Nghiem, P. T. , Bhatia, S. , Lipson, E. J. , Kudchadkar, R. R. , Miller, N. J. , Annamalai, L. , Berry, S. , Chartash, E. K. , Daud, A. , Fling, S. P. , Friedlander, P. A. , Kluger, H. M. , Kohrt, H. E. , Lundgren, L. , Margolin, K. , Mitchell, A. , Olencki, T. , Pardoll, D. M. , Reddy, S. A. , Shantha, E. M. & 11 others Sharfman, W. H., Sharon, E., Shemanski, L. R., Shinohara, M. M., Sunshine, J. C., Taube, J. M., Thompson, J. A., Townson, S. M., Yearley, J. H., Topalian, S. L. & Cheever, M. A. Jun 30 2016 In : New England Journal of Medicine. 374, 26, p. 2542-2552 11 p.

Research output: Research - peer-reviewArticle

Merkel Cell Carcinoma
pembrolizumab
Oncogenic Viruses
Merkel cell polyomavirus
Neoplasms

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N. J., Smith, K. N., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, D. M. & Sears, C. L. Apr 15 2016 In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Research - peer-reviewArticle

Colon
Carcinogenesis
Th17 Cells
Neoplasms
T-Lymphocytes

Systemic tolerance mediated by melanoma brain tumors is reversible by radiotherapy and vaccination

Jackson, C. M., Kochel, C. M., Nirschl, C. J., Durham, N. M., Ruzevick, J., Alme, A., Francica, B. J., Elias, J., Daniels, A., Dubensky, T. W., Lauer, P., Brockstedt, D. G., Baxi, E. G., Calabresi, P. A., Taube, J. M., Pardo, C. A., Brem, H., Pardoll, D. M., Lim, M. & Drake, C. G. Mar 1 2016 In : Clinical Cancer Research. 22, 5, p. 1161-1172 12 p.

Research output: Research - peer-reviewArticle

Central Nervous System Neoplasms
Brain Neoplasms
Melanoma
Vaccination
Radiotherapy

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, D. M. & Cox, A. L. Dec 1 2016 In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation

The intratumoral balance between metabolic and immunologic gene expression is associated with anti-PD-1 response in patients with renal cell carcinoma

Ascierto, M. L., McMiller, T. L., Berger, A. E., Danilova, L., Anders, R. A., Netto, G. J., Xu, H., Pritchard, T. S., Fan, J., Cheadle, C., Cope, L., Drake, C. G., Pardoll, D. M., Taube, J. M. & Topalian, S. L. Sep 1 2016 In : Cancer Immunology Research. 4, 9, p. 726-733 8 p.

Research output: Research - peer-reviewArticle

Renal Cell Carcinoma
Gene Expression
Neoplasms
Therapeutics
Intrinsic Factor

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

Mathios, D., Park, C. K., Marcus, W. D., Alter, S., Rhode, P. R., Jeng, E. K., Wong, H. C., Pardoll, D. M. & Lim, M. Jan 1 2016 In : International Journal of Cancer. 138, 1, p. 187-194 8 p.

Research output: Research - peer-reviewArticle

Interleukin-15
Glioblastoma
Survival
Therapeutics
ALT-803

Tumor regression and allograft rejection after administration of anti-PD-1

Lipson, E. J., Bagnasco, S. M., Moore, J., Jang, S., Patel, M. J., Zachary, A. A., Pardoll, D. M., Taube, J. M. & Drake, C. G. Mar 3 2016 In : New England Journal of Medicine. 374, 9, p. 896-898 3 p.

Research output: Research - peer-reviewArticle

2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Cancer and Immune System: Basic Concepts and Targets for Intervention

Pardoll, D. Aug 1 2015 In : Seminars in Oncology. 42, 4, p. 523-538 16 p.

Research output: Research - peer-reviewArticle

Immune System Phenomena
Neoplasms
Vaccination
Vaccines
T-Lymphocytes

Combination immunotherapy: Where do we go from here?

Overacre, A. E., Kurtulus, S., Sznol, M., Pardoll, D. M., Anderson, A. & Vignali, D. A. A. Aug 18 2015 In : Journal for ImmunoTherapy of Cancer. 3, 1, 38

Research output: Research - peer-reviewArticle

Immunotherapy
Neoplasms
Education
Research
Therapeutics

Concepts of immunotherapy for glioma

Patel, M. A. & Pardoll, D. M. Jul 23 2015 In : Journal of Neuro-Oncology. 123, 3, p. 323-330 8 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Glioma
Immunotherapy
Therapeutics
Neoplasms

Consensus nomenclature for CD8+ T cell phenotypes in cancer

Apetoh, L. , Smyth, M. J. , Drake, C. G. , Abastado, J. P. , Apte, R. N. , Ayyoub, M. , Blay, J. Y. , Bonneville, M. , Butterfield, L. H. , Caignard, A. , Castelli, C. , Cavallo, F. , Celis, E. , Chen, L. , Colombo, M. P. , Comin-Anduix, B. , Coukos, G. , Dhodapkar, M. V. , Dranoff, G. , Frazer, I. H. & 39 others Fridman, W. H., Gabrilovich, D. I., Gilboa, E., Gnjatic, S., Jäger, D., Kalinski, P., Kaufman, H. L., Kiessling, R., Kirkwood, J., Knuth, A., Liblau, R., Lotze, M. T., Lugli, E., Marincola, F., Melero, I., Melief, C. J., Mempel, T. R., Mittendorf, E. A., Odun, K., Overwijk, W. W., Palucka, A. K., Parmiani, G., Ribas, A., Romero, P., Schreiber, R. D., Schuler, G., Srivastava, P. K., Tartour, E., Valmori, D., van der Burg, S. H., van der Bruggen, P., van den Eynde, B. J., Wang, E., Zou, W., Whiteside, T. L., Speiser, D. E., Pardoll, D. M., Restifo, N. P. & Anderson, A. C. 2015 In : OncoImmunology. 4, 4

Research output: Research - peer-reviewArticle

Terminology
T-Lymphocytes
Phenotype
Neoplasms
Tumor Microenvironment

Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: Implications for PD-1 pathway blockade

Taube, J. M., Young, G. D., McMiller, T. L., Chen, S., Salas, J. T., Pritchard, T. S., Xu, H., Meeker, A. K., Fan, J., Cheadle, C., Berger, A. E., Pardoll, D. M. & Topalian, S. L. Sep 1 2015 In : Clinical Cancer Research. 21, 17, p. 3969-3976 8 p.

Research output: Research - peer-reviewArticle

Regulator Genes
Melanoma
Neoplasms
Antigen Presentation
Immunosuppression

Distinct Mechanisms of Tumor Resistance to NK Killing: Of Mice and Men

Pardoll, D. M. Apr 21 2015 In : Immunity. 42, 4, p. 605-606 2 p.

Research output: Research - peer-reviewArticle

Innate Immunity
Natural Killer Cells
Ligands
Neoplasms
Natural Killer Cell Receptors

Expression profile and in vitro blockade of programmed death-1 in human papillomavirus-negative head and neck squamous cell carcinoma

Malm, I. J., Bruno, T. C., Fu, J., Zeng, Q., Taube, J. M., Westra, W., Pardoll, D., Drake, C. G. & Kim, Y. J. 2015 In : Head and Neck. 37, 8, p. 1088-1095 8 p.

Research output: Research - peer-reviewArticle

Neoplasms
In Vitro Techniques
Carcinoma, squamous cell of head and neck
Ligands
Therapeutics

Immune checkpoint blockade: A common denominator approach to cancer therapy

Topalian, S. L., Drake, C. G. & Pardoll, D. M. Apr 13 2015 In : Cancer Cell. 27, 4, p. 451-461 11 p.

Research output: Research - peer-reviewArticle

Neoplasms
Therapeutics
Pharmaceutical Preparations
Self Tolerance
Antigen-Antibody Complex

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Chiappinelli, K. B. , Strissel, P. L. , Desrichard, A. , Li, H. , Henke, C. , Akman, B. , Hein, A. , Rote, N. S. , Cope, L. M. , Snyder, A. , Makarov, V. , Buhu, S. , Slamon, D. J. , Wolchok, J. D. , Pardoll, D. M. , Beckmann, M. W. , Zahnow, C. A. , Mergoub, T. , Chan, T. A. , Baylin, S. B. & 1 others Strick, R. Aug 27 2015 In : Cell. 162, 5, p. 974-986 13 p.

Research output: Research - peer-reviewArticle

Endogenous Retroviruses
Double-Stranded RNA
DNA Methylation
Interferons
Neoplasms

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, D. M., Pan, F., Priel, A., Clish, C. B., Robson, S. C. & Quintana, F. J. Jun 9 2015 In : Nature Medicine. 21, 6, p. 638-646 9 p.

Research output: Research - peer-reviewArticle

Aryl Hydrocarbon Receptors
Regulatory T-Lymphocytes
Cell Differentiation
Hypoxia
T-cells

Metabolism links bacterial biofilms and colon carcinogenesis

Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., Santidrian, A. F., Felding, B. H., Ivanisevic, J., Cho, K., Wick, E. C., Hechenbleikner, E. M., Uritboonthai, W., Goetz, L., Casero, R. A., Pardoll, D. M., White, J. R., Patti, G. J., Sears, C. L. & Siuzdak, G. Jun 2 2015 In : Cell Metabolism. 21, 6, p. 891-897 7 p.

Research output: Research - peer-reviewArticle

Biofilms
Colon
Carcinogenesis
Neoplasms
Colonic Neoplasms

Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer

Gettinger, S. N. , Horn, L. , Gandhi, L. , Spigel, D. R. , Antonia, S. J. , Rizvi, N. A. , Powderly, J. D. , Heist, R. S. , Carvajal, R. D. , Jackman, D. M. , Sequist, L. V. , Smith, D. C. , Leming, P. , Carbone, D. P. , Pinder-Schenck, M. C. , Topalian, S. L. , Hodi, F. S. , Sosman, J. A. , Sznol, M. , McDermott, D. F. & 9 others Pardoll, D. M., Sankar, V., Ahlers, C. M., Salvati, M., Wigginton, J. M., Hellmann, M. D., Kollia, G. D., Gupta, A. K. & Brahmer, J. R. Jun 20 2015 In : Journal of Clinical Oncology. 33, 18, p. 2004-2012 9 p.

Research output: Research - peer-reviewArticle

Non-Small Cell Lung Carcinoma
Safety
Survival
Antibodies
nivolumab

PD-1 blockade in tumors with mismatch-repair deficiency

Le, D. T. , Uram, J. N. , Wang, H. , Bartlett, B. R. , Kemberling, H. , Eyring, A. D. , Skora, A. D. , Luber, B. S. , Azad, N. S. , Laheru, D. , Biedrzycki, B. , Donehower, R. C. , Zaheer, A. , Fisher, G. A. , Crocenzi, T. S. , Lee, J. J. , Duffy, S. M. , Goldberg, R. M. , De La Chapelle, A. , Koshiji, M. & 15 others Bhaijee, F., Huebner, T., Hruban, R. H., Wood, L. D., Cuka, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Zhou, S., Cornish, T. C., Taube, J. M., Anders, R. A., Eshleman, J. R., Vogelstein, B. & Diaz, L. A. Jun 25 2015 In : New England Journal of Medicine. 372, 26, p. 2509-2520 12 p.

Research output: Research - peer-reviewArticle

DNA Mismatch Repair
Neoplasms
Turcot syndrome
Colorectal Neoplasms
Disease-Free Survival

PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation

Rodic, N., Anders, R. A., Eshleman, J. R., Lin, M. T., Xu, H., Kim, J. H., Beierl, K., Chen, S., Luber, B. S., Wang, H., LTopalian, S., Pardoll, D. M. & Taube, J. M. Feb 1 2015 In : Cancer immunology research. 3, 2, p. 110-115 6 p.

Research output: Research - peer-reviewArticle

Melanoma
Mutation
Tumor-Infiltrating Lymphocytes
Melanocytes
Cell Line

Regulatory T-cell response to enterotoxigenic bacteroides fragilis colonization triggers IL17-dependent colon carcinogenesis

Geis, A. L., Fan, H., Wu, X., Wu, S., Huso, D. L., Wolfe, J. L., Sears, C. L., Pardoll, D. M. & Housseau, F. Oct 1 2015 In : Cancer Discovery. 5, 10, p. 1098-1109 12 p.

Research output: Research - peer-reviewArticle

Bacteroides fragilis
Regulatory T-Lymphocytes
Colon
Carcinogenesis
Inflammation

Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

Lipson, E. J., Sharfman, W. H., Chen, S., McMiller, T. L., Pritchard, T. S., Salas, J. T., Sartorius-Mergenthaler, S., Freed, I., Ravi, S., Wang, H., Luber, B., Sproul, J. D., Taube, J. M., Pardoll, D. M. & Topalian, S. L. Jul 5 2015 In : Journal of Translational Medicine. 13, 1, 214

Research output: Research - peer-reviewArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Melanoma
Vaccines
Safety
Therapeutics

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., Sivick, K. E., Zeng, Q., Soares, K. C., Zheng, L., Portnoy, D. A., Woodward, J. J., Pardoll, D. M., Dubensky, T. W. & Kim, Y. Apr 15 2015 In : Science Translational Medicine. 7, 283, 283ra52

Research output: Research - peer-reviewArticle

Cancer Vaccines
Interferons
Genes
Neoplasms
T-Lymphocytes

Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab

McDermott, D. F., Choueiri, T. K., Puzanov, I., Hodi, S., Drake, C. G., Brahmer, J. R., Hammers, H. J., Topalian, S. L., Pardoll, D. M., Sznol, M., Powderly, J. D., Smith, D. C., Carvajal, R. D., Wigginton, J. M., Kollia, G. D., Gupta, A., McDonald, D., Sankar, V., Sosman, J. A. & Atkins, M. B. Jun 20 2015 In : Journal of Clinical Oncology. 33, 18, p. 2013-2020 8 p.

Research output: Research - peer-reviewArticle

Patient Safety
Renal Cell Carcinoma
Survival
nivolumab
Therapeutics

The bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., Platz, E. A., Pardoll, D. M. & Sears, C. L. Jan 15 2015 In : Clinical Infectious Diseases. 60, 2, p. 208-215 8 p.

Research output: Research - peer-reviewArticle

Colorectal Neoplasms
Colon
Mucous Membrane
Genes
Bacteroides fragilis toxin

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

Llosa, N. J., Cruise, M., Tam, A., Wicks, E. C., Hechenbleikner, E. M., Taube, J. M., Blosser, R. L., Fan, H., Wang, H., Luber, B. S., Zhang, M., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Sears, C. L., Anders, R. A., Pardoll, D. M. & Housseau, F. 2015 In : Cancer Discovery. 5, 1, p. 43-51 9 p.

Research output: Research - peer-reviewArticle

Microsatellite Repeats
Colonic Neoplasms
Neoplasms
Microsatellite Instability
Cytotoxic T-Lymphocytes

Tissue matrix arrays for high-throughput screening and systems analysis of cell function

Beachley, V. Z., Wolf, M. T., Sadtler, K., Manda, S. S., Jacobs, H., Blatchley, M. R., Bader, J. S., Pandey, A., Pardoll, D. & Elisseeff, J. H. Dec 1 2015 In : Nature Methods. 12, 12, p. 1197-1204 8 p.

Research output: Research - peer-reviewArticle

Screening
Systems analysis
Throughput
Tissue
Systems Analysis

Ubiquitin-dependent regulation of Foxp3 and Treg function

Barbi, J., Pardoll, D. M. & Pan, F. Jul 1 2015 In : Immunological Reviews. 266, 1, p. 27-45 19 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Ubiquitin
Transcription Factors
Therapeutics
Transcriptome
2014
Cancer Vaccines
Feasibility Studies
Granulocyte-Macrophage Colony-Stimulating Factor
Colonic Neoplasms
Colorectal Neoplasms
Tumor Microenvironment
Ligands
Neoplasms
Therapeutics
Renal Cell Carcinoma
Tumor Burden
Melanoma
DNA
Neoplasms
Therapeutics

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model

Belcaid, Z., Phallen, J. A., Zeng, J., See, A. P., Mathios, D., Gottschalk, C., Nicholas, S., Kellett, M., Ruzevick, J., Jackson, C., Albesiano, E., Durham, N. M., Ye, X., Tran, P. T., Tyler, B., Wong, J. W., Brem, H., Pardoll, D. M., Drake, C. G. & Lim, M. Jul 11 2014 In : PLoS One. 9, 7, e101764

Research output: Research - peer-reviewArticle

lymphocyte antigens
cytotoxic T-lymphocytes
radiotherapy
antigens
therapeutics